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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Localization of mrna for vascular endothelial growth factor (Vegf), angio- poietins and their receptors during the peri-implanta- tion period and early pregnancy in marmosets (Cal- lithrix Jacchus) 显示文摘 | Rowe A J Wulff C Fraser H M | 2003 | Reproduction2003，126，2： | 1 |
| 3 | The effects of infiltr-ation on the stability of a dry ash dump显示文摘 | FOURIE A B ROWE D BLIGHT G H | 1999 | Gé otechnique1999，49，1： | 1 |
| 4 | Biochemical networks and epistasis shape the Arabidopsis thaliana metabolome显示文摘 | Rowe H C Hansen B G Halkier B A | 2008 | Plant Cell2008，20，5： | 1 |
| 5 | Molecular cloning of polyoma virus DNA in Escherichia coli: plasmid vector system显示文摘 | Israel M A Chan H W Rowe W P | 1979 | Science1979，203，4383： | 1 |
| 6 | High-temperature refractory metal-intermetallic composites显示文摘 | JACKSON M R BEWLAY B P ROWE R G SKELLY D W LIPSITT H A | 1996 | JOM1996，48，1： | 1 |
| 7 | MBE growth and properties of ZnO on sapphire and SiC substrates 显示文摘 | Johnson M A L Fujita S Row landW H J | | Electron Mater0，25，5： | 1 |
| 8 | Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia显示文摘 | DiNardo C D Propert K J Loren A W Paietta E Sun Z X Levine R L Straley K S Yen K Patel J P Agresta S Abdel-Wahab O Perl A E Litzow M R Rowe J M Lazarus H M Fernandez H F Margolis D J Tallman M S Luger S M Carroll M | 2012 | Blood2012，121，24： | 1 |
| 9 | Molecular cloning of polyoma virus DNA in Escherichia coli:plasmid vector system显示文摘 | Israel M A Chan H W Rowe W P | 1997 | Science1997，203，4383： | 1 |
| 10 | Isolation of a cy topathic agent from human adenoids undergoing spontaneous degradation in tissue culture显示文摘 | Rowe W P H uebner R J Gilmore L K et a l | 1953 | Proceedings of the Society for Experimental Biology and Medicine1953，84，： | 1 |
| 11 | Collagen biomechanics in cerebral arteries and bifurcations assessed by polarizing microscopy显示文摘 | Rowe A J Finlay H M Canham P B | 2003 | J Vasc Res2003，40，4： | 1 |
| 12 | Embolotherapy for pelvic congestion syndrome:long-term results显示文摘 | KIM H S MALHOTRA A D ROWE P C | 2006 | J Vasc Interv Radiol2006，17，21： | 1 |
| 13 | Voltage - gated sodi- um channel in grasshopper mice defends against bark scor- pion toxin显示文摘 | Rowe A H Xiao Y Rowe M P | 2013 | Science2013，342，： | 1 |
| 14 | PhD students evaluation of research supervision: issues, complexities, and challenges in a nationwide Australian experiment in benchmarking universities 显示文摘 | Marsh H W Rowe K J Martin A | 2002 | Journal of Higher Education2002，73，03： | 1 |
| 15 | Investigation of the tissue effects of a new device for intracorporeal lithotripsy-the Swiss Lithoclast 显示文摘 | DENSTEDT J D RAZVI H A ROWE E | 1995 | J Urol1995，153，2： | 1 |
| 16 | Mapping of a plasmid, coding for colonization factor antigen Ⅰ and heat-stable enterotoxin production, isolated from an enterotoxigenic strain Escherichia coli显示文摘 | Smith H R Willshaw G A Rowe B | 1982 | Journal of Bacteriology1982，149，1： | 1 |
| 17 | PhD students' evaluations of research supervision :issues, complexities, and challenges in a nationwide Australian experiment in Benchmarking U- niversities显示文摘 | MARSH H ROWE K MARIN A | 2002 | The Journal of Higher Education2002，73，3： | 1 |
| 18 | Diffusion weighted magnetic resonance imaging in stroke显示文摘 | Row ley H A | 2003 | Eur Radiol2003，45，3： | 1 |
| 19 | Automatic P- wave arrival detection and picking with multiscale wavelet analysis for single-componem recordings 显示文摘 | Zhang H J Thurber T Rowe C A | 2003 | Bulletin of the Seismological Society of Ameri- ca2003，93，5： | 1 |
| 20 | When the levee breaks: Treating adolescents and families in the aftermath of Hurricane Katrina 显示文摘 | Rowe C L Liddle H A | 2008 | Journal of Marital and Family Therapy2008，34，2： | 1 |
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