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| 1 | Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes显示文摘Fas/CD95 表面受体调停各种各样的房间的快速的死亡打字,包括有为触发 autoimmunity 的潜力的 autoreactive T 房间。这里,我们表明那的船边交货的现在的新奇方面定义一种“社会”的尺寸到导致受体的 apoptosis。船边交货刺激很快导致在附近的 T 房间之间的广泛的膜 nanotube 形成。这极其依赖于 Rho GTPases 然而并非在 caspase 激活上。包括活跃 caspases 的膜和 cytosolic 元素的双向转移能被观察经由这些 nanotubes 发生。Nanotube 形成和死亡信号的细胞间的交换在从有在船边交货受体的自体免疫的 lymphoproliferative 症候群 harbouring 变化的病人的 T 淋巴细胞是有缺点的。我们断定调停 nanotube 的交换组成扩充在附近的 T 房间之间发信号的死亡的繁殖的细胞间的通讯的一种新奇形式。 | Peter D Arkwright Francesca Luchetti Julien Tour Charlotte Roberts Rahna Ayub Ana P Morales Jose J Rodriguez Andrew Gilmore Barbara Canonico Stefano Papa Mauro Degli Esposti | 2010 | Cell Research2010，20，1： | 4 |
| 2 | Effect of electrical stimulation of the lower esophageal sphincter in gastroesophageal reflux disease patients refractory to proton pump inhibitors显示文摘AIM: To evaluate the efficacy of lower esophageal sphincter(LES)-electrical stimulation therapy(EST) in a subgroup of patients that reported only partial response to proton pump inhibitors(PPIs) therapy, compared to a group of patient with complete response.METHODS: Bipolar stitch electrodes were laparoscopically placed in the LES and connected to an implantable pulse generator(EndoS tim BV, the Hague, the Netherlands), placed subcutaneously in the anterior abdominal wall. Stimulation at 20 Hz, 215 μsec, 3-8 m Amp in 30 min sessions was delivered starting on day 1 post-implant. Patients were evaluated using gastroesophageal reflux disease(GERD)-HRQL, symptom diaries; esophageal p H and esophageal manometry before and up to 24 mo after therapy and results were compared between partial and complete responders.RESULTS: Twenty-three patients with GERD on LESEST were enrolled and received continuous per-protocol stimulation through 12 mo and 21 patients completed 24 mo of therapy. Of the 23 patients, 16(8 male, mean age 52.1 ± 12 years) had incomplete response to PPIs prior to LES-EST, while 7 patients(5 male, mean age 52.7 ± 4.7) had complete response to PPIs. In the sub-group with incomplete response to PPIs, median(IQR) composite GERD-HRQL score improved significantly from 9.5(9.0-10.0) at baseline on-PPI and 24.0(20.8-26.3) at baseline off-PPI to 2.5(0.0-4.0) at 12-mo and 0.0(0.0-2.5) at 24-mo follow-up(P < 0.05 compared to on-and off-PPI at baseline). Median(IQR) % 24-h esophageal pH < 4.0 at baseline in this sub-group improved significantly from 9.8%(7.8-11.5) at baseline to 3.0%(1.9-6.3) at 12 mo(P < 0.001) and 4.6%(2.0-5.8) at 24 mo follow-up(P < 0.01). At their 24-mo follow-up, 9/11 patients in this sub-group were completely free of PPI use. These results were comparable to the sub-group that reported complete response to PPI therapy at baseline. No unanticipated implantation or stimulation-related adverse events, or any untoward sensation due to stimulation were reported in either group and LES-EST was safely tolerated by both groups. CONCLUSION: LES-EST is safe and effective in controlling symptoms and esophageal acid exposure in GERD patients with incomplete response to PPIs. These results were comparable to those observed PPI responders. | Edy Soffer Leonardo Rodríguez Patricia Rodriguez Beatriz Gómez Manoel G Neto Michael D Crowell | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 4 |
