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| 1 | Biomarkers for pancreatic cancer:Recent achievements in proteomics and genomics through classical and multivariate statistical methods显示文摘Pancreatic cancer(PC) is one of the most aggressive and lethal neoplastic diseases. A valid alternative to the usual invasive diagnostic tools would certainly be the determination of biomarkers in peripheral fluids to provide less invasive tools for early diagnosis. Nowadays, biomarkers are generally investigated mainly in peripheral blood and tissues through high-throughput omics techniques comparing control vs pathological samples. The results can be evaluated by two main strategies:(1) classical methods in which the identification of significant biomarkers is accomplished by monovariate statistical tests where each biomarker is considered as independent from the others; and(2) multivariate methods, taking into consideration the correlations existing among the biomarkers themselves. This last approach is very powerful since it allows the identification of pools of biomarkers with diagnostic and prognostic performances which are superior to single markers in terms of sensitivity, specificity and robustness. Multivariate techniques are usually applied with variable selection procedures to provide a restricted set of biomarkers with the best predictive ability; however, standard selection methods are usually aimed at the identification of the smallest set of variables with the best predictive ability and exhaustivity is usually neglected. The exhaustive search for biomarkers is instead an important alternative to standard variable selection since it can provide information about the etiology of the pathology by producing a comprehensive set of markers. In this review, the most recent applications of the omics techniques(proteomics, genomics and metabolomics) to the identification of exploratory biomarkers for PC will be presented with particular regard to the statistical methods adopted for their identification. The basic theory related to classical and multivariate methods for identification of biomarkers is presented and then, the most recent applications in this field are discussed. | Emilio Marengo Elisa Robotti | 2014 | World Journal of Gastroenterology2014，20，37： | 5 |
| 2 | Proteomic changes involved in tenderization of bovine Longissimus dorsi muscle during prolonged ageing显示文摘 | Rita Polati Michele Menini Elisa Robotti Renato Millioni Emilio Marengo Enrico Novelli Stefania Balzan Daniela Cecconi | 2012 | Food Chemistry2012，，3： | 2 |
| 3 | Develop- ment of calibration models for quality control in the produc- tion of ethylene/propylene copolymers by FTIR spectrosco- py, multivariate statistical tools, and artificial neural net- works 显示文摘 | Marengo Emilio Longo Valentina Robotti Elisa | 2008 | Journal of Applied Polymer Science2008，109，6： | 1 |
| 4 | Proteomic changes involved in tenderization of bovine Longissimus dorsi muscle during prolonged ageing显示文摘 | Rita Polati Michele Menini Elisa Robotti Renato Millioni Emilio Marengo Enrico Novelli Stefania Balzan Daniela Cecconi | 2012 | Food Chemistry2012，，3： | 1 |
| 5 | A traceability study on the Moscato wine chain显示文摘 | Maurizio Aceto Elisa Robotti Matteo Oddone Massimo Baldizzone Gabriella Bonifacino Guido Bezzo Rocco Di Stefano Fabio Gosetti Eleonora Mazzucco Marcello Manfredi Emilio Marengo | 2012 | Food Chemistry2012，，： | 1 |
| 6 | A traceability study on the Moscato wine chain显示文摘 | Maurizio Aceto Elisa Robotti Matteo Oddone Massimo Baldizzone Gabriella Bonifacino Guido Bezzo Rocco Di Stefano Fabio Gosetti Eleonora Mazzucco Marcello Manfredi Emilio Marengo | 2012 | Food Chemistry2012，，： | 1 |
| 7 | Identification of the regulatory proteins in human pancreatic cancers treated with Trichostatin A by 2D-PAGE maps and multivariate statistical analysis显示文摘 | Emilio Marengo Elisa Robotti Daniela Cecconi Mahmoud Hamdan Aldo Scarpa Pier Giorgio Righetti | 2004 | Analytical and Bioanalytical Chemistry (-)2004，，7： | 1 |
| 8 | Hydroxyl and acid number prediction in polyester resins by near infrared spectroscopy and artificial neural networks显示文摘 | Marco Bobba Elisa Robotti Marcello Lenti | 2004 | Analytical Chimica Acta2004，511，： | 1 |
| 9 | Investigation of anthropic effects connected with metal ions concentration, organic matter and grain size in Bormida river sediments显示文摘 | Emilio Marengo Maria Carla Gennaro Elisa Robotti | 2006 | Analytica Chemica Acta2006，560，： | 1 |
| 10 | Simultaneous determination of thirteen polycyclic aromatic hydrocarbons and twelve aldehydes in cooked food by an automated on-line solid phase extraction ultra high performance liquid chromatography tandem mass spectrometry显示文摘 | Fabio Gosetti Ugo Chiuminatto Eleonora Mazzucco Elisa Robotti Giorgio Calabrese Maria Carla Gennaro Emilio Marengo | 2011 | Journal of Chromatography A2011，，37： | 1 |
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