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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Antimicrobial Activity of the Methanolic Extract and Compounds from the Stem Bark of Drypetes tessmanniana显示文摘从茎评估甲醇摘录的抗菌剂活动的目的 Drypetes tessmanniana ,部分( DTB1-5 )以及混合物吠叫[ friedelin ( 2 ), 3,7-dioxofriedelane ( 3 ), 3,15-dioxofriedelane ( 4 ), 3 尾-O-(E) -3,5-dihydroxycinnamoyl-11-oxo-olean-12-ene ( 6 ),和 3 尾, 6 伪- dihydroxylup-20 ( 29 ) -ene ( 7 )。方法琼脂圆盘散开被用来决定上述样品的敏感,虽然 microdilution 方法被用于最小的禁止的集中(MIC ) 和最小的 microbicidal 集中(MMC ) 的决心。散开测试显示出的结果粗略的摘录能阻止所有的生长,这测试了有机体。所有另外的样品显示出选择活动。部分 DTB2 的禁止的效果在 63.7% 上被注意, 54.6% 上的 DTB1 和 DBT3,虽然 DTB4 和 DTB5 开是活跃的, 11 中的 9.1% 个测试了有机体。测试混合物为混合物阻止了 81.8% 测试微生物引起的种类的生长 3 和 4, 36.7% 为化合物 6,和 18.2% 为化合物 7。MIC 决心的结果为 DTB 和化合物显示了可察觉的价值 4 在 81.8% 测试有机体上。为另外的样品, MIC 在 0 鈥 ? 上被检测 3.7% 。为粗略的摘录和部分(DTB2 ) 的最低 MIC 价值(78.12 渭 g /mL ) 在 M 上被观察。audouinii。为孤立的混合物(156.25 渭 g /mL ) 的相应价值与混合物被注意 3 在 S 上。faecalis 并且 4 在 M 上。audouinii audouinii。MMC 决心的结果建议大多数学习微生物上的测试样品的 microbicidal 效果能被期望。结论从茎的甲醇摘录 Drypetes 吠叫。象一些孤立的混合物一样的 tessmanniana (Euphorbiaceae ) 可能是新抗菌剂药的潜在的来源。关键词 Drypetes tessmanniana - Euphorbiaceae - 混合物 - 抗菌剂活动为科学由国际基础支持了(没有。IFS/2624-3F ) 。 | Victor Kuete Marlise D.J.Dongfack Armelle T.Mbaveng Marie-Christine Lallemand Hanh T.Van-Dufat Jean-Duplex Wansi Elisabeth Seguin Francois Tillequin Jean Wandji | 2010 | Chinese Journal of Integrative Medicine2010，16，4： | 7 |
| 3 | A new friedelane triterpenoid and saponin with moderate antimicrobial activity from the stems of Drypetes laciniata显示文摘新 friedelane 类型 triterpene 说出 3-hydroxyfriedelane-7,12,22-trione,以及九已知的混合物从 Drypetes laciniata 兔笼的整个茎被孤立。(Euphorbiaceae ) 。他们的结构根据分光镜的方法被建立。新 triterpene 衍生物和已知的 saponin 为抗菌剂和抗真菌的活动被测试,他们显得中等积极。 | Simone Veronique Fannang Victor Kuete Celine Mbazoa Djama Marlise Diane J.Dongfack Jean Duplex Wansi Francois Tillequin Elisabeth Seguin Elizabeth Chosson Jean Wandji | 2011 | Chinese Chemical Letters2011，22，2： | 2 |
| 4 | First characterization of endophytic Corynespora cassiicola isolates with variant cassiicolin genes recovered from rubber trees in Brazil显示文摘Corynespora cassiicola is the causal agent of Corynespora Leaf Fall(CLF)disease.CLF is one of the most important fungal diseases of rubber trees in Asia and Africa but disease outbreaks have not been reported in South America.Cassiicolin,a small cysteine-rich glycoprotein secreted by the pathogenic C.cassiicola isolate CCP,was previously identified as a potential disease effector in rubber tree.Recently,the cassiicolin-encoding gene(Cas1)was characterized and shown to be expressed in the early phase of infection.In this study,we investigated whether previously undetected strains of C.cassiicola are present in South American rubber plantations by examining the fungal endophyte population found in asymptomatic rubber tree leaves.Four isolates were identified as C.cassiicola.Genes encoding new forms of the cassiicolin precursor protein(Cas3 and Cas4)were identified from these isolates.Three of four isolates were able to induce symptoms on the cultivar they were isolated from in a detached leaf assay,with different kinetics and intensities.One isolate had the same pathogenicity profile as the pathogenic isolate CCP;the other two isolates developed symptoms late during the course of infection,suggesting saprotrophic capabilities.However,no Cas3 or Cas4 transcripts could be detected upon inoculation with the endophytic isolates,whereas the reference gene Cas1 was expressed upon inoculation with the CCP isolate.This work demonstrated that C.cassiicola is present in South America in an endophytic form and that it may evolve from an endophytic to a saprophytic or even potentially pathogenic life style. | Marine Déon Ana Scomparin Aude Tixier Carlos R.R.Mattos Thierry Leroy Marc Seguin Patricia Roeckel-Drevet Valérie Pujade-Renaud | 2012 | Fungal Diversity2012，，3： | 2 |
