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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | Assessment of sala tolerance in rice cultivars in response to salinity problems in California 显示文摘 | Shannon M C Rhoades J D Draper J H | 1998 | Crop Science1998，38，2： | 2 |
| 3 | Prediction of plant microRNA targets 显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Cell2002，110，4： | 1 |
| 4 | MicroRNAs in plants 显示文摘 | REINHART B J WEINSTEIN E G RHOADES M W | 2002 | Gene & Dev2002，16，13： | 1 |
| 5 | In vitro analysis of tobacco vein mottling virus NIa cistron:evidence for a virusencoded protease显示文摘 | Hellmann G M Shaw J G Rhoads R E | 1988 | Virology1988，163，： | 1 |
| 6 | Inducible nitric oxide synthase mediates early epithelial repair of porcine ileum 显示文摘 | Gookin J L Rhoads J M Argenzio R A | 2002 | American Journal of Physiology-Gastrointes- tinal and Liver Physiology2002，283，1： | 1 |
| 7 | Assessment of salt tolerance in rice cultivars in response to salinity problems in California显示文摘 | SHANNON M C RHOADES J D DRAPER J H | 1998 | Crop Science1998，38，2： | 1 |
| 8 | The use of saline waters for crop production FAO irrigation and drainage paper 48显示文摘 | Rhoades J D Kandiah A Mashali A M | 1992 | FAO Rome1992，，： | 1 |
| 9 | Effectsof heat stress on energetic metabolism in lactating Holstein cows显示文摘 | WHEELOCK J B RHOADS R P VanBAALE M J et ai | 2010 | J Dairy Sci2010，93，2： | 1 |
| 10 | Assessment of salt tolerance in rice cultivars in response to salinity problems in California显示文摘 | SHANNON M C RHOADES J D DRAPER J H | 1998 | Crop Science1998，38，2： | 1 |
| 11 | MicroRNAs inplants显示文摘 | REINHART B J WEINSTEIN E G RHOADES M W | 2002 | Genes&Development2002，16，13： | 1 |
| 12 | Prediction of plant microRNA targets显示文摘 | RHOADES M W REINHART B J LIM L P BURGE C B BARTEL B BARTEL D P | 2002 | Cell2002，110，4： | 1 |
| 13 | The use of saline waters for crop production显示文摘 | Rhoades J D Kandiah A Mashali A M | 1992 | FAO Irrigation and Drainage Paper1992，，： | 1 |
| 14 | MicroRNAs in plants显示文摘 | Reinhart B J Weinstein E G Rhoades M W Bartel B and Bartel D P | 2002 | Genes & Der2002，16，： | 1 |
| 15 | MicroRNAs in plants显示文摘 | Reinhart B J Weinstein E G Rhoades M W | 2002 | Genes Development2002，16，13： | 1 |
| 16 | Pre- diction of plant microRNA targets显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Cell2002，110，4： | 1 |
| 17 | Prediction of plant microRNA targets显示文摘 | Rhoades M W Reinhart B J Lira L P | 2002 | Cell2002，110，4： | 1 |
| 18 | Oligosaccharide - mediated inhibition of the adhesion of pathogenic Eseheriehia coil strains to human gut epithelial cells in vitro 显示文摘 | Rhoades J Manderson K Wells A Hotchkiss AT Gibson GR Formentin K Beer M Rastall RA | 2008 | Journal of Food Protection2008，71，11： | 1 |
| 19 | miRNAs in plants显示文摘 | Reinhart B J Weinstein E G Rhoades M W | 2002 | Genes Dev2002，16，13： | 1 |
| 20 | Glutamine, arginine, and leucine signaling in the intestine 显示文摘 | Rhoads M J Wu G | 2009 | Amino Acids2009，37，1： | 1 |
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