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| 1 | New prospects in the diagnosis and treatment of immune-mediated inner ear disease显示文摘Autoimmune inner ear disease(AIED) represents a very fertile research field and the advancements in the understanding of this disease have a direct application not only in patients affected with this condition but also in other inner ear disorders that share the same injury mechanism, damage to the inner ear hair cells. AIED also presents many challenges that have still to be overcome. Firstly, access to the inner ear is limited, as many interventions such as biopsies can result in great irreversible damage. Secondly, there are no completely specific markers for AIED. Lack of a definitive diagnosis can result in the treatment of patients not affected with the disease and, therefore, no response. Finally, some patients become refractory to glucocorticoids and new therapies are needed. This review offers an overview of the animal models that have contributed to the understanding of AIED pathophysiology, the value of currently available diagnostic tests, and therapeutic options, with a special focus on new therapies for non responders or patients refractory to glucocorticoids. Among these new options for therapy, biological agents have been tested recently, whereas gene and stem celltherapy may have a role in the future. The intratympanic route of administration avoids the systemic side effects associated with currently used drugs, and may become a more frequent approach in the future. | David R Lobo Jose Ramon García-Berrocal Rafael Ramírez-Camacho | 2014 | World Journal of Methodology2014，4，2： | 7 |
| 2 | 膜型巨噬细胞集落刺激因子对人脑胶质细胞瘤的免疫治疗作用显示文摘摘要 目的 探讨基因转染膜型巨噬细胞集落刺激因子(mM-CSF)对U251MG人脑胶质瘤细胞的免疫治疗作用。方法 用逆转录病毒载体将mM-CSF基因转入U251MG细胞,采用流式细胞术检测mM-CSF的表达;通过细胞毒性实验、兔疫组化方法以及观察转染细胞在免疫缺陷小鼠体内的生长情况研究mM-CSF对U251MG细胞的作用。结果①获得了表达mM-CSF的MG-2F11细胞;②大鼠巨噬细胞、人外周血淋巴细胞(PBL)和人单核细胞均可杀伤MG-2F11细胞,但不能杀伤U251MG母细胞;③接种瘤细胞到裸小鼠皮下18 h后,侵入MG-2F11肿瘤的巨噬细胞明显多于侵入MG-VV(仅转染病毒载体的U251MG细胞)肿瘤的巨噬细胞;④接种MG-2F11细胞的8只裸小鼠均无肿瘤生长,而接种MG-VV细胞的8只裸小鼠中的7只有肿瘤生长(P<0.01);另一免疫缺陷更严重的NIH-bg-nu-xidBR 小鼠,接种MG-2F11细胞后8只中的1只有肿瘤生长,而接种MG-VV细胞后8只中的7只有肿瘤生长(P<0.01)。结论mM-CSF转染的人脑胶质瘤细胞致瘤性降低,有进一步对其进行临床研究的必要。 | 陈义军 Cheri Lloyd Ramon Sanchez Martin R Jadus H Terry Wepsic | 2002 | 中华神经外科疾病研究杂志2002，1，3： | 2 |
| 3 | ion homeostasis during salt stress in plants显示文摘 | Ramon S Alonso R N | 2001 | Current Opinion in Cell Biology2001，13，： | 1 |
| 4 | Ion homeostasis during salt stress in plants显示文摘 | Ramon S Alonso R N | 2001 | Current Opinion in Cell Biology2001，13，： | 1 |
| 5 | Influence of peritoneal fluid on the expression of angiogenic and proteolytic factors in cultures of endometrial cells from women with endometriosis 显示文摘 | COSIN R GILABERT-ESTELLES J RAMON LA | 2010 | Hum Reprod2010，25，2： | 1 |
| 6 | Psoriasis patients gen- erate increased serum levels of autoantibodies to tumor necrosis factor-alpha and interferon-alpha 显示文摘 | Bergman R Ramon M Wildbanm G | 2009 | J Dermatol Sci2009，56，3： | 1 |
| 7 | In vitro generation ofCD83+ human blood dendritic cells for active tumor immunotherapy 显示文摘 | Thurnher M Papesh C Ramoner R | 1997 | Exp Hematol1997，25，3： | 1 |
| 8 | A simple model-based control for Pichia pastoris allows a more efficient heterologous protein production bioprocess显示文摘 | COX O RAMON R MONTESINOS JL | 2006 | Bioteehnol Bioeng2006，95，： | 1 |
| 9 | Efficiency of chain codes to represent binary objects 显示文摘 | HERMILO S C BRIBIESCA E RAMON M R D | 2007 | Pattern Recognition2007，40，： | 1 |
| 10 | Operational strategies,monitoring and control of heterologous protein production in the methylotrophic yeast pichia pastoris under different promoters显示文摘 | Ramon R montesinos JL | 2006 | Micreb cell pact2006，5，1： | 1 |
| 11 | A simple model-based control for Pichia pastoris allows a more efficient heterologous protein production bioprocess显示文摘 | Cos O Ramon R Montesinos J.L Valero F | | 0，，： | 1 |
| 12 | Human renal-cell-carcinoma tissue contains dendritic cells 显示文摘 | Radmayar C Ramoner R | 1996 | Int J Cancer1996，67，： | 1 |
| 13 | Optimisation of soil VIS-NIR sensor-based variable rate application system of soil phosphorus 显示文摘 | Maleki M R Mouazen A M Ramon H | 2007 | Soil and Tillage Research2007，94，1： | 1 |
| 14 | Copper embrittlement by silver brazing alloys 显示文摘 | DIRNFELD S F GABBAY R RAMON J J | 1991 | Materials Characterization1991，26，1： | 1 |
| 15 | Increasedincidence of Leydig cell tumours of the testis in the era ofimproved imaging techniques 显示文摘 | Leonhartsberger N Ramoner R Aigner F | 2011 | BJU Int2011，108，10： | 1 |
| 16 | Shifting the genomic gold standard for the prokaryotic species definition显示文摘 | Michael R Ramon RM | 2009 | Proceedings of the National Academy of Sciences2009，106，19： | 1 |
| 17 | Operational strategies, monitoring and control of heterologous protein production in the methyl- otrophic yeast Pichia pastoris under different promoters: a review 显示文摘 | Cos O Ramon R Montesinos JL | 2006 | Microb Cell Fact2006，5，： | 1 |
| 18 | Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease显示文摘 | ANTHONY C A RAMON C VALTER R M L | 2001 | Prog Neuropsyehopharmacol Biol Psychiatry2001，25，7： | 1 |
| 19 | Inhibition of LNCaP prostate cancer cell by means of androgen receptor antisense oligonucleotides 显示文摘 | Eder I E Culig Z Ramoner R | 2000 | Cancer Gene Ther2000，7，： | 1 |
| 20 | Operational strategies, monitoring and control of heterologous protein production in the methylotrophic yeast Pichia pastoris under different promoters: a review显示文摘 | Cos O Ramon R Luis J | 2006 | Microbial Cell Factories2006，5，17： | 1 |
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