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| 1 | Applications of magnetic nanoparticles in surface-enhanced Raman scattering(SERS)detection of environmental pollutants显示文摘Environmental pollution, a major problem worldwide, poses considerable threat to human health and ecological environment. Efficient and reliable detection technologies, which focus on the appearance of emerging environmental and trace pollutants, are urgently needed. Surface-enhanced Raman scattering(SERS) has become an attractive analytical tool for sensing trace targets in environmental field because of its inherent molecular fingerprint specificity and high sensitivity. In this review, we focused on the recent developments in the integration of magnetic nanoparticles(MNPs) with SERS for facilitating sensitive detection of environmental pollutants. An overview and classification of different types of MNPs for SERS detection were initially provided, enabling us to categorize the huge amount of literature that was available in the interdisciplinary research field of MNPs based SERS technology. Then, the basic working principles and applications of MNPs in SERS detection were presented. Subsequently, the detection technologies integrating MNPs with SERS that eventually were used for the detection of various environmental pollutions were reviewed. Finally, the advantages of MNP-basedSERS detection technology for environmental pollutants were concluded, and the current challenges and future outlook of this technology in practical applications were highlighted. The application of the MNPsbasedSERS techniques for environmental analysis will be significantly advanced with the great progresses of the nanotechnologies, optics, and materials. | Dan Song Rong Yang Feng Long Anna Zhu | 2019 | Journal of Environmental Sciences2019，31，6： | 13 |
| 2 | Prognostic relevance of β-catenin expression in T2-3N0M0 esophageal squamous cell carcinoma显示文摘AIM: To study the expression of β-catenin in esophageal squamous cell carcinoma (ESCC) at stage T2-3N0M0 and its relation with the prognosis of ESCC patients. METHODS: Expression of β-catenin in 227 ESCC speci-mens was detected by immunohistochemistry (IHC). A reproducible semi-quantitative method which takes both staining percentage and intensity into account was applied in IHC scoring, and receiver operating char-acteristic curve analysis was used to select the cut-off score for high or low IHC reactivity. Then, correlation of β-catenin expression with clinicopathological features and prognosis of ESCC patients was determined. RESULTS: No significant correlation was observed between β-catenin expression and clinicopathological parameters in terms of gender, age, tumor size, tumor grade, tumor location, depth of invasion and pathologi-cal stage. The Kaplan-Meier survival curve showed that the up-regulated expression of β-catenin indicated a poorer post-operative survival rate of ESCC patients at stage T2-3N0M0 (P = 0.004), especially of those with T3 lesions (P = 0.014) or with stage ⅡB diseases (P = 0.007). Multivariate analysis also confirmed that β-catenin was an independent prognostic factor for the overall survival rate of ESCC patients at stage T2-3N0M0 (relative risk = 1.642, 95% CI: 1.159-2.327, P = 0.005). CONCLUSION: Elevated β-catenin expression level may be an adverse indicator for the prognosis of ESCC patients at stage T2-3N0M0, especially for those with T3 lesions or stage ⅡB diseases. | Dong-Rong Situ Yi Hu Zhi-Hua Zhu Jian Wang Hao Long Tie-Hua Rong | 2010 | World Journal of Gastroenterology2010，16，41： | 7 |
