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| 1 | The Arabidopsis thaliana HAK5 K+ Transporter Is Required for Plant Growth and K+ Acquisition from Low K+ Solutions under Saline Conditions显示文摘在集中和它的部件的高亲密关系的范围的 K+ 举起广泛地被学习了。在 Arabidposis thaliana, AtHAK5 transporter 和 AtAKT1 隧道被显示了是涉及这个过程的主要运输蛋白质。这里,我们在二个重要压力条件下面学习这二个系统的角色:低 K+ 供应或咸度的存在。破坏 AtHAK5 和 AtAKT1 的 T-DNA 插入线为允许变异的线的生理的描述的长期的实验被采用。我们发现 AtHAK5 为必要的 K+ 吸收被要求在缺席以及面对咸度在低 K+ 支撑植物生长。咸度极大地减少了 AtHAK5 抄本层次并且支持了调停 AtAKT1 的 K+ 流出,导致 K+ 营养的一个重要缺陷。尽管有一个有限能力, AtHAK5 面对咸度从低 K+ 集中为 K+ 获得起一个主要作用。 | Manuel Nieves-Cordones Fernando Aleman Vicente Martinez Francisco Rubio | 2010 | Molecular Plant2010，3，2： | 17 |
| 2 | Genomic and genetic alterations influence the progression of gastric cancer显示文摘Gastric cancer is one of the leading causes of cancerrelated deaths worldwide, although the incidence has gradually decreased in many Western countries. Two main gastric cancer histotypes, intestinal and diffuse, are recognised. Although most of the described genetic alterations have been observed in both types, different genetic pathways have been hypothesized. Genetic and epigenetic events, including 1q loss of heterozygosity (LOH), microsatellite instability and hypermethylation, have mostly been reported in intestinal-type gastric carcinoma and its precursor lesions, whereas 17p LOH, mutation or loss of E-cadherin are more often implicated in the development of diffuse-type gastric cancer.In this review, we summarize the sometimes contradictory findings regarding those markers which influence the progression of gastric adenocarcinoma. | Stefania Nobili Lorenzo Bruno Ida Landini Cristina Napoli Paolo Bechi Francesco Tonelli Carlos A Rubio Enrico Mini Gabriella Nesi | 2011 | World Journal of Gastroenterology2011，17，3： | 17 |
| 3 | State of the Art on Micromilling of Materials,a Review显示文摘The trend towards miniaturization has increased dramatically over the last decade, especially within the fields concerned with bioengineering, microelectronics, and aerospace. Micromilling is among the principal manufacturing processes which have allowed the development of components possessing micrometric dimensions, being used to the manufacture of both forming tools and the final product. The aim of this work is to present the principal aspects related to this technology, with emphasis on the work material requirements, tool materials and geometry, cutting forces and temperature, quality of the finished product, process modelling and monitoring and machine tool requirements. It can be noticed that size effect possesses a relevant role with regard to the selection of both work material (grain size) and tooling (edge radius). Low forces and temperature are recorded during micromilling, however, the specific cutting force may reach high values because of the ploughing effect observed as the uncut chip thickness is reduced. Finally, burr formation is the principal concern with regard to the quality of the finished part. | M.A.Cmara J.C. Campos Rubio A.M. Abro J.P. Davim | 2012 | Journal of Materials Science & Technology2012，28，8： | 10 |
| 4 | 血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂的使用与2019冠状病毒疾病检测阳性之间的关系显示文摘血管紧张素转换酶抑制剂(angiotensin-converting enzyme inhibitor,ACEI)和血管紧张素受体拮抗剂(angiotensin receptor blocker,ARB)在2019新型冠状病毒疾病(coronavirus disease 2019,COVID-19)全球大流行背景下的作用备受争议。此类药物是治疗一些慢性病的必须药物,有建议停止使用这些药物. | Mehta N KalraA Nowacki AS Anjewierden S Han Z Bhat p Rubio AEC Jacob M Procop GW Harrington S Milinovich A Svensson LG Jehi L Young JB Chung MK 周卫(译) 叶鹏(校) | 2020 | 中华高血压杂志2020，28，5： | 9 |
