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| 1 | Continuous wound infusion of local anaesthetic agents following colorectal surgery:Systematic review and meta-analysis显示文摘AIM:To provide a specifi c review and meta-analysis of the available evidence for continuous wound infusion of local anaesthetic agents following midline laparoto-my for major colorectal surgery. METHODS: Medline, Embase, trial registries, conference proceedings and article reference lists were searched to identify randomised, controlled trials of continuous wound infusion of local anaesthetic agents following colorectal surgery. The primary outcomes were opioid consumption, pain visual analogue scores (VASs), return to bowel function and length of hospital stay. Weighted mean difference were calculated for continuous outcomes. RESULTS: Five trials containing 542 laparotomy wounds were eligible for inclusion. There was a sig- nificant decrease in post-operative pain VAS at rest on day 3 (weighted mean difference: -0.43; 95% CI: -0.81 to -0.04; P = 0.03) but not on post-operative day 1 and 2. Local anaesthetic infusion was associated with a signifi cant reduction in pain VAS on movement on all three post-operative days (day 1 weighted mean difference: -1.14; 95% CI: -2.24 to -0.041; P = 0.04, day 2 weighted mean difference: -0.97, 95% CI: -1.91to -0.029; P = 0.04, day 3 weighted mean difference: -0.61; 95% CI: 1.01 to -0.20; P = 0.0038). Local an- aesthetic wound infusion was associated with a signifi - cant decrease in total opioid consumption (weighted mean difference: -40.13; 95% CI: -76.74 to -3.53; P = 0.03). There was no signifi cant decrease in length of stay (weighted mean difference: -20.87; 95% CI: -46.96 to 5.21; P = 0.12) or return of bowel function (weighted mean difference: -9.40; 95% CI: -33.98 to 15.17; P = 0.45). CONCLUSION: The results of this systematic re- view and meta-analysis suggest that local anaesthetic wound infusion following laparotomy for major color- ectal surgery is a promising technique but do not pro- vide conclusive evidence of benefi t. Further research is required including cost-effectiveness analysis. | Alan Karthikesalingam Stewart R Walsh Sheraz R Markar Umar Sadat Tjun Y Tang Charles M Malata | 2008 | World Journal of Gastroenterology2008，14，34： | 4 |
| 2 | Point-of-care testing in the diagnosis of gastrointestinal cancers: Current technology and future directions显示文摘Point-of-care(POC) tests enable rapid results and are well established in medical practice.Recent advances in analytical techniques have led to a new generation of POC devices that will alter gastrointestinal diagnostic pathways.This review aims to identify current and newtechnologies for the POC diagnosis of gastrointestinal cancer.A structured search of the Embase and Medline databases was performed.Papers reporting diagnostic tests for gastrointestinal cancer available as a POC device or containing a description of feasibility for POC application were included.Studies recovered were heterogeneous and therefore results are presented as a narrative review.Six diagnostic methods were identified(fecal occult blood, fecal proteins, volatile organic compounds, pyruvate kinase isoenzyme type M2, tumour markers and DNA analysis).Fecal occult blood testing has a reported sensitivity of 66%-85% and specificity greater than 95%.The others are at a range of development and clinical application.POC devices have a proven role in the diagnosis of gastrointestinal cancer.Barriers to their implementation exist and the transition from experimental to clinical medicine is currently slow.New technologies demonstrate potential to provide accurate POC tests and an ability to diagnose gastrointestinal cancer at an early stage with improved clinical outcome and survival. | Jeremy R Huddy Melody Z Ni Sheraz R Markar George B Hanna | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 3 | Laparoscopic versus open colorectal resection in the elderly population显示文摘 | Katherine Grailey Sheraz R. Markar Alan Karthikesalingam Rima Aboud Paul Ziprin Omar Faiz | 2013 | Surgical Endoscopy2013，，1： | 2 |
