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| 1 | 介绍一种新的具有重要临床意义的浸润性子宫颈管腺癌分类系统显示文摘最近,新子宫颈管腺癌分类系统被提出。该系统将肿瘤分为三型。A型:肿瘤常由界限清楚的呈巢、簇状腺体排列的小叶状结构;B型:肿瘤表现为局部破坏性浸润,显示促纤维增生间质围绕不规则或边界不清或不完整的腺体,间质中散在单个或小簇状肿瘤细胞;C型:肿瘤表现为弥漫浸润性生长,伴广泛的促纤维间质反应。 | Roma A A Diaz De Vivar A Park K J 康锶鹏 余英豪 | 2015 | 临床与实验病理学杂志2015，31，11： | 17 |
| 2 | Challenge of liver disease in systemic lupus erythematosus:Clues for diagnosis and hints for pathogenesis显示文摘Systemic lupus erythematosus(SLE) encompass a broad spectrum of liver diseases. We propose here to classify them as follows:(1) immunological comorbilities(overlap syndromes);(2) non-immunological comorbilities associated to SLE; and(3) a putative liver damage induced by SLE itself, referred to as 'lupus hepatitis'. In the first group, liver injury can be ascribed to overlapping hepatopathies triggered by autoimmune mechanisms other than SLE occurring with higher incidence in the context of lupus(e.g., autoimmune hepatitis, primary biliary cirrhosis). The second group includes non-autoimmune liver diseases, such as esteatosis, hepatitis C, hypercoagulation state-related liver lesions, hyperplasic parenchymal and vascular lesions, porphyria cutanea tarda, and drug-induced hepatotoxicity. Finally, the data in the literature to support the existence of a hepatic disease produced by SLE itself, or the occurrence of a SLE-associated prone condition that increases susceptibility to acquire other liver diseases, is critically discussed. The pathological mechanisms underlying each of these liver disorders are also reviewed. Despite the high heterogeneity in the literature regarding the prevalence of SLE-associated liver diseases and, in most cases, lack of histopathological evidence or clinical studies large enough to support their existence, it is becoming increasingly apparent that liver is an important target of SLE. Consequently, biochemical liver tests should be routinely carried out in SLE patients to discard liver disorders, particularly in those patients chronically exposed to potentially hepatotoxic drugs. Diagnosing liver disease in SLE patients is always challenging, and the systematization of the current information carried out in this review is expected to be of help both to attain a better understanding of pathogenesis and to build an appropriate work-up for diagnosis. | Ferno Bessone Natalia Poles Marcelo G Roma | 2014 | World Journal of Hepatology2014，6，6： | 7 |
| 3 | 新复合杂合突变致婴儿型低磷酸酯酶症1例及其家系分析显示文摘该文对1例婴儿型低磷酸酯酶症(HPP)患儿及其家系进行临床特点分析及碱性磷酸酯酶基因(ALPL)检测。先证者,男,5个月,多发骨骼畸形:胸骨凹陷、双侧桡骨弯曲畸形、双膝外翻畸形,伴喂养困难、体重下降、发育迟滞、反复肺炎并呼衰,血碱性磷酸酶显著降低。患儿父母、姐姐、叔父、姨母(其他家系成员未能配合)中除父母及姨母的碱性磷酸酶略低,姨母可见脊柱侧弯畸形,余均无临床表型及实验室异常。患者ALPL基因检测到来源于母亲的c.228delG突变及来源于父亲的c.407G>A复合杂合突变,其姨母携带c.228delG突变。c.407G>A突变为已报道的HPP致病突变,c.228delG为新的致病性突变。低磷酸酯酶症是由ALPL基因突变所致,ALPL基因检测是有效的诊断方法。该研究拓展了ALPL基因突变谱,为HPP的基因诊断提供了理论依据。 | 李登峰 蓝丹 钟京梓 Roma Kajal Dewan 谢彦舒 杨莹 | 2017 | 中国当代儿科杂志2017，19，5： | 6 |
| 4 | A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease显示文摘 | Shamsul Zain Rosmawati Mohamed Sanjiv Mahadeva Phaik Cheah Sanjay Rampal Roma Basu Zahurin Mohamed | 2012 | Human Genetics2012，，7： | 2 |
| 5 | TT virus infection and pancreatic cancer: Relationship or accidental coexistence显示文摘TT virus (TTV) was first isolated in 1997 from the patient with acute post-transfusion hepatitis. This fact led to the conclusion that the virus was hepatotropic and could be one of the causative agents of acute hepatitis. Afterwards, however, the virus was found in other human tissues and serological studies revealed that it was widespread. Multiple tropisms of TTV and the fact of its high incidence in general population are considered to indicate no medical significance of TTV in human pathology. Here we present a report of two cases of TTV infection in patients who developed pancreas cancer. The patients were hospitalized at the Department of Infectious Diseases due to hepatitis of unknown origin. Since serological and virological markers of common primary and secondary hepatotropic viruses were negative, TTV-DNA was found in serum and was believed to be the only causative agent with probable hepatotropic action. The patients later developed pancreas cancer and they underwent operation. The relationship is difficult to confirm, however the cases we present should be treated as a preliminary report and a comment on the real role of TTV in human pathology. | Krzysztof Tomasiewicz Roma Modrzewska Anna Lyczak Grazyna Krawczuk | 2005 | World Journal of Gastroenterology2005，11，18： | 2 |
