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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | Prediction of plant microRNA targets 显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Cell2002，110，4： | 1 |
| 3 | MicroRNAs in plants 显示文摘 | REINHART B J WEINSTEIN E G RHOADES M W | 2002 | Gene & Dev2002，16，13： | 1 |
| 4 | Pruification and charaterization of potyvirus helper component显示文摘 | THORNBURY D W HELLMANN G M Rhoads R E | 1985 | Virology1985，144，： | 1 |
| 5 | MicroRNAs inplants显示文摘 | REINHART B J WEINSTEIN E G RHOADES M W | 2002 | Genes&Development2002，16，13： | 1 |
| 6 | Prediction of plant microRNA targets显示文摘 | RHOADES M W REINHART B J LIM L P BURGE C B BARTEL B BARTEL D P | 2002 | Cell2002，110，4： | 1 |
| 7 | MicroRNAs in plants显示文摘 | Reinhart B J Weinstein E G Rhoades M W Bartel B and Bartel D P | 2002 | Genes & Der2002，16，： | 1 |
| 8 | MicroRNAs in plants显示文摘 | Reinhart B J Weinstein E G Rhoades M W | 2002 | Genes Development2002，16，13： | 1 |
| 9 | Pre- diction of plant microRNA targets显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Cell2002，110，4： | 1 |
| 10 | Prediction of plant microRNA targets显示文摘 | Rhoades M W Reinhart B J Lira L P | 2002 | Cell2002，110，4： | 1 |
| 11 | miRNAs in plants显示文摘 | Reinhart B J Weinstein E G Rhoades M W | 2002 | Genes Dev2002，16，13： | 1 |
| 12 | Prediction of plant microRNA targets显示文摘 | RHOADES M W REINHART B J LIM L P | 2002 | Cell2002，110，4： | 1 |
| 13 | MicroRNAs in plants 显示文摘 | Reinhart B J Weinstein E G Rhoades M W | 2002 | Genes & Development2002，16，13： | 1 |
| 14 | Predic- tion of mammalian mieroRNA targets 显示文摘 | LEWIS B P SHIH I H JONES - RHOADES M W | 2003 | Cell2003，115，7： | 1 |
| 15 | Pre diction of plant microRNA targets显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Cell2002，110，： | 1 |
| 16 | Prediction of plant microRNA targets 显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Cell2002，110，4： | 1 |
| 17 | An evaluation of an ultra-high strength steel strengthened by alloy carbide and intermetallic precipitates显示文摘 | Garrison W M Jr Rhoads M A | 1996 | Trans Indian Inst Met1996，49，3： | 1 |
| 18 | Prediction of plant microRNA targets显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Cell2002，110，4： | 1 |
| 19 | L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases显示文摘 | Rhoads J M Argenzio R A Chen W Rippe R A Westwick J K Cox A D Berschneider H M Brenner D A | 1997 | American Journal of Physiology-Gas- trointestinal and Liver Physiology1997，272，5： | 1 |
| 20 | MicroRNAs in plants显示文摘 | REINHART B J WEINSTEIN E G RHOADES M W | 2002 | Genes Dev2002，16，： | 1 |
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