| 3 | miR-106a confers cisplatin resistance by regulating PTEN/Akt pathway in gastric cancer cells显示文摘最近的研究证明了 microRNA-106a (miR-106a ) 是在胃的癌症的 overexpressed 并且贡献肿瘤生长。在这研究,我们调查了 miR-106a 是否调停了到化学疗法的代理人 cisplatin (DDP ) 的胃的癌症房间线 SGC7901 的抵抗。MiR-106a 表示与它的父母线 SGC7901 相比在 DDP 抵抗房间线 SGC7901/DDP 是起来调整的。miR-106a 的 Transfection 在 SGC7901 导致了 DDP 抵抗,当在 SGC7901/DDP 的 miR-106a 的抑制导致了提高的 DDP cytotoxicity 时。进一步的学习显示 miR-106a-induced DDP 抵抗的机制包含了从染色体 10 删除的磷酸酶和 tensin 相当或相同的事物(PTEN ) 的表示蛋白质和它的下游的 phosphatidylinositol 3 kinase (PI3K )/protein kinase B (AKT ) 小径。这研究在胃的癌症提供 DDP 抵抗的新奇机制。 | Yue Fang Huiling Shen Hao Li Yuan Cao Rong Qin Lulu Long Xiaolan Zhu Chanjuan Xie Wenlin XU | 2013 | Acta Biochimica et Biophysica Sinica2013，45，11： | 6 |
| 4 | Back-n white neutron source at CSNS and its applications显示文摘Back-streaming neutrons from the spallation target of the China Spallation Neutron Source(CSNS)that emit through the incoming proton channel were exploited to build a white neutron beam facility(the so-called Back-n white neutron source),which was completed in March 2018.The Back-n neutron beam is very intense,at approximately 29107 n/cm2/s at 55 m from the target,and has a nominal proton beam with a power of 100 kW in the CSNS-I phase and a kinetic energy of 1.6 GeV and a thick tungsten target in multiple slices with modest moderation from the cooling water through the slices.In addition,the excellent energy spectrum spanning from 0.5 eV to 200 MeV,and a good time resolution related tothe time-of-flight measurements make it a typical white neutron source for nuclear data measurements;its overall performance is among that of the best white neutron sources in the world.Equipped with advanced spectrometers,detectors,and application utilities,the Back-n facility can serve wide applications,with a focus on neutron-induced cross-sectional measurements.This article presents an overview of the neutron beam characteristics,the experimental setups,and the ongoing applications at Backn. | Jing-Yu Tang Qi An Jiang-Bo Bai Jie Bao Yu Bao Ping Cao Hao-Lei Chen Qi-Ping Chen Yong-Hao Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan Chang-Qing Feng Ke-Qing Gao Xiao-Long Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Xi-Ru Huang Hao-Yu Jiang Wei Jiang Zhi-Jie Jiang Han-Tao Jing Ling Kang Bo Li Chao Li Jia-Wen Li Qiang Li Xiao Li Yang Li Jie Liu Rong Liu Shu-Bin Liu Xing-Yan Liu Ze Long Guang-Yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Xin-Yi Tang Bin-Bin Tian Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Xiao-Yun Yang Yi-Wei Yang Han Yi Li Yu Tao Yu Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Zhi-Yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu 无 | 2021 | Nuclear Science and Techniques2021，32，1： | 4 |
| 5 | Prophylactic Use of Transjugular Intrahepatic Portosystemic Shunt Aids in the Treatment of Refractory Ascites: Metaregression and Trial Sequential Meta-analysis显示文摘 | Ren Pin Chen Xiao Ju Zhu Ge Zhi Ming Huang Xiao Hua Ye Chang Yuan Hu Guang Rong Lu De Yi Lu Igor Longe Phemba | 2014 | Journal of Clinical Gastroenterology2014，，3： | 2 |
