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| 1 | Small intestinal bacterial overgrowth syndrome显示文摘Human intestinal microbiota create a complex polymi-crobial ecology. This is characterised by its high population density, wide diversity and complexity of interaction. Any dysbalance of this complex intestinal microbiome, both qualitative and quantitative, might have serious health consequence for a macro-organism, including small intestinal bacterial overgrowth syndrome (SIBO).SIBO is defined as an increase in the number and/or alteration in the type of bacteria in the upper gastro-intestinal tract. There are several endogenous defence mechanisms for preventing bacterial overgrowth: gastric acid secretion, intestinal motility, intact ileo-caecal valve, immunoglobulins within intestinal secretion and bacte-riostatic properties of pancreatic and biliary secretion. Aetiology of SIBO is usually complex, associated with disorders of protective antibacterial mechanisms (e.g. achlorhydria, pancreatic exocrine insuff iciency, immuno-deficiency syndromes), anatomical abnormalities (e.g. small intestinal obstruction, diverticula, f istulae, surgical blind loop, previous ileo-caecal resections) and/or motility disorders (e.g. scleroderma, autonomic neuropathy in diabetes mellitus, post-radiation enteropathy, small intestinal pseudo-obstruction). In some patients more than one factor may be involved. Symptoms related to SIBO are bloating, diarrhoea, malabsorption, weight loss and malnutrition. The gold standard for diagnosing SIBO is still microbial investigation of jejunal aspirates. Noninvasive hydrogen and methane breath tests are most commonly used for the diagnosis of SIBO using glucose or lactulose. Therapy for SIBO must be com-plex, addressing all causes, symptoms and complica-tions, and fully individualised. It should include treatment of the underlying disease, nutritional support and cyclical gastro-intestinal selective antibiotics. Prognosis is usually serious, determined mostly by the underlying disease that led to SIBO. | Jan Bures Jiri Cyrany Darina Kohoutova Miroslav Frstl Stanislav Rejchrt Jaroslav Kvetina Viktor Vorisek Marcela Kopacova | 2010 | World Journal of Gastroenterology2010，16，24： | 52 |
| 2 | Peutz-Jeghers syndrome:Diagnostic and therapeutic approach显示文摘Peutz-Jeghers syndrome(PJS)is an inherited,autosomal dominant disorder distinguished by hamartomatous polyps in the gastrointestinal tract and pigmented mucocutaneous lesions.Prevalence of PJS is estimated from 1 in 8300 to 1 in 280 000 individuals.PJS predisposes sufferers to various malignancies(gastrointestinal,pancreatic,lung,breast,uterine,ovarian and testicular tumors).Bleeding,obstruction and intussusception are common complications in patients with PJS.Double balloon enteroscopy(DBE)allows examination and treatment of the small bowel.Polypectomy using DBE may obviate the need for repeated urgent operations and small bowel resection that leads to short bowel syndrome.Prophylaxis and polypectomy of the entire small bowel is the gold standard in PJS patients.Intraoperative enteroscopy(IOE)was the only possibility for endoscopic treatment of patients with PJS before the DBE era.Both DBE and IOE facilitate exploration and treatment of the small intestine. DBE is less invasive and more convenient for the pa- tient.Both procedures are generally safe and useful. An overall recommendation for PJS patients includes not only gastrointestinal multiple polyp resolution,but also regular lifelong cancer screening(colonoscopy, upper endoscopy,computed tomography,magnetic resonance imaging or ultrasound of the pancreas, chest X-ray,mammography and pelvic examinationwith ultrasound in women,and testicular examination in men).Although the incidence of PJS is low,it is important for clinicians to recognize these disorders to prevent morbidity and mortality in these patients,and to perform presymptomatic testing in the first-degree relatives of PJS patients. | Marcela Kopacova Ilja Tacheci Stanislav Rejchrt Jan Bures | 2009 | World Journal of Gastroenterology2009，15，43： | 45 |
