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| 1 | Ron receptor-dependent gene regulation of Kupffer cells during endotoxemia显示文摘BACKGROUND: Ron receptor tyrosine kinase signaling in macrophages, including Kupffer cells and alveolar macrophages,suppresses endotoxin-induced proinflammatory cytokine/chemokine production. Further, we have also identified genes from Ron replete and Ron deplete livers that were differentially expressed during the progression of liver inflammation associated with acute liver failure in mice by microarray analyses.While important genes and signaling pathways have been identified downstream of Ron signaling during progression of inflammation by this approach, the precise role that Ron receptor plays in regulating the transcriptional landscape in macrophages, and particular in isolated Kupffer cells, has still not been investigated.METHODS: Kupffer cells were isolated from wild-type(TK+/+)and Ron tyrosine kinase deficient(TK-/-) mice. Ex vivo, the cells were treated with lipopolysaccharide(LPS) in the presence or absence of the Ron ligand, hepatocyte growth factor-like protein(HGFL). Microarray and qRT-PCR analyses were utilized to identify alterations in gene expression between genotypes.RESULTS: Microarray analyses identified genes expressed differentially in TK+/+ and TK-/- Kupffer cells basally as well as after HGFL and LPS treatment. Interestingly, our studies identified Mefv, a gene that codes for the anti-inflammatory protein pyrin, as an HGFL-stimulated Ron-dependent gene.Moreover, lipocalin 2, a proinflammatory gene, which is induced by LPS, was significantly suppressed by HGFL treatment.Microarray results were validated by qRT-PCR studies on Kupffer cells treated with LPS and HGFL.CONCLUSION: The studies herein suggest a novel mechanism whereby HGFL-induced Ron receptor activation promotes the expression of anti-inflammatory genes while inhibiting genes involved in inflammation with a net effect of diminished inflammation in macrophages. | Rishikesh M Kulkarni William D Stuart Susan E Waltz | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，3： | 6 |
| 2 | Soil Carbon Dynamics Under Changing Climate A Research Transition from Absolute to Relative Roles of Inorganic Nitrogen Pools and Associated Microbial Processes:A Review显示文摘It is globally accepted that soil carbon(C) dynamics are at the core of interlinked environmental problems, deteriorating soil quality and changing climate. Its management remains a complex enigma for the scientific community due to its intricate relationship with soil nitrogen(N) availability and moisture-temperature interactions. This article reviews the management aspects of soil C dynamics in light of recent advances, particularly in relation to the availability of inorganic N pools and associated microbial processes under changing climate. Globally, drastic alterations in soil C dynamics under changing land use and management practices have been primarily attributed to the variation in soil N availability, resulting in a higher decomposition rate and a considerable decline in soil organic C(SOC) levels due to increased soil CO_2 emissions, degraded soil quality, and increased atmospheric CO_2 concentrations,leading to climate warming. Predicted climate warming is proposed to enhance SOC decomposition, which may further increase soil N availability, leading to higher soil CO_2 efflux. However, a literature survey revealed that soil may also act as a potential C sink, if we could manage soil inorganic N pools and link microbial processes properly. Studies also indicated that the relative, rather than the absolute, availability of inorganic N pools might be of key importance under changing climate, as these N pools are variably affected by moisture-temperature interactions, and they have variable impacts on SOC turnover. Therefore, multi-factorial studies are required to understand how the relative availability of inorganic N pools and associated microbial processes may determine SOC dynamics for improved soil C management. | pratap srivastava rishikesh singh sachchidanand tripathi pardeep singh shikha singh hema singh akhilesh singh raghubanshi pradeep kumar mishra | 2017 | Pedosphere2017，27，5： | 5 |
| 3 | Impact of sole and combined application of biochar,organic and chemical fertilizers on wheat crop yield and water productivity in a dry tropical agro-ecosystem显示文摘Agriculture under changing climate scenario is facing major challenges of water scarcity and resource imbalances.Crop water productivity(WP)may act as an indicator of crop responses to water limitation.Organic amendments such as biochar and manure application to soil are suggested for improving soil quality and reducing water requirements from agricultural sector.However,studies exploring the impact of biochar as sole or in combination with organic and/or chemical fertilizers on WP in dry tropical agro-ecosystems are limited.In this study,we observed the effect of rice-husk ash(RHA,biochar)along with farm-yard manure(FYM)and chemical fertilizers(CF)under varying water conditions on soil hydro-physical properties,yield and WP of wheat crop.Water-filled pore space(WFPS),grain and straw