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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Factors that impact health-related quality of life in adults with celiac disease:A multicenter study显示文摘AIM: To evaluate the factors involved in the impairment of health-related quality of life (HRQOL) in patients with celiac disease.METHODS: A multicenter, cross-sectional prospective study was performed in patients with celiac disease who completed two HRQOL questionnaires: the gastrointestinal quality of life index (GIQLI) and the EuroQol-5D (EQ).RESULTS: Three hundred and forty patients (163 controlled with a gluten-free diet, and 177 newly diagnosed with a normal diet) were included. The GIQLI score was significantly better in patients on a gluten-free diet (GFD) than in non-treated patients on their usual diet, both in terms of the overall score (3.3 vs 2.7, respectively; P < 0.001), as well as on the individual questionnaire dimensions. Both the preference value of the EQ as the visual analogue scale were significantly better in treated than in non-treated patients (0.93 vs 0.72 P < 0.001 and 80 vs 70 P < 0.001, respectively). Variables significantly associated with a worse HRQOL score were female gender, failure to adhere to a GFD, and symptomatic status.CONCLUSION: In untreated celiac disease, the most important factors that influence patient perception of health are the presence of symptoms and a normal diet. HRQOL improves to levels similar to those described in the general population in celiac disease patients well controlled with a GFD. | F Casellas L Rodrigo J López Vivancos S Riestra C Pantiga JS Baudet F Junquera V Puig Diví C Abadia M Papo J Gelabert JR Malagelada | 2008 | World Journal of Gastroenterology2008，14，1： | 2 |
| 4 | Characterization of Pinalate, a novel Citrus sinensis mutant with a fruit-specific alteration that results in yellow pigmentation and decreased ABA content显示文摘 | Rodrigo M J Marcos J F Alferez F | 2003 | J Exp Bot2003，54，： | 1 |
| 5 | Identification and partial characterization of the soybean-dust allergens involved in the Barcerona asthma epidemic 显示文摘 | Rodrigo M J Morell F Helm R M | 1990 | Allergy and Clinical Immunology1990，85，： | 1 |
| 6 | Anti-inflamma-to-ry effects of compounds alpha-humulene and (α)-trans- caryophyllene isolated from the essential oil of Cordia verbenacea显示文摘 | Elizabeth S Giselle F Rodrigo M | 2007 | Eur J Pharmacol2007，569，3： | 1 |
| 7 | P53 expression in squamous cell carcinomas of the supraglottic larynx and its lymph node metastases:new results for an old question显示文摘 | Cabanillas R Rodrigo J P Astudillo A Dominguez F Suarez C Chiara M D | 2007 | Cancer2007，109，： | 1 |
| 8 | Early Stages of Zebrafish Eye Formation Require the Coordinated Activity of Wnt 11, Fz5, and the Wnt/β-Catenin Pathway显示文摘 | Cavodeassi F Carreira-Barbosa F Rodrigo M | 2005 | Neuron2005，47，1： | 1 |
| 9 | Characterization of Pinalate, a novel Citrus sinensis mutant with a fruit-specific altera- tion that results in yellow pigmentation and decreased ABA content显示文摘 | RODRIGO M J MARCOS J F ALFEREZ F | 2003 | Journal of Experimental Botany2003，54，： | 1 |
| 10 | Detection of Ellipses Using Modified Hough Transform 显示文摘 | Patricia M B MANSO Rodrigo F PRESTES and Mariane R PETRAGLIA | 2003 | IEEE International Symposium2003，，2： | 1 |
| 11 | Prevalence of human papillornavirus in laryngeal and hypopharyngeal squarnous cell carcinomas in northern Spaln显示文摘 | RODRIGO J P HERMSEN M A FRESNO M F | 2015 | Cancer Epidemiol2015，39，： | 1 |
| 12 | Mathematical model for the combined effect of temperature and pH on the thermal resistance of Bacillus stearotherrmophilus and Clostridium spores 显示文摘 | FERNANDEZ P S OCIO M J RODRIGO F | 1996 | International Journal of Food Microbiology1996，32，12： | 1 |
| 13 | Inactivation kinetics of pectin methyl esterase under combined thermal-high pressure treat- ment in an orange juice-milk beverage显示文摘 | SAMPEDRO F RODRIGO D HENDRICKX M | 2008 | Journal of Food Engineering2008，86，1： | 1 |
| 14 | Spatial and tempo- ral patterns of precipitation in Spain for the period 1880 - 1992显示文摘 | Esteban - Parra M J Rodrigo F S Castro - Diez Y | 1998 | International Journal of Climatology1998，18，14： | 1 |
| 15 | Antioxidant therapy reduces oxida- tive and inflammatory tissue damage in patients subjec- ted to cardiac surgery with extracorporeal circulation 显示文摘 | Castillo R Rodrigo R Perez F Cereceda M Asenjo R Zamorano J | 2011 | Basic Clin Pharmacol Toxicol2011，108，： | 1 |
| 16 | Improved extraction procedures for coal products based on the Soxtec apparatus显示文摘 | Giner L M Rodrigo J V Navarro A C F | 1996 | Energy & Fuels1996，10，： | 1 |
| 17 | System of dynamic neutralization in the lumbar spine : experience on 94 cases 显示文摘 | Bordes - Monmeneu M Bordes - Garcia V Rodrigo - Baeza F | 2005 | Neurocirugia (Astur)2005，16，6： | 1 |
| 18 | Short-term effects of temperature and COD in a microbial fuel cell显示文摘 | GONZALEZ DEL CAMPO A LOBATO J CAIZARESB P RODRIGO M A FERNANDEZ MORALESA F J | 2013 | Appl Energy2013，101，： | 1 |
| 19 | Inactivation kinetics of pectin methyl esterase under combined thermal-high pressure treatment in an orange juice-milk beverage显示文摘 | Sampedro F Rodrigo D Hendrickx M | 2008 | Journal of Food Engineering2008，86，1： | 1 |
| 20 | Characterization of pinalate,anovel citrus sinensis mutant with a fruit-speeifc alteration that results in yellow pigmentation and decreased ABA content显示文摘 | Rodrigo M J Marcos J F Fernando A | | 0，，： | 1 |
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