| 3 | Double balloon enteroscopy and acute pancreatitis显示文摘Double balloon enteroscopy(DBE)is a new technique, first published and introduced into clinical practice in 2001 by Yamamoto,the inventor of this outstanding method.DBE allows complete visualization,biopsy and treatment of the small bowel.Nowadays,we have some experience of this method for evaluation of the complica- tion rate.Severe complications are described in 1%-1.7% of patients.Acute pancreatitis is a rare complication of the investigation.The incidence of acute pancreatitis after diagnostic DBE is 0.3%in most studies.More than 50 cases of acute pancreatitis have been described in the literature so far.On the contrary,hyperamylasemia after DBE seems to be a rather common condition.Association with acute pancreatitis is supposed to be possible,but not obligatory.The causal mechanism of post-DBE acute pancreatitis is uncertain,and there are several theories in the literature.The most probable cause seems to be a mechanical straining of the endoscope with over-tube on the pancreas or in the papillary area. | Marcela Kopacova Ilja Tacheci Stanislav Rejchrt Jolana Bartova Jan Bures | 2010 | World Journal of Gastroenterology2010，16，19： | 18 |
| 4 | Blood pressure and stature in Helicobacter pylori positive and negative persons显示文摘To evaluate vital signs and body indices in Helicobacter pylori(H.pylori)positive and negative persons.A total of 22 centres entered the study.They were spread over the whole country,corresponding well to the geographical distribution of the Czech population.A total of 1818 subjects(aged 5-98 years)took part in the study,randomly selected out of 38147 subjects.H.pylori infection was investigated by means of a 13Curea breath test.Data on height,weight,systolic and diastolic blood pressure and heart rate were collected at the clinics of general practitioners.The overall prevalence of H.pylori infection was 30.4%(402/1321)in adults(≥18 year-old)and 5.2%(26/497)in children and adolescents(≤17 year-old).Once adjusted for age and gender,only a difference in body mass index remained statistically significant with H.pylori positive adults showing an increase of 0.6 kg/m2 in body mass index.Once adjusted for age and gender,we found a difference in height between H.pylori positive and H.pylori negative children and adolescents.On further adjustment for place of residence,this difference became statistically significant,with H.pylori positive children and adolescents being on average 3.5 cm shorter.H.pylori positive adults were significantly older compared to H.pylori negative subjects.Once adjusted for age and gender,H.pylori infection had no impact on body weight,body mass index and vital signs either in adults or children and adolescents.Chronic H.pylori infection appeared to be associated with short stature in children.H.pylori infection did not influence blood pressure,body weight and body mass index either in adults or children and adolescents. | Marcela Kopacova Ilona Koupil Bohumil Seifert Miluska Skodova Fendrichova Jana Spirkova Viktor Vorisek Stanislav Rejchrt Tomas Douda Ilja Tacheci Jan Bures | 2014 | World Journal of Gastroenterology2014，20，19： | 9 |
