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| 1 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017，8，1： | 23 |
| 2 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 3 | Combination of repeated single-session percutaneous ethanol injection and transarterial chemoembolisation compared to repeated single-session percutaneous ethanol injection in patients with non-resectable hepatocellular carcinoma显示文摘瞄准:为病人评估经皮的乙醇注射(PEI ) 的治疗效果与先进, non-resectable HCC 与 transarterial chemoembolisation 的联合相比(不作声) 并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。方法:在学习时期期间接受了 PEI 治疗的所有病人根据物理地位和肿瘤程度被包括并且成层到下列治疗形式之一:联合不作声并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。包括Okuda分类,门静脉血栓的存在,腹水的存在,肿瘤的数字,最大的肿瘤直径,和假胆硷酯酶( CHE )的临床的参数的预示的价值,以及孩子呸上演, alpha-fetoprotein (法新社),发烧,复杂并发症的发生在这些组之间被估计并且比较。幸存用 Kaplan-Meier 被决定,多,变量回归分析。结果:所有病人的 1 年、 3 年的幸存是 73% 和 47% 。在亚群分析,联合不作声, PEI (1 ) 与更长的幸存被联系(1- , 3- , 5 年的幸存:90% , 52% ,和 43%) 与 PEI 治疗相比独自一个(2 )(1- , 3- , 5 年的幸存:65% , 50% ,和 37%) 。(3 ) 在起始的层化以后的第二等的 PEI 产出可比较的结果不作声(1- , 3- , 5 年的幸存:91% , 40% ,和 30%) 当在到最好的支持的照顾(4 ) 的层化以后的 PEI 与减少的幸存被联系时(1- , 3- , 5 年的幸存:50% , 23% , 12%) 。除了选择治疗形式,为更好的幸存的预言者是肿瘤数字(n <
5 ) ,肿瘤尺寸(<
5 厘米) ,在 PEI 前的没有腹水,和在 PEI 以后的稳定的假胆硷酯酶(P <
0.05 ) 。在在 PEI 以后的 2 wk 以内的死亡是 2.8%(n = 3 ) 。有 24 (8.9%) 主修在包括部分肝梗塞,焦点的肝坏死,和肝脓肿的 PEI 以后的复杂并发症。所有复杂并发症能非通过手术被管理。结论:重复单个会议的 PEI 在有以可接受、可管理的复杂并发症率的先进 HCC 的病人是有效的。病人们成层到联合不作声, PEI 能比那些独自成层到重复 PEI 期望更长的幸存。而且,有在好临床的地位的大或多重的肿瘤的病人可以也从联合获利不作声并且为第二等的 PEI 的再考虑。 | Arne Dettmer Timm D Kirchhoff Michael Gebel Lars Zender Nisar P Malek Bernhard Panning Ajay Chavan Herbert Rosenthal Stefan Kubicka Susanne Krusche Sonja Merkesdal Michael Galanski Michael P Manns Joerg S Bleck | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 4 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013，13，9： | 12 |
| 5 | Technical and conceptual considerations forusing animated stimuli in studies of animalbehavior显示文摘Rapid technical advances in the field of computeropened new avenues in animal behavior research.animation (CA) and virtual reality (VR) haveAnimated stimuli are powerful tools as theyoffer standardization, repeatability, and complete control over the stimulus presented, thereby"reducing" and "replacing" the animals used, and "refining" the experimental design in line withthe 3Rs. However, appropriate use of these technologies raises conceptual and technical questions.In this review, we offer guidelines for common technical and conceptual considerations related tothe use of animated stimuli in animal behavior research. Following the steps required to create ananimated stimulus, we discuss (I) the creation, (11) the presentation, and (111) the validation of CAsand VRs. Although our review is geared toward computer-graphically designed stimuli, consider-ations on presentation and validation also apply to video playbacks. CA and VR allow both new be-havioral questions to be addressed and existing questions to be addressed in new ways, thus weexpect a rich future for these methods in both ultimate and proximate studies of animal behavior. | Laura CHOUINARD-THULY Stefanie GIERSZEWSKI Gil G. ROSENTHAL Simon M. READER Guillaume RIEUCAU Kevin L. Woo Robert GERLAI Cynthia TEDORE Spencer J. INGLEY John R. STOWERS Joachim G.FROMMENI Francine L. DOLINS Klaudia WITTE | 2017 | Current Zoology2017，63，1： | 10 |