| 6 | A micro photocatalytic fuel cell with an air-breathing, membraneless and monolithic design显示文摘在这研究,有呼吸空气的阴极的一个无膜的、整体的微 photocatalytic 燃料房间为同时的废水治疗和电产生被开发。在这个最新开发的微 photocatalytic 燃料房间, photoanode 和阴极与一个 shoulder-to-shoulder 图案被安排,形成二个平面电极。提高的质量的几个优点转移的如此的设计提议,一致轻分发,短轻转移路径,膜消除和容易的制造,集成,和与另外的 microdevices 的相容性。这个类型燃料房间的表演被在碱的条件下面把甲醇用作一种模型污染物质评估。试验性的结果显示发达微 photocatalytic 燃料房间能象耐久性一样显示出好相片反应到照明和令人满意的性能。房间表演上的参量的学习也被执行。增加轻紧张,甲醇集中和 KOH 集中能改进房间表演,这被发现。要不是液体流动率的效果,房间表演第一与增加液体流动率增加了然后与进一步增加液体流动率减少了,这被显示出。这研究不仅为微 photocatalytic 燃料房间的设计打开一条新大街而且对操作条件的优化有用。 | Ming Xia Rong Chen Xun Zhu Qiang Liao Liang An Zhibin Wang Xuefeng He Long Jiao | 2016 | Science Bulletin2016，61，21： | 2 |
| 7 | Measurement of the ^(232)Th(n,f)cross section in the 1-200 MeV range at the CSNS Back-n显示文摘The ^(232)Th(n,f)cross section is very important in basic nuclear physics and applications based on the Th/U fuel cycle.Using the time-of-flight method and a multi-cell fast-fission ionization chamber,a novel measurement of the^(232)Th(n,f)cross sec-tion relative to^(235)U in the 1–200 MeV range was performed at the China Spallation Neutron Source Back-n white neutron source(Back-n).The fission event-neutron energy spectra of^(232)Th and^(235)U fission cells were measured in the single-bunch mode.Corrected 232Th/235U fission cross-sectional ratios were obtained,and the measurement uncertainties were 2.5–3.7%for energies in the 2–20 MeV range and 3.6–6.2%for energies in the 20–200 MeV range.The^(232)Th(n,f)cross section was obtained by introducing the standard cross section of^(235)U(n,f).The results were compared with those of previous theoreti-cal calculations,measurements,and evaluations.The measured 232Th fission cross section agreed with the main evaluation results in terms of the experimental uncertainty,and 232Th fission resonances were observed in the 1–3 MeV range.The present results provide^(232)Th(n,f)cross-sectional data for the evaluation and design of Th/U cycle nuclear systems. | Zhi-Zhou Ren Yi-Wei Yang Yong-Hao Chen Rong Liu Bang-Jiao Ye Jie Wen Hai-Rui Guo Zi-Jie Han Qi-Ping Chen Zhong-Wei Wen Wei-Li Sun Han Yi Xing-Yan Liu Tao Ye Jiang-Bo Bai Qi An Jie Bao Yu Bao Ping Cao Hao-Lei Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan Chang-Qing Feng Ke-Qing Gao Xiao-Long Gao Min-Hao Gu Chang-Cai Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Xi-Ru Huang Hao-Yu Jiang Wei Jiang Zhi-Jie Jiang Han-Tao Jing Ling Kang Bo Li Chao Li Jia-Wen Li Qiang Li Xiao Li Yang Li Jie Liu Shu-Bin Liu Ze Long Guang-Yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin Qi Jie Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Jing-Yu Tang Xin-Yi Tang Bin-Bin Tian Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Xiao-Guang Wu Xuan Wu Li-Kun Xie Xiao-Yun Yang Li Yu Tao Yu Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Zhi-Yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu | 2023 | Nuclear Science and Techniques2023，34，8： | 1 |
| 8 | A comparative study of biliary trace elements and clinical phenotypes in Wilson disease显示文摘AcomparativestudyofbiliarytraceelementsandclinicalphenotypesinWilsondiseaseRENMingShan1,FANYuXin2,YANGRenMin1,HANYongZhu... | REN MingShan1, FAN YuXin2, YANG RenMin1, HAN YongZhu1, WU GuoJun2, XIN YuRong2 and YU Long2 | 1997 | World Journal of Gastroenterology1997，3，4： | 1 |