| 5 | Buried bumper syndrome:A complication of percutaneousendoscopic gastrostomy显示文摘Percutaneous endoscopic gastrostomy(PEG) is a widely used method of nutrition delivery for patients with longterm insufficiency of oral intake. The PEG complication rate varies from 0.4% to 22.5% of cases, with minor complications being three times more frequent. Buried bumper syndrome(BBS) is a severe complication of this method, in which the internal fixation device migrates alongside the tract of the stoma outside the stomach. Excessive compression of tissue between the external and internal fixation device of the gastrostomy tube is considered the main etiological factor leading to BBS. Incidence of BBS is estimated at around 1%(0.3%-2.4%). Inability to insert, loss of patency and leakage around the PEG tube are considered to be a typical symptomatic triad. Gastroscopy is indicated in all cases in which BBS is suspected. The depth of disc migration in relation to the lamina muscularis propria of the stomach is critical for further therapy and can be estimated by endoscopic or transabdominal ultrasound. BBS can be complicated by gastrointestinal bleeding, perforation, peritonitis, intra-abdominal and abdominal wall abscesses, or phlegmon, and these complications can lead to fatal outcomes. The most important preventive measure is adequate positioning of the external bolster. A conservative approach should be applied only in patients with high operative risk and dismal prognosis. Choice of the method of release is based on the type of the PEG set and depth of disc migration. A disc retained inside the stomach and completely covered by the overgrowing tissue can be released using some type of endoscopic dissection technique(needle knife, argon plasma coagulation, or papillotome through the cannula). Proper patient selection and dissection of the overgrowing tissue are the major determinants for successful endoscopic therapy. A disc localized out of the stomach(lamina muscularis propria) should be treated by a surgeon. | Jiri Cyrany Stanislav Rejchrt Marcela Kopacova Jan Bures | 2016 | World Journal of Gastroenterology2016，22，2： | 9 |
| 6 | Significant decrease in prevalence ofHelicobacter pylori in the Czech Republic显示文摘AIM:To study possible decrease in prevalence of Helicobacter pylori(H.pylori) infection in the Czech Republic within a 10-year period.METHODS:A total of 22 centres entered the study.The catchment areas of these centres covered cities and towns with more than 20 000 inhabitants,smaller towns(≤ 20 000 inhabitants) with surrounding villages and rural areas,and were spread over the whole country,corresponding well to the geographical distribution of the Czech population.A total of 1 837 subjects(aged 5-98 years) took part in the study,randomly selected out of 38 147 people from the general population.H.pylori infection was investigated by means of a 13 C-urea breath test.Breath samples in duplicates were analysed using isotope ratio mass spectrometry.The cut-off point was 3.5.Social and demographic characteristics were based on data from self-completed questionnaires.RESULTS:The overall prevalence of H.pylori infection was 23.5%(430/1826),and 4.8%(20/420) in children aged 15 or less.There was no statistically significant difference in prevalence between males(24.3%;208/857) and females(22.9%,222/969,P = 0.494).H.pylori infection was strongly associated with higher age,among subjects aged 55+ years,prevalence of H.pylori infection was 39.8%(252/633,P < 0.001).The highest prevalence of H.pylori infection was found among persons aged 55-64 years(43.9%,97/221) and 75+ years(37.9%,58/153).Among study subjects aged 15+ years,prevalence of H.pylori infection was significantly increased in those with lowest education(odds risk 3.19,95% CI 1.87-5.47).Compared to never married(14.1%),the prevalence of H.pylori infection was statistically significantly higher among married(35.4%,246/694,P < 0.001),divorced(36.8%,49/133,P < 0.001) and widowed study subjects(40.2%,45/112,P < 0.001),both in minimally and fully adjusted analysis.There was no significant difference in the prevalence of H.pylori infection between married and widowed