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| 1 | Cellulose based polymers in development of amorphous solid dispersions显示文摘Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of cellulose derivatives as stabilizers, thus highlighting their importance in generation of amorphous solid dispersions. These polymers offer numerous advantages like drug solubilization, crystallization inhibition and improvement in release patterns of drugs. Exploring their potential and exploiting their chemistry and p H responsive behaviour have led to the synthesis of new derivatives that has broadened the scope of the use of cellulose derivatives in amorphous formulation development. The present review aims to provide an overview of different mechanisms by which these cellulose derivatives inhibit the crystallization of drugs in the solid state and from supersaturated solution. A summary of different categories of cellulose derivatives along with the newly explored polymers has been provided. A special segment on strengths, weaknesses, opportunities, and threats(SWOT) analysis and critical quality attributes(CQAs) which affect the performance of the cellulose based amorphous solid dispersion will aid the researchers in identifying the major challenges in the development of cellulose based solid dispersion and serve as a guide for further formulation development. | Rahul B Chavan Sneha Rathi Vaskuri G S Sainaga Jyothi Nalini R Shastri | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 5 |
| 2 | Shellfish allergy and relation to iodinated contrast media: United Kingdom survey显示文摘AIM: To assess current practice of United Kingdom cardiologists with respect to patients with reported shellfish/iodine allergy, and in particular the use of iodinated contrast for elective coronary angiography.Moreover we have reviewed the current evidence-base and guidelines available in this area.METHODS: A questionnaire survey was send to 500senior United Kingdom cardiologists(almost 50% cardiologists registered with British Cardiovascular Society)using email and first 100 responses used to analyze practise. We involved cardiologists performing coronary angiograms routinely both at secondary and tertiary centres. Three specific questions relating to allergy were asked:(1) History of shellfish/iodine allergy in pre-angiography assessment;(2) Treatments offeredfor shellfish/iodine allergy individuals; and(3) Any specific treatment protocol for shellfish/iodine allergy cases. We aimed to establish routine practice in United Kingdom for patients undergoing elective coronary angiography. We also performed comprehensive PubMed search for the available evidence of relationship between shellfish/iodine allergy and contrast media.RESULTS: A total of 100 responses were received, representing 20% of all United Kingdom cardiologists. Ninety-three replies were received from consultant cardiologists, 4 from non-consultant grades and 3 from cardiology specialist nurses. Amongst the respondents, 66% routinely asked about a previous history of shellfish/iodine allergy. Fifty-six percent would pre-treat these patients with steroids and anti-histamines. The other 44% do nothing, or do nonspecific testing based on their personal experience as following:(1) Skin test with 1 mL of subcutaneous contrast before intravenous contrast;(2) Test dose 2 mL contrast before coronary injection;(3) Close observation for shellfish allergy patients; and(4) Minimal evidence that the steroid and anti-histamine regime is effective but it makes us feel better.CONCLUSION: There is no evidence that allergy to shellfish alters the risk of reaction to intravenous contrast more than any other allergy and asking about such allergies in pre-angiogram assessment will not provide any additional information except propagating the myth. | Mudassar Baig Ahmad Farag Jamal Sajid Rahul Potluri R Bruce Irwin Hafiz Mohammed Idrees Khalid | 2014 | World Journal of Cardiology2014，6，3： | 3 |
| 3 | Characterization and 3D structure prediction of chitinase induced in sugarcane during pathogenesis of Colletotrichum falcatum显示文摘 | Rahul P R Kumar V G Sathyabhama M | | 0，，： | 1 |
| 4 | Adding more beds to the emergency department or reducing admitted patient boarding times:which has a more significant influence on emergency department congestion?显示文摘 | Rahul K Khare E S Powell G R | 2008 | Ann Emerg Med2008，23，7： | 1 |
