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| 1 | Clinical characteristics and outcome of a cohort of 101 patients with hepatocellular carcinoma显示文摘AIM To conduct a cohort study of 101 patients with hepatocellular carcinoma (HCC) presenting to a tertiary care medical referral center in Germany between 1997 and 1999.METHODS AND RESULTS Data were retrospectively analyzed by chart review. In 95cases (72 males and 23 females) sufficient data were available for analysis. Twenty-five (29%)of 8.5 patients were HBsAg or anti-HBc positive,21/85 (25%) were anti-HCV positive, and 6/85(7%) were positive for both HBV and HCV-markers. Age was significantly lower in HBV-positive patients than in the other two groups.Thirty-one (34%) of 90 patients had histories of alcohol abuse, In 79/ 94 (84%) patients,cirrhosis was diagnosed. Of these cirrhotic patients, 29/79 (37%) belonged to Child-Pugh's group (CHILD) A, 32/79 (40%) to CHILD B, and 18/79 (23%) to CHILD C. AFP was elevated in 61/91 (67%) patients. A single tumor nodule was found in 38/94 (40%), more than one nodule in 31/94 (34%), and 25/94 (26%) had a diffusely infiltrating tumor, i.e. the tumor margins could not be seen on imaging procedures. Portal vein thrombosis was present in 19/ 94 (20%).Imaging data consistent with lymph node metastases were found in 10/92 (11%), while distant metastases were found in 8/93 (9%).According to Okuda 28/94 (30%) were grouped to stage Ⅰ, 53/94 (56%) were grouped to stage Ⅱ, and 13/94 (14%) were grouped to stage Ⅲ.Survival data were available for 83 patients. The Kaplan-Meier estimate for median survival was 8.4 months. Factors influencing survival were the Okuda score, the presence of portal vein thrombosis, and the presence of ascites. The presence of non-complicated liver cirrhosis by itself, distant metastases, or infection with hepatitis viruses did not influence survival. AFP positivity by itself did not influence survival,though patients with an AFP value greater than 100μg/L did experience shortened survival.Treatment besides tamoxifen or supportive care was associated with prolonged survival. The influence of therapy on survival was most pronounced in Okuda stage Ⅱ patients. There was longer survival in those Okuda stage Ⅱpatients who were treated with percutaneous ethanol injection.CONCLUSION Even in a Iow incidence area such as Germany, the majority of HCC is caused by viral hepatitis and therefore potentially preventable. Reflecting the high proportion of advanced stage tumors in our patients, the median survival was poor. Patients who received active therapy had a longer survival. | Christian Rabe Tillmann Pilz Christoph Klostermann Marc Berna Hans H.Schild Tilman Sauerbruch Wolfgang H.Caselmann | 2001 | World Journal of Gastroenterology2001，7，2： | 60 |
| 2 | Cytomegalovirus infection after liver transplantation: Current concepts and challenges显示文摘Cytomegalovirus (CMV) is a common viral pathogen that influences the outcome of liver transplantation. In addition to the direct effects of CMV syndrome and tissue-invasive diseases, CMV is associated with an increased predisposition to acute and chronic allograft rejection, accelerated hepatitis C recurrence, and other opportunistic infections, as well as reduced overall patient and allograft survival. Risk factors for CMV disease are often interrelated, and include CMV D+/R-serostatus, acute rejection, female gender, age, use of high-dose mycophenolate mofetil and prednisone, and the overall state of immunity. In addition to the role of CMV-specif ic CD4+ and CD8+ T lymphocytes, there are data to suggest that functionality of the innate immune system contributes to CMV disease pathogenesis. In one study, liver transplant recipients with a specific polymorphism in innate immune molecules known as Toll-like receptors were more likely to develop higher levels of CMV replication and clinical disease. Because of the direct and indirect adverse effects of CMV disease, its prevention, whether through antiviral prophylaxis or preemptive therapy, is an essential component in improving the outcome of liver transplantation. In the majority of transplant centers, antiviral prophylaxis is