| 5 | Prefoldins Negatively Regulate Cold Acclimation in Arabidopsis thaliana by Promoting Nuclear Proteasome-Mediated HY5 Degradation显示文摘冷环境适应的过程是从适度的区域的许多植物在暴露于低不会结冻的温度以后增加他们的结冰忍耐的重要适应回答。这回答的正确发展依靠调整寒冷应答的基因的表示模式的很多个抄写因素的合适的累积。多重研究揭示了涉及支持这些抄写因素的累积的许多分子的机制。然而,有趣地,机制在控制如此的累积保证他们的足够的层次仍然保持大部分未知含有。在这个工作,我们证明 prefoldins (PFD ) 控制 HY5 的层次,有在由激活 anthocyanin 生合成的冷环境适应的一个关键角色的一个 Arabidopsis 抄写因素,响应低温度。在他们与 HY5 交往的地方,我们的结果证明在冷条件下面, PFD 通过 DELLA 依赖的机制积累进原子核,触发它的 ubiquitination 和随后的降级。接着, HY5 的降级将导致 anthocyanin 生合成变细,保证冷环境适应的精确发展。这些调查结果揭开为在对不能生活的压力的工厂回答的 PFD 的未预见到的原子功能。 | Carlos Perea-Resa Miguel A. Rodriguez-Milla Elisa Iniesto Vicente Rubio Julio Salinas | 2017 | Molecular Plant2017，10，6： | 8 |
| 6 | Modeling sarcomagenesis using multipotent mesenchymal stem cells显示文摘因为他们的唯一的性质,间充质的干细胞(MSC ) 代表最有希望的成年干细胞之一在临床的应用的一个宽数组全球正在被使用的 multipotent。总的来说,引人注目的证据支持前 vivo 的长期的安全扩展了人的 MSC,它不似乎自发地转变。然而,试验性的数据表明在 MSC 和癌症之间的一个连接,和 MSC 被报导了禁止或支持肿瘤生长取决于还未定义的条件。有趣地,稳固的证据为某些肉瘤基于转基因的老鼠和 MSC 的基因干预把这些房间放作为起源的最可能的房间。这个研究区域逐渐地正在被探索开发 sarcomagenesis 的精确基于 MSC 的模型,它将在关于间充质的癌症的病原学和致病提供更好的理解无疑是珍贵的,最后导致更特定的治疗的发展对开始肉瘤的房间指导了。不幸地,仍然,很少对位于 MSC 转变下面的机制被知道,进一步的研究被要求基于人的 MSC 开发真正的肉瘤模型。这里,我们包括地考察存在肉瘤的基于 MSC 的模型并且讨论导致 MSC 和 sarcomagenesis 的 tumoral 转变的最普通的机制。 | Rene Rodriguez Ruth Rubio Pablo Menendez | 2012 | Cell Research2012，22，1： | 8 |
| 7 | Feeder-free maintenance of hESCs in mesenchymal stem cell-conditioned media: distinct requirements for TGF-β and IGF-Ⅱ显示文摘 | Rosa Montes Gertrudis Ligero Laura Sanchez Purificacidn Catalina Teresa de la Cueva Ana Nieto Gustavo J Melen Ruth Rubio Javier Garcia-Castro Clara Bueno Pablo Menendez | 2009 | Cell Research2009，19，6： | 7 |
| 8 | The Study of Carbamoyl Phosphate Synthetase 1 Deficiency Sheds Light on the Mechanism for Switching On/Off the Urea Cycle显示文摘Carbamoyl phosphate synthetase 1(CPS1) deficiency(CPS1D) is an inborn error of the urea cycle having autosomal(2q34) recessive inheritance that can cause hyperammonemia and neonatal death or mental retardation. We analyzed the effects on CPS1 activity, kinetic parameters and enzyme stability of missense mutations reported in patients with CPS1 deficiency that map in the 20-k Da C-terminal domain of the enzyme. This domain turns on or off the enzyme depending on whether the essential allosteric activator of CPS1, N-acetylL-glutamate(NAG), is bound or is not bound to it. To carry out the present studies, we exploited a novel system that allows the expression in vitro and the purification of human CPS1, thus permitting site-directed mutagenesis. These studies have clarified disease causation by individual mutations, identifying functionally important residues, and revealing that a number of mutations decrease the affinity of the enzyme for NAG. Patients with NAG affinity-decreasing mutations might benefit from NAG site saturation therapy with N-carbamyl-Lglutamate(a registered drug, the analog of NAG). Our results, together with additional present and prior site-directed mutagenesis data for other residues mapping in this domain, suggest an NAG-triggered conformational change in the b4-a4 loop of the C-terminal domain of this enzyme. This change might be an early event in the NAG activation process. Molecular dynamics simulations that were restrained according to the observed effects of the mutations are consistent with this hypothesis, providing further backing for this structurally plausible signaling mechanism by which NAG could trigger urea cycle activation via CPS1. | Carmen Díez-Fernández José Gallego Johannes H?berle Javier Cervera Vicente Rubio | 2015 | Journal of Genetics and Genomics2015，42，5： | 7 |
