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| 1 | Serrated pathway in colorectal carcinogenesis显示文摘Serrated adenocarcinoma is a recently described subset of colorectal cancer(CRC),which account for about10%of all CRCs and follows an alternative pathway in which serrated polyps replace the traditional adenoma as the precursor lesion to CRC.Serrated polyps form a heterogeneous group of colorectal lesions that includes hyperplastic polyps(HPs),sessile serrated adenoma(SSA),traditional serrated adenoma(TSA)and mixed polyps.HPs are the most common serrated polyp followed by SSA and TSA.This distinct histogenesis is believed to have a major influence in prevention strategies,patient prognosis and therapeutic impact.Genetically,serrated polyps exhibited also a distinct pattern,with KRAS and BRAF having an important contribution to its development.Two other molecular changes that have been implicated in the serrated pathway include microsatellite instability and the CpG island methylator phenotype.In the present review we will address the current knowledge of serrated polyps,clinical pathological features and will update the most recent findings of its molecular pathways.The understanding of their biology and malignancy potential is imperative to implement a surveillance approach in order to prevent colorectal cancer development. | Letícia Yamane Cristovam Scapulatempo-Neto Rui Manuel Reis Denise Peixoto Guimares | 2014 | World Journal of Gastroenterology2014，20，10： | 8 |
| 2 | Furazolidone-based triple therapy for H pylori gastritis in children显示文摘AIM: To evaluate the furazolidone-based triple therapy in children with symptomatic H pylori gastritis.METHODS: A prospective and consecutive open trial was carried out. The study included 38 patients with upper digestive symptoms suffi ciently severe to warrant endoscopic investigation. H pylori status was defined based both on histology and on positive 13C-urea breath test. Drug regimen was a seven-day course of omeprazole, clarithromycin and furazolidone (100 mg, 200 mg if over 30 kg) twice daily. Eradication of H pylori was assessed two months after treatment by histology and 13C-urea breath test. Further clinical evaluation was performed 7 d, 2 and 6 mo after the treatment. RESULTS: Thirty-eight patients (24 females, 14 males) were included. Their age ranged from 4 to 17.8 (mean 10.9 ± 3.7) years. On intent-to-treat analysis (n = 38), the eradication rate of H pylori was 73.7% (95% CI, 65.2%-82%) whereas in per-protocol analysis (n = 33) it was 84.8% (95% CI, 78.5%-91%). All the patients with duodenal ulcer (n = 7) were successfully treated (100% vs 56.2% with antral nodularity). Side effects were reported in 26 patients (68.4%), mainly vomiting (14/26) and abdominal pain (n = 13). Successfully treated dyspeptic patients showed improvement in 78.9% of H pylori-negative patients after six months and in 50% of H pylori-positive patients after six months of treatment.CONCLUSION: Triple therapy with furazolidone achieves moderate effi cacy in H pylori treatment. The eradicationrate seems to be higher in patients with duodenal ulcer. | Elisabete Kawakami Rodrigo Strehl Machado Silvio Kazuo Ogata Marini Langner Erika Fukushima Anna Paula Carelli Vania Cláudia Guimares Bonucci Francy Reis Silva Patrício | 2006 | World Journal of Gastroenterology2006，12，34： | 2 |
| 3 | Methodological aspects about in vitro evaluation of antioxidant properties显示文摘 | Luís M. Magalh?es Marcela A. Segundo Salette Reis José L.F.C. Lima | 2008 | Analytica Chimica Acta2008，，1： | 1 |