| 6 | Looking at sound: optoacoustics with all-optical ultrasound detection显示文摘Originally developed for diagnostic ultrasound imaging,piezoelectric transducers are the most widespread technology employed in optoacoustic(photoacoustic)signal detection.However,the detection requirements of optoacoustic sensing and imaging differ from those of conventional ultrasonography and lead to specifications not sufficiently addressed by piezoelectric detectors.Consequently,interest has shifted to utilizing entirely optical methods for measuring optoacoustic waves.All-optical sound detectors yield a higher signal-to-noise ratio per unit area than piezoelectric detectors and feature wide detection bandwidths that may be more appropriate for optoacoustic applications,enabling several biomedical or industrial applications.Additionally,optical sensing of sound is less sensitive to electromagnetic noise,making it appropriate for a greater spectrum of environments.In this review,we categorize different methods of optical ultrasound detection and discuss key technology trends geared towards the development of all-optical optoacoustic systems.We also review application areas that are enabled by all-optical sound detectors,including interventional imaging,non-contact measurements,magnetoacoustics,and nondestructive testing. | Georg Wissmeyer Miguel A.Pleitez Amir Rosenthal Vasilis Ntziachristos | 2018 | Light(Science & Applications)2018，7，1： | 9 |
| 7 | Management of portal hypertension in children显示文摘Portal hypertension can be caused by a wide variety of conditions.It frequently presents with bleeding from esophageal varices.The approach to acute variceal hemorrhage in children is a stepwise progression from least invasive to most invasive.Management of acute variceal bleeding is straightforward.But data on primary prophylaxis and long term management prevention of recurrent variceal bleeding in children is scarce,therefore prospective multicenter trials are needed to establish best practices. | Roberto Gugig Philip Rosenthal | 2012 | World Journal of Gastroenterology2012，18，11： | 8 |
| 8 | 软骨母细胞瘤:射频消融术在部分病例中替代外科手术切除显示文摘目的证明射频(RF)消融可以安全有效地治疗有选择的软骨母细胞瘤(selected cases of chondroblastoma)。方法本研究得到机构伦理委员会批准,并符合HIPPA的要求。由于为回顾性研究,故未签署知情同意书。回顾性分析了1995年7月-2007年7月2个医学中心行射频消融治疗后经活检证实为软骨母细胞瘤的病例。在CT引导下进行单极RF消融,同时获得病变影像学资料。记录术前和术后1d症状。由病历记录获取长期随访情况。结果13例男性和4例女性经RF治疗(平均年龄17-3岁)。 | L.D. Rybak D.I. Rosenthal J.C. Wittig 屈瑾(译) 雷新玮(校) | 2009 | 国际医学放射学杂志2009，32，4： | 8 |
| 9 | 镍钛合金加压吻合技术应用于腹腔镜胃肠吻合的临床研究显示文摘目的评价一种新型的腹腔镜镍钛记忆合金加压吻合夹(LapCAC)进行胃肠吻合的安全性及有效性。方法2007年3月,对l例行全胃切除术和2例行远端胃大部切除术的胃癌患者,使用LapCAC进行Roux-en-Y空肠-空肠侧侧吻合和胃肠吻合;术后观察有无发生与胃肠吻合相关的并发症,并观察肠道恢复排气时间及LapCAC的排出时间。结果患者术后均未出现与吻合相关的吻合口瘘、吻合口狭窄及肠梗阻等并发症,术后肠道排气、排便均无异常。LapCAC均于术后12~18d排出体外。结论应用LapCAC进行腹腔镜胃肠吻合安全、可靠。 | 李心翔 郑成竹 印慨 蔡景理 Rosenthal Raul J | 2008 | 中华胃肠外科杂志2008，11，3： | 8 |
