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| 1 | Immunity Genes and Susceptibility to Otitis Media:A Comprehensive Review显示文摘Otitis media(OM) is a middle ear infection associated with inflammation and pain.This disease frequently afflicts humans and is the major cause of hearing loss worldwide.OM continues to be one of the most challenging diseases in the medical field due to its diverse host targets and wide range of clinical manifestations.Substantial morbidity associated with OM is further exacerbated by high frequency of recurrent infections leading to chronic suppurative otitis media(CSOM).Children have greater susceptibility to,and thus,suffer most frequently from OM,which can cause significant deterioration in quality of life.Genetic factors have been demonstrated,in large part by twin and family studies,to be key determinants of OM susceptibility.In this review,we summarize the current knowledge on immunity genes and selected variants that have been associated with predisposition to OM.In particular,polymorphisms in innate immunity and cytokine genes have been strongly linked with the risk of developing OM.Future studies employing state-of-the-art technologies,including next-generation sequencing(NGS),will aid in the identification of novel genes associated with susceptibility to OM.This,in turn,will open up avenues for identifying high-risk individuals and designing novel therapeutic strategies based on precise targeting of these genes. | Rahul Mittal Giannina Robalino Robert Gerring Brandon Chan Denise Yan M'hamed Grati Xue-Zhong Liu | 2014 | Journal of Genetics and Genomics2014，41，11： | 5 |
| 2 | New-onset diabetes: a potential clue to the early diagnosis of pancreatic cancer显示文摘 | Rahul Pannala Ananda Basu Gloria M Petersen Suresh T Chari | 2009 | Lancet Oncology2009，，1： | 3 |
| 3 | Metabolic complications of hepatitis C virus infection显示文摘Hepatitis C virus(HCV) infection is a systemic disease that is implicated in multiple extrahepatic organ dysfunction contributing to its protean manifestations. HCV is associated with diverse extrahepatic disorders including atherosclerosis, glucose and lipid metabolic disturbances, alterations in the iron metabolic pathways, and lymphoproliferative diseases over and above the traditional liver manifestations of cirrhosis and hepatocellular carcinoma. The orchestration between HCV major proteins and the liver-muscle-adipose axis, poses a major burden on the global health of human body organs, if not adequately addressed. The close and inseparable associations between chronic HCV infection, metabolic disease, and cardiovascular disorders are specifically important considering the increasing prevalence of obesity and metabolic syndrome, and their economic burden to patients, the healthcare systems, and society. Cellular and molecular mechanisms governing the interplay of these organs and tissues in health and disease are therefore of significant interest. The coexistence of metabolic disorders and chronic hepatitis C infection also enhances the progression to liver fibrosis and hepatocellular carcinoma. The presence of metabolic disorders is believed to influence the chronicity and virulence of HCV leading to liver disease progression. This comprehensive review highlights current knowledge on the metabolic manifestations of hepatitis C and the potential pathways in which these metabolic changes can influence the natural history of the disease. | Rahul Chaudhari Sherouk Fouda Ashik Sainu Joseph M Pappachan | 2021 | World Journal of Gastroenterology2021，27，13： | 3 |
| 4 | First United Arab Emirates consensus on diagnosis and management of inflammatory bowel diseases:A 2020 Delphi consensus显示文摘Ulcerative colitis and Crohn’s disease are the main entities of inflammatory bowel disease characterized by chronic remittent inflammation of the gastrointestinal tract.The incidence and prevalence are on the rise worldwide,and the heterogeneity between patients and within individuals over time is striking.The progressive advance in our understanding of the etiopathogenesis coupled with an unprecedented increase in therapeutic options have changed the management towards evidence-based interventions by clinicians with patients.This guideline was stimulated and supported by the Emirates Gastroenterology and Hepatology Society following a systematic review and a Delphi consensus process that provided evidence-and expert opinion-based recommendations.Comprehensive up-to-date guidance is provided regarding diagnosis,evaluation of disease severity,appropriate and timely use of different investigations,choice of appropriate therapy for induction and remission phase according to disease severity,and management of main complications. | Maryam Alkhatry Ahmad Al-Rifai Vito Annese Filippos Georgopoulos Ahmad N Jazzar Ahmed M Khassouan Zaher Koutoubi Rahul Nathwani Mazen S Taha Jimmy K Limdi | 2020 | World Journal of Gastroenterology2020，26，43： | 2 |