| 9 | Effect of alcoholic extract of Lepidium meyenii (Maca) on testicular function in male rats显示文摘Aim: To evaluate the effect of the alcoholic extract of Lepidium meyenii (Maca) on the spermatogenesisin male rats. Methods: In Holtzman rats, Maca alcoholic extract (5 %) was given by oral route at doses of 48 mg/day or 96 mg/day for 7 days, 14 days and 21 days. Testicular function was assessed by measurements of lengths of different stages of seminiferous epithelia and by epididymal sperm count. Results: Ethanolic extract of Maca increased the length of stages IX-XI of seminiferous epithelium at treatment day 7, day 14 and day 21. Progression of spermatogenesis was evident only after day 21 when lengths of stages XII-XIV of seminiferous epithelium were increased; at day 7 and day 14, no important change in spermatogenesis was observed. Epididymal sperm count was increased with 48 mg/day at all times. With 96 mg/day an increase in sperm count was observed at day 7, but it was reduced at day 14 and day 21 of treatment. Serum testosterone levels were not affected. Conclusion: The alcoholic extract of Maca activates onset ant progression of spermatogenesis at 48 mg/day or 96 mg/day in rats. | Gustavo F. Gonzales Julio Rubio Arturo Chung Manuel Gasco León Villegas | 2003 | Asian Journal of Andrology2003，5，4： | 6 |
| 10 | Rheostatic Control of ABA Signaling through HOS15-Mediated OST1 Degradation显示文摘Dehydrating stresses trigger the accumulation of abscisic acid(ABA),a key plant stress-signaling hormone that activates Snf1-Related Kinases(SnRK2s)to mount adaptive responses.However,the regulatory circuits that terminate the SnRK2s signal relay after acclimation or post-stress conditions remain to be defined.Here,we show that the desensitization of the ABA signal is achieved by the regulation of OST1(SnRK2.6)protein stability via the E3-ubiquitin ligase HOS15.Upon ABA signal,HOS15-induced degradation of OST1 is inhibited and stabilized OST1 promotes the stress response.When the ABA signal terminates,protein phosphatases ABI1/2 promote rapid degradation of OST1 via HOS15.Notably,we found that even in the presence of ABA,OST1 levels are also depleted within hours of ABA signal onset.The unexpected dynamics of OST1 abundance are then resolved by systematic mathematical modeling,demonstrating a desensitizing feedback loop by which OST1-induced upregulation of ABI1/2 leads to the degradation of OST1.This model illustrates the complex rheostat dynamics underlying the ABA-induced stress response and desensitization. | Akhtar Ali Jae Kyoung Kim Masood Jan Haris Ali Khan Irfan Ullah Khan Mingzhe Shen Junghoon Park Chae Jin Lim Shah Hussain Dongwon Baek Kai Wang Woo Sik Chung Vicente Rubio Sang Yeol Lee Zhizhong Gong Woe Yeon Kim Ray ABressan Jose MPardo Dae-Jin Yun | 2019 | Molecular Plant2019，12，11： | 5 |
| 11 | Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease显示文摘BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively investigated.AIM To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and UC.METHODS Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of endoscopy.Disease location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were recorded.RESULTS In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,P<0.001,vs r=0.285,P=0.15 for the Simple Endoscopic Score for CD;and r=0.402,P=0.01 vs r=0.054 P=0.84 for Disease Activity Index).Finally,FL was significantly correlated with the diseased mucosal surface(colon-ileocolon>small bowel)and the number of inflamed colon segments.CONCLUSION FL and CRP separated disease severity categories with FL showing lower discriminating P-values.FL showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL levels.FL can accurately and timely characterize intestinal inflammation in IBD. | Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，5： | 4 |
