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| 1 | Role of prophylactic antibiotics in cirrhotic patients with variceal bleeding显示文摘Bacterial infections are common in cirrhotic patients with acute variceal bleeding,occurring in 20%within48 h.Outcomes including early rebleeding and failure to control bleeding are strongly associated with bacterial infection.However,mortality from variceal bleeding is largely determined by the severity of liver disease.Besides a higher Child-Pugh score,patients with hepatocellular carcinoma are particularly susceptible to infections.Despite several hypotheses that include increased use of instruments,greater risk of aspiration pneumonia and higher bacterial translocation,it remains debatable whether variceal bleeding results in infection or vice versa but studies suggest that antibiotic prophylaxis prior to endoscopy and up to 8 h is useful in reducing bacteremia and spontaneous bacterial peritonitis.Aerobic gram negative bacilli of enteric origin are most commonly isolated from cultures,but more recently,gram positives and quinolone-resistant organisms are increasingly seen,even though their clinical significance is unclear.Fluoroquinolones(including ciprofloxacin and norfloxacin)used for short term(7 d)have the most robust evidence and are recommended in most expert guidelines.Short term intravenous cephalosporin(especially ceftriaxone),given in a hospital setting with prevalent quinolone-resistant organisms,has been shown in studies to be beneficial,particularly in high risk patients with advanced cirrhosis. | Yeong Yeh Lee Hoi-Poh Tee Sanjiv Mahadeva | 2014 | World Journal of Gastroenterology2014，20，7： | 31 |
| 2 | Factors influencing quality of bowel preparation for colonoscopy显示文摘Recent technological advances in colonoscopy have led to improvements in both image enhancement and procedural performance.However,the utility of these technological advancements remain dependent on the quality of bowel preparation during colonoscopy.Poor bowel preparation has been shown to be associated with lower quality indicators of colonoscopy performance,such as reduced cecal intubation rates,increased patient discomfort and lower adenoma detection.The most popular bowel preparation regimes currently used are based on either Polyethylene glycol-electrolyte,a non-absorbable solution,or aqueous sodium phosphate,a lowvolume hyperosmotic solution.Statements from various international societies and several reviews have suggested that the efficacy of bowel preparation regimes based on both purgatives are similar,although patients' compliance with these regimes may differ somewhat.Many studies have now shown that factors other than the type of bowel preparation regime used,can influence the quality of bowel preparation among adult patients undergoing colonoscopy.These factors can be broadly categorized as either patient-related or procedure-related.Studies from both Asia and the West have identified patient-related factors such as an increased age,male gender,presence of co-morbidity and socioeconomic status of patients to be associated with poor bowel preparation among adults undergoing routine out-patient colonoscopy.Additionally,procedure-related factors such as adherence to bowel preparation instructions,timing of bowel purgative administration and appointment waiting times for colonoscopy are recognized to influence the quality of colon cleansing.Knowledge of these factors should aid clinicians in modifying bowel preparation regimes accordingly,such that the quality of colonoscopy performance and delivery of service to patients can be optimised. | Ronald V Romero Sanjiv Mahadeva | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，2： | 13 |
| 3 | Split-dose vs same-day reduced-volume polyethylene glycol electrolyte lavage solution for morning colonoscopy显示文摘AIM:To compare same-day whole-dose vs split-dose of 2-litre polyethylene glycol electrolyte lavage solution(PEG-ELS)plus bisacodyl for colon cleansing for morning colonoscopy.METHODS:Consecutive adult patients undergoing morning colonoscopy were allocated into two groups i.e.,same-day whole-dose or split-dose of 2-litre PEGELS.Investigators and endoscopists were blinded to the allocation.All patients completed a questionnaire that was designed by Aronchick and colleagues to assess the tolerability of the bowel preparation regime used.In addition,patients answered an ordinal fivevalue Likert scale question on comfort level during bowel preparation.Endoscopists graded the quality of bowel preparation using the Boston bowel preparation scale(BBPS).In addition,endoscopists gave an overall grading