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| 1 | Superchiral near fields detect virus structure显示文摘Optical spectroscopy can be used to quickly characterise the structural properties of individual molecules.However,it cannot be applied to biological assemblies because light is generally blind to the spatial distribution of the component molecules.This insensitivity arises from the mismatch in length scales between the assemblies(a few tens of nm)and the wavelength of light required to excite chromophores(≥150 nm).Consequently,with conventional spectroscopy,ordered assemblies,such as the icosahedral capsids of viruses,appear to be indistinguishable isotropic spherical objects.This limits potential routes to rapid high-throughput portable detection appropriate for point-of-care diagnostics.Here,we demonstrate that chiral electromagnetic(EM)near fields,which have both enhanced chiral asymmetry(referred to as superchirality)and subwavelength spatial localisation(∼10 nm),can detect the icosahedral structure of virus capsids.Thus,they can detect both the presence and relative orientation of a bound virus capsid.To illustrate the potential uses of the exquisite structural sensitivity of subwavelength superchiral fields,we have used them to successfully detect virus particles in the complex milieu of blood serum. | Tarun Kakkar Chantal Keijzer Marion Rodier Tatyana Bukharova Michael Taliansky Andrew J.Love Joel J.Milner Affar S.Karimullah Laurence D.Barron Nikolaj Gadegaard Adrian J.Lapthorn Malcolm Kadodwala | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 2 | Radiopharmaceutical-guided surgeryin primary malignant melanoma of the vagina显示文摘 | Rodier JF Janser JC David E | 1999 | Gynecol Oncol1999，75，2： | 1 |
| 3 | The teratology of autism显示文摘 | Arndt TL Stodgell CJ Rodier PM | 2005 | Int J D Neuroscience2005，23，： | 1 |
| 4 | Converging evidence for brain stem injury in au- tism 显示文摘 | Rodier PM | 2002 | Dev Psychopathol2002，14，3： | 1 |
| 5 | Interferogram analysis using Fourier transform technique显示文摘 | ROD IER C RODIER F | 1987 | Applied Opties1987，26，9： | 1 |
| 6 | Two faces of p53 : aging and tumor suppression 显示文摘 | Rodier F Campisi J Bhaumik D | 2007 | Nucleic Acids Res2007，35，： | 1 |
| 7 | Interferogram analysis using Fourier transform techniques 显示文摘 | Roddier C Rodier F | 1987 | Appl Opt1987，26，： | 1 |
| 8 | Involvement of minerals in adher- ence of Legionella pneumophila to surfaces显示文摘 | Koubar M Rodier MH Frere J | 2013 | Curt Microbiol2013，66，5： | 1 |
| 9 | Laparoscopic vertical banded gastroplasty显示文摘 | D. Nocca R. Aggarwal P. Blanc B. Gallix G. L. Di Mauro B. Millat C. Seguin des Hons E. Deneve J. G. Rodier G. Tincani M. A. Pierredon J. M. Fabre | 2007 | Surgical Endoscopy2007，，6： | 1 |
| 10 | Evaluation of Advanced Transit Alternatives Using Consumer Welfare显示文摘 | RODIER C J JOHNSTON R A SHABAZIAN D R | 1998 | Transportation Research Part C1998，6，12： | 1 |
| 11 | Corneal gene therapy: basic science and translational perspective 显示文摘 | Mohan RR Rodier JT Sharma A | 2013 | Ocul Surf2013，11，3： | 1 |
| 12 | Frame- work for ecological risk assessment显示文摘 | Norton S B Rodier D J Schalie W H V D | 1992 | Environmental Toxicology & Chemistry1992，11，12： | 1 |
| 13 | Human bocavirus in children显示文摘 | Rodiere M Segondy M | 2006 | Emerg Infect Dis2006，12，5： | 1 |
| 14 | MicroRNAs miR-146a/b negatively modulate the senes- cence-associated inflammatory mediatom IL-6 and IL-8 显示文摘 | Bhaumik D Seott GK Sehokrpur S Patil CK Orjalo AV Rodier F | 2009 | Ag- ing2009，1，4： | 1 |
| 15 | Quantitative trait locusmapping of yield-related components and oligogeniccontrol of the cap color of the button mushroom,Agaricus bisporus显示文摘 | FOULONQNE-ORIOL M RODIER A ROUSSEAU T | 2012 | Appl Environ Microbiol2012，78，7： | 1 |
| 16 | Saliva promotes survival and even proliferation of Candida species in tap water显示文摘 | Barbot V Migeot V Rodier M H | 2011 | FEMS Microbiol Lett2011，324，1： | 1 |
| 17 | Two faces of p53 : aging and tumor suppression 显示文摘 | Rodier F Campisi J Bhaumik D | 2007 | Nucleic Acids Res2007，35，22： | 1 |
| 18 | One hundred laparoscopic choledochotomies with primary closure of the common bile duct显示文摘 | G. Decker F. Borie B. Millat J.C. Berthou A. Deleuze F. Drouard F. Guillon J.G. Rodier A. Fingerhut | 2002 | Surgical Endoscopy2002，，： | 1 |
| 19 | Purification and characterization of N-acetyl glucosaminidase from Trypanosoma cruzi显示文摘 | Moudni B E Rodier M H Jacquemin J L | 1996 | Experimental Parasitology1996，83，： | 1 |
| 20 | A variant form of the nuclear triiodothyronine receptor c-erbaalphal plays a direct role in regulation of mitochondrial rna synthesis显示文摘 | Casas F Rochard P Rodier A | | 0，，： | 1 |
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