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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Dimensioning large call centers显示文摘 | Borst S Mandelbaum A Reiman M | | 0，，01： | 1 |
| 3 | Functional imaging of an illusion of pain显示文摘 | Craig A D Reiman E M Evans A | 1996 | Nature1996，384，： | 1 |
| 4 | Exposure to endotoxinsand microbes in the treatment of waste water and in the industrial debarking of wood 显示文摘 | ] Sarantila R Reiman M Kangas J | 2001 | BuUetin of Environmental Contamination and Toxicology2001，67，2： | 1 |
| 5 | Designing a call center with impatient customers显示文摘 | Garnett O Mandelbaum A Reiman M | | 0，，03： | 1 |
| 6 | Tumor immunoediting and immunosculpting pathways to cancer progression 显示文摘 | Reiman JM Kmieciak M Manjili MH | 2007 | Semin Cancer Biol2007，17，4： | 1 |
| 7 | Interleukin-6 polymorphism is associated with chorioamnionitis and neonatal infections in preterm infants 显示文摘 | Reiman M Kujari H Ekholm E | 2008 | J Pediatr2008，153，1： | 1 |
| 8 | Designing a call center with impatient customers显示文摘 | Gamett O Mandelbaum A Reiman M | | 0，，： | 1 |
| 9 | Immune-in- duced epithelial to mesenehymal transition in vivo generates breast cancer stem celIs 显示文摘 | Santistehan M Reiman JM Asiedu MK | 2009 | Cancer Res2009，69，7： | 1 |
| 10 | Nonoperative treatment in lumbar spondylolysis and spondylolisthesis: a systematic review显示文摘 | Garet M Reiman MP Mathers J | 2013 | Sports Health2013，5，3： | 1 |
| 11 | Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells 显示文摘 | Santisteban M Reiman JM Asiedu MK | 2009 | Cancer Res2009，69，7： | 1 |
| 12 | Lithium insertion into TiO2 from aqueous solution显示文摘 | REIMAN K H BRACE K M GORDON-SMITH T J | | 0，，04： | 1 |
| 13 | Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia显示文摘 | Reiman E M Chen K Alexander G E | 2004 | Proc Natl Acad Sci U S A2004，101，： | 1 |
| 14 | Brain imaging in the study of Alzheimer's disease 显示文摘 | REIMAN E M JAGUST W J | 2012 | Neuroimage2012，61，2： | 1 |
| 15 | Exposure to microbes, endotoxins and total dust in cigarette and cigar manufacturing: an evaluation of health hazards 显示文摘 | Reiman M Uitti J | 2000 | Ann Occup Hyg2000，44，6： | 1 |
| 16 | Exposure to microbes, endotoxins and total dust in cigarette and cigar manufacturing: An evaluation of health hazards 显示文摘 | REIMAN M UITTI J | 2000 | Ann Occup Hyg2000，44，6： | 1 |
| 17 | GAB2 al- leles modify Alzheimer's risk in APOE epsilon4 carriers 显示文摘 | Reiman E M Webster J A Myers A J | 2007 | Neuron2007，54，5： | 1 |
| 18 | Comparison of needle biopsy with cytologic analysis for the evaluation of pleural effusions:analysis of 414 cases显示文摘 | Ppakash U B Reiman H M | | 0，，03： | 1 |
| 19 | IgG antbodies, chronic bronchitis, and pulmonary function values in famer' s lung pa- tients and matched controls显示文摘 | R Erkinjuntti-Pekkanen M Reiman JIKokkarinen | 1999 | Allergy1999，54，： | 1 |
| 20 | Poly (2,5-dihydroxy-1,4-benzoquinone-3, 6-methylene): a new organic polymer as positive electrode material for rechargeable lithium batteries 显示文摘 | Gall T L Reiman K H Grossel M C | 2003 | J Power Sources2003，，： | 1 |
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