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| 1 | Alcoholic liver disease显示文摘Alcohol use disorders affect millions of individuals worldwide.Alcohol consumption is directly associated with liver disease mortality and accounts for elevated social and economic costs.Alcoholic liver disease(ALD) may take the form of acute involvement(alcoholic hepatitis)or chronic liver disease(steatosis,steatohepatitis,fibrosis and cirrhosis).The severity and prognosis of alcohol-induced liver disease depends on the amount,pattern and duration of alcohol consumption,as well as on the presence of liver inflammation,diet,nutritional status and genetic predisposition of an individual.While steatosis is an almost completely benign disease,liver cirrhosis is associated with marked morbidity,mortal-ity and life expectancy shortening.The median survival of patients with advanced cirrhosis is 1-2 years.Se-vere acute alcoholic hepatitis(AH)is associated with mortality as high as 50%.It has been managed with corticoids,pentoxifylline and enteral nutrition,although evidence based data are still conflicting.Some author suggest that pentoxifylline could be a better first-line treatment in patients with severe AH.Absolute abstinence is a basic condition for any treatment of acute or chronic ALD,the other therapeutical procedure being of a supportive nature and questionable significance.Acamprosate appears to be an effective treatment strategy for supporting continuous abstinence in alco-hol dependent patients.Patients with advanced liver cirrhosis who demonstrably abstain can be considered for liver transplantation,which leads to a markedly pro-longed life expectancy.The crucial step in ALD preven-tion is in the prevention of alcohol abuse,whereas the prevention of liver injury in active alcohol abusers is not clinically applicable. | Radan Bruha Karel Dvorak Jaromir Petrty | 2012 | World Journal of Hepatology2012，4，3： | 28 |
| 2 | Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis显示文摘AIM: To investigate the relationship between osteopontin plasma concentrations and the severity of portal hypertension and to assess osteopontin prognostic value.METHODS: A cohort of 154 patients with confirmed liver cirrhosis(112 ethylic, 108 men, age 34-72 years)were enrolled in the study. Hepatic venous pressure gradient(HVPG) measurement and laboratory and ultrasound examinations were carried out for all patients. HVPG was measured using a standard catheterization method with the balloon wedge technique. Osteopontin was measured using the enzyme-linked immunosorbent assay(ELISA) method in plasma. Patients were followed up with a specific focus on mortality. The control group consisted of 137 healthy age- and sex- matched individuals.RESULTS: The mean value of HVPG was 16.18 ± 5.6 mm Hg. Compared to controls, the plasma levels of osteopontin in cirrhotic patients were significantly higher(P < 0.001). The plasma levels of osteopontin were positively related to HVPG(P = 0.0022, r = 0.25) and differed among the individual Child-Pugh groups of patients. The cut-off value of 80 ng/m L osteopontin distinguished patients with significant portal hypertension(HVPG above 10 mm Hg) at 75% sensitivity and 63% specificity. The mean follow-up of patients was 3.7 ± 2.6 years. The probability of cumulative survival was 39% for patients with HVPG > 10 mm Hg and 65% for those with HVPG ≤ 10 mm Hg(P = 0.0086, odds ratio(OR), 2.92, 95% confidence interval(CI): 1.09-7.76). Osteopontin showed a similar prognostic value to HVPG. Patients with osteopontin values above 80 ng/m L had significantly lower cumulative survival compared to those with osteopontin ≤ 80 ng/m L(37% vs 56%, P = 0.00035; OR = 2.23, 95%CI: 1.06-4.68).CONCLUSION: Osteopontin is a non-invasive parameter of portal hypertension that distinguishes patients with clinically significant portal hypertension. It is a strong prognostic factor for survival. | Radan Bruha Marie Jachymova Jaromir Petrtyl Karel Dvorak Martin Lenicek Petr Urbanek Tomislav Svestka Libor Vitek | 2016 | World Journal of Gastroenterology2016，22，12： | 20 |
