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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | The paternal epigenome and embryogenesis: poising mechanisms for development显示文摘父亲的贡献的范围长在早胚胎的开发期间被认为有限。在在整个精子发生的染色质结构的戏剧的变化被认为在 DNA 蓝图上 epigenetic 规定的复杂的层让精子空,因此把那条规定的平衡留给卵母细胞。然而, epigenetics 和男因素不孕的地里的最近的工作放了这长抓住、现在争论的教义,在一盏新灯。在发展中的精子房间调查染色质和 epigenetic 修正的漂亮研究提供了可以在发展中的胚胎为父亲的 epigenome 建立一个更关键的角色的新卓见。进染色质的 DNA methylation, histone 尾巴修正,指向的 histone 保留和鱼精朊加入在发展中的精子房间有大影响。在任何这些 epigenetic 标记的建立或维护的不安被表明了影响富饶地位,在严厉从变化对温和灾难。精子要求染色质的这个无数的结构的变化不仅在整个精子发生和未来交货起一个保护的作用到 DNA 到卵,而且,它出现,贡献未来胚胎的发展节目。这评论将集中于我们精子的 epigenetics 的当前的理解。我们将讨论导致对开发必要的基因在胚胎的开发,其混乱可以导致减少的肥沃早为激活被平衡的精子特定的染色质修正。 | Timothy G Jenkins Douglas T Carrell | 2011 | Asian Journal of Andrology2011，13，1： | 14 |
| 3 | 老化沥青胶结料的疲劳特性研究显示文摘采用动态剪切流变仪(DSR)研究了短期老化与长期老化的沥青胶结料在应变模式,应力模式下的抗疲劳性能.实验中,采用了旋转薄膜烘箱实验(RTFOT)及压力老化(PAV)来模拟沥青胶结料的短期及长期老化.沥青胶结料的应变疲劳实验中选取1.0%,1.5%,2.0%以及2.5%四个应变值,应力疲劳实验中选取了0.25,0.35,0.45,0.55MPa 4个应力值.实验结果表明,采用应变疲劳实验能够区别老化对沥青抗疲劳性能的影响,而应力疲劳并不能很好的显示老化对沥青抗疲劳性能的影响.因此,应变模式下的疲劳实验更适合用来评价老化沥青胶结料的抗疲劳性能. | 吴少鹏 江承建 林俊涛 KIN Jenkins 朱祖煌 | 2013 | 武汉理工大学学报(交通科学与工程版)2013，37，3： | 14 |
| 4 | Environment as the Stage for Economic Actors显示文摘The relative importance of economics and environment in debate may soon be reversed due to the influence of three fac- tors. Firstly, in the global economy it is hard to hide the unwanted products of economic processes. Secondly, huge advances in sci- ence will reduce the imperfect knowledge of markets, making some monitoring and analyzing tools show the design of sensible and equitable livelihood in communities, which is more important than the motivation of maximising profits for some individuals or firms. Thirdly, China, as the last major player on the planet to take on economic growth, comes from traditions fundamentally differ- ent from those economies that have experienced the Industrial Revolution previously. Its challenges with sustainability and en- vironmental conservation predate Western economics by millennia, and it is implementing policies domestically and starting to work on the world stage that acknowledges that the surroundings are the host for any economic and socio-political system. | John E Coulter Shi Lei Samantha Jenkins | 2007 | Chinese Journal of Population,Resources and Environment2007，5，1： | 10 |
| 5 | 激光诊断技术在脉冲爆震发动机研究中的应用显示文摘在美国海军研究生院及斯坦福大学的脉冲爆震发动机 (PDE)模型上 ,应用两种新发展的二极管激光诊断技术———光吸收 /高温辐射组合测定法和多路复合可调二极管激光 (TDL)技术 ,测量了其中的温度、各燃烧产物组分等重要参数 ,并与传统方法所得结果进行对比 ,说明新方法可靠、准确 ,适合爆震燃烧流场这种特殊环境 ,测量精度更高 ,而且更加简便。 | 范玮 Jenkins TP Sanders ST Hanson RK | 2001 | 推进技术2001，22，4： | 10 |
| 6 | 自动化实时监测系统在中国台湾高速铁路浅埋隧道的应用显示文摘中国台湾高速铁路新竹二高隧道以覆土深度9~12m穿越台湾北部第二高速公路。为了考虑高速公路下方隧道穿越施工时的行车安全,采用自动化监测系统,监控隧道施工产生之顶部路面沉降与隧道侧墙土层之变位。监测系统采用捷仪工程科技公司GeoAuto自动化实时监测软件系统,该系统分前端、中端、后端三部分。前端部分在隧道顶部沿隧道方向安装有自动量测水平倾斜计、在隧道两侧各安装有自动量测垂直倾斜计与伸张仪,另沿高速公路方向安装3排路面沉降点以全站仪自动监测,前述各类仪器皆连接至资料集录器;中端部分为ADSL、直接联机与无线传输等方式进行数据传输;后端部分为GeoAuto自动监测软件系统,所有路面沉降、土层变位等现场数据,皆由前端仪器量测、经中端传输,最后将所有现场有关沉降、变位等数据,皆显现于后端电脑显示器上。在自动监测系统配合下,有效协助浅埋隧道凿进,顺利完成隧道施工。 | Goh K.S.James Jenkins Paul 黄育君 郎剑 | 2007 | 铁道标准设计2007，，z1： | 10 |
