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| 1 | Hepatocellular carcinoma treated with transarterial chemoembolization: Dynamic perfusion-CT in the assessment of residual tumor显示文摘AIM: To asses the value of computed tomography (CT)-perfusion in the detection of residual hepatocellular carcinoma (HCC) vascularization after transarterial chemoembolization (TACE). METHODS: Thirty-two consecutive patients were pro-spectively included in this study. All patients had liver cirrhosis and a conf irmed HCC lesion which was treated with TACE. One month after treatment, perfusion measurements of treated lesions were carried out. The CTperfusion (CT-p) protocol was performed with 16 slice multidetector computed tomography which included the following parameters: 8 dynamic slices/scan per 40 scans after iv injection of 50 mL of iodinated contrast (350 mg/mL) at a flow rate of 6 mL/s. Treated lesions were evaluated using dedicated perfusion software, which generated a quantitative colour map of perfusion. The following parameters were considered: hepatic perfusion (HP), arterial perfusion (AP), blood volume (BV), hepatic perfusion index (HPI), and time to peak (TTP). Perfusion parameters were described with quartile values of their distribution and statistically analyzed. RESULTS: Perfusion parameters of the treated lesions could be quantitatively assessed using CT-p analysis. The presence of residual tumor tissue was observed in 13 of the 32 patients. The values of the perfusion parameters measured within the relapse tissue were: HP (mL/100 g per minute): median = 44.4 (1stqt = 31.3, 3rdqt = 55.8); BV (mL/100 g): median = 18.7 (1stqt = 11.5, 3rdqt = 22.5); AP (mL/min): median = 39.0 (1stqt = 36.5, 3rdqt = 61.3); HPI (%): median = 34.0 (1stqt = 30.4, 3rdqt = 38.9); TTP (s): median = 17.3 (1stqt = 15.8, 3rdqt = 26.5). With the use of the univariate paired Wilcoxon signed rank test, HP, AP and HPI were shown to be significantly higher (P<0.001) in the relapse site than in the primary lesion. The BV and TTP parameters showed a tendency to be greater and lower, respectively, in the relapse site than in the primary lesion. CONCLUSION: In patients with HCC treated with TACE, CT-p provides measurement of flow parameters related to residual arterial structures in viable tumor, thus helping in the assessment of therapeutic response. | Davide Ippolito Pietro Andrea Bonaff ini Laura Ratti Laura Antolini Rocco Corso Ferruccio Fazio Sandro Sironi | 2010 | World Journal of Gastroenterology2010，16，47： | 15 |
| 2 | Anti-HBc screening in Indian blood donors:Still an unresolved issue显示文摘AIM:To study the seroprevalence of antibody to hepatitis B core antigen (anti-HBc) in healthy blood donors negative for HBsAg and to evaluate whether anti-HBc detection could be adopted in India as a screening assay for HBV in addition to HBsAg. METHODS: A total of 1700 serum samples collected from HBsAg-negative healthy blood donors were tested for the presence of anti-HBc antibody (IgM + IgG). All samples reactive for anti-HBc antibody were then investigated for presence of anti-HBs and for liver function tests (LFTs). One hundred serum samples reactive for anti-HBc were tested for HBV DNA by PCR method. RESULTS: Out of 1700 samples tested, 142 (8.4%) blood samples were found to be reactive for anti-HBc. It was signif icantly lower in voluntary (6.9%) as compared to replacement donors (10.4%, P = 0.011). Seventy- two (50.7%) anti-HBc reactive samples were also reactive for anti-HBs with levels > 10 mIU/mL and 70 (49.3%) samples were non-reactive for anti-HBs, these units were labeled as anti-HBc-only. These 142 anti-HBc reactive units were also tested for liver function test. HBV DNA was detected in only 1 of 100 samples tested. CONCLUSION: Keeping in view that 8%-18% of donor population in India is anti-HBc reactive, inclusion of anti- HBc testing will lead to high discard rate. Anti-HBs as proposed previously does not seem to predict clearance of the virus. Cost effectiveness of introducing universalanti-HBc screening and discarding large number of blood units versus considering ID NAT (Individual donor nuclic acid testing) needs to be assessed. | Hari Krishan Dhawan Neelam Marwaha Ratti Ram Sharma Yogesh Chawla Beenu Thakral Karan Saluja Sanjeev Kumar Sharma Manish K Thakur Ashish Jain | 2008 | World Journal of Gastroenterology2008，14，34： | 8 |