yield,irrigation and total water productivity varied significantly(at P<0.001)at treatment level.Grain and straw yield were found higher under sole and combined CF applied treatments.Sole and combined RHA and FYM amendment improved water holding capacity(WHC)and WFPS,whereas a decrease in crop yield was observed as compared to the control.Irrigation and total water productivity were found higher under combined RHA+FYM and sole CF treatments with reduced water supply(except sole CF)as compared to control and sole RHA treatments with full water irrigation.Crop water productivity was found positively correlated with grain and straw yields,however,significant correlations were not observed with WHC and WFPS.Results indicate that increasing soil hydro-physical properties in silty-loam soil may hinder crop yield and WP under sole biochar applied soils.Overall,the implications of the study would help in devising agro-management practices based on combined application of RHA and FYM with reduced chemical fertilizer and water inputs to mitigate the impacts of climate change without compromising crop yield in the highly vulnerable dry tropical agro-ecosystem of India.Moreover,long-term studies are needed in these ecosystems to identify the appropriate agricultural package for mitigating the forthcoming water scarcity conditions. | Rishikesh Singh Pardeep Singh Hema Singh A.S.Raghubanshi | 2019 | Biochar2019，1，2： | 5 |
| 4 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 5 | Formulation and evaluation of novel stomach specific floating microspheres bearing famotidine for treatment of gastric ulcer and their radiographic study显示文摘Objective:To develop and characterize multiple-unit-type oral floating microsphere of famotidine to prolong gastric residence time and to target stomach ulcer.Methods:The floating microspheres were prepared by modified solvent evaporation method,Eudragil S-100 was used as polymer.Microspheres were characterized for the micromeritic properties,floating behavior,entrapment efficiency and scanning electron microscopy.The invitro release studies and floating behavior were studied in simulated gastric fluid at pH 1.2.Different drug release kinetics models were also applied for all the batches.Selected formulations were also subjected for X-ray radiographic study.Results:Floating microspheres were successfully prepared by modified solvent evaporation technique.Microspheres showed passable flow properties.The maximum yield of microspheres was up to(95.11±0.35)%.On the basis of optical microscopy particle size range was found to be ranging from(52.18±182.00) to(91.64±5.16) μm.Scanning electron microscopy showed their spherical size,perforated smooth surface and a cavity inside microspheres.Microspheres were capable to float up to 20 h in simulated gastric fluid.X-ray radiographic studies also proved its better retention in the stomach.Conclusions:On the basis of the results,such dosage forms may be a good candidate for stomach targeting and may be dispensed in hard gelatin capsules. | Rishikesh Gupta Sunil Kumar Prajapati Snigdha Pattnaik Peeyush Bhardwaj | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，9： | 2 |
| 6 | Crystal twins:self-supervised learning for crystalline material property prediction显示文摘Machine learning(ML)models have been widely successful in the prediction of material properties.However,large labeled datasets required for training accurate ML models are elusive and computationally expensive to generate.Recent advances in Self-Supervised Learning(SSL)frameworks capable of training ML models on unlabeled data mitigate this problem and demonstrate superior performance in computer vision and natural language processing.Drawing inspiration from the developments in SSL,we introduce Crystal Twins(CT):a generic SSL method for crystalline materials property prediction that can leverage large unlabeled datasets.CT adapts a twin Graph Neural Network(GNN)and learns representations by forcing graph latent embeddings of augmented instances obtained from the same crystalline system to be similar.We implement Barlow Twins and SimSiam frameworks in CT.By sharing the pre-trained weights when fine-tuning the GNN for downstream tasks,we significantly improve the performance of GNN on 14 challenging material property prediction benchmarks. | Rishikesh Magar Yuyang Wang Amir Barati Farimani | 2022 | npj Computational Materials2022，，1： | 1 |
| 7 | Multiple phase esti- mation in digital holographic interferometry using product cubic phase function显示文摘 | Kulkarni Rishikesh Rastogi Pramod | 2013 | Optics and Lasers in Engineer- ing2013，51，10： | 1 |
| 8 | Inverse relationship between serum high density lipoprotein and negative syndrome in antipsychotic-naive schizophrenia显示文摘 | Ganesan Venkatasubramanian Rashmi Arasappa Naren P. Rao Rishikesh V. Behere Sunil Kalmady Bangalore N. Gangadhar | 2010 | Clinical Chemistry and Laboratory Medicine2010，，1： | 1 |
| 9 | Progress in malaria vectorcontrol显示文摘 | Pant CP Rishikesh N Bang YH | 1981 | Bull World Health Organ1981，59，3： | 1 |
| 10 | Biological impact of phthalates显示文摘 | Rishikesh Mankidy Steve Wiseman Hong Ma John P. Giesy | 2012 | Toxicology Letters2012，，： | 1 |
