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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Root hair length determines beneficial effect of a Glomus species on shoot growth of some pasture species 显示文摘 | Schweiger P F Robson A D Barrow N J | 1995 | New Phytologist1995，131，： | 1 |
| 3 | Isolation and partial characterization of the Streptococcus mutans type AⅡ lantibiotic mutacin K8 显示文摘 | ROBSON C L WESCOMBE P A KLESSE N A | 2007 | Microbiology2007，153，5： | 1 |
| 4 | Dispersoid precipitation and process modeling in zirconium containing commercial alu- minum alloy显示文摘 | ROBSON J D PRANGNELL P B | 2001 | Acta Materialia2001，49，4： | 1 |
| 5 | Three-dimensional modelling of a Microeystis bloom event in the Swan River estuary, Western Australia 显示文摘 | Robson B J Hamilton D P | 2004 | Ecological Modelling2004，174，： | 1 |
| 6 | Natural products:potential for developing PheUodendron amurense Bark ex-tract for prostate cancer management显示文摘 | Kumar A P Graham H Robson C | 2010 | Mini Reviews inMedicinal Chemistry2010，10，5： | 1 |
| 7 | Dispersoid precipitation andprocess modeling in zirconium containing commercialaluminium alloys 显示文摘 | ROBSON J D PRANGNELL P B | 2001 | Acta Materialia2001，49，4： | 1 |
| 8 | Sequential eytokine therapy for pressure ulcers: clinical and mechanistic response 显示文摘 | Robson M C Hill D P Smith P D | 2000 | Ann Surg2000，231，4： | 1 |
| 9 | Acta Mater显示文摘 | Robson J D Jones M J Prangnell P B | 2003 | 51: 14532003，51，： | 1 |
| 10 | Leaf senescence is delayed in maize expressing the Agrobacterium IPT gene under the control of a novel maize senescence-enhanced promoter 显示文摘 | ROBSON P R H DONNISON I S WANG K | 2004 | Plant Biotechnology Journal2004，，2： | 1 |
| 11 | Three-dimensional modelling of a microcystis bloom event in the Swan River estuary, Western Australia显示文摘 | ROBSON B J HAMILTON D P | 2004 | Ecological Modelling2004，174，： | 1 |
| 12 | Determinants of Long-Distance Investing by Business Angels in the UK 显示文摘 | HARRISON R MASON C ROBSON P | 2010 | Entrepreneurship and Regional Development2010，22，2： | 1 |
| 13 | Leaf senescence is delayed in maize expressing the Agrobacterium IPT gene under the control of a novel maize senescence-enhanced promoter显示文摘 | Robson P R Donnison I S Wang K | | 0，，2： | 1 |
| 14 | On the Ground Estima- tion of Vegetation Cover in Australian Range-lands 显示文摘 | Zhou Q Robson M Pilesjo P | 1998 | International Journal of Remote Sensing1998，，9： | 1 |
| 15 | Predicting the recrystallized volume fraction in AAT050 hot rolled plate 显示文摘 | Robson J D Prangnell P B | 2002 | Materials Science and Technology2002，18，6： | 1 |
| 16 | Characterization of copper bioreduction and biosorption by a highly copper resistant bacterium isolated from copper-contaminated vineyard soil 显示文摘 | Robson A Simone P Lorraine W Lee MK Flavio AO Camargo BC | 2010 | Sci Total Environ2010，40，8： | 1 |
| 17 | Predicting recrystallised volume fraction in aluminiurn alloy 7050 hot rolled plate显示文摘 | ROBSON J D PRANGNELL P B | 2002 | Mater Sci Tech2002，18，6： | 1 |
| 18 | SME growth:The relationship with business advice andexternal collaboration显示文摘 | P ROBSON R BENNET | 2000 | Small Business Economics2000，，15： | 1 |
| 19 | CONSTANS mediates between the circadian clock and the control of flowering in Arabidopsis显示文摘 | Suarez-Lopez P Wheatley K Robson F | 2001 | Nature2001，410，6832： | 1 |
| 20 | Modelling Al3Zr dispersoid precipitation in multicomponent aluminum alloys显示文摘 | ROBSON J D PRANGNELL P B | 2003 | Materials Science and Engineering A2003，352，12： | 1 |
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