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| 1 | Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial显示文摘 | JY Douillard D Cunningham AD Roth M Navarro RD James P Karasek P Jandik T Iveson J Carmichael M Alakl G Gruia L Awad P Rougier | 2000 | The Lancet2000，，9209： | 4 |
| 2 | G蛋白信号转导调节因子5的缺失激活脑卒中时的神经血管保护显示文摘在缺血性脑卒中发生时,血脑屏障的破坏加重了脑损伤。周细胞脱离导致血脑屏障破坏和神经血管功能障碍,但对其在脑卒中中的调节知之甚少。在该研究中,研究者研究了周细胞中G蛋白信号转导调节因子5(Gprotein signaling5,RGS5)的缺失如何影响脑卒中时血脑屏障的破坏及其后果。 | zen I Roth M Barbariga M Gaceb A Deierborg T Genové G Paul G 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 2 |
| 3 | Hepatocellular carcinoma after Iocoregional therapy:Magnetic resonance imaging findings in falsely negative exams显示文摘AIM:To elucidate causes for false negative magnetic resonance imaging(MRI)exams by identifying imaging characteristics that predict viable hepatocellular carcinoma(HCC)in lesions previously treated with locoregional therapy when obvious findings of recurrence are absent.METHODS:This retrospective institutional review board-approved and Health Insurance Portability and Accountability Act-compliant study included patients who underwent liver transplantation at our center between 1/1/2000 and 12/31/2012 after being treated for HCC with locoregional therapy.All selected patients had a contrast-enhanced MRI after locoregional therapy within 90 d of transplant that was prospectively interpreted as without evidence of residual or recurrenttumor.Retrospectively,2 radiologists,blinded to clinica and pathological data,independently reviewed the pre transplant MRIs for 7 imaging features.Liver explan histopathology provided the reference standard,with clinically significant tumor defined as viable tumor≥1.0cm in maximum dimension.Fisher’s exact test was firs performed to identify significant imaging features.RESULTS:Inclusion criteria selected for 42 patients with 65 treated lesions.Fourteen of 42 patients(33%and 16 of 65 treated lesions(25%)had clinically significant viable tumor on explant histology.None o the 7 imaging findings examined could reliably and reproducibly determine which treated lesion had viable tumor when the exam had been prospectively read as without evidence of viable HCC.CONCLUSION:After locoregional therapy some treated lesions that do not demonstrate any MRI evidence o HCC will contain viable tumor.As such even patients with a negative MRI following treatment should receive regular short-term imaging surveillance because some have occult viable tumor.The possibility of occult tumo should be a consideration when contemplating any action which might delay liver transplant. | David Becker-Weidman Jesse M Civan Sandeep P Deshmukh Christopher G Roth Steven K Herrine Laurence Parker Donald G Mitchell | 2016 | World Journal of Hepatology2016，8，16： | 2 |
| 4 | Geometric primitive extraction using a genetic algorithm显示文摘 | Roth G Levin M D | 1994 | IEEE Trans on PAMI1994，16，9： | 2 |
| 5 | The association between quan titative measures of dementia and of senile change in the cerebral gray matter of elderly subjects显示文摘 | Tomlinson BE Roth M | 1968 | Br J Psychiatry1968，114，： | 1 |
| 6 | Structure, properties, and phase transitions of melt-spun poly(vinylidene fluoride) fibers显示文摘 | Steinmann W Walter S Seide G Gries T Roth G Schubnell M | 2011 | Journal of Applied Polymer Science2011，120，1： | 1 |
| 7 | A chimeric avian retrovirus containing the influenza virus hemagglutinin gene has an expanded host range显示文摘 | DONG J ROTH M G HUNTER E | 1992 | J Virol1992，66，： | 1 |
| 8 | Effect of potassium diformate in combination with different amounts and sources of excessive dietary copper on production performance in weaning piglets 显示文摘 | Windisch W M Gottetharm G G Roth F X | 2001 | Arch Anim Nutr2001，54，2： | 1 |
| 9 | BIBF 1120 :triple an- giokinase inhibitor with sustained receptor blockade and good antitumor efficacy显示文摘 | Hilberg F Roth G J Krssak M | 2008 | Cancer Res2008，68，12： | 1 |
| 10 | The selective amygdalohippocampectomy for intractable temporal limbic seizures显示文摘 | Yasargil M G Krayenbuhl N Roth P | 2010 | J Neurosurg2010，112，1： | 1 |
| 11 | Plant viral suppressors of RNA silencing显示文摘 | Roth B M Pruss G J Vance V B | | 0，，1： | 1 |
| 12 | A chimeric avian retrovirus containing the influenza virus hemagglutinin gene has an expanded host range 显示文摘 | Dong J Roth M G Hunter E | 1992 | J Virol1992，66，12： | 1 |
| 13 | Corticosteroids inhibit the expression of the vascular endothelial grow th factor gene in human vascular smooth mus-cle cells显示文摘 | Nauck M Karakiulakis G Perruchoud AP Papakonstantinou E Roth M | 1998 | Eur J Pharmacol1998，341，23： | 1 |
| 14 | Increased levels of soluble ST2 protein and IgG1 production in patients with sepsis and trauma 显示文摘 | Brunner M Krenn C Roth G | 2004 | Intensive Care Med2004，30，7： | 1 |
| 15 | Salient value similarity, social trust, and risk/benefit perception 显示文摘 | Siegrist M Cvetkovich G Roth C | 2000 | Risk Analysis2000，20，3： | 1 |
| 16 | Detection of DNA fragmentation in apoptosis:Application of in situ nick translation to cell culture systems and tissue sections显示文摘 | Gold R Schmied M Rothe G | 1993 | J Histochem Cytochem1993，41，7： | 1 |
| 17 | Detection of DVA fragmentation in apoptosis :application of in situ nick translation to cell culture systems and tissue sections显示文摘 | Gold R Schmied M Rothe G | 1993 | J Histochem Cytochem1993，41，7： | 1 |
| 18 | The association between quantitative measures of dementia and of se-nile change in the cerebral grey matter of elderly subjects 显示文摘 | Blessed G Tomlison BE Roth M | 1968 | British Journal of psychiatry1968，114，： | 1 |
| 19 | Effect of Potassium Diformate in Combination with Different Amounts and Sources of Excessive Dietary Copper on Production Performance in Weaning Piglets显示文摘 | Windisch W M Gotterbarm G G Roth F X | 2001 | Arch Anim Nutr2001，54，： | 1 |
| 20 | Finding DNA regulatory motifs within unaligned non-coding sequences clustered by whole-genome mRNA quantitation 显示文摘 | Roth F P Hughes J D Estep P W Church G M | 1998 | Nature Biotechnol1998，16，10： | 1 |
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