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| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | Photonic gas sensors exploiting directly the optical properties of hybrid carbon nanotube localized surface plasmon structures显示文摘Weinvestigate the modification of the optical properties of carbon nanotubes(CNTs)resulting from a chemical reaction triggered by the presence of a specific compound(gaseous carbon dioxide(CO_(2)))and show this mechanism has important consequences for chemical sensing.CNTs have attracted significant research interest because they can be functionalized for a particular chemical,yielding a specific physical response which suggests many potential applications in the fields of nanotechnology and sensing.So far,however,utilizing their optical properties for this purpose has proven to be challenging.We demonstrate the use of localized surface plasmons generated on a nanostructured thin film,resembling a large array of nano-wires,to detect changes in the optical properties of the CNTs.Chemical selectivity is demonstrated using CO_(2) in gaseous form at room temperature.The demonstrated methodology results additionally in a new,electrically passive,optical sensing configuration that opens up the possibilities of using CNTs as sensors in hazardous/explosive environments. | Thomas Allsop Raz Arif Ron Neal Kyriacos Kalli Vojtěch Kundrát Aleksey Rozhin Phil Culverhouse David J Webb | 2016 | Light(Science & Applications)2016，5，1： | 3 |
| 3 | Carbonation of calcium-containing mineral and industrial by-products显示文摘The use of carbon dioxide(CO_(2))and calciumcontaining by-products from industrial activities is receiving increasing interest as a route to valuable carbonate materials while reducing CO_(2) emissions and saving natural resources.In this work,wet-chemical experimental data was assessed,which involved the carbonation of three types of materials in aqueous solutions,namely,1)wollastonite,a calcium silicate mineral,2)steelmaking slag,a by-product of steel production,and 3)paper bottom ash(PBA)from waste paper incineration.Aims were to achieve either a high carbonation degree and/or a pure carbonate product with potential commercial value.Producing a pure precipitated calcium carbonate(PCC)material that may find use in paper industry products puts strong requirements on purity and brightness.The parameters investigated were particle size,CO_(2)pressure,temperature,solid/liquid ratio,and the use of additives that affect the solubilities of CO_(2)and/or calcium carbonate.Temperatures and pressures were varied up to 180℃and 4 MPa.Data obtained with the wollastinite mineral allowed for a comparison between natural resources and the industrial by-product materials,the latter typically being more reactive.With respect to temperature and pressure trends reported by others were largely confirmed,with temperatures above 150℃introducing thermodynamic limitations depending on CO_(2)pressure.The influence of additives showed some promise,although costs may make recycling and reuse of additives a necessity for a largescale process.When using steelmaking slag,magnetic separation may remove some iron-containing material from the process(although this is far from perfect),while the addition of bicarbonate supported the removal of phosphorous,aside from improving calcium extraction.The experiments with paper bottom ash(PBA)gave new data,showing that its reactivity resembles that of steelmaking slag,while its composition results in relatively pure carbonate product.Also,with PBA no additives were needed to achieve this. | Ron ZEVENHOVEN Anders WIKLUND Johan FAGERLUND Sanni ELONEVA Ben IN’T VEEN Hans GEERLINGS Gert VAN MOSSEL Harold BOERRIGTER | 2010 | Frontiers of Chemical Science and Engineering2010，4，2： | 2 |
