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| 1 | Synergy between CD26/DPP-IV Inhibition and G-CSF Improves Cardiac Function after Acute Myocardial Infarction显示文摘 | Marc-Michael Zaruba Hans Diogenes Theiss Markus Vallaster Ursula Mehl Stefan Brunner Robert David Rebekka Fischer Lisa Krieg Eva Hirsch Bruno Huber Petra Nathan Lars Israel Axel Imhof Nadja Herbach Gerald Assmann Ruediger Wanke Josef Mueller-Hoecker Gerha | 2009 | Cell Stem Cell2009，，4： | 1 |
| 2 | Tailored antireflective biomimetic nanostructures for UV applications显示文摘 | Christoph Morhard Claudia Pacholski Dennis Lehr Robert Brunner Michael Helgert Michael Sundermann Joachim P Spatz | 2010 | Nanotechnology2010，，42： | 1 |
| 3 | Spatial filtering and selection of optimized components in four class motor imagery EEG data using independent components analysis显示文摘 | Clemens Brunner Muhammad Naeem Robert Leeb Bernhard Graimann Gert Pfurtscheller | 2007 | Pattern Recognition Letters2007，，8： | 1 |
| 4 | 设计DNA必须根植于企业文化显示文摘 | Robert Brunner | 2010 | 数位时代2010，，07： | 1 |
| 5 | NAMD2: Greater Scalability for Parallel Molecular Dynamics显示文摘 | Laxmikant Kalé Robert Skeel Milind Bhandarkar Robert Brunner Attila Gursoy Neal Krawetz James Phillips Aritomo Shinozaki Krishnan Varadarajan Klaus Schulten | 1999 | Journal of Computational Physics1999，，1： | 1 |
| 6 | Meat, poultry and fish and risk of colorectal cancer: pooled analysis of data from the UK dietary cohort consortium显示文摘 | Elizabeth A. Spencer Timothy J. Key Paul N. Appleby Christina C. Dahm Ruth H. Keogh Ian S. Fentiman Tasnime Akbaraly Eric J. Brunner Victoria Burley Janet E. Cade Darren C. Greenwood Alison M. Stephen Gita Mishra Diana Kuh Robert Luben Angela A. Mulligan | 2010 | Cancer Causes & Control2010，，9： | 1 |
| 7 | Regarding the Optical Properties of Porous Layers Prepared on Si Substrates显示文摘 | Emil Pincik Robert Brunner Hikaru Kobayashi Pavel Vojtek Zuzana Zabudla Milan Mikula Jan Gregus Michal Kucera | 2017 | Journal of Energy and Power Engineering2017，11，11： | 0 |
| 8 | Screening for pancreatic cancer in individuals with genetic susceptibility显示文摘Pancreatic cancer is a highly lethal disease with a five-year survival rate of only about 10%(1).Early detection is crucial for improving patient outcomes,but pancreatic cancer is often diagnosed at an advanced stage when treatment options are limited(2).Individuals with a genetic susceptibility to pancreatic cancer,such as those with a strong family history or a genetic mutation associated with the disease,are at higher risk of developing pancreatic cancer than the general population.Screening these high-risk individuals could potentially lead to earlier detection and improved outcomes. | Robert Grützmann Maximilian Brunner | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 0 |
| 9 | Heterologous expression of the glucose oxidase gene in Trichoderma atroviride leads enhanced ability to attack phytopathogenic fungi and induction of plant systemic disease resistance显示文摘A transgenic strain of Trichoderma atroviride that expresses the Aspergillus niger glucose oxidase gene goxA under a homologous pathogen-inducible promoter (nag1) has been constructed, with the aim of increasing the ability of this biocontrol agent (BCA) to attack phytopathogenic fungi and enhance plant systemic disease resistance. The sporulation and growth rate of the transgenic progenies were similar to the wild-type strain P1. goxA expression occurred immediately after contact with the plant pathogen, and the glucose oxidase formed was secreted extracellularly. The transformed strain SJ3 4, containing 12-14 copies of the transgene, produced significantly less N-acetyl-glucosaminidase and endochitinase then wild type. However, the ability of its culture filtrate to inhibit the germination of Botrytis cinerea spores was increased by about 3-fold. In comparison to P1, the transgenic strain more quickly overgrew and lysed in vitro the pathogens Rhizoctonia solani and Pythium ultimum. In assays in vivo SJ3 4 showed a highly improved biocontrol ability in soil heavily infested with those pathogens, where the wild type was unable to protect the plant and allow seeds to germinate. The Trichoderma-gox was able to induce a much higher level of systemic resistance against the foliar pathogen B. cinerea, as compared to the parent strain. This work demonstrate that i) heterologous genes driven by pathogen-inducible promoters can improve the biocontrol and Induced Systemic Resistance properties of fungal BCAs such as Trichoderma spp., and ii) these microbes can be used as vectors to provide the plant with useful molecules able, for instance, to increase pathogen | Robert L Mach Brunner Kurt Matteo Lorito Susanne Zeilinger Rosalia Ciliento Sheridan Woo | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 0 |
| 10 | G protein signalling involved in host recognition and mycoparasitism-related chitinase expression in Trichoderma atroviride显示文摘Mycoparasitic species of Trichoderma are commercially applied as biological control agents against various fungal pathogens. The mycoparasitic interaction is host specific and includes recognition, attack and subsequent penetration and killing of the host. Investigations on the underlying events revealed that Trichoderma responds to multiple signals from the host (e.g. lectins or other ligands such as low molecular weight components released from the host’s cell wall) and host attack is accompanied by morphological changes and the secretion of hydrolytic enzymes and antibiotics. Degradation of the cell wall of the host fungus is-besides glucanases and proteases-mainly achieved by chitinases. In vivo studies showed that the ech42 gene (encoding endochitinase 42) is expressed before physical contact of Trichoderma with its host, probably representing one of the earliest events in mycoparasitism, whereas Nag1 (N-acetylglucosaminidase) plays a key role in the general induction of the chitinolytic enzyme system of T. atroviride . Investigations on the responsible signal transduction pathways of T. atroviride led to the isolation of several genes encoding key components of the cAMP and MAP kinase signaling pathways, as alpha and β subunits of heterotrimeric G proteins, the regulatory subunit of cAMP-dependent protein kinase, adenylate cyclase, and three MAP kinases. Analysis of knockout mutants, generated by Agrobacterium-mediated transformation, revealed that at least two alpha-subunits of heterotrimeric G proteins are participating in mycoparasitism-related signal transduction. The Tga1 G alpha subunit was shown to be involved in mycoparasitism-related processes such as chitinase expression and overproduction of toxic secondary metabolites, whereas Tga3 was found to be completely avirulent showing defects in chitinase formation and host recognition. | Susanne Zeilinger Barbara Reithner Kurt Brunner Valeria Scala Isabel Peiβl Matteo Lorito Robert L Mach | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 0 |
| 11 | Physical Properties and Light-Related Applications ol Black Silicon Structures显示文摘 | Emil Pincik Hikaru Kobayashi Robert Brunner Kentaro Imamura Milan Mikula Michal Kucera Pavel Vojtek Zuzana Zabudla PeterSvec Sr Jan Gregus PeterSvec Jr | 2016 | 材料科学与工程(中英文B版)2016，6，3： | 0 |
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