the preferred strategy over preemptive therapy for the prevention of CMV disease in CMV-seronegative recipients of liver allografts from CMV-seropositive donors (D+/R-). However, the major drawback of antiviral prophylaxis is the occurrence of delayed-onset primary CMV disease. In several prospective and retrospective studies, the incidence of delayed-onset primary CMV disease ranged from 16% to 47% of CMV D+/R-liver transplant recipients.Current data suggests that delayed-onset CMV disease is associated with increased mortality after liver transplantation. Therefore, optimized strategies for prevention and novel drugs with unique modes of action are needed. Currently, a randomized controlled clinical trial is being performed comparing the effi cacy and safety of maribavir, a novel benzimidazole riboside, and oral ganciclovir as prophylaxis against primary CMV disease in liver transplant recipients. The treatment of CMV disease consists mainly of intravenous (IV) ganciclovir, and if feasible, a reduction in the degree of immunosuppression. A recent controlled clinical trial demonstrated that valganciclovir is as effective and safe as IV ganciclovir for the treatment of CMV disease in solid organ (including liver) transplant recipients. In this article, the author reviews the current state and the future perspectives of prevention and treatment of CMV disease after liver transplantation. | Raymund Rabe Razonable | 2008 | World Journal of Gastroenterology2008，14，31： | 19 |
| 3 | The joint automated repository for various integrated simulations (JARVIS) for data-driven materials design显示文摘The Joint Automated Repository for Various Integrated Simulations(JARVIS)is an integrated infrastructure to accelerate materials discovery and design using density functional theory(DFT),classical force-fields(FF),and machine learning(ML)techniques.JARVIS is motivated by the Materials Genome Initiative(MGI)principles of developing open-access databases and tools to reduce the cost and development time of materials discovery,optimization,and deployment. | Kamal Choudhary Kevin F.Garrity Andrew C.E.Reid Brian DeCost Adam J.Biacchi Angela R.Hight Walker Zachary Trautt Jason Hattrick-Simpers A.Gilad Kusne Andrea Centrone Albert Davydov Jie Jiang Ruth Pachter Gowoon Cheon Evan Reed Ankit Agrawal Xiaofeng Qian Vinit Sharma Houlong Zhuang Sergei V.Kalinin Bobby G.Sumpter Ghanshyam Pilania Pinar Acar Subhasish Mandal Kristjan Haule David Vanderbilt Karin Rabe Francesca Tavazza | 2020 | npj Computational Materials2020，，1： | 10 |
| 4 | 卵巢组织冻存与移植对宫颈癌患者卵巢内分泌功能的影响显示文摘国际生育力保护保存专家强烈建议所有年轻癌症患者当诊断为癌症时,应立即得到医生关于生育力保护保存的建议。宫颈癌是女性最常见的妇科恶性肿瘤,放化疗会导致卵巢功能不同程度的减退或衰竭,本文主要评述卵巢组织冻存与移植对宫颈癌患者卵巢内分泌功能的保护作用。 | 阮祥燕 程姣姣 杜娟 金凤羽 李扬璐 Matthias Korell Thomas Rabe Alfred O. Mueck | 2019 | 中国临床医生杂志2019，47，7： | 9 |
| 5 | Intracellular transport of hepatitis B virus显示文摘For genome multiplication hepadnaviruses use the tran-scriptional machinery of the cell that is found within the nucleus.Thus the viral genome has to be transported through the cytoplasm and nuclear pore.The intracy-tosolic translocation is facilitated by the viral capsid that surrounds the genome and that interacts with cellular microtubules.The subsequent passage through the nu-clear pore complexes(NPC) is mediated by the nuclear transport receptors importin α and β.Importin α binds to the C-terminus of the capsid protein that comprises a nuclear localization signal(NLS).The exposure of the NLS is regulated and depends upon genome maturation and/or phosphorylation of the capsid protein.As for oth-er karyophilic cargos using this pathway importin α inter-acts with importin β that facilitates docking of the import complex to the NPC and the passage through the pore.Being a unique strategy,the import of the viral capsid is incomplete in that it becomes arrested inside the nuclear basket,which is a cage-like structure on the karyoplas-mic face of the NPC.Presumably only this compartment provides the factors that are required for capsid disas-sembly and genome release that is restricted to those capsids comprising a mature viral DNA genome. | Michael Kann André Schmitz Birgit Rabe | 2007 | World Journal of Gastroenterology2007，13，1： | 6 |