| 3 | FDG avidity and PET/CT patterns in primary gastric lymphoma显示文摘 | Radan L Fischer D Bar-Shalom R | 2008 | Eur J Nucl Med MolImaging2008，35，8： | 1 |
| 4 | Nutrient uptake and benthic regeneration in Danube Delta Lakes显示文摘 | Jana Friedrich Christian Dinkel Erwin Grieder Silviu Radan Dan Secrieru Sandra Steingruber Bernhard Wehrli | 2003 | Biogeochemistry2003，，3： | 1 |
| 5 | All-optical phase and am- plitude regenerator for next-generation telecommunications systems显示文摘 | RADAN S FRANCESCA P JOSEPH K | 2010 | Na- ture photonics2010，，： | 1 |
| 6 | The role of FDG- PET/CT in suspected recurrence of breast cancer 显示文摘 | Radan L Ben-Haim S Bar-Shalom R | 2006 | Cancer2006，107，： | 1 |
| 7 | Nutrient uptake and benthic regeneration in Danube Delta Lakes显示文摘 | Jana Friedrich Christian Dinkel Erwin Grieder Silviu Radan Dan Secrieru Sandra Steingruber Bernhard Wehrli | | 0，2003，： | 1 |
| 8 | Ring Protection for Transport Network Based on PDH Digital Microwave Links with k X 2Mbit&s and El like Frame显示文摘 | Miroslav Perid Branko Radan Dragana PeriC | 2003 | Conference TELSIKS Nis2003，2，02： | 1 |
| 9 | Novel spectral fiber optic sensor based on surface plasmon resonance显示文摘 | Radan SlavAk JirIoA Homola JirIoA C I tyroky A Eduard Brynda | 2001 | Sensors and Actuators2001，，74： | 1 |
| 10 | The role of FDG-PET/CT in suspected recurrence of breast cancer 显示文摘 | Radan L Ben-Haim S Bar-Shalom R | 2006 | Cancer2006，107，11： | 1 |
| 11 | FDG avidity and PET/CT patterns in primary gastric lymphoma显示文摘 | Lea Radan Doron Fischer Rachel Bar-Shalom Eldad J. Dann Ron Epelbaum Nissim Haim Diana Gaitini Ora Israel | 2008 | European Journal of Nuclear Medicine and Molecular Imaging2008，，8： | 1 |
| 12 | Single-dose intravenous simvastatin treatment attenuates renal injury in an experimental model of ischemia-reperfusion in the rat显示文摘 | Zorica N Zoran T Radan S | 2006 | J Pharmacol Sci2006，，102： | 1 |
| 13 | Loss of heterozygosity testing using real-time PCR analysis of single nucleotide polymorphisms显示文摘 | Tamara ?a?ev Mladen Joki? Radan Spaventi Kre?imir Paveli? Sanja Kapitanovi? | 2006 | Journal of Cancer Research and Clinical Oncology2006，，3： | 1 |
| 14 | Accurate loss modelling of fuel cell boost converter and traction inverter for efficiency calculation in fuel cell-battery hybrid vehicles显示文摘 | NIKZAD M R RADAN A | | 0，，01： | 1 |
| 15 | The role of FDG---PET/ CT in suspected recurrence of breast cancer显示文摘 | Radan L Ben-Haim S Bar-shalom R | 2006 | Cancer2006，107，11： | 1 |
| 16 | imultaneous analysis of climatic trends in multiple variables: an example of application of multivariate statistical methods 显示文摘 | Radan Huth Lucie Pokorn | 2005 | International Journal of Climatology (S1097-0088)2005，25，4： | 1 |
| 17 | Theanteriortibialisarteryperforator(ATAP)flapfortraumatickneeandpatelladefects:clinicalcasesandanatomicstudy显示文摘 | RadAN ChristyMR RodriguezED etal | 2010 | AnnPlastSurg2010，64，2： | 1 |
| 18 | A novel strategy for minimizing the variation of neutral point voltage and switching frequency in DTC controlled, NPC driven induction motors 显示文摘 | RADAN G A | 2007 | IEEE International Electric Machines and Drives Conference2007，，： | 1 |
| 19 | FDG avidity and PET/CT patterns in primary gastric lymphoma 显示文摘 | Radan L Fischer D Bar-Shalom R | 2008 | Eur J Nucl Med Md Imaging2008，35，8： | 1 |
| 20 | FDG avidityand PET/CT patterns in primary gastric lymphoma显示文摘 | Radan L Fischer D Bar-Shalom R | 2008 | EurJ Nucl Med Mol Imaging2008，35，8： | 1 |
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