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| 1 | Personalizing therapies for gastric cancer: Molecular mechanisms and novel targeted therapies显示文摘Globally,gastric cancer is the 4thmost frequently diagnosed cancer and the 2ndleading cause of death from cancer,with an estimated 990000 new cases and738000 deaths registered in 2008.In the advanced setting,standard chemotherapies protocols acquired an important role since last decades in prolong survival.Moreover,recent advances in molecular therapies provided a new interesting weapon to treat advanced gastric cancer through anti-human epidermal growth factor receptor 2(HER2)therapies.Trastuzumab,an anti-HER2 monoclonal antibody,was the first target drug in the metastatic setting that showed benefit in overall survival when in association with platinum-5-fluorouracil based chemotherapy.Further,HER2 overexpression analysis acquired a main role in predict response for trastuzumab in this field.Thus,we conducted a review that will discuss the main points concerning trastuzumab and HER2 in gastric cancer,providing a comprehensive overview of molecular mechanisms and novel trials involved. | Michael Luis Ana Tavares Liliana S Carvalho Lúcio Lara-Santos António Araújo Ramon Andrade de Mello | 2013 | World Journal of Gastroenterology2013，19，38： | 6 |
| 2 | Diffuse intestinal ganglioneuromatosis an uncommon manifestation of Cowden syndrome显示文摘Diffuse intestinal ganglioneuromatosis is a hamartomatous polyposis characterized by a disseminated, intramural or transmural proliferation of neural elements involving the enteric plexuses. It has been associated with MEN Ⅱ, neurofibromatosis type 1 and hamartomatous polyposis associated with phosphatase and tensin homolog mutation. We report the case of a female patient with a history of a breast and endometrial tumor who presented in a colonoscopy performed for rectal bleeding diffuse ganglioneuromatosis, which oriented the search for other characteristic findings of Cowden syndrome given the personal history of the patient. The presence of an esophagogastric polyposis was also noted. Cowden syndrome is characterized by skin lesions, but it is rarely diagnosed by these lesions, because they are usually overlooked. Intestinal polyposis is not a major diagnostic criterion but it is very useful for early diagnosis. The combination of colonic polyposis and glucogenic acanthosis should orient the diagnosis to Cowden syndrome. | Maria Teresa Herranz Bachiller Jesus Barrio Andrés Fernando Pons Noelia Alcaide Suárez Rafael Ruiz-Zorrilla Lorena Sancho del Val Sara Lorenzo Pelayo Carlos De La Serna Higuera Ramon Atienza Sánchez Manuel Perez Miranda | 2013 | World Journal of Gastrointestinal Oncology2013，5，2： | 5 |
| 3 | BCL-XL regulates TNF-α-mediated cell death independently of NF-κB, FLIP and IAPs显示文摘 | Raffaella Gozzelino Carme Sole Nuria Llecha Miguel F Segura Rana S Moubarak Victoria Iglesias-Guimarais M Jose Perez-Garcia Stephanie Reix Jisheng Zhang Nahuai Badiola Daniel Sanchis Jose Rodriguez-Alvarez Ramon Trullas Victor J Yuste Joan X Comella | 2008 | Cell Research2008，18，10： | 4 |