| 7 | Interaction of the Arabidopsis UV-B-Specific Signaling Component UVR8 with Chromatin显示文摘Arabidopsis 紫外抵抗 LOCUS8 (UVR8 ) 是表明调整担心紫外保护的基因的一个范围的表示的部件的 UV-B-specific。这里,我们与染色质调查 UVR8 的相互作用。用对在染色质 immunoprecipitation (薄片) 的 UVR8 特定的抗体有野类型的植物的试金,我们证明本国的 UVR8 在 vivo 绑在染色质。用有表示 GFPUVR8 熔化的植物的 anti-GFP 抗体的类似的实验证明 UVR8 与包含 HY5 基因的染色质的一个相对小的区域联系。UVR8 与包含另外的基因的倡导者区域的染色质交往,然而并非与所有基因,它调整。因为有几基因 loci 的协会当 UV-B 不在时被观察, UV-B 没为和染色质的 UVR8 的相互作用被要求。下拉试金证明有在 vivo 和比赛实验的 histones 的 UVR8 伙伴显示相互作用是优先地与 histone H2B。用认出特定的 histone 修正的抗体的薄片实验显示一些基因的 UV-B-stimulated 抄写可以与 histone 修正被相关。特别地, ELIP1 倡导者显示出跟随 UV-B 暴露的 diacetyl histone H3 (K9/K14 ) 的重要丰富。有染色质的关键 UV-B-specific 管理者 UVR8 的相互作用的这些调查结果增加理解。 | Catherine Cloix Gareth I. Jenkins | 2008 | Molecular Plant2008，1，1： | 9 |
| 8 | Tibetan Plateau Geladaindong black carbon ice core record(1843-1982):Recent increases due to higher emissions and lower snow accumulation显示文摘Black carbon(BC) deposited on snow and glacier surfaces can reduce albedo and lead to accelerated melt. An ice core recovered from Guoqu glacier on Mt. Geladaindong and analyzed using a Single Particle Soot Photometer(SP2) provides the ?rst long-term(1843-1982) record of BC from the central Tibetan Plateau. Post 1940 the record is characterized by an increased occurrence of years with above average BC, and the highest BC values of the record. The BC increase in recent decades is likely caused by a combination of increased emissions from regional BC sources, and a reduction in snow accumulation. Guoqu glacier has received no net ice accumulation since the 1980 s, and is a potential example of a glacier where an increase in the equilibrium line altitude is exposing buried high impurity layers. That BC concentrations in the uppermost layers of the Geladaindong ice core are not substantially higher relative to deeper in the ice core suggests that some of the BC that must have been deposited on Guoqu glacier via wet or dry deposition between 1983 and 2005 has been removed from the surface of the glacier, potentially via supraglacial or englacial meltwater. | Matthew JENKINS Susan KASPARI KANG Shi-Chang Bjorn GRIGHOLM Paul A.MAYEWSKI | 2016 | Advances in Climate Change Research2016，7，3： | 8 |
| 9 | 2007北京国际全科医学学术峰会会议摘登——美国家庭医生的工作原则和能力显示文摘2007北京国际全科医学学术峰会于3月31日~4月1日召开,众多国内外专家出席了本次大会并发表了精彩演讲。本刊自2007年10卷8期开始连续摘登部分专家的演讲内容。 | Chris Jenkins 无 | 2007 | 中国全科医学2007，10，11： | 6 |
| 10 | Diagnostic and prognostic value of glycosyltransferase mRNA in glioblastoma multiforme patients.显示文摘 | Oblinger JL Pearl DK Boardman CL Saqr H Prior TW Scheithauer BW Jenkins RB Burger PC Yates AJ | 2006 | 中国神经肿瘤杂志2006，4，2： | 5 |
| 11 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 12 | Tetracycline-inducible protein expression in pancreatic cancer cells: Effects of CapG overexpression显示文摘AIM: To establish stable tetracycline-inducible pancreatic cancer cell lines. METHODS: Suit-2, MiaPaca-2, and Panc-1 cells were transfected with a second generation reverse tetracycline-controlled transactivator protein (rtTA2S-M2), under the control of either a cytomegalovirus (CMV) or a chicken β-actin promoter, and the resulting clones were characterised.RESULTS: Use of the chicken (β-actin) promoter proved superior for both the production and maintenance of doxycycline-inducible cell lines. The system proved versatile, enabling transient inducible expression of a variety of genes, including GST-P, CYP2E1, S100A6, and the actin capping protein, CapG. To determine the