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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Detection of Epstein- Barr virus in recurrent tonsillitis 显示文摘 | Dias EP Rocha ML Carvalho MO | 2009 | Braz J Otorhinolaryngol2009，75，1： | 1 |
| 3 | Effect of sucrose ester on the kinetics of polymorphic transition in hydrogenated sunflower oil显示文摘 | ML Herrera FJ Marquez Rocha | 1996 | JAOCS1996，73，3： | 1 |
| 4 | Vulnerabilityof postnatal hippocampal neurons to seizures varies regionallywith their maturational stage显示文摘 | Lopez-Meraz ML Wasterlain CG Rocha LL | 2010 | Neurobiol Dis2010，37，2： | 1 |
| 5 | Effect of alendronate on periodontal disease in post-menopausal women:a randomized placebo con-trolled trial显示文摘 | Rocha ML Malacara JM Saachez | 2004 | J Periodontl2004，79，9： | 1 |
| 6 | Low frequcy stimulation modifies receptor bindings in rat brain显示文摘 | López-Meraz ML Neri-Bazán L Rocha L | | 0，，： | 1 |
| 7 | Risk factors for bronchopulmonary dys- plasia in five Portuguese neonatal intensive care units 显示文摘 | Guimaraes H Rocha G Vasconcellos G Proenqa E Carreira ML Sossai Mdo R | 2010 | Rev Port Pneumol2010，16，3： | 1 |
| 8 | Mechanisms involved in the gastroprotective activity of esculin on acute gastric lesions in mice显示文摘 | Rios ER Rocha NF Ven(a)ncio ET Moura BA Feitosa ML Cerqueira GS Soares PM Woods D J de Sousa FC Leal LK Fonteles MM | | 0，，1： | 1 |
| 9 | Blood pressure variability increases connexin expression in the vascular smooth muscle of rats显示文摘 | Rocha ML Kihara AH Davel AP | 2008 | Cardiovascular Research2008，80，1： | 1 |
| 10 | 5-HT1A receptor agonists modify epileptic seizures in three experimental models in rats显示文摘 | López-Meraz ML González-Trujano ME Neri-Bazán L Hong E Rocha LL | | 0，，03： | 1 |
| 11 | Detection of EpsteinBarr virus in recurrent tonsillitis显示文摘 | Dias EP Rocha ML Carvalho MO | | 0，，1： | 1 |
| 12 | Effects of fasting and intermittent fasting on rat hepatocarcinogenesis induced by diethylni- trosamine显示文摘 | Rocha NS Barbisan LF de Oliveira ML | 2002 | Teratog Carcinog Mutagen2002，22，2： | 1 |
| 13 | Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats显示文摘 | Blasi ER Rocha R Rudolph AE Blomme EA Poly ML McMahon EG | 2003 | Kidney Int2003，63，： | 1 |
| 14 | Effect of alendronate on periodontal disease in postmenopausal women:a randomized placebo-controlled trial显示文摘 | Rocha ML Malacara JM Sanchez-Marin FJ | 2004 | J Periodontol2004，75，9： | 1 |
| 15 | Do single seizures cause neuronal death in the human hippocampus? 显示文摘 | Rocha LL Lopez-Meraz ML Niquet J | 2007 | Epilepsy Curr2007，7，3： | 1 |
| 16 | Severe maternal morbidity and near miss due to postpartum hemorrhage in a national muhicenter surveillance study显示文摘 | Rocha Filho EA Costa ML Cecatti JG | 2015 | Int J Gynaecol Obstet2015，128，2： | 1 |
| 17 | Detection of Epstein- Barr virus in recurrent tonsillitis显示文摘 | Dias EP Rocha ML Carvalho MO | 2009 | Braz J Otorhinolaryngol2009，75，1： | 1 |
| 18 | Atypical pneumococcal scleritis after pterygium excision: case report and literature review显示文摘 | Paula JS Simgo ML Rocha EM | 2006 | Cornea2006，25，1： | 1 |
| 19 | Micro-Process based management of medical equipment maintenance显示文摘 | Bassani JWM Rocha LS Luders ML | 2002 | Engineering in Medicine & Biology2002，3，： | 1 |
| 20 | Vulnerability of postnatal hippocampal neurons to seizures varies regionally with theirmatumtional stage显示文摘 | Lopez- Meraz ML Wasterlain CG Rocha LL | 2010 | Neurobiol Dis2010，，37： | 1 |
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