| 9 | A Novel Reassortant H3N8 Influenza Virus Isolated from Drinking Water for Duck in a Domestic Duck Farm in Poyang Lake Area显示文摘Objective To conduct a full genome sequence analysis for genetic characterization of an H3N8 influenza virus isolated from drinking water of a domestic duck farm in Poyang Lake area in 2011. Methods The virus was cultivated by specific pathogen free (SPF) chicken embryo eggs and was subtyped into hemagglutinin (HA) and neuraminidase (NA) by real-time PCR method. Eight gene segments were sequenced and phylogenetic analysis was conducted. Results The NA gene of this virus belongs to North American lineage; other seven genes belong to Eurasian lineage. Compared with the viruses containing NA gene, the PB2 and PB1 gene came from different clades. And this indicates that the virus was a novel reassortant genotype. The HA receptor binding preference was avian-like and the cleavage site sequence showed a low pathogenic feature. There was no drug resistancemutation of M2 protein. Themutations of Asn30Asp, and Thr215Ala of the M1 protein implied the potential of pathogenicity increase in mice. Conclusion The finding of novel genotype of H3N8 virus in drinking water in this duck farm near Poyang Lake highlighted the importance of strengthening the surveillance of avian influenza in this region, which could contribute to pinpointing the influenza ecological relations among avian, swine, and human. | DONG Bei Bei XU Cui Ling DONG Li Bo CHENG Hui Jian YANG Lei ZOU Shu Mei CHEN Min BAI Tian ZHANG Ye GAO Rong Bao LI Xiao Dan SHI Jing Hong YUAN Hui YANG Jing CHEN Tao ZHU Yun XIONG Ying YANG Shuai SHU Yue Long | 2013 | Biomedical and Environmental Sciences2013，26，7： | 1 |
| 10 | Synthesis and in Vitro Cytotoxicity of a Novel Conjugate of Polyamide and Phospholipid显示文摘In order to increase the cell penetration and decrease the cytotoxicity of the synthetic molecule, we designed and synthesized a DNA-binding ligand, which was a conjugate of polyamide and phospholipid. We examined the differences in the effect on cytotoxicity between the conjugate and the native polyamide. As expected that the in vitro cytotoxicity of the conjugate was obviously lower than that of the native polyamide either in HeLa cells or SH-SY5Y neuroblastoma cells. | Yi LIU Yu Lin DENG Rong ZHENG Pei Long ZHANG Hui ZHAI Kc Zhong LIU Chang Jin ZHU | 2006 | Chinese Chemical Letters2006，17，5： | 0 |
| 11 | C/EBP-β and SIRT1 regulate IL-18 expression in the proliferative phase endometria of polycystic ovary syndrome patients显示文摘Background:Previous studies have shown that polycystic ovary syndrome(PCOS)patients suffer from low-grade chronic inflammation.Furthermore,our previous studies have confirmed that IL-18 is highly expressed in the serum and endometria of PCOS patients.Nevertheless,the mechanisms underlying IL-18 elevation remain unclear.This study aims to explore the signaling pathways that lead to IL-18 upregulation in the endometria of PCOS patients.Methods:Using the TF-Search tool,we predicted that C/EBP-βmay be a transcription factor for IL-18 and that deacetylase SIRT1 could be involved in its regulation.Subsequently,we analyzed SIRT1 and C/EBP-βin the proliferative endometria of PCOS patients and healthy control using immunohistochemistry,real-time