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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Muscle-sparing latissimus dorsi myocutaneous flap with maintenance of muscle innervation,function,and aesthetic appearance of the donor site显示文摘 | Schwabegger AH Harpf C Rainer C | 2003 | Plast Reconstr Surg2003，111，4： | 1 |
| 3 | The differentiation of humane adult mesenchimal stem cells of bone marrow (hMSC) into urothelial cells on bio-engineering support (scaffold):preliminary experience of tissue engineering显示文摘 | Falavolti C Rainer A Centola M | | 0，，03： | 1 |
| 4 | Risk Analysis for Information Technology 显示文摘 | RAINER R K J R SNYDER C A CARR H H | 1991 | Journal of Management Information Systems1991，8，1： | 1 |
| 5 | Executive Information Systems:A Framework for Development and a Survey of Current Practices显示文摘 | Watson H J Rainer R K Koh C E | 1991 | MIS Quarterly1991，15，1： | 1 |
| 6 | Behavior of chromium,nickel,copper,zinc,cadmium,mercury,and lead during the pyrolysis of sewage sludge显示文摘 | Rainer C Kistler Frltz Wldmer | 1987 | Environ Sci Technol1987，21，21： | 1 |
| 7 | A three-dimentsional, physically based compact model for IC VDMOS transistors显示文摘 | Victory James McAndrew Colin C Thoma Rainer | 1998 | Microelectronics Journal1998，29，： | 1 |
| 8 | Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb surgery:double bind randomised controlled trial显示文摘 | Rainer T H Jacobs P Ng Y C | | 0，，05： | 1 |
| 9 | Partial coherence interferometry:a novel approach to biometry in cataract surgery显示文摘 | Drexler W Findl O Menapace R Rainer G Vass C Hitzenberger CK | 1998 | Am J Ophthalmol1998，126，4： | 1 |
| 10 | Conjugated linoleic acid: Health implications and effects on body composition显示文摘 | Rainer L Heiss C'J | 2004 | Journal of the American Dietetic Association2004，104，： | 1 |
| 11 | Electrospun hydroxyapatite-functionalized PLLA scaffold: potential applications in sternal bone healing显示文摘 | Rainer A Spadaccio C Sedati P | 2011 | Ann Biomed Eng2011，39，7： | 1 |
| 12 | Combining electrospinning and fused deposition modeling for the fabrication of a hybrid vascular graft显示文摘 | M Centola A Rainer C Spadaccio S De Porcellinis J A Genovese M Trombetta | 2010 | Biofabrication2010，，1： | 1 |
| 13 | Structural characterization and tensile properties of a high niobium containing gamma TiAl sheet obtained by powder metallurgical processing显示文摘 | ARNO B HELMUT C | 2004 | Intermetallics2004，12，3： | 1 |
| 14 | Heavy metal contamination along a soil transect in the vicinity of the iron smelter of Kremikovtzi (Bulgaria) 显示文摘 | Rainer S Fabien C Margarita M | 2007 | Geoderma2007，140，： | 1 |
| 15 | Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury:double blind randomised controlled trial显示文摘 | Rainer T H Jacobs P Ng Y C | 2000 | BMJ2000，321，7271： | 1 |
| 16 | On-road measurement of particle emission in the exhaust plume of a diesel passenger car 显示文摘 | RAINER V VOLKER S ROBERTO C | 2003 | Environmental Science & Technology2003，19，37： | 1 |
| 17 | Comparisons of envelope through 5B sequences of infectious bronchitis coronaviruses indicates recombination occurs in the envelope and membrane genes显示文摘 | Brooks J E Rainer A C Parr R L | 2004 | Virus Res2004，100，2： | 1 |
| 18 | Glucocorticoid-induced apop-tosis and glucocorticoid resistance:molecular mechanisms and clini-cal relevance显示文摘 | Schmidt S Rainer J Ploner C | 2004 | Cell Death Differ2004，11，1： | 1 |
| 19 | Cognitive relapse after discontinuation of drug therapy in Alzheimer's disease:cholinesterase inhibitors versus no tropics显示文摘 | Rainer M Mucke H A Rainer C | 2001 | J Neural Transm2001，108，13： | 1 |
| 20 | Modelling blue and green water resources availability in Iran 显示文摘 | Monireh F Karim C A Rainer S | 2009 | Hydrological Processes2009，23，3： | 1 |
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