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| 1 | 镉对生命活动的毒作用机制显示文摘镉是一种众所周知的环境毒物,对人体健康有重大危害。镉与众多疾病相关,例如癌症、神经退化性疾病和代谢综合征等。虽然疾病种类各异,但是都与镉的化学性质和毒作用机制有关。镉易与含硫氮功能基结合,从而取代金属酶内的必需元素锌。镉的促炎症效应伴随促炎因子[肿瘤坏死因子(TNF-α)、白介素(IL)-1、IL-6]的大量产生和抗炎因子(IL-1拮抗剂、IL-4、IL-6、IL-10、IL-13)的明显减少,并且镉的促炎症活性与其通过各种途径所诱导的氧化应激紧密相关。镉还能取代各种蛋白质内的铁铜原子,从而增加自由氧化还原反应的活性金属库,激活芬顿(Fenton)反应;反之,镉对电子传递链的抑制损害了对氧气的利用,增加了活性氧的产生。最后,镉对抗氧化酶的抑制加剧自由基对核酸等生物大分子的损伤,引起遗传毒性并改变基因调控。因此,干扰镉的毒作用机制是预防镉暴露不良健康效应的有效措施。 | Alexey A.TINKOV Olga P.AJSUVAKOVA Jan AASETH Yordanka G.GLUHCHEVA Juliana M.IVANOVA Geir BJФRKLUND Margarita G.SKALNAYA Oksana A.SKALNAYA 黄百粲 林雪 Anatoly V.SKALNY | 2018 | 环境与职业医学2018，35，5： | 11 |
| 2 | 农场规模和有机耕作对瑞典一个景观区域内鸟类、传粉者和植物多样性的影响显示文摘本研究比较了瑞典东南部罗斯拉根(Roslagen)6个小型农场(耕种面积<52 hm^2)和6个大型农场(耕种面积>135 hm^2)之间鸟类多样性和多度,蝴蝶、大黄蜂和草本植物的多度。2个大型农场和4个小型农场为有机农场。所有农场大尺度上的景观镶嵌结构和地下岩床是相似的。统计分析采用中位数箱线图和均值方差分析。小型农场的鸟类物种及其领域、蝴蝶和草本植物物种数目是大型农场的2倍以上,而小型农场的大黄蜂数目是大型农场的5倍。各指标间的最大差异来自于小型有机农场和大型常规农场之间。小型和大型有机农场之间也具有显著差异:尽管都不使用杀虫剂,小型农场的鸟类比大型农场多56%。因此,农场规模是研究有机农业对生物多样性的影响时必须考虑的因素。 | Kristina Belfrage Johanna Bjrklund Lennart Salomonsson 梁虹 | 2005 | AMBIO-人类环境杂志2005，34，B12： | 3 |
| 3 | Homeopathic potencies of Arnica montana L. change gene expression in a Tamm-Horsfall protein-1 cell line in vitro model: the role of ethanol as a possible confounder and statistical bias显示文摘Marzotto et al. showed that homeopathic preparations of Arnica montana L. acted directly on gene expression of Tamm-Horsfall protein-1(THP-1) monocyte/macrophage cell lines activated with phorbol12-myristate13-acetate and interleukin-4(IL-4). A. montana homeopathic dilutions are used in complementary and alternative medicine to treat inflammation disorders and post-traumatic events as well as for wound repair. The French Pharmacopoeia of these remedies uses 0.3% ethanol in each centesimal dilution. In this paper, we discuss how ethanol-containing A. montana homeopathic centesimal dilutions can change gene expression in IL-4-treated monocyte/macrophage THP-1. We assessed the role of ethanol in the Arnica homeopathic dilutions containing this alcohol by investigating its action on gene expression of THP-1 cell. Evidence would strongly suggest that the presence of ethanol in these remedies might play a fundamental role in the dilutions ability to affect gene expression, particularly for doses from 5c to 15 c. Where, rather than playing a major role in the mesoscopic structure of water, the ethanol might have a chemical-physical role in the induction of THP-1 gene expression, apoptosis, and deoxyribonucleic acid function. This evidence generates a debate about the suggestion that the use of a binary-mixed solvent in homeopathic chemistry, used by Hahnemann since 1810, may be fundamental to explain the activity of homeopathy on cell models. | Salvatore Chirumbolo Geir Bj?rklund | 2017 | Journal of Integrative Medicine2017，15，4： | 2 |