physiological utility of this system in pancreatic cancer cells, stable inducible CapG expressors were established. Overexpressed CapG was localised to the cytoplasm and the nuclear membrane, but was not observed in the nucleus. High CapG levels were associated with enhanced motility, but not with changes to the cell cycle, or cellular proliferation. In CapG-overexpressing cells, the levels and phosphorylation status of other actin-moduating proteins (Cofilin and Ezrin/Radixin) were not altered. However, preliminary analyses suggest that the levels of other cellular proteins, such as ornithine aminotransferase and enolase, are altered upon CapG induction. CONCLUSION: We have generated pancreatic-cancer derived cell lines in which gene expression is fully controllable. | Sarah Tonack Sabina Patel Mehdi Jalali Taoufik Nedjadi Rosalind E Jenkins Christopher Goldring John Neoptolemos Eithne Costello | 2011 | World Journal of Gastroenterology2011，17，15： | 4 |
| 13 | Outcome predictors for severely brain-injured patients directly admitted or transferred from emergency departments to a trauma center显示文摘Dear editor,After sustaining severe traumatic brain injury(TBI),patients frequently require invasive mechanical ventilation(MV).However,up to 26%of patients require tracheostomy due to failure to wean from the ventilator.[1]The decision of when to perform tracheostomy is important as it balances the risk between avoiding prolonged MV and avoiding risk of tracheostomy.Early predictors for tracheostomy,i.e.,clinical factors when patients first present to an Emergency Department after trauma or when patient fi rst arrive at a regional trauma center,can help clinicians’medical decision-making process. | Ryne Jenkins Nicholas A.Morris Bryce Haac Richard Van Besien Deborah MStein Neeraj Badjatia Amir Medic Gaurika Mester Quincy K.Tran | 2020 | World Journal of Emergency Medicine2020，11，2： | 4 |
| 14 | Molecular diagnostics in a teacup:Non-Instrumented Nucleic Acid Amplification(NINA) for rapid,low cost detection of Salmonella enterica显示文摘We report on the use of a novel non-instrumented platform to enable a Loop Mediated isothermal Amplification(LAMP) based assay for Salmonella enterica.Heat energy is provided by addition of a small amount(<150 g) of boiling water,and the reaction temperature is regulated by storing latent energy at the melting temperature of a lipid-based engineered phase change material.Endpoint classification of the reaction is achieved without opening the reaction tube by observing the fluorescence of sequence-specific FRET-based assimilating probes with a simple handheld fluorometer.At or above 22℃ ambient temperature the non-instrumented devices could maintain reactions above a threshold temperature of 61℃ for over 90 min-significantly longer than the 60 min reaction time.Using the simple format,detection limits were less than 20 genome copies for reactions run at ambient temperatures ranging from 8 to 36℃.When used with a pre-enrichment step and non-instrumented DNA extraction device,trace contaminations of Salmonella in milk close to 1 CFU/mL could be reliably detected.These findings illustrate that the non-instrumented amplification approach is a simple,viable,low-cost alternative for field-based food and agricultural diagnostics or clinical applications in developing countries. | KUBOTA Ryo LABARRE Paul WEIGL Bernhard H LI Yong HAYDOCK Paul JENKINS Daniel M | 2013 | Chinese Science Bulletin2013，58，10： | 4 |
