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| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | Inguinal recurrence of malignant mesothelioma of the tunica vaginalis: one case report with delayed recurrence and review of the literature显示文摘亲爱的先生,我是 Giovanni Liguori 从泌尿学的部门, Trieste 的大学,意大利。我们 wrtite 到你讨论大桶集成通信适配器的恶意的间皮瘤阴道。恶意的间皮瘤最经常包含肋膜或到石棉的腹洞和暴露是为它的发展的一个著名风险因素[1 ] 。在他们注意在几个月的功课期间的阴囊的胀大以后,大多数病人寻求治疗。在临床的评价以后,这些瘤经常被相信代表阴囊积水或 epididymal 包囊。作为结果,大多数病人开始为一个怀疑的良性的实体保存地被对待,恶意的诊断经常手术后地被做。 | Giovanni Liguori Giulio Garaffa Carlo Trombetta Rossana Bussani Stefano Bucci Emanuele Belgrano | 2007 | Asian Journal of Andrology2007，9，6： | 2 |
| 3 | Fertility preservation after bilateral severe testicular trauma显示文摘 | Giovanni Liguori Nicola Pavan Gianluca d'Aloia Stefano Bucci Bernardino de Concilio Giorgio Mazzon Giangiacomo Ollandini Carlo Trombetta | 2014 | Asian Journal of Andrology2014，16，4： | 2 |
| 4 | Standard laparoscopic versus single-incision laparoscopic colectomy for cancer: early results of a randomized prospective study显示文摘 | Cristiano G. Huscher Andrea Mingoli Giovanna Sgarzini Andrea Mereu Barbara Binda Gioia Brachini Silvia Trombetta | 2012 | The American Journal of Surgery2012，，1： | 2 |
| 5 | New fluorinated thermoplastic elastomers显示文摘 | Tonelli C Trombetta T Scicchitano M | 1996 | Journal of Applied Polymer Science1996，59，2： | 1 |
| 6 | Hybrid siloxane-based nano building blocks for optical applications:Optimization of the synthetic procedures by spectroscopic analysis显示文摘 | DI Vona M L Trombetta M DIR'E S | 2005 | Journal of Sol-Gel Science and Technology2005，35，： | 1 |
| 7 | Objective and subjective evaluation of the acoustic comfort in classrooms显示文摘 | Paulo Henrique Trombetta Zannin Carolina Reich Marcon | 2007 | Applied Ergonomics2007，，38： | 1 |
| 8 | A framework for modeling and evaluating automatic semantic reconciliation显示文摘 | Gal A Anaby-Tavor A Trombetta A | 2003 | VLDB Journal2003，14，1： | 1 |
| 9 | Disclosure interactionsand the cost of equity capital: evidence from the spanish continuous market 显示文摘 | Espinosa M Trombetta M | 2007 | Journal of Business Finance & Accounting2007，34，910： | 1 |
| 10 | Toxic effect of nic-kel in an in vitro model of human oral epithelium显示文摘 | Trombetta D Mondello MR Cimino F | 2005 | Toxicol Lett2005，159，3： | 1 |
| 11 | Characterization of silica-contalning aluminum hydroxide and oxide aerogels 显示文摘 | TROMBETTA M BUSCA G WILLEY R J | 1997 | Journal of Colloid and Interface Science1997，190，2： | 1 |
| 12 | Weight lossassociated with exercise training restores ventilatory efficien-cy in obese children 显示文摘 | Prado DM Silva A G Trombetta I C* | 2009 | Int J Sports Med2009，30，11： | 1 |
| 13 | SPARC/osteonectin functions to maintain homeostasis of the collagenous extracellular matrix in the periodontal ligament显示文摘 | Trombetta JM Bradshaw AD | 2010 | Journal of Histochemistry & Cytochemistry2010，58，10： | 1 |
| 14 | Pharmacist instruction of physical assessment for pharmacy students 显示文摘 | Bolesta S Trombetta DP Longyhore DS | 2011 | Am J Pharm Educ2011，75，2： | 1 |
| 15 | Cell biology of antigen processing in vitro and in vivo显示文摘 | Trombetta E S Mellman I | 2005 | Annu Rev Immunol2005，23，： | 1 |
| 16 | Biodegradation behavior of gellan gum in simulated colonic media 显示文摘 | Singh BN Trombetta LD Kim KH | 2004 | Pharm Dev Technol2004，9，4： | 1 |
| 17 | Analysis and evaluation of soundscapes in public parks through interviews and measurement of noise显示文摘 | Bani Szeremeta Paulo Henrique Trombetta Zannin | 2009 | Science of the Total Environment2009，，24： | 1 |
| 18 | Mechanisms of antibacterial action of three monoterpenes显示文摘 | Trombetta D Castelli F Sarpietro M G | 2005 | Antimicrob Agents Chemother2005，49，6： | 1 |
| 19 | Toxic effect of nickel in an in vitro model of human oral epithelium 显示文摘 | Trombetta D Mondello M R Cimino F | 2005 | Toxicology Letters2005，159，3： | 1 |
| 20 | In vitro protective effect of a Jacquez grapes wine extract on UVB-induced skin damage显示文摘 | A. Tomaino M. Cristani F. Cimino A. Speciale D. Trombetta F. Bonina A. Saija | 2006 | Toxicology in Vitro2006，，8： | 1 |
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