| 5 | The tumor necrosis factor alpha-stimulation region of galactose-inhibitable letin of Entamoeba histolytica activities interferon-primed macrophages for amebicidal activity mediated by nitric oxide显示文摘 | Seguin R Mann BJ Keller K | | Infection and Immunity0，，： | 2 |
| 6 | Static and quasi-dynamic load balancing in parallel FDTD codes for signal integrity, power integrity and packaging applications 显示文摘 | S A Seguin M A Cracraft J L Drewniak | 2004 | Electromagnetic Compatibility2004，1，： | 1 |
| 7 | Retroperitoneal laparo- scopic versus open pyeloplasty with a minimal incision: comparison of two surgical approaches 显示文摘 | Soulie M Thoulouzan M Seguin P | 2001 | Urology2001，57，3： | 1 |
| 8 | An integrin β3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition显示文摘 | Seguin L Kato S Franovic A | 2014 | Nat Cell Biol2014，16，5： | 1 |
| 9 | Seed compo- sition of ten industrial hemp cultivars approved for pro- duction in Canada显示文摘 | Vonapartis E Aubin M P Seguin P | 2015 | Journal of Food Composition and Analysis2015，39，： | 1 |
| 10 | Greenhouse gas emissions and climate change: causes and consequences observed for agriculture and animal production显示文摘 | Bernard Seguin B Soussana J F | 2008 | Courrier De l''Environnement De I''INRA2008，55，1： | 1 |
| 11 | Strength training and olderwomen:a cross-sectional study examining factors related to exercise ad-herence显示文摘 | Seguin RA Economos CD Palombo R | 2010 | J Aging Phys Act2010，18，2： | 1 |
| 12 | Endothelial progenitor cells:new biomarkers and potential therapy in intensive care显示文摘 | SEGUIN T BRAUN T MIRA J P | 2007 | {H}MéDECINE ET MALADIES INFECTIEUSES2007，，06： | 1 |
| 13 | An exact algorithm for the vehicle routing problem with stochastic demands and customers 显示文摘 | GENDREAU M LAPORTE G SEGUIN R | 1995 | Transportation Science1995，29，2： | 1 |
| 14 | New second generation current conveyor with reduced parasitic resistance and bandpass filter application 显示文摘 | F Seguin A Fabre | 2001 | IEEE transactions on circuit and systems-Ⅰ: Fundamental theory and applications2001，48，6： | 1 |
| 15 | Effects of feeding forage soybean silage on milk production, nutrient digestion, and ruminal fermentation of lactating dairy cows显示文摘 | Vargas Bello-Perez E Mustafa AF Seguin P | 2008 | J Dairy Sci2008，91，1： | 1 |
| 16 | Photo emission and photoionization measurements in the CO2 laser environment显示文摘 | Seguin H J J Mcken D Tulip J | 1976 | Appl Phys Lett1976，28，9： | 1 |
| 17 | Expression of the gene encoding metallothionein-3 in organs of the reproductive system 显示文摘 | Moffatt P Seguin C | 1998 | DNA Cell Biol1998，17，6： | 1 |
| 18 | Associations between sleep duration patterns and behavioral/cognitive functioning at school entry显示文摘 | Touchette E Petit D Seguin JR | 2007 | Sleep2007，30，9： | 1 |
| 19 | Physical aggression during early childhood:Trajectories and predictors显示文摘 | TREMBLAY R E NAGIN D S SEGUIN J R | | 0，，01： | 1 |
| 20 | Non -traumatic necrosis of bone (osteonecrosis) is associated with endothelial cell activation but not thrombophilia显示文摘 | Seguin C Kassis J Busque L | 2008 | Rheumatology (Oxford)2008，47，8： | 1 |
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