| 6 | Bearing capacity and settlement of strip footing on geosynthetic reinforced clayey slopes显示文摘The effect of geosynthetic reinforcing on bearing capacity of a strip footing resting on georeinforced clayey slopes was investigated.The results of a series of numerical study using finite element analyses on strip footing upon both reinforced and unreinforced clayey slopes were presented.The objectives of this work are to:1) determine the influence of reinforcement on the bearing-capacity of the strip footings adjacent slopes,2) suggest an optimum number of reinforcement and 3) survey the effect of friction angle in clayey soils reinforced by geogrids.The investigations were carried out by varying the edge distance of the footing from slope.Also different numbers of geosynthetic layers were applied to obtaining the maximum bearing capacity and minimum settlement.To achieve the third objective,two different friction angles were used.The results show that the load?settlement behavior and ultimate bearing capacity of footing can be considerably improved by the inclusion of reinforcing layer.But using more than one layer reinforcement,the ultimate bearing capacity does not change considerably.It is also shown that for both reinforced and unreinforced slopes,the bearing capacity increases with an increase in edge distance.In addition,as the soil friction angle is increased,the efficiency of reinforcing reduces. | S.A.Naeini B.Khadem Rabe E.Mahmoodi | 2012 | Journal of Central South University2012，19，4： | 5 |
| 7 | Treatment of metastatic colorectal carcinomas by systemic inhibition of vascular endothelial growth factor signaling in mice显示文摘AIM: Tumor angiogenesis has been shown to be promoted by vascular endothelial growth factor (VEGF) via stimulating endothelial cell proliferation, migration, and survival. Blockade of VEGF signaling by different means has been demonstrated to result in reduced tumor growth and suppression of tumor angiogenesis in distinct tumor entities. Here, we tested a recombinant adenovirus, AdsFIt1-3, that encodes an antagonistically acting fragment of the VEGF receptor 1 (Flt-1), for systemic antitumor effects in pre-established subcutaneous CRC tumors in mice. METHODS: Murine colorectal carcinoma cells (CT26) were inoculated subcutaneously into Balb/c mice for in vivo studies. Tumor size and survival were determined. 293 cell line was used for propagation of the adenoviral vectors. Human lung cancer line A549 and human umbilical vein endothelial cells were transfected for in vitro experiments. RESULTS: Infection of tumor cells with AdsFlt1-3 resulted in protein secretion into cell supernatant, demonstrating correct vector function. As expected, the secreted sFlt1-3 protein had no direct effect on CT26 tumor cell proliferation in vitro, but endothelial cell function was inhibited by about 46% as compared to the AdLacZ control in a tube formation assay. When AdsFlt1-3 (5×109 PFU/animal) was applied to tumor bearing mice, we found a tumor inhibition by 72% at d 12 after treatment initiation. In spite of these antitumoral effects, the survival time was not improved. According to reduced intratumoral microvessel density in AdsFIt1-3-treated mice, the antitumor mechanism can be attributed to angiostatic vector effects. We did not detect increased systemic VEGF levels after AdsFlt1-3 treatment and liver toxicity was low as judged by serum alanine aminotransferase determination. CONCLUSION: In this study we confirmed the value of a systemic administration of AdsFIt1-3 to block VEGF signaling as antitumor therapy in an experimental metastatic colorectal carcinoma model in mice. | Volker Schmitz Miroslaw Kornek Tobias Hilbert Christian Dzienisowicz Esbher Raskopf Christian Rabe Tilman Sauerbruch Cheng Qian Wolfgang H Caselmann | 2005 | World Journal of Gastroenterology2005，11，28： | 4 |