| 6 | 1,8-Naphthyridines IV. 9-Substituted N , N -dialkyl-5-(alkylamino or cycloalkylamino) [1,2,4]triazolo[4,3- a ][1,8]naphthyridine-6-carboxamides, new compounds with anti-aggressive and potent anti-inflammatory activities显示文摘 | Giorgio Roma Mario Di Braccio Giancarlo Grossi Francesca Mattioli Marco Ghia | 2000 | European Journal of Medicinal Chemistry2000，，11： | 2 |
| 7 | Impact of Thrombectomy With EXPort Catheter in Infarct-Related Artery During Primary Percutaneous Coronary Intervention (EXPIRA Trial) on Cardiac Death显示文摘 | Gennaro Sardella Massimo Mancone Emanuele Canali Angelo Di Roma Giulia Benedetti Rocco Stio Roberto Badagliacca Luigi Lucisano Luciano Agati Francesco Fedele | 2010 | The American Journal of Cardiology2010，，5： | 2 |
| 8 | Burden of celiac disease in the Mediterranean area显示文摘AIM: To estimate the burden of undiagnosed celiac disease (CD) in the Mediterranean area in terms of morbidity, mortality and health cost. METHODS: For statistics regarding the population of each country in the Mediterranean area, we accessed authoritative international sources (World Bank, World Health Organization and United Nations). The prevalence of CD was obtained for most countries from published reports. An overall prevalence rate of 1% cases/total population was finally estimated to represent the frequency of the disease in the area, since none of the available conf idence intervals of the reported rates significantly excluded this rate. The distribution of symptoms and complications was obtained from reliable reports in the same cohort. A standardized mortality rate of 1.8 was obtained from recent reports. Crude health cost was estimated for the years between symptoms and diagnosis for adults and children, and was standardized for purchasing power parity to account for the different economic prof iles amongst Mediterranean countries. RESULTS: In the next 10 years, the Mediterranean area will have about half a billion inhabitants, of which 120 million will be children. The projected number of CD diagnoses in 2020 is 5 million cases (1 million celiac children), with a relative increase of 11% compared to 2010. Based on the 2010 rate, there will be about 550 000 symptomatic adults and about 240 000 sick children: 85% of the symptomatic patients will suffer from gastrointestinal complaints, 40% are likely to have anemia, 30% will likely have osteopenia, 20% of children will have short stature, and 10% will have abnormal liver enzymes. The estimated standardized medical costs for symptomatic celiac patients during the delay between symptom onset and diagnosis (mean 6 years for adults, 2 years for children) will be about €4 billion (€387 million for children) over the next 10 years. A delay in diagnosis is expected to increase mortality: about 600 000 celiac patients will die in the next 10 years, with an excess of 44.4% vs age-and sexmatched controls. CONCLUSION: In the near future, the burden of CD will increase tremendously. Few Mediterranean countries are able to face this expanding epidemic alone. | Luigi Greco Laura Timpone Abdelhak Abkari Mona Abu-Zekry Thomas Attard Faouzi Bouguerrà Paskal Cullufi Aydan Kansu Dusanka Micetic-Turk Zrinjka Miak Eleftheria Roma Raanan Shamir Selma Terzic | 2011 | World Journal of Gastroenterology2011，17，45： | 2 |
