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| 1 | Differential regulation of protein synthesis in skeletal muscle and liver of neonatal pigs by leucine through an mTORC1-dependent pathway显示文摘Neonatal growth is characterized by a high protein synthesis rate that is largely due to an enhanced sensitivity to the postprandial rise in insulin and amino acids, especially leucine. The mechanism of leucine's action in vivo is not well understood. In this study, we investigated the effect of leucine infusion on protein synthesis in skeletal muscle and liver of neonatal pigs. To evaluate the mode of action of leucine, we used rapamycin, an inhibitor of mammalian target of rapamycin (mTOR) complex-1 (mTORC1). Overnight-fasted 7-day-old piglets were treated with rapamycin for 1 hour and then infused with leucine (400 μmol·kg -1 ·h -1 ) for 1 hour. Leucine infusion increased the rate of protein synthesis, and ribosomal protein S6 kinase 1 (S6K1) and eukaryotic initiation factor (eIF) 4E-binding protein-1 (4E-BP1) phosphorylation in gastrocnemius and masseter muscles (P < 0.05), but not in the liver. The leucine-induced stimulation of protein synthesis and S6K1 and 4E-BP1 phosphorylation were completely blocked by rapamycin, suggesting that leucine action is by an mTORC1-dependent mechanism. Neither leucine nor rapamycin had any effect on the activation of the upstream mTORC1 regulators, AMP-activated protein kinase and protein kinase B, in skeletal muscle or liver. The activation of eIF2a and elongation factor 2 was not affected by leucine or rapamycin, indicating that these two pathways are not limiting steps of leucine-induced protein synthesis. These results suggest that leucine stimulates muscle protein synthesis in neonatal pigs by inducing the activation of mTORC1 and its downstream pathway leading to mRNA translation. | Agus Suryawan Hanh V Nguyen Rosemarie D Almonaci Teresa A Davis | 2012 | Journal of Animal Science and Biotechnology2012，3，1： | 9 |
| 2 | 木霉菌制剂对禾谷全蚀病的防治作用(英文)显示文摘木霉菌是对多种植物病原真菌有作用的拮抗体,包括Gaeumannomycesgraminisvar.tritici(Ggt),Pythiumspp.,Rhizoctoniasolani以及Fusariumspp.木霉菌能产生抑制植物病原真菌生长与活力的抗菌物质,是理想的植物病害生物防治菌。有效的生物防治方法可为农民提供低风险而又灵活的病害防治措施,特别是在需要减缓病原菌对化学杀菌剂产生抗药性的情况下。本文综合介绍了在南澳大利亚田间进行的利用康宁木霉菌(T.koningii)防治禾谷类根部病害的结果,并重点介绍澳大利亚在商品化开发方面的工作进展。在病害发生严重的情况下,康宁木霉菌可降低小麦全蚀病和丝核菌根腐病发病程度分别达24%和48%。小麦产量增加7%,也能降低大麦丝核菌根腐病发病程度达59%。康宁木霉菌也能够防治由Ceratocystisparadoxa引起的甘蔗凤梨病。 | Rosemary A WARREN Maarten H RYDER | 2005 | 山东科学2005，18，3： | 3 |
| 3 | Review: Improving our knowledge of male mosquito biology in relation to genetic control programmes显示文摘 | Rosemary Susan Lees Bart Knols Romeo Bellini Mark Q. Benedict Ambicadutt Bheecarry Hervé Christophe Bossin Dave D. Chadee Jacques Charlwood Roch K. Dabiré Luc Djogbenou Alexander Egyir-Yawson René Gato Louis Clément Gouagna Mo’awia Mukhtar Hassan Shakil A | 2013 | Acta Tropica2013，，： | 2 |
| 4 | Strontium isotopes as trancers of ecosystem processes:theory and methods显示文摘 | Rosemary C C Brian W S Oliver A C | 1998 | Geoderma1998，82，： | 1 |
| 5 | Risk Factors for hepatic morbidity following nonoperative management显示文摘 | Rosemary A K Frederick A M Clay C | 2006 | Archives of Surgery2006，141，5： | 1 |
| 6 | PPARγ,PTEN and the Fight against Cancer显示文摘 | ROSEMARY E TERESI KRISTIN A | 2008 | PPAR Research2008，，： | 1 |
| 7 | The effect of the degree of hydrolysis of the PVA and the plasticizer concentration on the color,opacity,and thermal and mechanical properties of films based on PVA and gelatin blends显示文摘 | Maria Thais M C Carvalho Rosemary A de Sobral Paulo J A | | 0，，02： | 1 |
| 8 | Political Science and the Three New Institutionalisms显示文摘 | Peter A Hall Rosemary C.R.Taylor | | 0，，05： | 1 |
| 9 | Hydntoin-hydrolyzing enzymes for the enantioselective production of amino acids:new insights and applications显示文摘 | Rosemary A D | 2004 | Tetrahedron:Asymmetry2004，15，： | 1 |
| 10 | The effect of the degree of hydrolysis of the PVA and the plasticizer con- centmtion on the color, opacity, and thermal and mechanical properties of films based on PVA and gelatin blends 显示文摘 | Maria Thais M C Carvalho Rosemary A de Sobral Paulo J A | 2008 | Journal of Food Engineering2008，87，2： | 1 |
| 11 | Growth arrest and DNA damage-45alpha(GADD45alpha)显示文摘 | Rosemary Siafakas A Richardson DR | 2009 | Int J Biochem Cell Biol2009，41，5： | 1 |
| 12 | Carbon accumu- lation in Colorado ponderosa pine stands显示文摘 | Jeffrey A H Rosemary L S Thomas T V | 2004 | Canadian Journal of Forest Research2004，34，6： | 1 |
| 13 | Dose-effect relationships between manganes exposure and neurological,neuropsychological and pulmonary function in confined space bridge welders显示文摘 | ROSEMARIE M B HARRY A R SANAE N | | 0，，03： | 1 |
| 14 | Modeling the evolution of volatile species during tobacco pyrolysis显示文摘 | Marek A Wo' jtowicz Rosemary Bassilakis Wayne W Smith | 2003 | J Anal Appl Pyrolysis2003，66，： | 1 |
| 15 | Interaction Between Nitric Oxide and Mineralocorticoids in the Long-Term Control of Blood Pressure显示文摘 | Gracia A Antonio O Rosemary W | 2000 | Hypertension2000，35，： | 1 |
| 16 | A Comparison of Change in the 0-10 Numeric Rating Scale to a Pain Relief Scale and Global Medication Performance Scale in a Short-term Clinical Trial of Breakthrough Pain Intensity显示文摘 | JOHN T ROSEMARY C JESSE A | 2010 | Anesthesiology2010，112，6： | 1 |
| 17 | Cancer in older persons;an internal issue in an aging world显示文摘 | Rosemary Y Lynn A G R | 2004 | Semin Oncol2004，31，2： | 1 |
| 18 | The relationship between urban conservation programmes and property renovation:evidence from Quito,Ecuador显示文摘 | Rosemary D F Bromley | 1996 | Cities1996，，13： | 1 |
| 19 | Cervical spine Motion:A fluoroscopic comparison during intubation with Lighted stylet,glide scope,and Macintosh Laryngoscope显示文摘 | Timoty P Turkstra L Rosemary A | 2005 | Anesth Analg2005，101，： | 1 |
| 20 | Influence of the CYP2C9 and CYP2C19 polymorphisms on phenytoin hydi'oxylation in healthy individuals from south India 显示文摘 | Rosemary J Surendiran A Rajan S | 2006 | Indian J Med Res2006，12，3： | 1 |
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