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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Sequential eytokine therapy for pressure ulcers: clinical and mechanistic response 显示文摘 | Robson M C Hill D P Smith P D | 2000 | Ann Surg2000，231，4： | 1 |
| 3 | Acta Mater显示文摘 | Robson J D Jones M J Prangnell P B | 2003 | 51: 14532003，51，： | 1 |
| 4 | On the Ground Estima- tion of Vegetation Cover in Australian Range-lands 显示文摘 | Zhou Q Robson M Pilesjo P | 1998 | International Journal of Remote Sensing1998，，9： | 1 |
| 5 | Ionisation Coefficients Measured in Abrupt InP Junctions显示文摘 | UMEBU I CHOUDHURY A N M M ROBSON P N | 1980 | Appl Phys Lett1980，36，： | 1 |
| 6 | Characterization of species and races of the genus Meloidogyne by DNA restriction enzyme analysis显示文摘 | Garate T Robson M P Chacon M R | 1991 | Journal of Nematology1991，23，： | 1 |
| 7 | Application of land use regression to identify sources and assess spatial variation in urban SVOC concentrations 显示文摘 | MELYMUK L ROBSON M HELM P A | 2013 | Environ Sci Technol2013，47，4： | 1 |
| 8 | Extension of the N-model to predict competing homogeneous and heterogeneous precipitation in Al-Sc alloys显示文摘 | Robson J D Jones M J Prangnell P B | 2003 | Acta Met2003，51，5： | 1 |
| 9 | Description of a new species of Phylloscopus warbler from Vietnam and Laos显示文摘 | Alstr(o)m P Davidson P Duckworth JW Eames JC Le TT Nguyen C Olsson U Robson C Timmins RJ | | 0，，： | 1 |
| 10 | On-the-ground estimation ofvegetation cover in Australian rangelands显示文摘 | Zhou Q Robson M Pilesjo P | 1998 | InternationalJournal of Remote Sensing1998，19，9： | 1 |
| 11 | On the ground estimation of vegetation cover in Australian rangelands 显示文摘 | Zhou Q Robson M Pilesjo P | 1998 | International Journal of Remote Sensing1998，19，9： | 1 |
| 12 | BRCA - associated breast- cancer: absence of a characteristic immunophenotype 显示文摘 | Robson M Rajan P Rosen P P | 1998 | Cancer Res1998，58，9： | 1 |
| 13 | PCBs, PBDEs, and PAHs in Toronto air: Spatial and seasonal trends and implications for contaminant transport显示文摘 | Melymuk L Robson M Helm P A | 2012 | Science of the Total Environment2012，429，： | 1 |
| 14 | Extension of the n-model to predict competing homogeneous and heterogeneous precipitation in Al-Sc alloy显示文摘 | ROBSON J D JONES M J PRANGNELL P B | 2003 | Acta Materialia2003，51，： | 1 |
| 15 | Wound healing alterations caused by infection显示文摘 | ROBSON M C STENBERG B D HEGGERS J P | 1990 | Clin Plast Surg1990，17，： | 1 |
| 16 | The effect of intermittent high intensity exercise on blood Zinc status and urinary Zinc exertion显示文摘 | ROBSON P J BLANNIN A K GLEESON M | 1998 | Sports Sci1998，，16： | 1 |
| 17 | Comparison of behavior ther-apy and cognitive behavior therapy in the treatment of generalizedanxiety disorder 显示文摘 | Butler G Fennell M Robson P | 1991 | J Consult Clin Psychol1991，59，1： | 1 |
| 18 | Predicting the toxicity of metal-spiked laboratory sediments using acid-volatile sulfide and interstitial water normalizations 显示文摘 | Berry W J Hanseo D J Mahony J D Robson D L Di Toro D M Shipley B P Rogers B Corbin J M Boothman W S | 1996 | Environ Toxicol Chem1996，15，12： | 1 |
| 19 | On the ground estimation of vegetation cover in Australian rangelands 显示文摘 | Zhou Qiming Robson M Pilesjo P | 1998 | International Journal of Remote Sensing1998，19，9： | 1 |
| 20 | Amidines PartⅡ:Preparation of cyanides,amides,and amidines from carboxylic acids显示文摘 | Oxley P Partridge M W Robson T D | 1946 | J Chem Soc1946，149，： | 1 |
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