| 12 | Serrated adenoma of the stomach:Case report and literature review显示文摘Gastric serrated adenomas are histologically characterized by protruding glands with lateral saw tooth-like indentations lined with stratified dysplastic cells containing abundant eosinophilic cytoplasm.Since the first case of gastric serrated adenoma found in 2001,18 additional cases have been reported.Gastric serrated adenomas have a particular proclivity to progress to invasive carcinoma;75% or 15 of the 20 cases now in record-including the present one-exhibited invasive carcinoma.The 20 th case of gastric serrated adenoma reported here differs from the preceding ones in as much as it evolved in a patient with Lynch syndrome,implying that this adenoma phenotype may develop not only sporadically but also in patients with hereditary traits. | Carlos A Rubio Jan Bjrk | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，5： | 4 |
| 13 | Ranibizumab for Diabetic Macular Edema显示文摘 | Quan Dong Nguyen David M. Brown Dennis M. Marcus David S. Boyer Sunil Patel Leonard Feiner Andrea Gibson Judy Sy Amy Chen Rundle J. Jill Hopkins Roman G. Rubio Jason S. Ehrlich | 2012 | Ophthalmology2012，，4： | 4 |
| 14 | 猪轮状病毒感染显示文摘轮状病毒是影响新生仔猪的几种重要的肠道致病因子之一。它们可导致仔猪爆发肠胃炎。病原学轮状病毒是一种RNA病毒,其特点是有一个二十面的衣壳结构(图1),衣壳外无覆盖物。研究表明,该病毒至少有7种不同的血清群(A、B、c、D、E、F和G血清群)。 | 马晓迪 Ana Carvajal Pedro Rubio Nistal | 2012 | 国外畜牧学(猪与禽)2012，，4： | 3 |
| 15 | Knockdown of OLA1,a regulator of oxidative stress response,inhibits motility and invasion of breast cancer cells显示文摘To explore the role of a novel Obg-like ATPase 1 (OLA1) in cancer metastasis,small interference RNA (siRNA) was used to knockdown the protein,and the cells were subjected to in vitro cell migration and invasion assays. Knockdown of OLA1 significantly inhibited cell migration and invasion in breast cancer cell line MDA-MB-231. The knockdown caused no changes in cell growth but affected ROS production. In wound-healing assays,decreased ROS in OLA1-knockdown cells were in situ associated with the cells’ decreased motile morphology. Further,treatment of N-acetylcysteine,a general ROS scavenger,blunted the motility and invasiveness of MDA-MB-231 cells,similar to the effect of OLA1-knockdown. These results suggest that knockdown of OLA1 inhibits breast cancer cell migration and invasion through a mechanism that involves the modulation of intracellular ROS levels. | Jia-wei ZHANG Valentina RUBIO Shu ZHENG Zheng-zheng SHI | 2009 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2009，10，11： | 3 |
| 16 | LJItrasensitive H2S gas sensors based on p-type WS2 hybrid materials显示文摘 | Georgies Alene Asrest Jose J. Baldovi Aron Dombovari Topias Jarvinen Gabriela Simone Lorite Melinda Mohl Andrey Shchukarev Alejandro Perez Paz Lede Xian Jyri-Pekka Mikkola Anita Lloyd Spetz Heli Jantunen Angel Rubio Krisztian Kordas | 2018 | Nano Research2018，11，8： | 3 |
| 17 | INMA-Sabadell队列中孕期双酚A及邻苯二甲酸酯暴露与胎儿发育的超声测量(续完)显示文摘暴露于ΣMWPm与任何胎儿大小或胎儿发育结局(见补充材料,表8)及所评估的出生结局(表2及补充材料表S7)都没有显著相关性。代谢物MnBP与12-20孕周HC增长降低有显著相关性(-4.88%;95%CI:-8.36,-1.36),且与EFW增长减低也有显著相关性(-4.32%;95%CI:-8.33,-0.27)(图3及补充材料表S8)。 | Maribel Casas Damaskini Valvi Ana Ballesteros-Gomez Mireia Gascon Mariana F.Fernández Raquel Garcia-Esteban Carmen I?iguez David Martínez Mario Murcia Nuria Monfort Noelia Luque Soledad Rubio Rosa Ventura Jordi Sunyer Martine Vrijheid 袁亚群(翻译) 金泰廙(审校) | 2016 | 环境与职业医学2016，33，9： | 3 |
| 18 | Germanene: a novel two-dimensional germanium allotrope akin to graphene and silicene显示文摘 | M E Dávila L Xian S Cahangirov A Rubio G Le Lay | 2014 | New Journal of Physics2014，，： | 3 |
| 19 | Study and Characterization of Organically Modified Silica-Zirconia Anti-Graffiti Coatings Obtained by Sol-Gel显示文摘 | M. Rosario Elvira M. Alejandra Mazo Aitana Tamayo Fausto Rubio Juan Rubio Jose Luis Oteo | 2013 | Journal of Chemistry and Chemical Engineering2013，7，2： | 2 |
| 20 | Dead-time compensation for ABR traffic control over ATM networks显示文摘 | Gomez S F Fornes J M Rubio F R | 2002 | Control Engineering Practice2002，10，5： | 2 |
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