| 4 | Anti-angiogenic therapies for metastatic colorectal cancer:Current and future perspectives显示文摘Colorectal cancer(CRC)is the fourth most commonly diagnosed cancer and the second leading cause of cancer death in both men and women in the United States,with about 142820 new cases and 50830 deaths expected in 2013.Metastatic disease(mCRC)remains a challenge for oncologists worldwide due to its potential comorbidities.Recently,chemotherapy regimens containing 5-fluorouracil,leucovorin,oxaliplatin and irinotecan combinations are a standard of care in the metastatic disease.Currently,biological therapies involving vascular endothelial growth factor and epidermal growth factor receptor pathways,such as bevacizumab and cetuximab,have emerged as good option for improving mCRC patient survival.Now,aflibercept plus standard chemotherapy has also been approved in second line regimen for mCRC patients.Our review will discuss novel biological drugs and their indications for mCRC patients and will bring future perspectives in this regard. | Inês Marques António Araújo Ramon Andrade de Mello | 2013 | World Journal of Gastroenterology2013，19，44： | 3 |
| 5 | ion homeostasis during salt stress in plants显示文摘 | Ramon S Alonso R N | 2001 | Current Opinion in Cell Biology2001，13，： | 1 |
| 6 | Ion homeostasis during salt stress in plants显示文摘 | Ramon S Alonso R N | 2001 | Current Opinion in Cell Biology2001，13，： | 1 |
| 7 | Sarcoplasmic calcium-binding protein is an EF-hand–type protein identified as a new shrimp allergen显示文摘 | Rosalía Ayuso Galina Grishina María Dolores Ibá?ez Carlos Blanco Teresa Carrillo Ramon Bencharitiwong Silvia Sánchez Anna Nowak-Wegrzyn Hugh A. Sampson | 2009 | The Journal of Allergy and Clinical Immunology2009，，1： | 1 |
| 8 | Anaerobic fermentation of glycerol: A path to economic viability for the biofuels industry显示文摘 | Syed S Y Ramon G | 2007 | Curr Opin Biotechnol2007，18，3： | 1 |
| 9 | Novel Proresolving and TissueRegenerative Resolvin and Protectin Sulfido-Conjugated Pathways显示文摘 | Dalli J Ramon S Norris PC | 2015 | FASEB J2015，29，5： | 1 |
| 10 | Peroxisome proliferator-activated receptorγB cell-specific-deficient mice have an impaired antibody response显示文摘 | Ramon S Bancos S Thatcher T H | 2012 | Immunology2012，189，10： | 1 |
| 11 | Efficiency of chain codes to represent binary objects 显示文摘 | HERMILO S C BRIBIESCA E RAMON M R D | 2007 | Pattern Recognition2007，40，： | 1 |
| 12 | Technical efficiency and costanalysis in wastewater treatment processes : a DEA approach 显示文摘 | FRANCESC H S RAMON S G | 2009 | Desalination2009，249，1： | 1 |
| 13 | Early nonsurgical correction ofcongenital auricular deformities显示文摘 | Ullmann Y Blazer S Ramon Y | 2002 | Plast Reconstr Surg2002，109，3： | 1 |
| 14 | Copper embrittlement by silver brazing alloys 显示文摘 | DIRNFELD S F GABBAY R RAMON J J | 1991 | Materials Characterization1991，26，1： | 1 |
| 15 | Differentiation of Re- current Glioblastoma Muhiforme from Radiation Necrosis after External Beam Radiation Therapy with Dynamic Sus- ceptibility weighted Contrast - enhanced Perfusion MR Ima- ging显示文摘 | Ramon F Barajas Jamie S | 2009 | Radiology2009，253，2： | 1 |
| 16 | Traumatic spinal cord injury complicating ankylosing spondylitis显示文摘 | Tico N Ramon S Carcia-Ortun F | 1998 | Spinal Cord1998，36，： | 1 |
| 17 | Performance of activated carbon and bentonite for adsorption of amoxieillin from wastewater: mechanisms, isotherms and kinetics 显示文摘 | Eric K P Ramon P Jaka S | 2009 | Water Research2009，43，9： | 1 |
| 18 | The Influence of Brain Tissue Anisotropy on Human EEG and MEG显示文摘 | Haueisen J Tuch D S Ramon C | 2002 | Neurolmage2002，15，1： | 1 |
| 19 | Effects of micro- wave reheating on surimi gel texture显示文摘 | GROPPER M O RAMON I J KOPELMAN S | 1997 | Food Research International1997，30，10： | 1 |
| 20 | Genetic algorithm - based multi - objective optimization of cutting parameters in turning processes显示文摘 | Ramon Q S Marcelino R S Eleno A B | 2006 | Engineering Applications of Artifi- cial Intelligence2006，19，： | 1 |
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