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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 3 | The ultraviolet sensitivity of Kevlar 149 and teehnora fibres 显示文摘 | DOBB M G ROBSON R M ROBERTYS A H | 1993 | Journal of Materials Science1993，28，3： | 1 |
| 4 | Making sense of regulatory T cell suppressive function显示文摘 | Shalev I Schmelzle M Robson S C | | 0，，04： | 1 |
| 5 | Extension of the Nmodelto predict competing homogeneous and heterogeneous precipitation in Al-Sc alloys显示文摘 | Robson J D Jonesl M J | 2003 | Acta Materialia2003，51，： | 1 |
| 6 | Epidural analgesia need not increase operative delivery rates显示文摘 | Impey L MacQuillan K Robson M | 2000 | Am J Obstet Gynecol2000，182，： | 1 |
| 7 | Effects of postmortem aging time, animal age, and sex on degradation of titin and nebulin in bovine longissimus muscle显示文摘 | HUFF-LONERGAN E PARRISH F C ROBSON R M | 1995 | Anim Sci1995，73，4： | 1 |
| 8 | Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-con- cept trlal显示文摘 | Tutt A Robson M C arber JE | 2010 | Lancet2010，376，9737： | 1 |
| 9 | Direct and indirect effects of solar ultraviolet-B radiation on longterm decomposition显示文摘 | Pancotto V A Sala O E Robson T M | 2005 | Glob Chang Biol2005，，11： | 1 |
| 10 | Direct and indirect effects of solar ultraviolet-B radiation on long-term decomposition 显示文摘 | PANCOTTO V A SALA O E ROBSON T M | 2005 | Global Change Biology2005，11，： | 1 |
| 11 | The size distribution of innovating finns in the UK: 1945 - 1983 显示文摘 | PAVITI' K ROBSON M TOWNSEND J | 1987 | Journal of Indus- trial Economics1987，35，3： | 1 |
| 12 | A micronetralization test for canine distemper virus显示文摘 | Appel M Robson D S | | 0，，： | 1 |
| 13 | Oral poly(ADP-ribose) polymer- ase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial 显示文摘 | Tutt A Robson M Garber JE | 2010 | Lancet2010，376，9737： | 1 |
| 14 | Sequential eytokine therapy for pressure ulcers: clinical and mechanistic response 显示文摘 | Robson M C Hill D P Smith P D | 2000 | Ann Surg2000，231，4： | 1 |
| 15 | Emissions, and fate of polybrominated diphenyl ethers and polychlorinated biphenyls indoors in Toronto, Canada 显示文摘 | Zhang X M Diamond M L Robson M | 2011 | Environmental Science & Technology2011，45，8： | 1 |
| 16 | Acta Mater显示文摘 | Robson J D Jones M J Prangnell P B | 2003 | 51: 14532003，51，： | 1 |
| 17 | Major ion concentrations and inorganic carbon chemistry of the Humber river 显示文摘 | Neal C Robson A J Harrow M | 1997 | Sci Total Environ1997，，： | 1 |
| 18 | Leaf emergence, tiller growth and apical development of nitrogen deficient spring wheat显示文摘 | Longnecker N Kirby E J M Robson A | 1993 | Crop Science1993，33，1： | 1 |
| 19 | Breast conservation therapy for invasive breast cancer in Ashkenazi women with BRCA gene founder mutations显示文摘 | Levin D Fedetici M | 1999 | J Natl Cancer Inst1999，91，： | 1 |
| 20 | Effects of granulocyte-macrophage colony-stimulating factor on wound contraction显示文摘 | Robson M Kucukcelebi A Carp SS | 1994 | Eur J Clin Microbiol Infect Dis1994，132，： | 1 |
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