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| 1 | Virological course of hepatitis A virus as determined by real time RT-PCR: Correlation with biochemical, immunological and genotypic profiles显示文摘瞄准:承担肝炎 A 的分析,并且相关病毒的负担,丙氨酸 aminotransferase (中高音) ,和有病毒血的持续时间的病毒的遗传型有控制调停房间的免疫的 CD4 (+)/ CD8 (+) 淋巴细胞人口的这些参数。方法:房间计数用用荧光在乙二胺四乙酸小瓶收集的新鲜全血被执行激活的房间 sorter。肝炎 A 病毒(HAV ) RNA 从血浆液被提取,抄录进 cDNA 并且由实时聚合酶链反应确定了并且是 genotyped 的颠倒。结果:在 11 个病人之中, 10 能完全被分析。这些, 3 有严重尖锐肝炎(s -- 啊) 并且剩余物有自我限制尖锐肝炎 A (啊哈) ,在第 4 d 上与有暴发性的疾病(脑病等级 IV ) 的一个病人一起死。中高音水平在啊哈两个都是显著地更高的(1070.9 +/- 894.3;P = 0.0014 ) 并且 s -- 啊(1713.9 +/- 886.3;P = 0.001 ) 与正常控制相比(23.6 +/- 7.2 ) 。在 s 的前凝血酶时间 -- 啊病人(21.0 +/- 2.0;P = 0.02 ) 比在啊哈显著地高(14.3 +/- 1.1;P = 0.44 ) 。在啊哈病人的 CD4 (+)/CD8 (+) 比率(1.17 +/- 0.11;P = 0.22 ) 并且 s -- 啊(0.83 +/- 0.12;P = 0.0002 ) 比在正常健康控制(1.52 ) 看低。有的自我限制盒子达到顶点在分析的开始的病毒的负担当时在 s -- 啊病人这发生在第 15 或第 30 d。在敏锐、严格的组,一耐心的各个属于遗传型 IA,与仍然是 8 个盒子属于遗传型 IIIA。唯一的暴发性的肝的失败大小写属于遗传型 IA。在自我限制感染的全部功课期间收集的 HAV 病毒的负担和中高音价值直接为 s 被相关,但是这不是事实 -- 啊病人。结论:基于小规模的研究, s 的固执地更高的病毒的负担 -- 啊可能由于减少的细胞免疫和溶血。病毒血的持续时间依赖于主人,当病毒的遗传型没在 AVH 和 s 的临床的结果有明显的角色 -- 啊盒子。 | Zahid Hussain Bhudev C Das Syed A Husain Sunil K Polipalli Tanzeel Ahmed Nargis Begum Subhash Medhi Alice Verghese Mohammad Raish Apiradee Theamboonlers Yong Poovorawan Premashis Kar | 2006 | World Journal of Gastroenterology2006，12，29： | 10 |
| 2 | Evaluation of immunogenicity and reactogenicity of recombinant DNA hepatitis B vaccine produced in India显示文摘AIM: (1) To gain information on immune responses to an accelerated schedule of 0, 1, and 2 mo in paramedical staff and BDS students who are at an increased risk of getting hepatitis B infection and come under high risk groups. (2) To assess the efficacy and safety of EnivacHB in different age groups, using genetically modified yeast strain Pichia pastoris, a new recombinant hepatitis B vaccine developed and manufactured in India.METHODS: A prospective, comparative, and single blinded trial of rapid (0, 1, and 2 mo) hepatitis B immunization schedulewas reported. A total of three hundred and seven (212 females and 95 males) healthy volunteers divided into three age groups (18-29, 30-39,and 40-49) were enrolled after screening for markers of hepatitis B. All the volunteers received 20 mg of the vaccine intramuscularly at 0, 1, and 2 mo.RESULTS: Geometric mean titers were calculated pre and post vaccination. Before immunization the GMT was 0.0124 mIU/mL. One month after the administration of the third dose of recombinant vaccine 296/307 (96.5%)subjects achieved seroprotective levels of anti-HBs. The geometric mean anti-HBs titers achieved after one month of the third dose was 2 560.0 mIU/mL. The geometric mean anti-HBs titer of males was 2 029.0 mIU/mL, while that of the females was 2 759.0 mIU/mL. In the age group of 18-29 years, anti-HBs titer was 3 025.0 mIU/mL, while that in the age group of 30-39 years was 2096.0 mIU/mL. In third age group of 40-49 years, antiHBs titer was 1 592.0 mIU/mL. Hyper-responses (antiHBs≥100 mIU/mL) were shown in 88.0% (271/307) of subjects. Eleven (3.5%) subjects responded poorly to the vaccine in the age group of 40-49 years. There was only mild pain at the site of injection otherwise there were no other adverse drug reactions (ADRs).CONCLUSION: This vaccine (Enivac-HB) is safe and efficacious, providing significant protection after the third dose and rapid hepatitis B immunization schedule of 0, 1, and 2 mo can be recommended whenever rapid protection is the goal. | Zahid Hussain Syed S Ali Syed A Husain Mohammad Raish Deepika R Sharma Premashis Kar | 2005 | World Journal of Gastroenterology2005，11，45： | 3 |