| 4 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 5 | Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats显示文摘 | Staffan Holmqvist Oldriska Chutna Luc Bousset Patrick Aldrin-Kirk Wen Li Tomas Bj?rklund Zhan-You Wang Laurent Roybon Ronald Melki Jia-Yi Li | 2014 | Acta Neuropathologica2014，，6： | 2 |
| 6 | Distribution and variation of NV genes in fish rhabdoviruses显示文摘 | Kurath G Higman K H Bjrklund H V | 1997 | The Journal of General Virology1997，78，： | 1 |
| 7 | Residues of oxytetracycline in wild fish and sediments from fish farm 显示文摘 | BJΦRKLUND H BONDESTEAM J BYLUND G | 1990 | Aquaculture1990，86，： | 1 |
| 8 | Gelatinase-mediated migration and invasion of cancer cells显示文摘 | Bjo rklund M Koivunen E | 2005 | Biochim Biophys Acta2005，1755，1： | 1 |
| 9 | Impact of Production Intensity on the Ability of the Agricultural Landscape to Generate Ecosystem Services:an Example from Sweden显示文摘 | Bj(o)rklund J Limburg K E Rydberg T | 1999 | Ecological Economics1999，29，： | 1 |
| 10 | Self-repair in the brain显示文摘 | Bjrklund A Lindvall O | 2000 | Nature2000，405，89： | 1 |
| 11 | Temperature-related Absorption and Excretion or Oxytetracyline in Rainbow Trout(Salmo gairdneri R)显示文摘 | Bjǒrklund H Bylund G | 1990 | Aquaculture1990，84，： | 1 |
| 12 | Impact of production intensity on the ability of the agricultural landscape to generate ecosystem services:An example from Sweden显示文摘 | Bjrklund J Limburg K Rydberg T | 1999 | Ecol Econ1999，29，： | 1 |
| 13 | The glycoprotein genes and gene junctions of the fish rhabdoviruses spring viremia of carp virus and hirame rhabdovirus:analysis of relationships with other rhabdoviruses显示文摘 | Bjrklund H V Higman K H Kurath G | 1996 | Virus Research1996，42，12： | 1 |
| 14 | The glycoprotein genes and gene junctions of the fish rhabdoviruses spring viremia of carp virus and hirame rhabdovirus:analysis of relationships with other rhabdoviruses显示文摘 | Bjrklund H V Higman K H Kurath G | 1996 | Virus Research1996，42，12： | 1 |
| 15 | Growth-differe ntiation factor-15 improves risk stratification in ST-segment elevation myocardial infarction显示文摘 | Kempf T Bj(o)rklund E Olofsson S | | 0，，23： | 1 |
| 16 | Gene therapy for Parkinson's disease shows promise显示文摘 | Bj(o)rklund A Bj(o)rklund T | | 0，，79： | 1 |
| 17 | Polycystine radiolarians in the Greenland-Iceland-Norwegian seas:Species and assemblage distribution显示文摘 | CORTESE G BJ?RKLUND K R DOLVEN J K | | 0，，： | 1 |
| 18 | Cell replacement therapies for central nervous system disorders显示文摘 | Bj(o)rklund A Lindvall O | 2000 | Nat Neurosci2000，3，6： | 1 |
| 19 | Fermented,ropy,oat-based products reduce cholesterol levels and stimulate the bifidobacteria flora in humans显示文摘 | M Aa Rtensson O Bi O Rklund M Lambo A M | | 0，，05： | 1 |
| 20 | Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient显示文摘 | Piccini P Brooks DJ Bj(o)rklund A | | 0，，12： | 1 |
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