| 3 | Infrared, blue and ultraviolet upconversion emissions in Yb3+:Tm3+-doped fluoroindate glasses 显示文摘 | Martin I R Rodriguez V D Lavin V | 1999 | Spectrochimica Acta Part A1999，55，： | 2 |
| 4 | Quantification of bioactive acylethanolamides in rat plasma by electrospray mass spectrometry 显示文摘 | Giuffrida A Rodriguez de Fonseca F Piomelli D | 2000 | Anal Biochem2000，280，1： | 1 |
| 5 | Building geometric fealure based maps for indoor service robots 显示文摘 | RODRIGUEZ L D MATIA F GALAN R | 2006 | Robotics and Autonomous Systems2006，54，7： | 1 |
| 6 | expansion embedding techniques for reversible watermarking显示文摘 | Thodi D M Rodriguez J J | 2007 | IEEE Trans on image processing2007，16，3： | 1 |
| 7 | Carbon nanotubes for electrochemical biosensing显示文摘 | Rivas G A Rubianes M D Rodriguez M C | 2007 | Talanta2007，74，3： | 1 |
| 8 | Bullet: high bandwidth data dissemination using an overlay mesh 显示文摘 | Kostie D Rodriguez A Albrecht J | 2003 | ACM SOSR2003，37，5： | 1 |
| 9 | L-arginine availability regu-lates T-lymphocyte cell-cycle progression显示文摘 | Rodriguez P C Quiceno D G Ochoa A C | 2007 | Blood2007，109，4： | 1 |
| 10 | Transplantation of a multipotent cell population from human adipose tissue induces dystrophin expression in the immunocompetent mdx mouse显示文摘 | Rodriguez AM Pisani D Dechesne CA | 2005 | J Exp Med2005，201，9： | 1 |
| 11 | Matrix metalloproteinases: What do they not do? New substrates and biological roles identified by murine models and proteomics显示文摘 | Rodriguez D Morrison C J Overall CM | 2010 | Biochim Biophys Acta2010，1803，1： | 1 |
| 12 | Pre- diction of haematoma growth and outcome in patients with in- tracerebral haemorrhage using the CT-angiography spot sign (PREDICT) a prospective observational study显示文摘 | Demchuk A M Dowlatshahi D Rodriguez Luna D | 2012 | Lancet Neu- rol2012，11，4： | 1 |
| 13 | Value of accessibility to Bogata's bus rapid transit system显示文摘 | Rodriguez D Targa F | | 0，，05： | 1 |
| 14 | Comparative sequence stratigraphy and organic geochemistry of gas shales:Commonality or coincidence?显示文摘 | Slatt R M Rodriguez N D | 2012 | Journalof Natural Gas Scienceand Engineering2012，，： | 1 |
| 15 | Infectious bursal dis- ease virus capsid assembly and maturation by structural rear- rangements of a transient molecular switch 显示文摘 | Luque D Saugar I Rodriguez J F | 2007 | J Virol2007，81，13： | 1 |
| 16 | Expansion embedding techniques for reversible watermarking 显示文摘 | THODI D M RODRIGUEZ J J | 2007 | IEEE Transactions on Image Processing2007，16，3： | 1 |
| 17 | Analysis of the influence of pH and pressure on the elimination of boron in reverse osmosis 显示文摘 | D Prats M F Chillon - Arias M Rodriguez - Pastor | 2000 | Desalination2000，128，3： | 1 |
| 18 | Removal of pharmaceuticals and kinetics of mineralization by 03/HzOz in a biotreated municipal wastewater显示文摘 | Rosal R Rodriguez A Perdigon-Melon J A Mezcua M Hcrnando M D | 2008 | Water Research2008，42，： | 1 |
| 19 | Alterations in membrane fiuidity of diabetic polymorphonuclear leukocytes Biochem显示文摘 | Kantar A Kurose L Rodriguez V D | 1991 | Med Metab Biol1991，46，： | 1 |
| 20 | In vivo evaluation of acellular human dermis for abdominal wall repair显示文摘 | Eberli D Rodriguez S Atala A | 2010 | J Biomed Mater Res A2010，93，4： | 1 |
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