| 4 | Biodiesel compatibility with carbon steel and HDPE parts显示文摘 | Marcia Marie Maru Marcia Maria Lucchese Cristiano Legnani Welber Gianini Quirino Andrea Balbo Isabele Bulh?es Aranha Lílian Terezinha Costa Cecília Vilani Lídia ágata de Sena Jailton Carreteiro Damasceno Talita dos Santos Cruz Leandro Reis Lidízio Rui Fer | 2009 | Fuel Processing Technology2009，，9： | 1 |
| 5 | Qualityevaluation of cone biopsy specimens obtained by large loop excisionof the transformation zone显示文摘 | Garcia Ramos AM Garcia Ramos ES Dos Reis HL | | J Clin Med Res0，7，4： | 1 |
| 6 | Targeted complementinhibition as a promising strategy for preventinginflammatory complications in hemodialysis显示文摘 | DeAngelis RA Reis ES Ricklin D | 2012 | Immuno -biology2012，217，11： | 1 |
| 7 | Methodological aspects about in vitro evaluation of antioxidant properties显示文摘 | MAGALH(A)ES LM SEGUNDO MA REIS S | | 0，，01： | 1 |
| 8 | Evaluation of basal FSHserum levels in infertile patients with deep ovarian endometriosiswho under went surgery显示文摘 | Frankfurt S Nun es AL Reis AD | 2009 | Rev Bras Ginecol Obstet2009，319，5： | 1 |
| 9 | CD14 mediate endotoxin induction of nitric oxide synthase in cultured brain glial cells显示文摘 | Galea E Reis DJ Fox ES Xu H Feinstein DL | 1996 | J Neuroimmunol1996，64，： | 1 |
| 10 | Clinical improvement following therapy for periodontitis:association with a decrease in IL-1 and IL-6显示文摘 | Reis C DA Costa A V Guimares J T | 2014 | Exp Ther Med2014，8，1： | 1 |
| 11 | Bone marrow-derived mesenchymal stem cells repaired but did not prevent gentamicin induced acute kidneyinjury through paracrine effects in rats显示文摘 | Reis LA Borges FT Sim (o)es M J | 2012 | PLoS One2012，7，44： | 1 |
| 12 | Autonomic control of heart rate in patients with chronic cardiorespiratory disease and in healthy participants at rest and during a respiratory sinus arrhythmia maneuver显示文摘 | Reis MS Deus AP Sim es RP | 2010 | Rev Bras Fisioter2010，14，2： | 1 |
| 13 | Supercritical fluid extrac-tion of lipids from the heterotrophic microalga Crypthecodinium cohnii显示文摘 | Couto RM Sim?es PC Reis A | | 0，，02： | 1 |
| 14 | Physical activity and better medication compliance improve mini-mental state examination scores in the elderly显示文摘 | Guimar?es FC Amorim PR Reis FF | 2015 | Dement Geriatr Cogn Disord2015，39，12： | 1 |
| 15 | BJcuL, a lectin purified from Bothrops jararacussu venom, induces apoptosis in human gastric carcinoma cells accompanied by inhibition of cell adhesion and actin cytoskeleton disassembly显示文摘 | Stefanie Nolte Danusa de Castro Damasio Adriana Cristina Baréa Joana Gomes Ana Magalh?es Luciana F.C. Mello Zischler Patrícia M. Stuelp-Campelo Selene L. Elífio-Esposito Maria Cristina Roque-Barreira Celso A. Reis Andréa Novais Moreno-Amaral | 2011 | Toxicon2011，，1： | 1 |
| 16 | Diagnostic investigation and multidisciplinary management in motor neuron disease显示文摘 | Rocha JA Reis C Sim(o)es F | 2005 | J Neurol2005，252，12： | 1 |
| 17 | Preliminary report: Leucine supplementation enhances glutamate dehydrogenase expression and restores glucose-induced insulin secretion in protein-malnourished rats显示文摘 | Priscilla Muniz Ribeiro da Silva Claudio Cesar Zoppi Eliane Filiputti Leonardo Reis Silveira Ivan Quesada Antonio Carlos Boschero Everardo Magalh?es Carneiro | 2010 | Metabolism2010，，6： | 1 |
| 18 | Methodologicalaspects about in vitro evaluation of antioxidant properties显示文摘 | MAGALH ES L M SEGUNDO M A REIS S | 2008 | Anal ChimActa2008，613，1： | 1 |
| 19 | Human monocyte-derived dendritic cells are a source of several complement proteins显示文摘 | Barbuto JA Isaac L | 2006 | InflammRes2006，55，5： | 1 |
| 20 | Methodological aspects about in vitro evaluation of anfioxidant properties显示文摘 | MAGALH ES L M SEGUNDO M A REIS S | 2008 | Anal Chirn Acta2008，613，1： | 1 |
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