of the quality of bowel preparation.Cecal intu-bation time,withdrawal time,total colonoscopy time,adenoma detection rate and number of adenomas detected for each patient were recorded.Sample size was calculated using an online calculator for binary outcome non-inferiority trial.Analyses was based upon intent-to-treat.Significance was assumed at P-value<0.05.RESULTS:Data for 295 patients were analysed.Mean age was 62.0±14.4 years old and consisted of 50.2%male.There were 143 and 152 patients in the split-dose and whole-dose group,respectively.Splitdose was as good as whole-dose for quality of bowel preparation.The total BBPS score was as good in the split-dose group compared to the whole-dose group[6(6-8)vs 6(6-7),P=0.038].There was no difference in cecal intubation rate,cecal intubation time,withdrawal time,total colonoscopy time and adenoma detection rate.Median number of adenoma detected was marginally higher in the split-dose group[2(1-3)vs 1(1-2),P=0.010].Patients in the whole-dose group had more nausea(37.5%vs 25.2%,P=0.023)and vomiting(16.4%vs 8.4%,P=0.037),and were less likely to complete the bowel preparation(94.1%vs 99.3%,P=0.020).Patients in the split-dose group were less likely to refuse the same bowel preparation regime(6.3%vs 13.8%,P=0.033)and less likely to want to try another bowel preparation regime(53.8%vs 78.9%,P<0.001).CONCLUSION:Splitting reduced-volume PEG-ELS for morning colonoscopy is as effective as taking the whole dose on the same morning but is better tolerated and preferred by patients. | Wah-Kheong Chan Najib Azmi Sanjiv Mahadeva Khean-Lee Goh | 2014 | World Journal of Gastroenterology2014，20，39： | 7 |
| 4 | Redox-active humics support interspecies syntrophy and shift microbial community显示文摘The network of microbial electron transfer can establish a syntrophic association of microbes by connecting interspecies metabolisms, and a variety of redox-active shuttles in environment have been proved to accelerate the electron flow in a microbial community. Using humic substances as models, we investigated how different redox-active shuttles with different electrochemical properties influence interspecies electron transfer, and affect the shift of microbial communities. The co-culture of two species was constructed with supplements of humics, and the electron transfer between these two strains was found to be linked by humic acid with a wider window of redox potential and multi-peaks of redox reactions. Based on the shift of microbial composition, the humic substances with a wide potential window and multi-peaks of redox reactions for accepting and donating electrons could increase the biodiversity(Chao 1 and phylogenetic diversity) with a large extent. The mechanism by which redox-active shuttles mediate the microbial electron transfer network could facilitate our understanding of syntrophic interactions between microbes. | ZHENG Yue KAPPLER Andreas XIAO Yong YANG Fan MAHADEVA Gurumurthy Dummi ZHAO Feng | 2019 | Science China(Technological Sciences)2019，62，10： | 5 |
| 5 | Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers显示文摘OBJECTIVE Platinum compounds such as cisplatin and carboplatin are frequently used as the first-line chemotherapy for the treatment of the head and neck squamous cell carcinoma(HNSCC).In the present study,we investigated whether garcinol,apolyisoprenylated benzophenone can chemosensitize HNSCC to cisplatin.METHODS The effect of garcinol and cisplatin on HNSCC was assessed by MTT,Western blotting,real time PCR,FACS,immunohistochemistry,DNA binding assay and xenograft mouse model.RESULTS We found that garcinol inhibited the viability of a panel of diverse HNSCC cell lines,enhanced the apoptotic effect of cisplatin,suppressed constitutive as well as cisplatin-induced NF-κB activation,and downregulated the expression of various oncogenic gene products(cyclin D1,Bcl-2,survivin and VEGF).In vivo study showed that administration of garcinol alone(0.5 mg·kg-1,ip five times/week)significantly suppressed the growth of the tumor,and this effect was further increased by cisplatin.Both the markers of proliferation index(Ki-67)and microvessel density(CD31)were downregulated in tumor tissues by the combination of cisplatin and garcinol.The pharmacokinetic results of garcinol indicated that good systemic exposure was achievable after ip administration of garcinol at 0.5and 2mg·kg-1 with mean peak concentration(cmax)of 1825.4 and 6635.7nmol·L-1 in the mouse serum,respectively.CONCLUSION Overall,our results suggest that garcinol can indeed potentiate the effects of cisplatin by negative regulation of various inflammatory and proliferative biomarkers. | Feng Li Muthu K. Shanmugam Kodappully Sivaraman Siveen Fan Wang Tina H. Ong Ser Yue Loo Mahadeva M.M. Swamy Somnath Mandal Alan Prem Kumar Boon Cher Goh Tapas Kundu Kwang Seok Ahn Ling Zhi Wang Kam Man Hui Gautam Sethi | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 4 |