quantitative PCR and western blot;PCOS diagnosis was based on the 2003 Rotterdam ESHRE/ASRM criteria.We further verified the interaction between C/EBP-βand IL-18 using a double luciferase assay.Results:SIRT1 and C/EBP-βgene and protein levels in the proliferative endometria of PCOS patients were significantly higher than the control group.Immunohistochemical experiments confirmed that SIRT1 was primarily expressed in the endometrial nucleus,while C/EBP-βwas predominantly expressed in the endometrial nucleus and cytoplasm.Double luciferase assay verified the interaction between C/EBP-βand IL-18.Conclusion:SIRT1 and C/EBP-βare probable IL-18 regulatory mechanism in the endometria of PCOS patients. | Xiaoyu Long Honghao Wang Xiaohui Zhu Rong Li Yan Yang Jie Qiao | 2021 | Gynecology and Obstetrics Clinical Medicine2021，1，2： | 0 |
| 12 | THE CHEMICAL STRUCTURE OF HYPODEMAPYRAZIN显示文摘A novel alkaloid named Hypodemapyrazine was isolated from the whole plantof a fern,Hypodematium sinense Iwatsuki. Its chemical structure has been elucidated to be a novel skeleton containing ahydro-pyrazine by means of UV, IR, 1H-NMR, 13C-NMR and HRMS spectroscopy. | Ying Hua LU Ya Min CHEN Xin Min WUN Hong En WANG Cun Shen MA Rong Long ZHU De Quan YU Jining Medical College, Jining. Shandong 272113 Institute of Materia Medica, Chinese Academy of Medical Sciences, Bejing 100050 | 1993 | Chinese Chemical Letters1993，4，7： | 0 |
| 13 | Seroprevalence of IgM and IgG Antibodies against SARS-CoV-2 in Asymptomatic People in Wuhan: Data from a General Hospital Near South China Seafood Wholesale Market during March to April in 2020显示文摘The aim of this study was to estimate the seroprevalence of immunoglobulin M(IgM)and G(IgG)antibodies against SARS-CoV-2 in asymptomatic people in Wuhan.This was a cross-sectional study,which enrolled 18,712 asymptomatic participants from 154 work units in Wuhan.Pearson Chi-square test,t-test,and Mann-Whitney test were used to compare the standardized seroprevalence of IgG and IgM for age and gender between different groups. | LING Rui Jie YU Yi Han HE Jia Yu ZHANG Ji Xian XU Sha SUN Ren Rong ZHU Wang Cai CHEN Ming Feng LI Tao JI Hong Long WANG Huan Qiang | 2021 | Biomedical and Environmental Sciences2021，34，9： | 0 |
| 14 | 全基因组关联研究发现中国人群前列腺癌两个新易感位点9q31.2和19q13.4显示文摘0前言在全球范围内,前列腺癌的发病率和病死率存在着巨大差异。该病在西方发达国家发病率最高,在非裔美国人群病死率最高,而在亚洲人群中发病率及病死率均为全球最低,提示不同人种在前列腺癌的遗传方面存在异质性。在欧美和日本人群中,全基因组关联研究(GWAS)技术已经被用于检测前列腺癌的遗传易感性位点,但至今尚无关于GWAS检测中国人群前列腺癌易感位点的报道。 | Jianfeng Xu Zengnan Mo Dingwei Ye Meilin Wang Fang Liu Guangfu Jin Chuanliang Xu Xiang Wang Qiang Shao Zhiwen Chen Zhihua Tao Jun Qi Fangjian Zhou Zhong Wang Yaowen Fu Dalin He Qiang Wei Jianming Guo Denglong Wu Xin Gao Jianlin Yuan Gongxian Wang Yong Xu Guozeng Wang Haijun Yao Pei Dong Yang Jiao Mo Shen Jin Yang Jun Ou-Yang Haowen Jiang Yao Zhu Shancheng Ren Zhengdong Zhang Changjun Yin Xu Gao Bo Dai Zhibin Hu Yajun Yang Qijun Wu Hongyan Chen Peng Peng Ying Zheng Xiaodong Zheng Yongbing Xiang Jirong Long Jian Gong Rong Na Xiaoling Lin Hongjie Yu Sha Tao Junjie Feng Jishan Sun Wennuan Liu Ann Hsing Jianyu Rao Qiang Ding Fredirik Wiklund Henrik Gronberg Xiao-Ou Shu Wei Zheng Hongbing Shen Li Jin Rong Shi Daru Lu Xuejun Zhang Jielin Sun S Lilly Zheng Yinghao Sun | 2013 | 第二军医大学学报2013，34，4： | 0 |
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