| 8 | Improved Blocking Time Analysis and Evaluation for the Multiprocessor Priority Ceiling Protocol显示文摘The Multiprocessor Priority Ceiling Protocol(MPCP) is a classic suspension-based real-time locking protocol for partitioned fixed-priority(P-FP) scheduling. However,existing blocking time analysis is pessimistic under the P-FP +MPCP scheduling,which negatively impacts the schedulability for real-time tasks. In this paper,we model each task as an alternating sequence of normal and critical sections,and use both the best-case execution time(BCET) and the worst-case execution time(WCET) to describe the execution requirement for each section. Based on this model,a novel analysis is proposed to bound shared resource requests. This analysis uses BCET to derive the lower bound on the inter-arrival time for shared resource requests,and uses WCET to obtain the upper bound on the execution time of a task on critical sections during an arbitrary time interval of △t. Based on this analysis,improved blocking analysis and its associated worst-case response time(WCRT) analysis are proposed for P-FP + MPCP scheduling. Schedulability experiments indicate that the proposed method outperforms the existing methods and improves the schedulability significantly. | 杨茂林 雷航 廖勇 Furkan Rabee | 2014 | Journal of Computer Science & Technology2014，29，6： | 2 |
| 9 | Acute hepatitis induced by an Aloe vera preparation: A case report显示文摘AIM: Aloe vera, plant extracts of Aloe barbadensis miller,is widely used in phytomedicine. The first case of acute hepatitis due to this compound was described.METHODS: Description of a clinical case.RESULTS: Hepatitis in a 57-year old female could be linked to the ingestion of Aloe barbadensis miller compounds. The patient's hepatitis resolved completely after discontinuing this medication.CONCLUSION: The case emphasizes the importance of considering phytopharmaceutical over-the-counter drugs as causative agents of hepatitis. | Christian Rabe Annemarie Musch Peter Schirmacher Wolfgang Kruis Robert Hoffmann | 2005 | World Journal of Gastroenterology2005，11，2： | 2 |
| 10 | Structure and properties of sylramicTM silicon carbide fiber--a polycrystalline 显示文摘 | Lipowitz J Rabe J A Zangvil A | 1997 | Ceram Eng Sci Proc1997，18，3： | 2 |
| 11 | IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality显示文摘 | Zhang Hong Neuh?fer Patrick Song Liang Rabe Bj?rn Lesina Marina Kurkowski Magdalena U Treiber Matthias Wartmann Thomas Regnér Sara Thorlacius Henrik Saur Dieter Weirich Gregor Yoshimura Akihiko Halangk Walter Mizgerd Joseph P Schmid Roland | 2013 | Journal of Clinical Investigation2013，，3： | 2 |
| 12 | Powered Phlebectomy (TriVexTM) in Treatment of Varicose Veins显示文摘 | Nick Cheshire Steven M. Elias Blair Keagy R. Kolvenbach Austin L. Leahy W. Marston F. Pannier-Fischer Eberhard Rabe Gregory A. Spitz | 2002 | Annals of Vascular Surgery2002，，4： | 2 |
| 13 | Efficacy and Safety of Great Saphenous Vein Sclerotherapy Using Standardised Polidocanol Foam (ESAF): A Randomised Controlled Multicentre Clinical Trial显示文摘 | E. Rabe J. Otto D. Schliephake F. Pannier | 2007 | European Journal of Vascular & Endovascular Surgery2007，，2： | 2 |
| 14 | Targeting the HGF/Met signaling pathway in cancer therapy显示文摘 | Fabiola Cecchi Daniel C Rabe Donald P Bottaro | 2012 | Expert Opinion on Therapeutic Targets2012，，6： | 2 |
| 15 | Experimental investigation of stepped tip gap effects on the performance of a transonic axial-flow Compressor Rotor显示文摘 | THOMPSON D W KING P I RABE D C | 1998 | ASME Journal of Turbomachinery1998，120，： | 1 |
| 16 | Identification of PDE iso-zymes in human pulmonary artery and effect of selective PDE inhibitors显示文摘 | Tenor H Dent G | 1994 | Am J Physiol1994，266，： | 1 |
| 17 | From COPD to chronic systemic inflam matorysyndrome? 显示文摘 | LM FABBRI KF RABE | 2007 | The Lancet2007，9589，： | 1 |
| 18 | Burden and clinical features of chronic obstructive pulmonary disease(COPD)显示文摘 | Pauwels RA Rabe KF | 2004 | Lancet2004，364，： | 1 |
| 19 | Measurement of young's modulus of nanocrystalline ferrites with spinel structures by atomic force acoustic microscopy显示文摘 | KESTER E RABE U PRESMANES L | 2000 | Journal of Physics and Chemistry of Solids2000，619，8： | 1 |
| 20 | Global strategy for thed iagnosis,m anagem ent and prevent ion of chron ic obstructivepu lm onary d isease:GOLD execu tive summ ary显示文摘 | Rabe KF H urd S An zueto A | 2007 | Am J Resp ir C rit C areM ed2007，9，6： | 1 |
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