| 6 | Epidemiological and clinical perspectives on irritable bowel syndrome in India, Bangladesh and Malaysia: A review显示文摘Irritable bowel syndrome(IBS) is a chronic gastrointestinal disorder, common in clinic and in the community. It has a significant impact on both society and patients' quality of life. The epidemiology, clinical presentation, and management of IBS may vary in different geographical regions due to differences in diet, gastrointestinal infection, socio-cultural and psychosocial factors, religious and illness beliefs, symptom perception and reporting. Although previous reviews and consensus reports on IBS in Asia have been published, Asia is quite diverse socio-demographically. In this context, India, Bangladesh and Malaysia share some similarities, including:(1) large proportion of the population living in rural areas;(2) rapid development and associated lifestyle changes in urban areas; and(3) dietary, cultural and religious practices. The present review explores the clinical and epidemiological data on IBS from these three major nations in South and South-East Asia. In-depth review of the literature revealed important differences between IBS in the East, as revealed by studies from these three countries, and the West; these include a predominantly rural profile, differences in bowel habit and symptom profile, raising concern with regards to diagnostic criteria and subtyping of IBS, higher dietary fiber consumption, frequent lactose malabsorption, parasitosis, and possible overlap between post-infectious IBS and tropical sprue. Moreover, the current perception on difference in prevalence of the disorder in these countries, as compared to the West, might be related to variation in survey methods. | M Masudur Rahman Sanjiv Mahadeva Uday C Ghoshal | 2017 | World Journal of Gastroenterology2017，23，37： | 3 |
| 7 | A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease显示文摘 | Shamsul Zain Rosmawati Mohamed Sanjiv Mahadeva Phaik Cheah Sanjay Rampal Roma Basu Zahurin Mohamed | 2012 | Human Genetics2012，，7： | 2 |
| 8 | Adsorptive removal of phenol by bagasse fly ash and activated carbon: Equilibrium, kinetics and thermodynamics显示文摘 | Vimal C. Srivastava Mahadeva M. Swamy Indra D. Mall Basheswar Prasad Indra M. Mishra | 2005 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2005，，1： | 2 |
| 9 | Alpha(1)-antitrypsin deficiency, liver disease and emphysema显示文摘 | Parfrey H Mahadeva R Lomas DA | 2003 | Int J Biochem Cell Biol2003，35，7： | 1 |
| 10 | A chemical examination of Emblica officinalis 显示文摘 | PILLAY P P MAHADEVA IYER K | 1958 | Current Science1958，，27： | 1 |
| 11 | Alpha l antitrypsin polymerisation and the serpinopathies:pathobiology and prospects for treatment显示文摘 | Lomas DA Mahadeva R | | 0，，110： | 1 |
| 12 | Chronic obstructive pulmonary disease * 3 : Experimental animal models of pulmonary emphysema 显示文摘 | Mahadeva R Shapiro SD | 2002 | Thorax2002，57，： | 1 |
| 13 | Epidemiology of functional dys- pepsia:a global perspective显示文摘 | Mahadeva S Goh KL | 2006 | World J Gastroenterol2006，，12： | 1 |
| 14 | Open reduction and internalfixation versus hybrid fixation for bicondylar/severe tibial plateaufractures:a systematic review of the literature 显示文摘 | Mahadeva D Costa M L Gaffey A | 2008 | Arch OrthopTrauma Surg2008，128，10： | 1 |
| 15 | Reliability of the Neer classification system in proximal humeral frac- tures : a systematic review of the literature 显示文摘 | Mahadeva D Mackay DC Tumer SM | 2008 | Eur J Orthop Surg Traum2008，18，6： | 1 |
| 16 | Anxiety and depression in various functional gastrointestinal disorders: do differences ex- ist显示文摘 | Hartono JL Mahadeva S Goh KL | 2012 | Dig Dis2012，，13： | 1 |
| 17 | Further Studies of the Accuracy of Clamp-on Transit-Time Ultrasonic Flowmeters for Liquids 显示文摘 | Mahadeva D V Baker R C Woodhouse J | 2009 | Instrumentation and Measurement2009，58，5： | 1 |
| 18 | Epidemiology of functional dyspepsia:A Global perspective 显示文摘 | Mahadeva S Goh KL | 2006 | World Gastroentero2006，12，17： | 1 |
| 19 | Epidemiology of func- tional dyspepsia:a global perspective显示文摘 | MAHADEVA S GOH K L | 2006 | World Gas- troentero2006，12，： | 1 |
| 20 | Chronic obstructive pulmonary disease: experimental animalmodels of pulmonary emphysema显示文摘 | Mahadeva R Shapiro S D | 2002 | Thorax2002，57，10： | 1 |
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