| 10 | 与耐多药肺结核相关的放射学征象的文献分析显示文摘背景尽管肺药物敏感结核(DS-TB)和耐多药结核(MDR-TB)的诊断需要微生物检查证实,但胸部影像学早期识别可疑MDR-TB可以对诊断过程提供指引。本文对文献资料中与MDR-TB相关的放射学征象进行分析。方法于2018年1月29日搜索PubMed数据库,搜索关键字组合为'((extensive drug resistant tuberculosis)OR(multidrug-resistant tuberculosis))AND(CT or radiograph or imaging or X-ray or computed tomography)',并分析了报道DS-TB和MDR-TB放射学征象的英文文献。结果我们发现和分析了与分析目的有充分相关性的17篇文章。我们将报告的肺MDR-TB病例分为四个类别:(1)之前治疗过(继发或获得性)的HIV阴性成人MDRTB;(2)新发(或原发)HIV阴性成人MDR-TB;(3)HIV阳性成人MDR-TB;(4)儿童MDR-TB。肺MDR-TB的常见放射学表现包括:小叶中央小结节、分枝状线征和结节影(树芽征)、斑块或叶实变、空洞和支气管扩张。虽然总体上MDR-TB病例倾向病变更广泛、更容易双侧发病、胸膜受累、支气管扩张,及肺体积缩小;但仅依据这些征象难以作出MDR-TB的鉴别诊断。迄今的文献提示,肺MDR-TB特异性较高的放射学征象是厚壁多发空洞病变(特别是空洞≥3个时),虽然可能其敏感性不高。对于成人HIV阴性患者,与继发MDR-TB一致,新发MDR-TB也往往有较高的空洞病变发生率,估计在70%左右。结论厚壁多发空洞病变是提示MDR-TB诊断最有意义的放射学征象。未来的研究应该细致地量化空洞病变形态特征。 | 王毅翔 Myung Jin Chung Aliaksandr Skrahin Alex Rosenthal Andrei Gabrielian Michael Tartakovsky 于英杰 陆普选 | 2018 | 新发传染病电子杂志2018，3，4： | 7 |
| 11 | What artifice can and cannot tell us aboutanimal behavior显示文摘Artifice--the manipulation of social and environmental stimuli--is fundamental to research in ani-mal behavior. State-of-the-art techniques have been developed to generate and present complexvisual stimuli. These techniques have unique strengths and limitations. However, many of theissues with synthetic animation and virtual reality are common to playback experiments in general,including those using unmanipulated video or auditory stimuli. Playback experiments, in turn, fallinto the broader category of experiments that artificially manipulate the array of stimuli experi-enced by a subject. We argue that the challenges of designing and interpreting experiments usingvirtual reality or synthetic animations are largely comparable to those of studies using oldertechnologies or addressing other modalities, and that technology alone is unlikely to solve thesechallenges. We suggest that appropriate experimental designs are the key to validating behavioralresponses to artificial stimuli and to interpreting all studies using artifice, including those that pre-sent complex visual displays. | Daniel L. POWELL Gil G. ROSENTHAL | 2017 | Current Zoology2017，63，1： | 3 |
| 12 | NASPGHAN Practice Guidelines: Diagnosis and Management of Hepatitis C Infection in Infants, Children, and Adolescents显示文摘 | Cara L. Mack Regino P. Gonzalez-Peralta Nitika Gupta Daniel Leung Michael R. Narkewicz Eve A. Roberts Philip Rosenthal Kathleen B. Schwarz | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，6： | 2 |
| 13 | The Combination of Ribavirin and Peginterferon Is Superior to Peginterferon and Placebo for Children and Adolescents With Chronic Hepatitis C显示文摘 | Kathleen B. Schwarz Regino P. Gonzalez–Peralta Karen F. Murray Jean P. Molleston Barbara A. Haber Maureen M. Jonas Philip Rosenthal Parvathi Mohan William F. Balistreri Michael R. Narkewicz Lesley Smith Steven J. Lobritto Stephen Rossi Alexandra Valsamaki | 2011 | Gastroenterology2011，，2： | 2 |
| 14 | Target coverage for head and neck cancers treated with IMRT: review of clinical experiences显示文摘 | Adam S Garden William H Morrison David I Rosenthal K.S.Clifford Chao K.Kian Ang | 2004 | Seminars in Radiation Oncology2004，，： | 2 |
| 15 | Fate and effects of cadmium in an experimental marine ecosystem显示文摘 | H. Westernhagen V. Dethlefsen H. Rosenthal G. Fürstenberg J. Klinckmann | 1978 | Helgol?nder Wissenschaftliche Meeresuntersuchungen1978，，4： | 2 |