| 9 | Dynamic localization of hepatocellular transporters in health and disease显示文摘Vesicle-based traffi cking of hepatocellular transporters involves delivery of the newly-synthesized carriers from the rough endoplasmic reticulum to either the plasma membrane domain or to an endosomal,submembrane compartment,followed by exocytic targeting to the plasma membrane. Once delivered to the plasma membrane,the transporters usually undergo recycling between the plasma membrane and the endosomal compartment,which usually serves as a reservoir of pre-existing transporters available on demand. The balance between exocytic targeting and endocytic internalization from/to this recycling compartment is therefore a chief determinant of the overall capability of the liver epithelium to secrete bile and to detoxify endo and xenobiotics. Hence,it is a highly regulated process. Impaired regulation of this balance may lead to abnormal localization of these transporters,which results in bile secretory failure due to endocytic internalization of key transporters involved in bile formation. This occurs in several experimental models of hepatocellular cholestasis,and in most human cholestatic liver diseases. This review describes the molecular bases involved in the biology of the dynamic localization of hepatocellular transporters and its regulation,with a focus on the involvement of signaling pathways in this process. Their alterations in different experimental models of cholestasis and in human cholestatic liver disease are reviewed. In addition,the causes explaining the pathological condition (e.g. disorganization of actin or actin-transporter linkers) and the mediators involved (e.g. activation of cholestatic signaling transduction pathways) are also discussed. Finally,several experimental therapeutic approaches based upon the administration of compounds known to stimulate exocytic insertion of canalicular transporters (e.g. cAMP,tauroursodeoxycholate) are described. | Marcelo G Roma Fernando A Crocenzi Aldo D Mottino | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 10 | Application of Superresolution Techniques to Radar Imaging显示文摘ApplicationofSuperresolutionTechniquestoRadarImagingA.Fanrina,F.Prodi&F.Vinelli(Alenia.UnaAziendaFinmeccanica.Radar&C2Divisio... | A. Fanrina, F.Prodi & F. Vinelli(Alenia. Una Azienda Finmeccanica. Radar & C2 DivisionVia Tiburtina km. 12.400. 00131 Roma, Italy) | 1994 | Journal of Systems Engineering and Electronics1994，5，1： | 2 |
| 11 | Andean foothills structures in northern Magallanes basin, Argentina 显示文摘 | Romas V A | 1989 | AAPG Bull1989，73，： | 1 |
| 12 | Obstructive sleep apnoea syndrome and the metabolic syndrome in an internal medicine setting显示文摘 | Francesco Angelico Maria del Ben Teresa Augelletti Rosanna de Vita Rocco Roma Francesco Violi Mario Fabiani | 2010 | European Journal of Internal Medicine2010，，3： | 1 |
| 13 | The measurement of engagement and burnout:A two sample con- firmatory factor analytic approach 显示文摘 | Schaufeli WB Salanova M Gonzalez - Roma V | 2002 | Journal of Happiness Studies2002，，3： | 1 |
| 14 | Enhancing catalytic promiscuity for biocatalysis显示文摘 | Romas J Kazlauskas | 2005 | Current Opinion in Chemical Biology2005，，2： | 1 |
| 15 | Expression of osteoclast differentiation factor at sites of bone erosion in collagen- induced arthritis 显示文摘 | Romas E Bakharevski O Hards DK | 2000 | Arthritis Rheum2000，43，4： | 1 |
| 16 | CIN:multicentric study of therapeutic strategies显示文摘 | Di Roma E Parlavecchio E Vettraino G | 2001 | Minerva Ginecol2001，53，6： | 1 |
| 17 | Solving the trust-region subproblem using the Lanczos method显示文摘 | Gould N I M Lucidi S Roma M | 1999 | SIAM Journal on Optimization1999，9，2： | 1 |
| 18 | CIN: multi-centric study of therapeutic strategies显示文摘 | Di Roma E Parlavecchio E Vettraino G | 2001 | Minerva Ginecol2001，53，6： | 1 |
| 19 | The Measurement of Engagement and Burnout : A Confirmatory Analytic Approach 显示文摘 | Schaufeli W B Salanova M Gonzalez - Roma V | 2002 | Journal of Happiness Studies2002，，3： | 1 |
| 20 | Red meat and poultry intake, polymorphisms in the nueleotide excision repair and mismatch repair pathways and colorectal cancer risk显示文摘 | Amit D Joshi Roma'n Corral | 2009 | Carcinogenesis2009，30，3： | 1 |
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