| 4 | Detection and management of oligometastatic disease in oesophageal cancer and identification of prognostic factors: A systematic review显示文摘BACKGROUND Oesophageal cancer is the eighth most common cancer worldwide.The prognosis of oesophageal cancer patients still remains poor.The 5-year survival rate rarely exceeds 5%in case of metastatic disease.Some patients may however present with oligometastasis which can be treated with loco-regional therapy.AIM To assess the current practice regarding the management of patients with oligometastatic oesophageal cancer and identify prognostic factors affecting survival following treatment for oligometastasis.METHODS A systematic search of the literature was performed in Cochrance Library,MEDLINE and EMBASE databases from September 1950 to January 2019.Relevant electronic databases were searched for studies assessing the clinical outcome of oligometastasis.RESULTS A total of 14 publications were included,of which 12 studies assessing metachronous oligometastasis and 2 on synchronous oligometastasis.All included articles evaluated the specific outcomes of metastasis,management modality and survival outcomes.The majority of the patients presented with oesophageal squamous cell carcinoma.The median disease free interval(time to recurrence)in patients was 19.6 mo and the overall survival reached 30.8 months.Unfavourable prognostic factors were assessed in eight studies and included time to recurrence<12 mo,large diameter pulmonary lesions(>20 mm),disease free interval(DFI)<12 mo,extra-pulmonary metastasis,primary tumour pathological stage III/IV.CONCLUSION Oligometastatic oesophageal cancer in selected patients is amenable to locoregional treatment,and the overall survival of this patient cohort may be improved with patient and tumour-specific treatments. | Sara Jamel Karina Tukanova Sheraz Markar | 2019 | World Journal of Gastrointestinal Oncology2019，11，9： | 2 |
| 5 | Influence of cir- cular stapler diameter on postoperative stenosis after laparo- scopic gastrojejunal anastomosis in morbid obesity 显示文摘 | Markar SR Penna M Venkat-Ramen V | 2012 | SurgObes Relat Dis2012，8，2： | 1 |
| 6 | 急性上消化道出血显示文摘每年,每10万人中就有约100例发生上消化道(食道、胃和十二指肠)出血“。这是一个具有较高病死率的内科急症。2007年英国的一项调査发现,上消化道出血的总病死率为10%。消化性溃疡是上消化道出血最常见的原因(框图1),这一实践指南为上消化道出血的初期处理以及消化性溃疡出血的后续管理提供了指导。 | Emma Sverden Sheraz R Markar Lars Agreus Jesper Lagergren 龚亮(译) 吴东(校) 无 | 2019 | 英国医学杂志中文版2019，22，7： | 1 |
| 7 | Transfusion drains versus suction drains in total knee replacement: meta-analysis显示文摘 | Markar SR Jones GG Karthikesalingam A | 2012 | Knee Surg Sports Traumatol Arthrosc2012，20，9： | 1 |
| 8 | Systematic review and pooled analysis assessing the association between elder- ly age and outcome following siJrgcl resection of esophageal ma- lignancy显示文摘 | Markars R Karthikesalirtgam A Thrumurhy S | 2012 | Dis EsoPhagus2012，26，3： | 1 |
| 9 | Systemat- ic review and pooled analysis assessing the association between elderlyage and outcome following surgical resection o: esophageal malignancy显示文摘 | Markar SR Karthikesalingam A Thrumurthy S | 2013 | Diseases of the Esophagus2013，26，3： | 1 |
| 10 | The impact of pancreatic duct drainage following pancreaticojejunos- tomy on clinical outcome显示文摘 | Markar SR Vyas S Karthikesalingam A | 2012 | J Gastrointest Surg2012，16，8： | 1 |
| 11 | The clinical and economic costs of delirium after surgical resection for esophageal malignancy显示文摘 | Markar SR Smith IA Karthikesalingam A | | 0，，01： | 1 |
| 12 | Portal vein embolization and ligation for extended hepatectomy显示文摘 | Vyas S Markar S Partelli S | 2014 | Indian J Surg Oncol2014，5，1： | 1 |
| 13 | Laparoscopic versus open appendectomy for complicated and uncomplicated appendicitis in children 显示文摘 | Markar SR Blackburn S Cobb R | 2012 | J Gastrointest Surg2012，16，10： | 1 |
| 14 | The clinical and economic costs of delirium after surgical resection fin' esophageal nmlignancy显示文摘 | Markar SR Smith IA Karthikesahngam A | 2013 | Ann Surg2013，258，1： | 1 |
| 15 | The pink pulseless hand:a re- view of the literature regarding management of vascular complications of supracondylar humeral fractures in children 显示文摘 | Griffin KJ Walsh SR Markar S | 2008 | Eur J Vasc Endo- vasc Surg2008，36，6： | 1 |
| 16 | Laparoscopic versus open colorectal resection in the elderly population显示文摘 | Grailey K Markar S R Karthikesalingam A | 2013 | Surg Endosc2013，27，1： | 1 |
| 17 | Single-incision versus conventional multiport laparoscopic colorectal surgery-systematic review and pooled analysis显示文摘 | Markar SR Wiggins T Penna M | 2014 | J Gastrointest Surg2014，18，12： | 1 |
| 18 | Surgery for borderline tumor of the ovary显示文摘 | Trope CG Kristensen G Markar A | 2001 | Seminars in Surgical Oncology2001，19，1： | 1 |
| 19 | Clinical outcomes of single versus staged hybrid repair for thoracoabdominal aortic aneurysm显示文摘 | Ludovic Canaud Alan Karthikesalingam Dan Jackson Lynne Cresswell Michael Cliff S. Sheraz Markar Gary Maytham Steven Black Matt Thompson | 2013 | Journal of Vascular Surgery2013，，： | 1 |
| 20 | Application of gold nanoparticles for gastrointestinal cancer theranostics:a systematic review显示文摘 | Singh M Harris-Birtill DCC Markar SR | 2015 | Nanomedicine2015，11，8： | 1 |
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