| 16 | Lightweight in Automotive Components by Forming Technology显示文摘Lightweight design is one of the current key drivers to reduce the energy consumption of vehicles.Design methodologies for lightweight components,strategies utilizing materials with favorable specific properties and hybrid materials are used to increase the performance of parts for automotive applications.In this paper,various forming processes to produce light parts are described.Material lightweight design is discussed,covering the manufacturing processes to produce hybrid components like fiber-metal,polymer-metal and metal-metal composites,which can be used in subsequent deep drawing or combined forming processes.Approaches to increasing the specific strength and stiffness with thermomechanical forming processes as well as the in situ control of the microstructure of such components are presented.Structure lightweight design discusses possibilities to plastically form high-strength or high-performance materials like magnesium or titanium in sheet,profile and tube forming operations.To join those materials and/or dissimilar materials,new joining by forming technologies are shown.To economically produce lightweight parts with gears or functional elements,incremental sheet-bulk metal forming is pre-sented.As an important part property,the damage evolution during the forming operations will be discussed to enable even lighter parts through a more reliable design.New methods for predicting and tailoring the mechanical properties like strength and residual stresses will be shown.The possibilities of system lightweight design with forming technologies are presented.A combination of additive manufacturing and forming to produce highly complex parts with integrated functions will be shown.The integration of functions by a hot extrusion process for the manufacturing of shape memory alloys is presented.An in-depth understanding of the newly developed processes,methodologies and effects allows for a more accurate dimen-sioning of components.This facilitates a reduction in the total mass and an increasing performance of vehicle components. | Stephan Rosenthal Fabian Maaß Mike Kamaliev Marlon Hahn Soeren Gies A.Erman Tekkaya | 2020 | Automotive Innovation2020，3，3： | 2 |
| 17 | Predictors of Sexual Risk Behaviors Among Newly Homeless Youth: A Longitudinal Study显示文摘 | M. Rosa Solorio Doreen Rosenthal Norweeta G. Milburn Robert E. Weiss Philip J. Batterham Marla Gandara Mary Jane Rotheram-Borus | 2008 | Journal of Adolescent Health2008，，4： | 2 |
| 18 | Performance, structure, and mechanism of CeO 2 in HCl oxidation to Cl 2显示文摘 | Amol P. Amrute Cecilia Mondelli Maximilian Moser Gerard Novell-Leruth Núria López Dirk Rosenthal Ramzi Farra Manfred E. Schuster Detre Teschner Timm Schmidt Javier Pérez-Ramírez | 2011 | Journal of Catalysis2011，，： | 2 |
| 19 | WONCA研究论文摘要汇编——“以病人为中心的医疗团队”工作环境及满意度调查显示文摘目的探讨初级保健医疗机构中'以病人为中心的医疗团队'的改革对工作满意度的影响。方法2009—2011年,研究者收集罗得岛州和科罗拉多州参加'以病人为中心的医疗团队'试验项目的 20个初级保健机构的原始数据,就工作环境的质量(如:诊室噪声、交流、提供安全和优质服务的困难)及满意度进行从基线至30个月时的调查,同时就压力、倦怠、30个月时离开的意向进行调查;就试验项目的影响与机构领导进行访谈;评估工作环境及满意度的纵向变化,在项目的最后一年,检查工作环境与工作满意度、压力、倦怠、离开意向之间的横断面联系。结果从基线至30个月时,罗德岛州工作满意度有所改善(P=0.03),科罗拉多州未见明显改善。两个试点项目所报告的提供安全、高质量服务的困难有所减少(P<0.001),但诊室噪声水平及质量并无明显改善。横断面分析表明,更少的提供安全和优质服务的困难、优质服务和更加开放的沟通与工作满意度提高相关。更大的诊室噪声及加强电子信息与压力及倦怠增加相关。结论 '以病人为中心的医疗团队'的改革强调质量和开放式沟通,最大限度地降低诊室噪声有助于改善工作满意度。 | Alidina S Rosenthal MB Schneider EC 本刊编辑部 | 2014 | 中国全科医学2014，17，35： | 2 |
| 20 | Spellings of Words: A Neglected Facilitator of Vocabulary Learning显示文摘 | Linnea C. Ehri Julie Rosenthal | 2007 | Journal of Literacy Research2007，，4： | 2 |
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