subjects(35.4%,246/694 vs 40.2%,45/112,P = 0.389).There was little variation in smoking prevalence across categories of smoking and there was no evidence of an increased risk ofH.pylori infection among current or past smokers in our data(odds risk 1.04 with 95% CI 0.78-1.40 for current smokers;odds ratio 0.83 with 95% CI 0.60-1.16 for former smokers).The current prevalence of H.pylori in 2011 was significantly lower compared to the prevalence reported from identical geographical areas in 2001(23.5%vs 41.7%,P < 0.001).CONCLUSION:The overall prevalence of H.pylori infection in the general population has fallen substantially in the Czech Republic over the past 10 years. | Jan Bure Marcela Kopáová Ilona Koupil Bohumil Seifert Miluka kodová Fendrichová Jana pirková Viktor Voíek Stanislav Rejchrt TomáDouda Norbert Král Ilja Tachecí | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 7 | Complications of ERCP: ethical obligations and legal consequences 显示文摘 | Ricz I Rejchrt S Hassan M | 2008 | Dig Dis2008，26，1： | 1 |
| 8 | Use of bio-degradable stents for the treatment of refractory benign gastrointestinal stenoses显示文摘 | Rejchrt S Bures J Brozfk J | 2011 | Acta Medica ( Hradec Kralove)2011，54，： | 1 |
| 9 | Trimodality imaging of colonic lymphoma显示文摘 | J. Cyrany M. Pintér V. Ty?ová J. Krejsek D. Belada S. Rejchrt J. Bure? | 2009 | Endoscopy (S )2009，，02： | 1 |
| 10 | Small intestinal tumours 显示文摘 | Kopacova M Rejchrt S Bures J | 2013 | Gastroenterol Res Pract2013，2013，70： | 1 |
| 11 | Biodegradable stents for the treatment of benign stenoses of the small and large intestines显示文摘 | Rejchrt S Kopacova M Brozik J | | 0，，： | 1 |
| 12 | Bacteriologic testing of endoseopes after high-level disin-cfiou显示文摘 | Rejchrt S Cerm0k P PavlatovL | 2004 | Gas trointest Endosc2004，60，： | 1 |
| 13 | Biodegradable stents for the treatment of benign stenoses of the small and large intestines显示文摘 | Rejchrt S Kopacova M Brozik J | | 0，，： | 1 |
| 14 | Epidemiology of Helicobacter pylori infection in the Czech Republic 显示文摘 | Bures J Kopdcov6 M Koupil I Vorisek V Rejchrt S BerOnek M Seifert B Pozler O Zivny P Douda T Kolesdrov6 M Pint6r M Palicka V Holcik J European Society for Primary Care Gastroenterology | 2006 | Helicobacter2006，11，1： | 1 |
| 15 | The role of capsule endoscopy in obscure gastrointestinal bleeding显示文摘 | Mohamed Serag Zakaria Magdy Amin El-Serafy Iman Mohamed Hamza Khaled Serag Zachariah Tamer Mahmoud El-Baz Jan Bures Ilja Tacheci Stanislav Rejchrt | 2009 | Arab Journal of Gastroenterology2009，，2： | 1 |
| 16 | Prevalence and sociodemographic determinants of uninvestigated dyspepsia in the Czech Republic显示文摘 | Stanislav Rejchrt Ilona Koupil Marcela Kopá?ová Viktor Vo?í?ek Bohumil Seifert Old?ich Pozler Pavel ?ivny Tomá? Douda Vladimír Pali?ka Jan Hol?ík Jan Bure? | 2008 | European Journal of Gastroenterology & Hepatology2008，，9： | 1 |
| 17 | A new approach to blue rubber bleb nevus syndrome: the role of capsule endoscopy and intra-operative enteroscopy显示文摘 | Marcela Kopá?ová Ilja Tachecí Jaroslav Koudelka Miroslava Králová Stanislav Rejchrt Jan Bure? | | 0，，： | 1 |
| 18 | Hyperamylasemia of uncertain significance associated with oral double-balloon enteroscopy <ce:link locator='fx1'/>显示文摘 | Marcela Kopá?ová Stanislav Rejchrt Ilja Tachecí Jan Bure? | 2007 | Gastrointestinal Endoscopy2007，，6： | 1 |
| 19 | Comparison of intraoperative enteroscopy and double-balloon enteroscopy for the diagnosis and treatment of Peutz-Jeghers syndrome显示文摘 | Marcela Kopá?ová Jan Bure? Alexander Ferko Ilja Tachecí Stanislav Rejchrt | 2010 | Surgical Endoscopy2010，，8： | 1 |
| 20 | Intraoperative enteroscopy显示文摘 | M. Kopá?ová J. Bure? L. Vykou?il P. Hladík D. ?imkovi? B. Jon A. Ferko I. Tachecí S. Rejchrt | 2007 | Surgical Endoscopy2007，，7： | 1 |
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