| 15 | Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype显示文摘AIM To identify whether Cp G island methylator phenotype(CIMP) is predictive of response to neoadjuvant chemoradiotherapy(NACRT) and outcomes in rectal cancer.METHODS Patients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status(high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined uponhistological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed.RESULTS There were 160 patients analysed with a median followup time of 46.4 mo. Twenty-one(13%) patients demonstrated high levels of CIMP methylation(CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion(EMVI) compared with CIMP-L [8/21(38%) vs 15/99(15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival(P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation(P = 0.01). There were 14(9%) patients with a pathological complete response(pC R) compared to 116(73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pC R had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant(P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced 'T' stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurrence.CONCLUSION We report a novel association of pre-treatment characterisation of CIMP-H with EMVI status which has prognostic implications and is not readily detectable on pre-treatment histological examination. | Jeremy Stuart Williamson Huw Geraint Jones Namor Williams Anthony Paul Griffiths Gareth Jenkins John Beynon Dean Anthony Harris | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 4 |
| 16 | Identification of Differentially Expressed Genes Associated with Cotton Fiber Development in a Chromosomal Substitution Line(CS-B22sh)显示文摘One of the impediments in the genetic improvement of cotton fiber is the paucity of information about genes associated with fiber development.Availability of chromosome arm substitution line CS- | SOLIMAN Khairy M BOLTON James J SAHA Sukumar JENKINS Johnie N | 2008 | 棉花学报2008，20，S1： | 4 |
| 17 | Meeting population needs for mental health --the Chinese example显示文摘 | Rachel JENKINS | 2012 | 上海精神医学2012，24，3： | 4 |
| 18 | “本族语特性”与可理解性:浅析跨文化交际中英语作为通用语的使用经历对中国英语使用者的语言态度之影响(英文)显示文摘本文旨在考察以使用英语作为通用语的跨文化交际对于语言态度的影响,着眼于中国的英语使用者如何描述跨文化交际中的英语使用,从而探讨中国使用者如何看待多种英语。研究数据涉及769份问卷调查以及35个访谈,表明了在跨文化交际中使用英语作为通用语的经历会从四个方面对研究对象的语言态度产生影响。首先,缺乏跨文化交际体验,会促使人迷信英语本族语使用规范是保证跨文化交流的必须条件;其次,跨文化交际中使用英语作为通用语的经历能够激励研究对象去质疑本族语特性与可理解性之间的必然联系;再次,跨文化交际中的英语使用经历促使人去审视本族语英语与成功的跨文化交际之间的绝对相关性;最后,跨文化交际中的英语使用经历有助于培养跨文化交际策略意识,继而成功应对英语多样化环境中的跨文化交际。这四个方面所表现出来的语言态度都折射出研究对象对于什么是可理解的英语的考虑。本文考虑了语言的可理解性与(非)本族语特性之间的联系,以及跨文化交际在理解这种联系中所起的作用,从而探讨对教学的启示。 | 王颖 Jennifer JENKINS | 2016 | Chinese Journal of Applied Linguistics2016，39，1： | 4 |
| 19 | Analysis of the relationship between ambient levels of O 3 , NO 2 and NO as a function of NO x in the UK显示文摘 | Lynette J. Clapp Michael E. Jenkin | 2001 | Atmospheric Environment2001，，36： | 3 |
| 20 | Models for predicting flicker induced by large wind turbines显示文摘 | Saad-Saoud Z Jenkins N | 1999 | IEEE Trans on Energy Conversion1999，14，3： | 3 |
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