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| 1 | 一种缓冲回填材料的筛选及其特性:西班牙实例(英文)显示文摘介绍了西班牙在高放废物深地质处置中用于缓冲回填材料的泥岩的筛选及其特性的研究成果,这项研究在西班牙核废料管理委员会资助下进行,始于 20 世纪 80 年代,且在开始阶段主要是开展泥岩沉积层及黏土供应商的筛选工作。黏土这些特性与标准已被国际社会广泛接受,但进一步的研究主要涉及到泥岩的矿物纯度、持水特性、可塑性、低渗透性、较高的膨胀压力和热导性。经初步研究,确定两种膨润土沉积层被选中,并在实验室中对其特性进行了研究,主要包括:热–水–力特性的确定、预加热和温度的影响以及石英添加剂的作用。由于膨润土具有较高的膨胀性以及低渗透性,因而必须对传统的试验技术进行改进,并设计出新的试验设备。最终确定Cortijo de Archidona(Almería)选为西班牙膨润土的供应区,其开采的膨润土已在近期结束的数个研究课题中得到了应用。无论是从矿物学、热学、水力学、力学和地质化学,还是从可变性等方面看来,该区膨润土的特性都是最好的;另外,处置库中膨润土的变化特征在实验室以及现场都已经作了相应的研究。 | Villar María Victoria Astudillo Julio Huertas Fernando | 2006 | 岩石力学与工程学报2006，25，4： | 6 |
| 2 | Glucocorticosteroid therapy in inflammatory bowel diseases: From clinical practice to molecular biology显示文摘Inflammatory bowel diseases(IBDs),such as ulcerative colitis and Crohn's disease,are chronic pathologies associated with a deregulated immune response in the intestinal mucosa,and they are triggered by environmental factors in genetically susceptible individuals.Exogenous glucocorticoids(GCs)are widely used as anti-inflammatory therapy in IBDs.In the past,patients with moderate or severe states of inflammation received GCs as a first line therapy with an important effectiveness in terms of reduction of the disease activity and the induction of remission.However,this treatment often results in detrimental side effects.This downside drove the development of second generation GCs and more precise(non-systemic)drugdelivery methods.Recent clinical trials show that most of these new treatments have similar effectiveness to first generation GCs with fewer adverse effects.The remaining challenge in successful treatment of IBDs concerns the refractoriness and dependency that some patients encounter during GCs treatment.A deeper understanding of the molecular mechanisms underlying GC response is key to personalizing drug choice for IBDs patients to optimize their response to treatment.In this review,we examine the clinical characteristics of treatment with GCs,followed by an in depth analysis of the proposed molecular mechanisms involved in its resistance and dependence associated with IBDs.This thorough analysis of current clinical and biomedical literature may help guide physicians in determining a course of treatment for IBDs patients and identifies important areas needing further study. | Karen Dubois-Camacho Payton A Ottum Daniel Franco-Munoz Marjorie De la Fuente Alejandro Torres-Riquelme David Díaz-Jiménez Mauricio Olivares-Morales Gonzalo Astudillo Rodrigo Quera Marcela A Hermoso | 2017 | World Journal of Gastroenterology2017，23，36： | 6 |
| 3 | Oleanolic acid promotes healing of acetic acid - induced chronic gastric lesions in rats显示文摘 | Rodriguez J A Astudillo L Schmeda - Hirschmann G | 2003 | Pharmacol Res2003，48，3： | 1 |
| 4 | Simulaneous laparoscopic biliary and retrocolic gastric bypass in patients with unresectable carcinoma of the pancreas显示文摘 | Kuriansky J Sáenz A Astudillo E | 2000 | Surg Endosc2000，14，2： | 1 |
| 5 | Immunohistochemical study of distribution of apolipoproteins E and D in human cerebral beta amyloid deposits显示文摘 | NAVARRO A del VALLE E ASTUDILLO A | 2003 | Exp Neurol2003，184，2： | 1 |