| 3 | Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria显示文摘BACKGROUND Surgical resection and radiofrequency ablation(RFA)represent two possible strategy in treatment of hepatocellular carcinoma(HCC)in Milan criteria.AIM To evaluate short-and long-term outcome in elderly patients(>70 years)with HCC in Milan criteria,which underwent liver resection(LR)or RFA.METHODS The study included 594 patients with HCC in Milan criteria(429 in LR group and 165 in RFA group)managed in 10 European centers.Statistical analysis was performed using the Kaplan-Meier method before and after propensity score matching(PSM)and Cox regression.RESULTS After PSM,we compared 136 patients in the LR group with 136 patients in the RFA group.Overall survival at 1,3,and 5 years was 91%,80%,and 76%in the LR group and 97%,67%,and 41%in the RFA group respectively(P=0.001).Diseasefree survival at 1,3,and 5 years was 84%,60%and 44%for the LR group,and 63%,36%,and 25%for the RFA group(P=0.001).Postoperative Clavien-Dindo IIIIV complications were lower in the RFA group(1%vs 11%,P=0.001)in association with a shorter length of stay(2 d vs 7 d,P=0.001).In multivariate analysis,Model for End-stage Liver Disease(MELD)score(>10)[odds ratio(OR)=1.89],increased value of international normalized ratio(>1.3)(OR=1.60),treatment with radiofrequency(OR=1.46),and multiple nodules(OR=1.19)were independent predictors of a poor overall survival while a high MELD score(>10)(OR=1.51)and radiofrequency(OR=1.37)were independent factors associated with a higher recurrence rate.CONCLUSION Despite a longer length of stay and a higher rate of severe postoperative complications,surgery provided better results in long-term oncological outcomes as compared to ablation in elderly patients(>70 years)with HCC in Milan criteria. | Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Letizia Laera Francesca Ratti Maximiliano Gelli Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño AntonioRampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 4 | 范式转换:共享机动性及规划和治理响应显示文摘机动性是城市活力的根本来源之一。历史上城市机动性有两次主要范式的转换,其一是从原始交通方式向电气化轨道交通转移,其二是私家车的崛起。后者虽然满足了城市出行需要,却带来负面影响,变得不可持续。正在涌现的新范式,即在信息技术支撑下以共享出行取代私家车,既支撑大范围个性化的出行需求,又提升整体运行效率。以范式转换为视角引介共享机动性的概念、类型和重要意义,重点介绍了国际上前沿议题和研究进展,讨论了共享范式下的规划响应和协作治理。认为,共享机动性是以公共部门为主导,公众和相关企业为主要参与者,以高校科研机构等为支撑的协作治理模式。提出应追求出行更高效、社会更公平、环境更友好的“可持续范式转换”,努力寻求共识行动,促进理想范式的真正到来。 | 晏龙旭 任熙元 王德 Carlo Ratti | 2019 | 城市规划学刊2019，，4： | 2 |
| 5 | HCV ‐associated B ‐cell non‐ H odgkin lymphomas and new direct antiviral agents显示文摘 | Paul Carrier Arnaud Jaccard Jérémie Jacques Tessa Tabouret Marilyne Debette‐Gratien Julie Abraham Laura Mesturoux Pierre Marquet Sophie Alain Denis Sautereau Marie Essig Véronique Loustaud‐Ratti | 2015 | Liver Int2015，，10： | 2 |
| 6 | Hilar Cholangiocarcinoma: Preoperative Liver Optimization with Multidisciplinary Approach. Toward a Better Outcome显示文摘 | Francesca Ratti Federica Cipriani Fabio Ferla Marco Catena Michele Paganelli Luca A. M. Aldrighetti | 2013 | World Journal of Surgery2013，，6： | 2 |
| 7 | CCN3/nephro- blastoma overexpressed matficellular protein regulates integrin expression, adhesion, and dissemination in melanoma显示文摘 | Vallacchi V Daniotti M Ratti F | 2008 | Cancer Res2008，68，3： | 1 |
| 8 | Predictors of adverse perinatal outcome in twins delivered at <?37 weeks显示文摘 | Patrizia Vergani Anna Locatelli Marta Ratti Antonietta Scian Giulia Zangheri John Pezzullo Alessandro Ghidini | 2004 | Journal of Maternal-Fetal and Neonatal Medicine2004，，6： | 1 |
| 9 | In?uence of ge- netic and environmental factors on selected nutritional traits of Triticum monococcum显示文摘 | Hidalgo A Brandolini A Ratti S | 2009 | Journal of Agricultural and Food Chemistry2009，，57： | 1 |
| 10 | Hot air and freeze-drying of high-value food: a review显示文摘 | Ratti C | 2001 | Journal of Food Engineering2001，49，4： | 1 |
| 11 | Eigenplaces: Analysing Cities Using the Space-Time Structure of the Mobile Phone Network显示文摘 | Reades J Calabrese F Ratti C | 2009 | Environment and Planning B: Planning and Design2009，36，： | 1 |
| 12 | Hot air and freeze-drying of high-value foods: a review 显示文摘 | Ratti C | 2001 | Journal of Food Engineering2001，49，4： | 1 |
| 13 | Monetary policy, oil price shocks, and the Japanese economy显示文摘 | Byung Rhae Lee Kiseok Lee Ronald A Ratti | 2001 | Japan & The World Economy2001，，3： | 1 |
| 14 | Understanding individual mobility patterns from urban sensing data: A mobile phone trace example显示文摘 | Francesco Calabrese Mi Diao Giusy Di Lorenzo Joseph Ferreira Carlo Ratti | 2013 | Transportation Research Part C2013，，： | 1 |
| 15 | Influence of titanium on nano-cluster (Y, Ti, O) stability in ODS ferritic materials 显示文摘 | RATTI M LEUVREY D MATHON M H | 2009 | J Nucl Mater2009，386，1： | 1 |
| 16 | A multiplex RT-PCR assay capable of distinguishing beet necrotic yellow vein virus types A and B 显示文摘 | Ratti C Clover G R G Autonell C R Harju V A Henry C M | 2005 | J Virol Methods2005，124，： | 1 |
| 17 | Pramipexole for the treat- ment of early Parkinson' s disease 显示文摘 | Perez-Lloret S Rey MV Ratti L | 2011 | Expert Rev Neurother2011，11，7： | 1 |
| 18 | Habitat use and home range of gray partridge in eastern south Dakota显示文摘 | Smith L M Hupp J W Ratti J T | 1982 | Journal of Wildlife Management1982，46，3： | 1 |
| 19 | A role for the ELAV RNA-bind-ing proteins in neural stem cells:stabilization of Msi1 mRNA显示文摘 | Ratti A Fal ini C Cova L | | 0，，7： | 1 |
| 20 | Uncovering cabdrivers’ behavior patterns from their digital traces显示文摘 | Liang Liu Clio Andris Carlo Ratti | 2010 | Computers Environment and Urban Systems2010，，： | 1 |
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