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| 1 | Recent advances in bone regeneration using adult stem cells显示文摘Bone is a highly vascularized tissue reliant on the close spatial and temporal association between bloodvessels and bone cells. Therefore, cells that participate in vasculogenesis and osteogenesis play a pivotal role in bone formation during prenatal and postnatal periods. Nevertheless, spontaneous healing of bone fracture is occasionally impaired due to insufficient blood and cellular supply to the site of injury. In these cases, bone regeneration process is interrupted, which might result in delayed union or even nonunion of the fracture. Nonunion fracture is difficult to treat and have a high financial impact. In the last decade, numerous technological advancements in bone tissue engineering and cell-therapy opened new horizon in the field of bone regeneration. This review starts with presentation of the biological processes involved in bone development, bone remodeling, fracture healing process and the microenvironment at bone healing sites. Then, we discuss the rationale for using adult stem cells and listed the characteristics of the available cells for bone regeneration. The mechanism of action and epigenetic regulations for osteogenic differentiation are also described. Finally, we review the literature for translational and clinical trials that investigated the use of adult stem cells(mesenchymal stem cells, endothelial progenitor cells and CD34+ blood progenitors) for bone regeneration. | Hadar Zigdon-Giladi Utai Rudich Gal Michaeli Geller Ayelet Evron | 2015 | World Journal of Stem Cells2015，7，3： | 9 |
| 2 | Laparoscopic Cholecystectomy in the Cirrhotic Patient: Predictors of Outcome显示文摘 | Ralph C. Quillin Justin M. Burns Jaime A. Pineda Dennis Hanseman Steven M. Rudich Michael J. Edwards Amit D. Tevar | 2012 | Surgery2012，，： | 2 |
| 3 | The formation, properties and impact of secondary organic aerosol: current and emerging issues显示文摘 | Hallquist M. Wenger J. C. Baltensperger U. Rudich Y. Simpson D. Claeys M. Dommen J. Donahue N. M. George C. Goldstein A. H. Hamilton J. F. Herrmann H. Hoffmann T. Iinuma Y. Jang M. Jenkin M. E. Jimenez J. L. Kiendler-Scharr A. Maenhaut W. McFiggans G. Men | 2009 | Atmospheric Chemistry and Physics2009，，173： | 2 |
| 4 | Experience with more than 500 minimally invasive hepatic procedures显示文摘 | Buell JF Thomas MT Rudich S | 2008 | Ann Surg2008，248，3： | 1 |
| 5 | Treating clouds with a grain of salt 显示文摘 | Rudich Y Khersonsky O Rosenfeld D | 2002 | Geophys Res Lett2002，29，22： | 1 |
| 6 | Are normal narcissists psychologically healthy self-esteem matters显示文摘 | Sedikides C Rudich E A Gregg A P | 2004 | Journal of personal- ity and social psychology2004，87，3： | 1 |
| 7 | Dietary Intervention to Reverse Carotid Atherosclerosis显示文摘 | Iris Shai J. David Spence Dan Schwarzfuchs Yaakov Henkin Grace Parraga Assaf Rudich Aaron Fenster Christiane Mallett Noah Liel-Cohen Amir Tirosh Arkady Bolotin Joachim Thiery Georg Martin Fiedler Matthias Blüher Michael Stumvoll Meir J. Stampfer | 2010 | Circulation2010，，10： | 1 |
| 8 | Auxin, biosynthesis of ethylene and sex expression in cucumber (Cucumis sativus)显示文摘 | Trebitsh T Rudich J Riov J | 1987 | Plant Growth Regulation1987，5，2： | 1 |
| 9 | Distinct and sequential up-regulation of genes regulating cell growth and cell cycle progression during hepatic ischemia-reperfusion injury显示文摘 | Barone S Okaya T Rudich S | 2005 | Am J Physiol Cell Physiol2005，289，4： | 1 |
| 10 | Peroxidase and IAA oxidase activity an d isoenzyme patterns in encumber plants, as aftcted by sex expression and ethephon显示文摘 | Retig N Rudich J | 1972 | Physiologia Plantarum1972，27，2： | 1 |
| 11 | Orthotopic liver transplanta- tion from a donor with a history of schistosomiasis显示文摘 | Kayler LK Rudich SM Merion RM | 2003 | Transplant Proc2003，35，8： | 1 |
| 12 | Desert dust suppressing precipitation:a possible desertification feedback loop显示文摘 | Rudich Y Lahav R | 2001 | Proceedings of the National Academy of Science2001，98，11： | 1 |
| 13 | Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells显示文摘 | PATEL N RUDICH A KHAYAT Z A | 2003 | Mol Cell Biol2003，23，13： | 1 |
| 14 | Distinct long-term of glycerol and non-esterified fatty acid release by insulin and TNF-in 3T3-L1 adipacytes显示文摘 | Rosenstock M Greenberg AS Rudich A | 2000 | Diabetologia2000，44，： | 1 |
| 15 | Prolonged oxidative stress impairs insulin-induced GLUT4translocation in 3T3-L1 adipocytes显示文摘 | Rudich A Tirosh A Potashnik R | 1998 | Diabetes1998，47，： | 1 |
| 16 | The role of BrNO3 in marine tropospheric chemistry: A model study 显示文摘 | Sander R Rudich Y yon Glasow R | 1999 | Geophysics of Research Letter1999，26，： | 1 |
| 17 | Lipoic acid protects against oxidative stress induced impairment in insulin stimulation of protein kinase B and glucose transport in 3T3-LI adipoeytes 显示文摘 | Rudich A Tirosh A Potashnik R | 1999 | Diabetologia1999，42，8： | 1 |
| 18 | Effect of leaf age and shading on photosynthesis in potatoes (Solanum tuberosum)显示文摘 | Olesinski A A Wolf S Rudich J Marani A | 1989 | Annuals of Botany1989，64，6： | 1 |
| 19 | Changed sex expres- sion and possibilities for F1 hybrid seed production in some cucurbits by application of Ethrel and Alar (B - 995 ) 显示文摘 | Rudich J Kedar N Halevy A H | 1970 | Euphytica1970，19，： | 1 |
| 20 | Genotypic variation for sensitivity to high temperature in tomato: pollination and fruit set显示文摘 | Rudich J | 1977 | Bot Gaz1977，138，： | 1 |
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