| 4 | Switching characteristics of a gas trigatron operated in single and double trigger mode显示文摘 | NANU K RON P H IYENGAR S T | 1990 | IEEE Transactions on Electrical Insulation1990，25，2： | 1 |
| 5 | From safety verification to safety testing 显示文摘 | Rusu V MARCHAND H TSCHAEN V JE'RON T JEANNET B | 2004 | Lecture Notes in Computer Science LNCS2004，2978，： | 1 |
| 6 | The correlation between palliation of bone pain by intravenous strontium-89 and external beam radiation to linked field in patients with osteoblastic bone metastases显示文摘 | Ron IG Stav O Vishne T | 2004 | Am J Clin Oncol2004，27，： | 1 |
| 7 | 成人2型糖尿病不同筛查及预防策略成本效益分析显示文摘目的 比较针对2型糖尿病预防及治疗的4种筛查策略及随后予以的干预措施:(a)筛查2型糖尿病患者使其能接受早期检查及治疗,(b)筛查2型糖尿病和糖耐量受损患者,对糖耐量受损的人群予以生活方式干预以延缓或预防糖尿病的发生,(c)同(b)但予以药物干预措施,(d)不筛查。
设计 成本效益决策分析建立在对概率的发展和评估基础上,是从筛查到死亡的综合性经济决策分析模型。
研究对象 一组假设人群,筛查时年龄45岁,高于平均糖尿病风险水平。
数据来源 电子书目数据库收录的已发表的临床试验和流行病学研究;补充数据分别来自英国和威尔士健康统计署、风险筛查(STAR)研究和ADDITION研究的Leicester部分。
方法 建立一种决策树/Markov混合模型,以模拟每一种筛查策略的长期效用,包括临床和成本效益终点。该模型假设水平跨度为50年时间,其成本效益折损率为3.5%。采用敏感度分析以验证模型假设及确定哪种模型数据输入对结果的影响最大。
结果 与不筛查策略比较,筛查2型糖尿病、筛查糖尿病和糖耐量受损并予以生活方式干预、筛查糖尿病和糖耐量受损并予以药物干预治疗3种策略,每获得一个质量调整生命年(QALY)估计所需成本分别为(每年成本效益贴现率为3.5%)14150英镑(17560欧元;27860美元)、6242英镑和7023英镑。在支付意愿阈值为20000英镑时,各主动筛查策略通过干预产生的成本效益概率分别为49%,93%和85%。
结论 对年龄45岁、高于平均风险水平的人群进行2型糖尿病和糖耐量受损的筛查,并对糖耐量受损人群予以适当的干预似乎具有很好的成本效益。单独筛查糖尿病而不对糖耐量受损人群予以干预的策略具有的成本效益仍不确定,需要进一步研究确定早期检测糖尿病的作用。 | Clare L Gillies Paul C Lambert Keith R Abrams Alex J Sutton Nicola J Cooper Ron T Hsu Melanie J Davies Kamlesh Khunti 张晓梅(译) 纪立农(校) | 2008 | 英国医学杂志中文版2008，11，5： | 1 |
| 8 | Architecture and origin of an amalgamated fluvial sheet sand, lower Castlegate Forrnation , Book Cliffs, Utah 显示文摘 | Brett T McLaurin Ron J Steel | 2007 | Sedimentary Geology2007，197，： | 1 |
| 9 | Microwave reduction of a nickeliferous laterite ore 显示文摘 | MICHAIL S MARIA T RON H | 2012 | Minerals Engineering2012，34，： | 1 |
| 10 | Modularity, Flexibility and Knowledge Management in Product and Organizational Design 显示文摘 | SANCHEZ RON MAHONEY JOSEPH T | 1997 | Strategic Management Journal1997，，17： | 1 |
| 11 | Mandibular condyle lesions,jaw movements,and occlusal status in 15 - years- old children with juvenile rheumatoid arthritis显示文摘 | Karhulahti T Ronning O Jamsa T | 1990 | Scand J Dent Res1990，98，： | 1 |
| 12 | Modularity, flexibility, and knowledge management in product and organization design 显示文摘 | Ron Sanchcz Joseph T Mahoney | 1996 | Strategic Management Journal Winter Special Issue1996，7，： | 1 |
| 13 | Volatile constituents of Asian pear(Pyrus serotina)显示文摘 | Gary R T Ron G B Robert A F | 1992 | Food Chemistry1992，4，： | 1 |
| 14 | Relation of the glenoid fossa to craniofacial morphology,studied on dry human skulls显示文摘 | Pirttiniemi P Kantomaa T Ronning O | 1990 | Acta Odontol Scand1990，48，6： | 1 |
| 15 | Modularity, Flexibility, and Knowledge Management in Product and Organization Design显示文摘 | Sanchez Ron and Mahoney Joseph T | 1996 | Strategic Management Journal1996，，17： | 1 |
| 16 | Punicic acid, a conjugated linolenic acid, inhibits TNF α-induced neutrophil hyperactivation and protects from experimental colon inflammation in rats显示文摘 | Boussetta T Raad H Lette'ron P | 2009 | PLoS One2009，4，7： | 1 |
| 17 | Modularity, Flexibility, and Knowledge Management in Product and Organization Design显示文摘 | Sanchez Ron and Mahoney Joseph T | 1996 | Strategic Management Journal1996，，17： | 1 |
| 18 | Male breast cancer incidence among atomic bomb survivors 显示文摘 | Ron E Ikeda T Preston DL | 2005 | J Natl Cancer Inst2005，97，8： | 1 |
| 19 | Genetic study of the CD36 gene In a French diabetic population显示文摘 | F Leprêtre KJ Linton C Lacquemant V Vatin C Samson C Dina M Chikri S Ali P Scherer K Séron F Vasseur T Aitman P Froguel | 2004 | Diabetes and Metabolism2004，，5： | 1 |
| 20 | C-Type cytochromes andmanganese oxidation in Pseudom onas putida MnB1 显示文摘 | Ron C Bradley M T Haygood M G | 1998 | App l EnvironMicrobiol1998，64，10： | 1 |
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