| 6 | Gastroprotective and cytotoxic effect of dehydroabietic acid derivatives 显示文摘 | Sept~lveda B Astudillo L Rodrfguez J A | 2005 | Pharmacolog- ical Research2005，52，5： | 1 |
| 7 | Gastro- protective activity of oleanoJic acid derivatives on experimentally induced gastric lesions in rats and mice 显示文摘 | Astudillo L Rodriguez J A Schmeda-Hirschmann G | 2002 | J Pharm Pharmacol2002，54，4： | 1 |
| 8 | Topology-oriented self-organizing maps: a survey显示文摘 | ASTUDILLO C A JOHN OOMMEN B | 2014 | Pattern analysis and applications2014，17，2： | 1 |
| 9 | On Achieving Semi-supervised Pattern Recognition by Utilizing Tree-based SOMs显示文摘 | Astudillo Cesar A John Oommen B | 2013 | Pattern Recognition2013，46，： | 1 |
| 10 | Inflammation and matrix remodeling during repair of ventilator-induced lung injury显示文摘 | González-López A Astudillo A García-Prieto E | 2011 | Am J Physiol Lung Cell Mol Physiol2011，301，4： | 1 |
| 11 | A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer显示文摘 | Covadonga Huidobro Rocío G. Urdinguio Ramón María Rodríguez Cristina Mangas Vincenzo Calvanese Pablo Martínez-Camblor Cecilia Ferrero Adolfo Parra-Blanco Luis Rodrigo álvaro J. Obaya Laura Suárez-Fernández Aurora Astudillo Henar Hernando Esteban Ballestar | 2011 | European Journal of Cancer2011，，14： | 1 |
| 12 | Skp2, p27 ( kip1) and EGFR assessment in head and neck squamous cell carcinoma: Prognostic implications 显示文摘 | Carracedo DG Astudillo A Rodrigo JP | 2008 | Oncol Rep2008，20，3： | 1 |
| 13 | Transgastric Cholecystectomy Using a Prototype Endoscope with 2 Deflecting Working Channels显示文摘 | Astudillo J A Sporn E Bachman S | 2009 | Gastrointest Endosc2009，69，2： | 1 |
| 14 | Prognostic value of chronic obstructive pulmonary disease in 2994 cases of lung canc- er显示文摘 | Lopez-Encuentra A Astudillo J Cerezal J | 2005 | Eur J Cardiothorac Surg2005，27，1： | 1 |
| 15 | Gastroprotective and cytotoxic effect of dehydroabietic acid derivatives 显示文摘 | SEPuLVEDA B ASTUDILLO L RODRIGUEZ J A | 2005 | Pharmacological Research2005，52，5： | 1 |
| 16 | Gastroprotective and cytotoxic effect of dehydroabietic acid derivatives显示文摘 | Sepulveda B Astudillo L Rodriguez J A | 2005 | Pharmacological Research2005，52，5： | 1 |
| 17 | Gastroprotective and cytotoxic effect of dehydroabietic acid derivatives 显示文摘 | SEPULVEDA B ASTUDILLO L RODRIGUEZ A | 2005 | Pharmacological Research2005，52，5： | 1 |
| 18 | Simultaneous laparoscopic biliary and retrocolic gastric bypass in patients with unresectable carcinoma of the pancreas显示文摘 | Kuriansky J Saenz A Astudillo E | 2000 | Surg Endosc2000，14，： | 1 |
| 19 | P53 expression in squamous cell carcinomas of the supraglottic larynx and its lymph node metastases:new results for an old question显示文摘 | Cabanillas R Rodrigo J P Astudillo A Dominguez F Suarez C Chiara M D | 2007 | Cancer2007，109，： | 1 |
| 20 | p53 expression in squamous cell carcinomas ofthe supraglottic larynx and its lymph node metasta-ses: New results for an old question 显示文摘 | CABANILLAS R RODRIGO J P ASTUDILLO A | 2007 | Cancer2007，109，： | 1 |
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