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| 1 | Colorectal cancer in inflammatory bowel disease:What is the real magnitude of the risk?显示文摘The association between inflammatory bowel disease(IBD) and colorectal cancer(CRC) has been recognised since 1925 and still accounts for 10%-15% of deaths in IBD.IBD-associated CRC(IBD-CRC) affects patients at a younger age than sporadic CRC.The prognosis for sporadic CRC and IBD-CRC is similar,with a 5-year survival of approximately 50%.Identifying at risk patients and implementing appropriate surveillance for these patients is central to managing the CRC risk in IBD.The increased risk of colorectal cancer in association with IBD is thought to be due to genetic and acquired factors.The link between inflammation and cancer is well recognised but the molecular biology,immune pathobiology and genetics of IBD-CRC are areas of much ongoing research.This review examines the literature relating to IBD-CRC,focusing on the incidence of IBD-CRC and examining potential risk factors including age at diagnosis,gender,duration and extent of colitis,severity of inflammation,family history of sporadic CRC and co-existent primary sclerosing cholangitis(PSC).Confirmed risk factors for IBD-CRC are duration,severity and extent of colitis,the presence of co-existent PSC and a family history of CRC.There is insufficient evidence currently to support an increased frequency of surveillance for patients diagnosed with IBD at a younger age.Evidence-based guidelines advise surveillance colonoscopy for patients with colitis 8 to 10 years after diagnosis,with the interval for further surveillance guided by risk factors(extent of disease,family history of CRC,post-inflammatory polyps,concomitant PSC,personal history of colonic dysplasia,colonic strictures).There is a move away from using random colonic biopsies towards targeted biopsies aimed at abnormal areas identified by newer colonoscopic techniques(narrow band imaging,chromoendoscopy,confocal microendoscopy). | Jessica K Dyson Matthew D Rutter | 2012 | World Journal of Gastroenterology2012，18，29： | 22 |
| 2 | Surveillance of colonic polyps:are we getting it right?显示文摘Colorectal cancer(CRC) is the third most commonly diagnosed cancer worldwide. The identification of colonic polyps can reduce CRC mortality through earlier diagnosis of cancers and the removal of polyps: the precursor lesion of CRC. Following the finding and removal of colonic polyps at an initial colonoscopy, some patients are at an increased risk of developing CRC in the future. This is the rationale for postpolypectomy surveillance colonoscopy. However, not all individuals found to have colonic adenomas have a risk of CRC higher than that of the general population. This review examines the literature on post-polypectomy surveillance including current international clinical guidelines. The potential benefits of surveillance procedures must be weighed against the burden of colonoscopy: resource use, the potential for patient discomfort, and the risk of complications. Therefore surveillance colonoscopy is best utilised in a selected group of individuals at a high risk of developing cancer. Further study is needed into the specific factors conferring higher risk as well as the efficacy of surveillance in mitigating this risk. Such evidence will better inform clinicians and patients of the relative benefits of colonoscopic surveillance for the individual. In addition, the decision to continue with surveillance must be informed by the changing profile of risks and benefits of further procedures with the patient's advancing age. | Stewart N Bonnington Matthew D Rutter | 2016 | World Journal of Gastroenterology2016，22，6： | 6 |
| 3 | Outcomes of the Bowel Cancer Screening Programme (BCSP) in England after the first 1 million tests显示文摘 | Richard F A Logan Julietta Patnick Claire Nickerson Lynn Coleman Matt D Rutter Christian von Wagner | 2012 | Gut2012，，10： | 2 |
| 4 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 5 | Insulin- stimulated fatty acid synthase gene expression does not require increased sterol response element binding protein 1 transcription in primary adipoeytes显示文摘 | PALMER D G RUTTER G A TAVARE J M | 2002 | Biochem Bio- ph Res Commun2002，291，3： | 1 |
| 6 | Influence of rare earth metals on the nucleation and solidification behavior of iron and 1045 steel显示文摘 | Li H McLean A Rutter J W and Sommerville I D | 1988 | Metallurgical Transactions B1988，19，3： | 1 |
| 7 | No pain relief frome morphine?Individual variation in sensitivity to morphine and the need toswitch to an alternative opioid in cancer patients显示文摘 | Heily J Ross JR Rutter D | 2006 | SupportCare Cancer2006，14，： | 1 |
| 8 | The prolactin gene is located on chromosome 6 in humans显示文摘 | OWERBACH D RUTTER W J COOKE N E | 1981 | Science1981，212，4496： | 1 |
| 9 | Single-stage tracheal resection for severe tracheal stenosis in older children 显示文摘 | Preciado D Cotton RT Rutter MJ | 2004 | Int J Pediatr Otorhinolaryngol2004，68，1： | 1 |
| 10 | Mortality from pandemic A/ H1N1 2009 influenza in England:public health surveillance study 显示文摘 | Liam J Donaldson Paul D Rutter | 2009 | BMJ2009，339，： | 1 |
| 11 | Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole ST Brosch R Parkhill J Garnier T Churcher C Harris D Gordon SV Eiglmeier K Gas S Barry CE Tekaia F Badcock K Basham D Brown D Chillingworth T Connor R Davies R Devlin K Feltwell T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Krogh A Mclean J Moule S Murphy L Oliver K Osborne J Quail MA Rajandream MA Rogers J Rutter S Seeger K Skelton J Squares R Squares S Sulston JE Taylor K Whitehead S Barrell BG | 1998 | Nature1998，393，6685： | 1 |
| 12 | Directed expression of NGF to pancreatic beta cells in transgenic mice leads to selective hyperinnervation of the islets显示文摘 | Edwards RH Rutter WJ Hanahan D | 1989 | Cell1989，58，： | 1 |
| 13 | No pain relief from morphine Individual variation in sensitivity to morphine and the need to switch to an alternative opioid in cancer patients 显示文摘 | Riley J Ross JR Rutter D | 2006 | Support Care Cancer2006，14，1： | 1 |
| 14 | No pain relief from morphine? 显示文摘 | Riley J Ross J R Rutter D | 2006 | Supportive care in cancer2006，14，1： | 1 |
| 15 | Rapid detection of toxigenic Pasteurella multocida by an agar overlay method显示文摘 | Chanter N Rutter J M Luther P D | 1986 | Vet Rec1986，119，2526： | 1 |
| 16 | Enhanced external counterpulsation for the relief of angina in patients with diabetes: safety, efficacy and 1-year clinical outcomes显示文摘 | Georgiann Linnemeier Martin K Rutter Gregory Barsness Elizabeth D Kennard Richard W Nesto | 2003 | American Heart Journal2003，，3： | 1 |
| 17 | Can automated dispensing decrease prescription turn-around time and alter staff work patterns?显示文摘 | Rutter P Brown D Portlock J | 2001 | International Journal of Pharmacy Practice2001，，： | 1 |
| 18 | Breeding blight-resistant chestnut显示文摘 | Burnham C R Rutter P A French D W | 1986 | Plant Breed Rev1986，4，： | 1 |
| 19 | Exposure to invasive procedures in neonatal inten- sive care Lmit admissions 显示文摘 | Barker D Rutter N | 1995 | Areh Dis Child Fetal Neonatal Med1995，72，1： | 1 |
| 20 | Desert margins near the Chinese Loess Plateau during the mid-Holocene and at the Last Glacial Maximum: A model data intercomparison 显示文摘 | Bush A B G Rokosh D Rutter N W | 2002 | Global and Planetary Change2002，32，4： | 1 |
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