| 5 | Minimally invasive spleen-preserving distal pancreatectomy: Does splenic vessel preservation have better postoperative outcomes? A systematic review and meta-analysis显示文摘BACKGROUND: Minimally invasive spleen-preserving distal pancreatectomy(SPDP) can be performed with either splenic vessel preservation(SVP) or resection [Warshaw procedure(WP)]. The aim of this study was to evaluate the postoperative clinical outcomes of patients undergoing both methods.DATA SOURCES: Database search of PubM ed, Embase, Scopus,Cochrane, and Google Scholar was performed(2000-2014); key bibliographies were reviewed. Qualified studies comparing patients undergoing SPDP with either SVP or WP, and assessing postoperative complications were included. Calculated pooled risk ratio(RR) with the corresponding 95% confidence interval(CI) by random effects methods were used in the meta-analyses. RESULTS: The search yielded 215 studies, of which only 14 observational studies met our selection criteria. The studies included 943 patients in total; 652(69%) underwent SVP and 291(31%) underwent WP. Overall, there was a lower incidence of splenic infarction(RR=0.17; 95% CI: 0.09-0.33; P<0.001),gastric varices(RR=0.16; 95% CI: 0.05-0.51; P=0.002), and intra/postoperative splenectomy(RR=0.20; 95% CI: 0.08-0.49; P<0.001) in the SVP group. There was no difference in incidence of pancreatic fistula(WP vs SVP, 23.6% vs 22.9%;P=0.37), length of hospital stay, operative time or blood loss. There was moderate cross-study heterogeneity.CONCLUSIONS: SVP is a safe, efficient and feasible technique that may be used to preserve the spleen. WP may be more suitable for large tumors close to the splenic hilum or those associated with splenomegaly. Randomized clinical trials are justified to examine the long-term benefits of SVP-SPDP. | Fady Elabbasy Rahul Gadde Mena M Hanna Danny Sleeman Alan Livingstone Danny Yakoub | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，4： | 2 |
| 6 | Characterization and 3D structure prediction of chitinase induced in sugarcane during pathogenesis of Colletotrichum falcatum显示文摘 | Rahul P R Kumar V G Sathyabhama M | | 0，，： | 1 |
| 7 | Preparation solubilization and bio- degradation of crosslinked gelatin 显示文摘 | Rahul D P James E M | 2005 | Polym Sci Part A: Polym Chem2005，38，： | 1 |
| 8 | Enhanced protective immune responses against Salmonella Enteritidis infection by Salmonella secreting an Escherichia coli heat-labile enterotoxin B subunit protein显示文摘 | Rahul M Nandre Chetan V Jawale John Hwa Lee | 2013 | Comparative Immunology Microbiology and Infectious Diseases2013，36，： | 1 |
| 9 | Energy Aware Routing for Low Energy AdHoc Sensor Networks 显示文摘 | Rahul C Shah Jan M Rabaey | 2002 | Proe IEEE Wireless Communications and Networking Con-ference ( WCNC) March2002，1，3： | 1 |
| 10 | Direct and moderating effects of human capital on strategy and performance in professional service firms:a re- source - based perspective 显示文摘 | Hitt M A Leonard Bierman Katsuhiko Shimizu Rahul Kochhar | 2001 | Academy of Management Journal2001，44，1： | 1 |
| 11 | XORs in the air:practical wireless network coding 显示文摘 | Katti S Rahul H Hu W Katabi D M6dard M | 2008 | IEEFJACM Trans- actions on Networking2008，16，3： | 1 |
| 12 | Syringe-based wound irrigating device显示文摘 | Rahul Shetty M Paul Elvino Barreto Harinatha Sreekar Sanddep Dawre | 2012 | Indian Journal of Plastic Surgery2012，，3： | 1 |
| 13 | Assessment of risk factors of heli- cobacter pylori infection and peptic ulcer disease 显示文摘 | Rahul S Izurieta M Azizan R | 2013 | Global Infec Dis2013，5，2： | 1 |
| 14 | XORs in the air显示文摘 | Sachin Katti Hariharan Rahul Wenjun Hu Dina Katabi Muriel Médard Jon Crowcroft | 2008 | IEEE/ACM Transactions on Networking (TON)2008，，3： | 1 |
| 15 | What is a spectrum hole and what does it take to recognize one显示文摘 | RAHUL T SHRIDHAR M M ANANT S | 2009 | Proceedings of the IEEE2009，97，5： | 1 |
| 16 | Preparation Solu -bilization and Biodegradation of Crosslinked Gelatin 显示文摘 | RAHUL D P JAMES E M | 2004 | Polym Sci : ( Part A ) : Polym Chem2004，38，： | 1 |
| 17 | Use of evolutionary strategies to develop an adaptive fuzzy logic controller for a cooling coil显示文摘 | NAVALE Rahul L NELSON Ron M | 2010 | Energy and Buildings2010，42，11： | 1 |
| 18 | POSS-nylon 6 nanocomposites:Influence of POSS structure on surface and bulk properties显示文摘 | Rahul M Bruce X F Andreas P | 2009 | Journal of Polymer Science(part B):Polymer Physics2009，47，11： | 1 |
| 19 | An efficientalgorithm for rigorous dynamic simulation of reactivedistillation columns显示文摘 | RAHUL M KUMAR M V P DWIVEDI D | 2009 | Computers and Chemical Engineering2009，33，8： | 1 |
| 20 | Fiher optic sensors for transporta-tion infrastructural health monitoring显示文摘 | CHIN C RAHUL M | 2010 | American Journal of Engineering and Applied Sciences2010，3，1： | 1 |
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