| 3 | Sinapic acid ameliorates D-galactosamine/lipopolysaccharideinduced fulminant hepatitis in rats:Role of nuclear factor erythroidrelated factor 2/heme oxygenase-1 pathways显示文摘BACKGROUND Sinapic acid(SA)has been shown to have various pharmacological properties such as antioxidant,antifibrotic,anti-inflammatory,and anticancer activities.Its mechanism of action is dependent upon its ability to curb free radical production and protect against oxidative stress-induced tissue injuries.AIM To study the hepatoprotective effects of SA against lipopolysaccharide(LPS)/Dgalactosamine(D-GalN)-induced acute liver failure(ALF)in rats.METHODS Experimental ALF was induced with an intraperitoneal(i.p.)administration of 8μg LPS and 800 mg/kg D-GalN in normal saline.SA was administered orally once daily starting 7 d before LPS/D-GalN treatment.RESULTS Data showed that SA ameliorates acute liver dysfunction,decreases serum levels of alanine transaminase(ALT),and aspartate aminotransferase(AST),as well as malondialdehyde(MDA)and NO levels in ALF model rats.However,pretreatment with SA(20 mg/kg and 40 mg/kg)reduced nuclear factor kappalight-chain-enhancer of activated B cells(NF-κB)activation and levels of inflammatory cytokines(tumor necrosis factor-αand interleukin 6).Also,SA increased the activity of the nuclear factor erythroid-related factor 2/heme oxygenase-1(Nrf2/HO-1)signaling pathway.CONCLUSION In conclusion,SA offers significant protection against LPS/D-GalN-induced ALF in rats by upregulating Nrf2/HO-1 and downregulating NF-κB. | Mushtaq Ahmad Ansari Mohammad Raish Yousef A Bin Jardan Ajaz Ahmad Mudassar Shahid SheikhFayaz Ahmad Nazrul Haq Mohammad Rashid Khan Saleh A Bakheet | 2021 | World Journal of Gastroenterology2021，27，7： | 2 |
| 4 | Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck cancers显示文摘 | Bonner JA Raish KP Trummell HQ | 2000 | J Clin Oncol2000，18，21： | 1 |
| 5 | Employer Perceptions of Critical Information Literacy Skills and Digital Badges显示文摘 | RAISH V and RIMLAND E | 2016 | College & Research Libraries2016，，3： | 1 |
| 6 | Influence of fermented milk products, prebiotics and probiotics on microbiota composition and health显示文摘 | Corina Ceapa Harm Wopereis Lahcene Reza?ki Michiel Kleerebezem Jan Knol Raish Oozeer | 2013 | Best Practice & Research Clinical Gastroenterology2013，，1： | 1 |
| 7 | Promoter Hypermethylationin Tumor Suppressing Genes p16 and FHIT and Their Relationship with Estrogen Receptor and Progesterone Receptor Status in Breast Cancer Patients from Northern India 显示文摘 | Raish M Dhillon VS Ahmad A | 2009 | Transl Oncol2009，2，4： | 1 |
| 8 | Specific 50'CpG Island Methylation Signatures of FHIT and p16 Genes and Their Potential Diagnostic Relevance in Indian Breast Cancer Patients显示文摘 | Naqvi RA Hussain A Raish M | 2008 | DNA Cell Biol2008，27，9： | 1 |
| 9 | Pyonephrosis : diagnosis and treatment : Report of 14 cases显示文摘 | RabiiR JoualA RaisH | 2000 | Ann Urol2000，34，： | 1 |
| 10 | Promoter hypermethylation in tumor suppressing genes p16 and FHIT and their relationship with estrogen receptor and progesterone receptor status in breast cancer patients from northern India 显示文摘 | Raish M Dhillon VS Ahmad A | 2009 | Transl Oncol2009，2，4： | 1 |
| 11 | Application of Box-Behnken design for ultrasonic-assisted extraction of polysaccharides from Paeonia emodi 显示文摘 | AHMAD A ALKHARFY K M WANI T A RAISH M | 2015 | International Journal of Biological Macromolecules2015，72，： | 1 |
