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| 1 | FOLFIRI regimen in metastatic pancreatic adenocarcinoma resistant to gemcitabine and platinum-salts显示文摘AIM: To evaluate the efficacy and safety of the FOLFIRI regimen in patients with metastatic pancreatic adenocarcinoma (PAC) after the failure of gemcitabine and platinum salts. METHODS: All consecutive patients with histologically confirmed, metastatic PAC and World Health Organiza-tion performance status (PS) ≤ 2 received FOLFIRI-1 [irinotecan 180 mg/m2 on day 1 and leucovorin 400 mg/m2 followed by 5-fluorouracil (5-FU) 400 mg/m2 bolus, then 5-FU 2400 mg/m2 as a 46-h infusion, biweekly] or FOLFIRI-3 (irinotecan 100 mg/m2 on day 1 and leucovorin 400 mg/m2, then 5-FU 2400 mg/m2 as a 46-h infusion and irinotecan 100 mg/m2 repeated on day 3, biweekly) after failure of gemcitabine and platinum-based chemotherapies as a systematic policy in two institutions between January 2005 and May 2010. Tumor response, time to progression (TTP), overall survival rate (OS) and grade 3-4 toxicities were retrospectively studied. Subgroup analyses were performed to search for prognostic factors. RESULTS: Sixty-three patients (52.4% male, median age 59 years) were analyzed. Among them, 42.9% were PS 0, 38.1% were PS 1 and 19.0% were PS 2. Fifty one patients (81.0%) had liver metastases. Before the FOLFIRI regimen, patients had received 1 line (n = 19), 2 lines (n = 39) or 3 lines (n = 5) of chemotherapy. Median TTP obtained with the line before FOLFIRI was 3.9 mo (95% CI: 3.4-5.3 mo). A total of 480 cycles was completed (median: 6 cycles, range: 1-51 cycles). The main reason for discontinuing FOLFIRI was tumor progression (90.3%). Tumor control was achieved in 25 patients (39.7%) (partial response: n = 5, stable disease: n = 20) with FOLFIRI. Median TTP was 3.0 mo (95% CI: 2.1-3.9 mo) and median OS was 6.6 mo (95% CI: 5.3-8.1 mo). Dose adaptation was required in 36 patients (57.1%). Fifteen patients (23.8%) had grade 3-4 toxicities, mainly hematological (n = 11) or digestive (n = 4). Febrile neutropenia occurred in 3 patients. There was no toxic death. PS 2 was significantly associated with poor TTP [hazard ratio (HR): 16.036, P < 0.0001] and OS (HR: 4.003, P = 0.004). CONCLUSION: The FOLFIRI regimen had an acceptable toxicity and an interesting efficacy in our study, limited to patients in good condition (PS 0-1). | Cindy Neuzillet Olivia Hentic Benot Rousseau Vinciane Rebours Léla Bengrine-Lefèvre Franck Bonnetain Philippe Lévy Eric Raymond Philippe Ruszniewski Christophe Louvet Pascal Hammel | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 2 | Role of endoscopic ultrasound in the screening and follow-up of high-risk individuals for familial pancreatic cancer显示文摘Managing familial pancreatic cancer(FPC)is challenging for gastroenterologists,surgeons and oncologists.High-risk individuals(HRI)for pancreatic cancer(PC)(FPC or with germline mutations)are a heterogeneous group of subjects with a theoretical lifetime cumulative risk of PC over 5%.Screening is mainly based on annual magnetic resonance imaging(MRI)and endoscopic ultrasound(EUS).The goal of screening is to identify early-stage operable cancers or high-risk precancerous lesions(pancreatic intraepithelial neoplasia or intraductal papillary mucinous neoplasms with high-grade dysplasia).In the literature,target lesions are identified in 2%-5%of HRI who undergo screening.EUS appears to provide better identification of small solid lesions(0%-46%of HRI)and chronicpancreatitis-like parenchymal changes(14%-77%of HRI),while MRI is probably the best modality to identify small cystic lesions(13%-49%of HRI).There are no specific studies in HRI on the use of contrast-enhanced harmonic EUS.EUS can also be used to obtain tissue samples.Nevertheless,there is still limited evidence on the accuracy of imaging procedures used for screening or agreement on which patients to treat.The cost-effectiveness of screening is also unclear.Certain new EUS-related techniques,such as searching for DNA abnormalities or protein markers in pancreatic fluid,appear to be promising. | Diane Lorenzo Vinciane Rebours Frédérique Maire Maxime Palazzo Jean-Michel Gonzalez Marie-Pierre Vullierme Alain Aubert Pascal Hammel Philippe Lévy Louis de Mestier | 2019 | World Journal of Gastroenterology2019，25，34： | 2 |