| 5 | CIL: Intermediate Language and Tools for Analysis and Transformation of C Programs显示文摘 | Necula G C McPeak S Rahul S R | 2002 | Lecture Notes in Computer Science2002，2304，： | 1 |
| 6 | The role of carotid stenosis in vascular cognitive impairment 显示文摘 | Rahul R | 2002 | Neurol Sci2002，203，： | 1 |
| 7 | A novel polymeric flocculant based on polyacrylamide grafted inulin: Aqueous microwave assist- ed synthesis显示文摘 | Rahul R Jha U Sen G | 2014 | Carbohydrate Polymers2014，99，： | 1 |
| 8 | Assessment of risk factors of heli- cobacter pylori infection and peptic ulcer disease 显示文摘 | Rahul S Izurieta M Azizan R | 2013 | Global Infec Dis2013，5，2： | 1 |
| 9 | High voltage spinel cathode materials for high energy density and high rate capability Li-ion rechargeable batteries显示文摘 | KATIYAR R 1< RAHUL S KARINA A R | 2009 | Journal of Power Sources2009，，194： | 1 |
| 10 | Surface Modification of Silica Nanoparticles to Reduce Aggregation and Nonspecific Binding显示文摘 | Rahul P Bagwe Lisa R Hilliard | 2006 | Langmuir 20062006，，： | 1 |
| 11 | Calendar agents on the semantic web 显示文摘 | Terry R Payne Rahul Singh Katia Sycara | 2002 | IEEE Intelligent Systems2002，17，3： | 1 |
| 12 | An Empirical Examination Of VolatiliW Spillover Between the Indian and Us Swap Markets显示文摘 | Vivek B Malhotra D K Philip R Rahul S | 2012 | Intemational Journal of Emerging Markets2012，7，3： | 1 |
| 13 | Strengthening in carbon nanotube/aluminium ( CNT/A1 ) composites 显示文摘 | George R Kashyap K T Rahul R | 2005 | Scripta Materialia2005，53，10： | 1 |
| 14 | Strengthening in carbon nanotubes/aluminium composites 显示文摘 | George R Kashyap K T Rahul R | 2005 | Scripta Materials2005，53，： | 1 |
| 15 | Electrofocusing of methanolic extracts for identification of individual flavonol biomolecules in Camellia species显示文摘 | JOHN K M VIJAYAN D RAHUL P R | 2006 | J Agric Food Chem2006，54，8： | 1 |
| 16 | Quality of life and oral potentially malignant disorders: Critical appraisal and prospects显示文摘Quality of life(QoL) is a vital and often required health outcome measure that is relevant to patient care. A healthy oral cavity enables person to perform daily activities without any limitations. However, any disturbance may result in impaired QoL. The oral health-remains an essential element of people's health and well-being. In recent years, the tradition of clinical practice and research has been changed by incorporating QoL assessment, as it helps in assessment of patients' needs and monitoring treatment responses. Oral potentially malignant disorders(OPMDs) are a group of chronic disorders including oral leukoplakia(OL), oral lichen planus and oral submucous fibrosis(OSF). It is evident that patients with OPMDs experience significant health-related symptoms, functional limitations and psycho-social impairment, compromising their Qo L. Moreover, the worsening of Qo L has been associated with advanced stages of OPMDs. Despite of increasing number of OPMD cases in recent decades, limited literature is available regarding QoL in this population. Although, there is higher prevalence of habit-related OPMDs, particularly OSF and OL in Southern Asian countries, only a few studies have been performed in these populations. Moreover, these studies administered generic Qo L instruments, which offer less sensitivity to clinical changes. However, condition-specific instruments are more sensitive and allows better measurement of QoL. As the impacts of different conditions on OHRQoL may vary, the development and validation of a QoL instrument specific to each clinical entity of OPMDs is currently needed. | Shailesh M Gondivkar Rahul R Bhowate Amol R Gadbail Sachin C Sarode Shankargouda Patil | 2018 | World Journal of Clinical Oncology2018，9，4： | 1 |
| 17 | Analysing the effect of different aggregation approaches on remotely sensed data显示文摘 | RAHUL R NICHOLAS A S HAMM A | | 0，，14： | 1 |
| 18 | Problems and limitations in thrombolysis of acute stroke patients at a tertiary care center显示文摘 | Sushma Gurav Kapil Zirpe R Wadia Manishprasad Pathak Abhijeet Deshmukh Rahul Sonawane Nikhil Goli | 2015 | Indian Journal of Critical Care Medicine2015，，： | 1 |
| 19 | Management of coronora- dicular grooves in maxillary anterior teeth : a report of two cases显示文摘 | Rahul M Smita D Prathmesh R | 2014 | indian journal of dentist13~2014，5，1： | 1 |
| 20 | A hybrid approach for feature subset selection using neural networks and ant colony optimization显示文摘 | Rahul K S Sreeram R | 2007 | Expert Systems with Applications2007，33，11： | 1 |
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