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| 1 | Role of bacterial and genetic factors in gastric cancer in Costa Rica显示文摘AIM: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). METHODS: According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1β and IL-10 by PCR-RFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. RESULTS: Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were signif icantly associated with high GCIR (P = 0.026 and 0.041, respectively). IL- 1β+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with GC, and a combination of these cytokine polymorphisms with H pylori vacA s1b and m1 further increased the risk (OR 7.2, 1.4-36.4). CONCLUSION: Although a proinflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of H pylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica. | Sergio A Con Hiroaki Takeuchi Gil R Con-Chin Vicky G Con-Chin Nobufumi Yasuda Reinaldo Con-Wong | 2009 | World Journal of Gastroenterology2009，15，2： | 9 |
| 2 | Clinical relevance of Helicobacter pylori babA2 and babA2/B in Costa Rica and Japan显示文摘AIM:To evaluate the prevalence of Helicobacter pylori(H.pylori ) babA2 ,babB and a recombinant gene between babA2 and babB(babA2/B ),and their role in the development of atrophic gastritis in Costa Rican and Japanese clinical isolates.METHODS:A total of 95 continuous H.pylori-positive Costa Rican(41 males and 54 females;mean age,50.65 years;SD,± 13.04 years) and 95 continuous H.pylori-positive Japanese(50 males and 45 females;mean age,63.43;SD,± 13.21 years) patients underwent upper endoscopy from October 2005 to July 2006.They were enrolled for the polymerase chain reaction(PCR)-based genotyping of the H.pylori babA2 ,babB and babA2/B genes.Statistical analysis was performed using the χ2 test and the Fisher's exact probability test and multivariate analysis was performed by logistic regression adjusting for gender and age.P < 0.05 was regarded as statistically significant.RESULTS:The PCR-based genotyping of 95 Costa Rican and 95 Japanese isolates showed a higher prevalence of babA2 in Japan(96.8%) than in Costa Rica(73.7%),while that of babA2/B was higher in Costa Rica(11.6%) than in Japan(1.1%).In Costa Rican isolates only,babA2 was significantly associated with atrophic gastritis(P = 0.01).CONCLUSION:These results suggest that the status of babA2 and babA2/B shows geographic differences,and that babA2 has clinical relevance in Costa Rica. | Sergio A Con Hiroaki Takeuchi Mitsuaki Nishioka Norihito Morimoto Tetsuro Sugiura Nobufumi Yasuda Reinaldo Con-Wong | 2010 | World Journal of Gastroenterology2010，16，4： | 4 |
| 3 | Specific and cross-reactive immune response against Mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from Mycobacterium bovis BCG显示文摘Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis(M. tuberculosis) of a proteoliposome(PL)from Mycobacterium bovis Bacillus Calmette–Guerin(BCG) with and without alum hydroxide(AL) as adjuvant(PLBCG-AL and PLBCG, respectively) in BALB/c mice.Methods: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G(Ig G), Ig G1 and Ig G2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western blot.Results: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total Ig G and Ig G1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in vivo.Conclusions: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages. | Nadine Alvarez DaymíSerpa Ramlah Kadir Yanely Tirado Reinier Borrero Sonsire Fernández Rubén Cabrera Yolanda Valdes Caridad Zayas Reinaldo Acevedo Luis Izquierdo María Elena Sarmiento Mohd-Nor Norazmi JoséLuis Pérez Armando Acosta | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，3： | 3 |
| 4 | Fracture detection in a carbonate reservoir using a variety of seismic methods显示文摘 | Maria A P Vladimir G Reinaldo J M | 1999 | Geophysics1999，64，4： | 1 |
| 5 | Effectiveness of a multidimensional approach for prevention of ventilator-associated pneumonia in adult intensive care units from 14 developing countries of four continents: Findings of the International Nosocomial Infection Control Consortium*显示文摘 | Victor D. Rosenthal Camilla Rodrigues Carlos álvarez-Moreno Naoufel Madani Zan Mitrev Guxiang Ye Reinaldo Salomao Fatma Ulger Humberto Guanche-Garcell Souha S. Kanj Luis E. Cuéllar Francisco Higuera Trudell Mapp Rosalía Fernández-Hidalgo | 2012 | Critical Care Medicine2012，，： | 1 |
| 6 | Preparation and properties of zinc containing biphasic calcium phosphate Bioceramics 显示文摘 | ANDREA M C GLORIA A S REINALDO C | 2004 | Key Eng Mater2004，254，： | 1 |
| 7 | Accelerating autonomous learning by using heuristic selection of actions 显示文摘 | Reinaldo A C Bianchi Carlos H C | 2008 | Journal of Heuristics2008，14，2： | 1 |
| 8 | Effect of antenna polarization on the capacity of a multiple element system in an indoor environment显示文摘 | PERSEFONI K DONALD C C REINALDO A V | 2002 | IEEE Journal on Selected Areas in Communications2002，20，6： | 1 |
| 9 | Forecasting river uruguay flow using rainfall forecasts from a regional weather-prediction model显示文摘 | WALTER C REINALDO H IVANILTO A | 2005 | Journal of Hydrology2005，305，： | 1 |
| 10 | Designing systems-on-chip using cores显示文摘 | Reinaldo A B William R L | 2000 | Annual ACM IEEE Design Automation Conference Proceedings of 37th conference on design automation2000，，： | 1 |
| 11 | Heuristically accelerated multi agent reinforcement learning显示文摘 | REINALDO A C B MARTINS M F RIBEIRO C H C | 2014 | IEEE Transactions on Cybernetics2014，44，2： | 1 |
| 12 | Accelerating autonomous learning by using heuristic selection of actions显示文摘 | Reinaldo A C Bianchi Carlos H C Ribeiro Anna H R Costa | 2008 | Journal of Heuristics2008，14，2： | 1 |
| 13 | Bridging the domains of high-level and logic synthesis 显示文摘 | Reinaldo A B | 2002 | IEEE Computer-Aided Design of Integrated Circuits and Systems2002，21，5： | 1 |
| 14 | Generatingcapacity reliability evaluation based on Monte Carlo simulationand cross-entropy methods显示文摘 | Armando M Leite da Silva Reinaldo A G | 2010 | IEEE Transactions on PowerSystems2010，25，1： | 1 |
| 15 | Data Center Power and Performance Optimization through Global Selection of PStates and Utilization Rates显示文摘 | Reinaldo A Bergamaschi Leonardo Piga Sandro Rigo | 2012 | Informatics and Systems2012，2，4： | 1 |
| 16 | A Statistical Model of Indoor Muhipath Propagation 显示文摘 | Adel A M Saleh Reinaldo A | 1987 | IEEE Journal on Selected Areas in Communications1987，5，2： | 1 |
| 17 | Cadmium uptake by hydroxyapatite synthesized in different conditions and submitted to thermal treatment显示文摘 | Nillce C C Rocha D A Reinaldo C | 2002 | Environ Sci Techonl2002，36，7： | 1 |
| 18 | Triple-negative breast cancer 显示文摘 | Reinaldo D Chac6 n Mari a V | 2010 | Breast Cancer Research2010，12，2： | 1 |
| 19 | Bridging the domains of high-level and logic synthesis 显示文摘 | Reinaldo A B | 2002 | IEEE JCAD2002，21，5： | 1 |
| 20 | A statistical model for indoor multipath propagation 显示文摘 | Adel A M Saleh Reinaldo A Valenzuela | 1987 | IEEE Journal on selected areas in communications1987，5，2： | 1 |
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