| 3 | Improving Software Quality Prediction by Noise Filtering Techniques显示文摘机器学习者的精确性被数据的质量影响学习者上被劝诱。在这篇论文,训练数据集的质量被移开划分过滤器作为吵闹检测的例子改进。合适的数据集首先被分成子集,;不同基础学习者在每这些裂口上被劝诱。如果它被某些基础学习者分类,预言以如此的一个方法被联合,一个例子作为吵闹被识别。划分过滤器的二个版本被使用:多重划分的过滤器;反复划分的过滤器。过滤器移开的例子的数字被过滤器的投票的计划调节;重复的数字。这研究的主要目的是比较造在上的最后模型的预兆的表演过滤;未过滤的训练数据集。一个高保证软件项目的软件测量数据的案例研究被执行。模型的预兆的表演在过滤合适的数据集上造了,这被显示出;在吵闹的测试数据集上评估了通常比造在上的那些好吵闹(未过滤) 合适的数据集。然而,预兆的性能被噪音的存在在评估数据集基于某些好攻击的过滤器影响。 | Taghi M.Khoshgoftaar Pierre Rebours | 2007 | Journal of Computer Science & Technology2007，22，3： | 2 |
| 4 | Odor-based naviga- tional strategies for mobile agents显示文摘 | Lytridis C Virk G S Rebour Y | 2001 | Adaptive Behavior2001，9，34： | 1 |
| 5 | The long term risk of malignancy in patients with branch duct intraductal papillary mucinous neoplasms of the pancreas显示文摘 | Wafaa Khannoussi Marie Pierre Vullierme Vinciane Rebours Frédérique Maire Olivia Hentic Alain Aubert Alain Sauvanet Safi Dokmak Anne Couvelard Pascal Hammel Philippe Ruszniewski Philippe Lévy | 2012 | Pancreatology2012，，3： | 1 |
| 6 | Hydrotalcite decomposition mechanism:a clue to the structure and reactivity of spine-like mixed oxides显示文摘 | REBOURS B KLAUSE O | 1996 | J Phys Chem1996，100，2： | 1 |
| 7 | Reducibility of Cobalt Species in Silica-Supported Fischer–Tropsch Catalysts显示文摘 | A.Yu. Khodakov J. Lynch D. Bazin B. Rebours N. Zanier B. Moisson P. Chaumette | 1997 | Journal of Catalysis1997，，1： | 1 |
| 8 | Preoperative CT scan helps to predict the occurrence of severe pancreatic fistula after pancreaticoduodenectomy 显示文摘 | Tranchart H Gaujoux S Rebours V | 2012 | Ann Surg2012，256，1： | 1 |
| 9 | Fatty pancreas and increased body mass index are risk factors of pancreatic fistula after pancreaticoduodenectomy显示文摘 | Sébastien Gaujoux Alexandre Cortes Anne Couvelard Séverine Noullet Laurent Clavel Vinciane Rebours Philippe Lévy Alain Sauvanet Philippe Ruszniewski Jacques Belghiti | 2010 | Surgery2010，，1： | 1 |
| 10 | Mortality rate and risk factors in patients with hereditary pancreatitis: uni - and multidimensional analyses显示文摘 | Rebours V Boutron-Ruault MC Jooste V | 2009 | AmJ Gastroenterol2009，104，： | 1 |
| 11 | Deactivation of palla-dium catalyst in catalytic combustion of methane 显示文摘 | Euzen P Le Gal J H Rebours B | 1999 | Cataly- sis Today1999，47，14： | 1 |
| 12 | Acute pancreatitis: an overview of the management显示文摘 | Rebours V | 2014 | Rev MedInterne2014，35，10： | 1 |
| 13 | Preoperative CT scan helps to predict the occurrence of severe pancreatic fis- tula after pancreaticoduodenectomy 显示文摘 | Tranchart H Gaujoux S Rebours V | 2012 | Ann Surg2012，256，1： | 1 |
| 14 | Hydrotalcite decomposition mechanism: a clue to the structure and reactivity of spinel- like mixed oxides显示文摘 | Bellotto M Rebours B Clause O | 1996 | Phys Chem1996，100，20： | 1 |
| 15 | Are- examination of hydrotalcite crystal chemistry 显示文摘 | BELLOTTO M REBOURS B CLAUSE O | 1996 | J Phys Chem1996，100，： | 1 |
| 16 | Extrahepatic portalvenous system thrombosis in recurrent acute and chronic alcoholic pancreatitis is caused by local inflammation and not thrombophilia显示文摘 | Rebours V Boudaoud L Vullierme M P | 2012 | Am ] Gastroenterol2012，107，10： | 1 |
| 17 | Acute pancreatitisin patients operated on for intraductal papillary mutinous neoplasmsof the pancreas : frequency,severity, and clinicopathologic correlations显示文摘 | PELLETIER AL HAMMEL P REBOURS V | 2010 | Pancreas2010，39，： | 1 |
| 18 | Effect of genotype, sex and rearing temperature on carcase and meat quality of Guinea Fowl显示文摘 | Baeza E Juin H Rebours G | 2001 | British Poultry Science2001，42，4： | 1 |
| 19 | Does tobacco influence the natural history of autoimmune pancreatitis?显示文摘 | Frédérique Maire Vinciane Rebours Marie Pierre Vullierme Anne Couvelard Philippe Levy Olivia Hentic Maxime Palazzo Pascal Hammel Philippe Ruszniewski | 2014 | Pancreatology2014，，： | 1 |
| 20 | Is adjuvant therapy with streptozotocin and 5-fluorouracil useful after resection of liver metastases from digestive endocrine tumors?显示文摘 | Frédérique Maire Pascal Hammel Reza Kianmanesh Olivia Hentic Anne Couvelard Vinciane Rebours Magaly Zappa Eric Raymond Alain Sauvanet Christophe Louvet Philippe Lévy Jacques Belghiti Philippe Ruszniewski | 2009 | Surgery2009，，1： | 1 |
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