| 12 | Altered gut microbiota and activity in a murine model of autism spectrum disorders显示文摘 | Caroline G.M. de Theije Harm Wopereis Mohamed Ramadan Tiemen van Eijndthoven Jolanda Lambert Jan Knol Johan Garssen Aletta D. Kraneveld Raish Oozeer | 2013 | Brain Behavior and Immunity2013，，： | 1 |
| 13 | Promoter hypermethylation in tumor suppressing genes p16 and FHIT and their relationship with estrogen receptor and progesterone receptor status in breast cancer patients from Northern India显示文摘 | Raish M Dhillon V S Ahmad A | 2009 | Transl Oncol2009，2，4： | 1 |
| 14 | Specific 5'CpG island methylation signatures of FHIT and P16 genes and their potential diagnostic relevance in Indian breast cancer patients显示文摘 | Naqvi RA Hussain A Raish M | 2008 | DNA Cell Biol2008，27，： | 1 |
| 15 | Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome显示文摘 | Anne Vrieze Els Van Nood Frits Holleman Jarkko Saloj?rvi Ruud S. Kootte Joep F.W.M. Bartelsman Geesje M. Dallinga–Thie Mariette T. Ackermans Mireille J. Serlie Raish Oozeer Muriel Derrien Anne Druesne Johan E.T. Van Hylckama Vlieg Vincent W. Bloks Albert | 2012 | Gastroenterology2012，，4： | 1 |
| 16 | Detection and relevance of germline genetic polymorphisms in glutathione S-transferases (GSTs) in breast cancer patients from northern Indian population显示文摘 | Saxena A Dhillon VS Raish M | 2009 | Breast Cancer Res Treat2009，115，3： | 1 |
| 17 | Specific 50'CpG islandmethylation signatures of FHIT and pl6 genes and their potentialdiagnostic relevance in Indian breast cancer patients 显示文摘 | Naqvi R A Hussain A Raish M | 2008 | DNACell Biol2008，27，9： | 1 |
| 18 | Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome显示文摘 | Anne Vrieze Els Van Nood Frits Holleman Jarkko Saloj?rvi Ruud S. Kootte Joep F.W.M. Bartelsman Geesje M. Dallinga–Thie Mariette T. Ackermans Mireille J. Serlie Raish Oozeer Muriel Derrien Anne Druesne Johan E.T. Van Hylckama Vlieg Vincent W. Bloks Albert | 2012 | Gastroenterology2012，，4： | 1 |
| 19 | Pharmacokinetic interaction of Acacia catechu with CYP1A substrate theophylline in rabbits显示文摘OBJECTIVE:To investigate the effect of black catechu(BC) on the pharmacokinetics of theophylline(CYP1A2 substrate,with narrow therapeutic index)in rabbits.METHODS:In the present investigation the effect of BC on the pharmacokinetics of theophylline,a CYP1A2 substrate was determined.In the study,BC(264 mg/kg,p.o.) or saline(control group) was given to rabbits for 7 consecutive days and on the 8^(th)day theophylline(16 mg/kg) was administered orally one hour after BC or saline treatment.Blood samples were withdrawn at different time intervals(0.5,1,1.5,2,3,4,6,8,12,24 and 36 h) from the marginal ear vein.RESULTS:The pretreatment of rabbits with BC resulted in a significant increase in maximum blood concentration,time of peak concentration and area under the concentration time profile curve until last observation which was about 41.32%,35.71%and 15.03%,respectively.While decreases in clearance,volume of distribution,and half-life were observed.It is suggested that BC pretreatment decreases the CYP1 A metabolic activity leading to increase in bioavailability and decrease in oral clearance of theophylline,which may be due to inhibition of CYP1 A.CONCLUSION:BC can significantly alter theophylline pharmacokinetics in vivo possibly due to inhibition of CYP1 A and P-glycoprotein activity.Based on these results,precaution should be exercised when administering BC with CYP1 A substrate. | Abdullah Mohammed AI-Mohizea Mohammad Raish Abdul Ahad Fahad Ibrahim AI-Jenoobi Mohd Aftab Alam | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 0 |
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