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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Soil boron fertilization:The role of nutrient sources and rootstocks in citrus production显示文摘Boron(B) is a key element for citrus production, especially in tropical regions, where the nutrient availability is commonly low in the soil. In addition, information about doses, fertilizer sources, methods of application, and particularly, differential nutrient demand of scion/rootstock combinations are required for efficient fertilization of commercial groves. In a non-irrigated sweet orange orchard(cv. Natal), grafted onto Rangpur lime, Swingle citrumelo or Sunki mandarin, we studied the application of two sources of B: boric acid(17% B, soluble in water) and ulexite(12% B, partially soluble in water) at four levels of supply(control without B, and soil application of 2, 4 and 6 kg ha^(-1) yr^(-1) of B). The experiment was carried out for three years(2004-2006). Boron availability in the soil and concentration in the leaves, as well as the fruit yield and quality of trees were evaluated. Soil B extracted with hot water and total leaf B positively correlated with doses of the nutrient applied to the trees. Levels of B in the soil and in the leaves did not vary with fertilizer sources. Fruit yield of trees grafted onto Rangpur lime and Swingle citrumelo was more responsive to B doses than those grafted onto Sunki mandarin. The maximum fruit yield of trees grafted onto Swingle was obtained with 3.2 kg ha^(-1) yr^(-1) of B, and leaf B level of 280 mg kg^(-1) that point out to a highest demand for B when this combination was compared with other rootstocks. Furthermore, fertilization with B did not affect the quality of fruits, but correlated with B and potassium(K) concentrations in the leaves. These results also support that the current recommendations for levels of B in leaves should be revisited. | Dirceu Mattos Jr Franz W R Hippler Rodrigo M Boaretto Eduardo S Stuchi Jose A Quaggio | 2017 | Journal of Integrative Agriculture2017，16，7： | 5 |
| 3 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 4 | Predictors of morbidity and mortality after the first episode of upper gastrointestinal bleeding in liver cirrhosis显示文摘 | Juan A.del Olmo Andrés Pe?a Miguel A Serra Abdallah H Wassel Adolfo Benages José M Rodrigo | 2000 | Journal of Hepatology2000，，1： | 2 |
| 5 | Factors that impact health-related quality of life in adults with celiac disease:A multicenter study显示文摘AIM: To evaluate the factors involved in the impairment of health-related quality of life (HRQOL) in patients with celiac disease.METHODS: A multicenter, cross-sectional prospective study was performed in patients with celiac disease who completed two HRQOL questionnaires: the gastrointestinal quality of life index (GIQLI) and the EuroQol-5D (EQ).RESULTS: Three hundred and forty patients (163 controlled with a gluten-free diet, and 177 newly diagnosed with a normal diet) were included. The GIQLI score was significantly better in patients on a gluten-free diet (GFD) than in non-treated patients on their usual diet, both in terms of the overall score (3.3 vs 2.7, respectively; P < 0.001), as well as on the individual questionnaire dimensions. Both the preference value of the EQ as the visual analogue scale were significantly better in treated than in non-treated patients (0.93 vs 0.72 P < 0.001 and 80 vs 70 P < 0.001, respectively). Variables significantly associated with a worse HRQOL score were female gender, failure to adhere to a GFD, and symptomatic status.CONCLUSION: In untreated celiac disease, the most important factors that influence patient perception of health are the presence of symptoms and a normal diet. HRQOL improves to levels similar to those described in the general population in celiac disease patients well controlled with a GFD. | F Casellas L Rodrigo J López Vivancos S Riestra C Pantiga JS Baudet F Junquera V Puig Diví C Abadia M Papo J Gelabert JR Malagelada | 2008 | World Journal of Gastroenterology2008，14，1： | 2 |
| 6 | MR imaging helps predict time from symptom onset in patients with acute stroke:implications for patients with unknown onset time显示文摘 | Petkova M Rodrigo S Lamy C | | 0，，： | 1 |
| 7 | The Wnt signalling pathway and rheumatoid arthritis 显示文摘 | FRANCIELI S R LICIA M H RODRIGO A C | 2010 | Autoimmunity Rev2010，9，4： | 1 |
| 8 | Characterization of en- tomopathogenie nematodes and symbiotic baeteria active against Spodoptera frugiperda ( Lepidoptera : Noctuidae ) and contribution of bacterial urease to the insecticidal effect 显示文摘 | Juliana M S Marina S D Rodrigo L B | 2012 | Biological Control2012，63，： | 1 |
| 9 | Brain networks of spatial awareness: evidence from diffusion tensor im aging tractography显示文摘 | Urbanski M Thiebaut De Schotten M Rodrigo S | 2008 | Journal of Neurology Neurosurgery and Psychiatry2008，79，5： | 1 |
| 10 | Adaptive edge-preserving image denois-ing using wavelet transforms 显示文摘 | RICARDO D D S RODRIGO M WILLIAM R S | 2013 | Pattern Analy- sis & Applications2013，16，4： | 1 |
| 11 | Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials 显示文摘 | RODRIGO M L PREMRANJAN P S RICHARD W N | 2007 | Lancet2007，370，9593： | 1 |
| 12 | Anti-inflamma-to-ry effects of compounds alpha-humulene and (α)-trans- caryophyllene isolated from the essential oil of Cordia verbenacea显示文摘 | Elizabeth S Giselle F Rodrigo M | 2007 | Eur J Pharmacol2007，569，3： | 1 |
| 13 | Can competition improve outcomes in UK health care'? Lessons from the past two decades 显示文摘 | Martin G Rodrigo M S Carol P | 2012 | Journal of Health Services Research & Policy2012，171，1： | 1 |
| 14 | Genetic alterations in squamous cell carcinomas of the hypopharynx with correlations to clinicopathological features显示文摘 | Rodrigo J P Gonzalez M V Lazo P S | 2002 | Oral Oncol2002，38，4： | 1 |
| 15 | Materials Scienceand Engineering: 5显示文摘 | Femdndez S Pena R Rodrigo M T | 2007 | 2007, 143(1-3): 552007，143，13： | 1 |
| 16 | Better to be frustrated than bored: The incidence, persist- ence, and impact of learners'cognitive - affective states during interactions with three different computer- based learning environments 显示文摘 | Baker R S D'Mello S K Rodrigo M T Graesser A C | 2011 | International Journal of Human - Computer Studies2011，，68： | 1 |
| 17 | Prognostic significance of neuroendocrine expression in lymph node-positive prostate cancer显示文摘 | Quek M L Daneshmand S Rodrigo S | 2006 | Urology2006，67，6： | 1 |
| 18 | As- sociation between bone mineral density, lean mass, and fat mass among healthy middle-aged premenopausal women: a cross-sectional study in southern Sri Lanka 显示文摘 | Lekamwasam S Weerarathna T Rodrigo M | 2009 | J Bone Miner Metab2009，27，： | 1 |
| 19 | Explicit solutions to European options in a regime-switching economy显示文摘 | Maroon R S Rodrigo M R | 2005 | Operations Research Letters2005，33，： | 1 |
| 20 | Kashin - Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status 显示文摘 | Rodrigo MR Carl S Franqoise M | 1998 | NEJM1998，339，16： | 1 |
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