| 11 | Thermal tolerance and oxygen consumption rates of the catfish Horabagrus brachysnma (GUnther) acclimated to different temperatures 显示文摘 | Rishikesh S D Asim K P Lalchand R T | 2009 | Aquaculture2009，295，12： | 1 |
| 12 | Thermal tolerance and oxygen consumption rates of the catfish Horabagrus brachysoma (Günther) acclimated to different temperatures显示文摘 | Rishikesh S. Dalvi Asim K. Pal Lalchand R. Tiwari Tilak Das Kartik Baruah | 2009 | Aquaculture2009，，1： | 1 |
| 13 | Thermal tolerance and oxygen consumption rates of the catfish Horabagrus brachysoma (Giinther) acclimated to different temperatures 显示文摘 | Rishikesh S D Asim K P Lalchand R T | 2009 | Aquaculture2009，295，12： | 1 |
| 14 | Effect of tung- sten content on microstmcture and mechanical properties of swaged tungsten alloys 显示文摘 | KIRAN U R Venkat S Rishikesh B | 2013 | Materials Science and Engineer- ing A2013，582，： | 1 |
| 15 | Biological impact of phthalates显示文摘 | Rishikesh M Steve W Hong M | 2013 | Toxicology Letters2013，217，： | 1 |
| 16 | Plant dormancy in the perennial context显示文摘 | Antje Rohde Rishikesh P. Bhalerao | 2007 | Trends in Plant Science2007，，5： | 1 |
| 17 | Effect of tungsten content on microstructure and mechanical properties of swaged tungsten alloys显示文摘 | KIRAN U R Venkat S Rishikesh B Iyer V R Sankaranarayana Nandy T K | 2013 | Materials Science and Engineering A2013，582，： | 1 |
| 18 | 印度喀拉拉邦伊都基水库附近小震的精确定位和震源机制:地震成因的启示显示文摘应用印度南部新建的一个拥有21个台站的临时台阵的地震波形,显著提高了喀拉拉邦伊都基水库附近地区小震的检测阀值和参数。我们给出了这一地区16个地震的精确定位,地方震级为1.5~3.6,震源深度7.2~9.9kin。所选6个最好地震的断层面解显示走滑断层错动兼右旋运动。水库加载通常会导致应力的产生和在浅层深度(〈5km)弓l发地震,但是在伊都基水库区域内却没有该深度的地震。记录到的地震仅限于靠近Karur-Kambam-Painavu-Trichur(KKPT)剪切带西北-东南走向的断层。这些结果表明,伊都基水库区域内的地震均属于天然构造地震,而与水库没有联系。 | utpal saikia s.s.rai m.subrahmanyam satyajit dutta somasish bose kajaljyoti borah rishikesh meena 任家琪(译) 李艳娥(校) | 2016 | 世界地震译丛2016，47，3： | 0 |
| 19 | Growth's secret maestros:LBD11-ROS harmony drives vascular cambium activity in Arabidopsis显示文摘Integration of metabolic products such as reactive oxygen species(ROS)into vital processes play essential roles in plants.ROS refers to oxygen-derived free radicals,which exhibit a higher reactivity compared to the diatomic oxygen molecule(O2)(Waszczak et al.,2018).Numerous forms of ROS have been identified in plants with various degrees of stability:singlet oxygen(1O2),superoxide anion(O2·−),hydrogen peroxide(H2O2),and hydroxyl radical(HO·)are the major forms.ROS are generated during normal plant growth as products of aerobic metabolism in almost all cellular compartments,including chloroplasts,mitochondria,and peroxisomes as well as in apoplast.However,elevated ROS levels are detrimental to plant cells,posing a substantial risk of DNA damage and improper initiation of programmed cell death.Thus,the levels of ROS are meticulously balanced through intricate antioxidant systems,which tightly control their generation and breakdown(Waszczak et al.,2018;Huang et al.,2019). | Melis Kucukoglu Topcu Rishikesh P.Bhalerao | 2023 | Molecular Plant2023，16，8： | 0 |
| 20 | Lensless polarimetric coded ptychography for high-resolution,high-throughput gigapixel birefringence imaging on a chip显示文摘Polarimetric imaging provides valuable insights into the polarization state of light interacting with a sample.It can infer crucial birefringence properties of specimens without using labels,thereby facilitating the diagnosis of diseases such as cancer and osteoarthritis.In this study,we present a novel polarimetric coded ptychography(pol-CP)approach that enables high-resolution,high-throughput gigapixel birefringence imaging on a chip.Our platform deviates from traditional lens-based systems by employing an integrated polarimetric coded sensor for lensless coherent diffraction imaging.Utilizing Jones calculus,we quantitatively determine the birefringence retardance and orientation information of biospecimens from the recovered images.Our portable pol-CP prototype can resolve the 435 nm linewidth on the resolution target,and the imaging field of view for a single acquisition is limited only by the detector size of 41 mm2.The prototype allows for the acquisition of gigapixel birefringence images with a 180 mm^(2) field of view in~3.5 min,a performance that rivals high-end whole slide scanner but at a small fraction of the cost.To demonstrate its biomedical applications,we perform high-throughput imaging of malaria-infected blood smears,locating parasites using birefringence contrast.We also generate birefringence maps of label-free thyroid smears to identify thyroid follicles.Notably,the recovered birefringence maps emphasize the same regions as autofluorescence images,underscoring the potential for rapid on-site evaluation of label-free biopsies.Our approach provides a turnkey and portable solution for lensless polarimetric analysis on a chip,with promising applications in disease diagnosis,crystal screening,and label-free chemical imaging,particularly in resource-constrained environments. | LIMING YANG RUIHAI WANG QIANHAO ZHAO PENGMING SONG SHAOWEI JIANG TIANBO WANG XIAOPENG SHAO CHENGFEI GUO RISHIKESH PANDEY GUOAN ZHENG | 2023 | Photonics Research2023，11，12： | 0 |
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