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| 1 | Diet and microbiota in inflammatory bowel disease: The gut in disharmony显示文摘Bacterial colonization of the gut shapes both the local and the systemic immune response and is implicated in the modulation of immunity in both healthy and disease states. Recently, quantitative and qualitative changes in the composition of the gut microbiota have been detected in Crohn's disease and ulcerative colitis, reinforcing the hypothesis of dysbiosis as a relevant mechanism underlying inflammatory bowel disease(IBD) pathogenesis. Humans and microbes have coexisted and co-evolved for a long time in a mutually beneficial symbiotic association essential for maintaining homeostasis. However, the microbiome is dynamic, changing with age and in response to environmental modifications. Among such environmental factors, food and alimentary habits, progressively altered in modern societies, appear to be critical modulators of the microbiota, contributing to or co-participating in dysbiosis. In addition, food constituents such as micronutrients are important regulators of mucosal immunity, with direct or indirect effects on the gut microbiota. Moreover, food constituents have recently been shown to modulate epigenetic mechanisms, which can result in increased risk for the development and progression of IBD. Therefore, it is likely that a better understanding of the role of different food components in intestinal homeostasis and the resident microbiota will be essential for unravelling the complex molecular basis of the epigenetic, genetic and environment interactions underlying IBD pathogenesis as well as for offering dietary interventions with minimal side effects. | Davy CM Rapozo Claudio Bernardazzi Heitor Siffert Pereira de Souza | 2017 | World Journal of Gastroenterology2017，23，12： | 24 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | Bacterial sensing, cell signaling, and modulation of the immune response during sepsis显示文摘 | Salomao R Brunialti MK Rapozo MM | 2012 | Shock2012，38，3： | 1 |
| 4 | Bacterial sensing, cell signaling, and modulation of the immune response during sepsis 显示文摘 | Selomao R Brunialti MK Rapozo MM | 2012 | Shock2012，38，3： | 1 |
| 5 | Bacterial Sensing, Cell Signaling, and Modulation of the Immune Response During Sepsis显示文摘 | Reinaldo Salomao Milena Karina Colo Brunialti Marjorie Marini Rapozo Giovana Lotici Baggio-Zappia Chris Galanos Marina Freudenberg | 2012 | Shock2012，，3： | 1 |
| 6 | Analysis of mutations in TP53, APC, K-ras, and DCC genes in the non-dysplastic mucosa of patients with inflammatory bowel disease显示文摘 | Davy Carlos Mendes Rapozo Ana Braunstein Grinmann Ana Teresa Pugas Carvalho Heitor Siffert P. Souza Sheila Coelho Soares-Lima Tatiana Almeida Sim?o Daurita Paiva Flávio Abby Rodolpho Mattos Albano Luiz Felipe Ribeiro Pinto | 2009 | International Journal of Colorectal Disease2009，，10： | 1 |
| 7 | Frequencies of GSTM1, GSTT1, and GSTP1 polymorphisms in a Brazilian population 显示文摘 | Rossini A Rapozo DC Amorim LM | 2002 | Genet Mol Res2002，1，23： | 1 |
| 8 | Bacterial sensing, cell signaling, and modulation of the immune response during sepsis 显示文摘 | Salomao R Brunialti MK Rapozo MM | 2012 | Shock2012，38，3： | 1 |
| 9 | Bacteri- al sensing, cell signaling and modulation of the immune response during sepsis 显示文摘 | Salomao R Brunialti M K Rapozo M M | 2012 | Shock2012，38，3： | 1 |
| 10 | Bacterial sensing, cell signaling, and modulation of the immune response during sepsis 显示文摘 | Salomao R Brunialti MK Rapozo MM | 2012 | Shock2012，38，3： | 1 |
| 11 | Bacterial sensing,cell signaling,and modulation of the immune response during sepsis显示文摘 | Salomao R Brunialti MK Rapozo MM | | 0，，03： | 1 |
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