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	题名	作者	年代	出处	被引量
1	CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL.	Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed	2018	Cellular & Molecular Immunology2018，15，2：	2
2	Evaluation of laparoscopic management of common bile duct stones in 220 patients显示文摘	Berthou JC Drouard F Charbonneau P	1998	Surg Endosc1998，12，1：	2
3	Diagnosis and treatment of common bile duct stones (CBDS)显示文摘	A. Paul B. Millat U. Holthausen S. Sauerland E. Neugebauer J. C. Berthou H.-J. Brambs J. E. Dominguez-Mu?oz P. Goh L. E. Hammarstr?m E. Lezoche J. Périssat P. Rossi M. A. R?thlin R. C. G. Russell P. Spinelli Y. Tekant	1998	Surgical Endoscopy1998，，6：	2
4	Evaluation of laparoscopic treatment of common bile duct stones in a prospective series of 505 patients: indications and results显示文摘	J. Ch. Berthou B. Dron Ph. Charbonneau K. Moussalier L. Pellissier	2007	Surgical Endoscopy2007，，11：	2
5	Optical-fiber temperature sensor based on upconversion excited fiuorescence显示文摘	Berthou H Jrgensen C	1990	Optics Letters1990，15，19：	1
6	One hundred laparoscopic choledochotomies with primary closure of the common bile duct显示文摘	G. Decker F. Borie B. Millat J.C. Berthou A. Deleuze F. Drouard F. Guillon J.G. Rodier A. Fingerhut	2002	Surgical Endoscopy2002，，：	1
7	CD5-induced apoptosis of B cells in some patients with chronic lymphocytic leukemia显示文摘	Pers JO Berthou C Porakishvili N	2002	Leukemia2002，16，1：	1
8	Influence of the ligands on 3d photoelectron spectra of the first four lanthanides显示文摘	Berthou H Jorgensen C K Bonnele C	1976	Chem Phys Lett1976，，38：	1
9	Financial Market Imperfections and the hnpact of Exchange Rate Movements on Exports 显示文摘	Berman N Berthou A	2009	Review of International Economics2009，17，1：	1
10	Morphology and Raman spectra of diamond films grown with a plasma torch显示文摘	Berthou H Faure C Hanni W Perret A	1999	Diamond and Related Materials1999，8，：	1
11	Supporting end-to-end quality of service properties in OMG data distribu-tion service publish/subscribe middleware over widearea networks 显示文摘	Hakiri A Berthou P Gokhale A	2013	Journal of Systems and Software2013，86，10：	1
12	Immunostimulating Properties and Three-dimensional Structure of Two Tripeptides from Human and Cow Caseins显示文摘	BERTHOU J MIGLIORE-SAMOUR D	1987	FEBS Letter1987，218，1：	1
13	Supporting SIP-Based End-to- End Data Distribution Service QoS in WANs 显示文摘	HAKIRI A BERTHOU P	2014	Journal of Systems and Software2014，，95：	1
14	Cytochrome P450 2E1 activity and oxidative stress in alcoholic patients显示文摘	Dupont I Bodenez P Berthou F	2000	Alcohol and alcoholism2000，35，1：	1
15	Opposite regulation of human versus mouse apolipoprotein A-Ⅰ by fibrates in human apolipoprotein A-Ⅰ transgenic mice显示文摘	BERTHOU L DUVERGER N EMMANUEL F	1996	J Clin Invest1996，97，11：	1
16	Evaluation of laparoseopic treatment of common bile duct stones in a prospective series of 505 patients : indications and results 显示文摘	Berthou JCh Dron B Charbonneau P	2007	Surg Endosc2007，21，11：	1
17	Morphology and Raman Spectra of Diamond Films Grown with a Plasma Torch 显示文摘	Berthou H Faure C Hanni W	1999	Diamond and Related Materials1999，8，：	1
18	Split Pthoto-electron Sing-nals from the Unique Closed-Shell Cation Lanthanum (Ⅲ) 显示文摘	Jorgensen C K Berthou H	1985	Chemical Physics Letters1985，13，3：	1
19	显示文摘	Berthou C Bourge JF Zhang Y	2000	Blood2000，95，7：	1
20	Inhibition of CYP3A,CYPIA and CYP2EI activities by resveratrol and other non volatile red wine components显示文摘	PIVER B BERTHOU F DREANO Y	2001	Toxicol Lett2001，125，13：	1

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