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| 1 | REVIEW ON RESEARCH AND DEVELOPMENT OF MAGNESIUM ALLOYS显示文摘镁合金的当前的研究和发展被总结。镁合金的几个方面被描述:演员组 Mg 合金,做 Mg 合金,并且小说处理。这些题目个别地被讨论,为进一步的学习的建议在最后的节被列出。 | Z. Yang J.P. Li J.X. Zhang G.W. Lorimer J. Robson | 2008 | Acta Metallurgica Sinica(English Letters)2008，21，5： | 93 |
| 2 | Renin-angiotensin system in the pathogenesis of liver fibrosis显示文摘Hepatic fibrosis is considered a common response to many chronic hepatic injuries.It is a multifunctional process that involves several cell types,cytokines,chemokines and growth factors leading to a disruption of homeostatic mechanisms that maintain the liver ecosystem.In spite of many studies regarding the development of fibrosis,the understanding of the pathogenesis remains obscure.The hepatic tissue remodeling process is highly complex,resulting from the balance between collagen degradation and synthesis.Among the many mediators that take part in this process,the components of the Renin angiotensin system(RAS) have progressively assumed an important role.Angiotensin(Ang)□acts as a profibrotic mediator and Ang-(1-7),the newly recognized RAS component,appears to exert a counter-regulatory role in liver tissue.We briefly review the liver fibrosis process and current aspects of the RAS.This review also aims to discuss some experimental evidence regarding the participation of RAS mediators in the pathogenesis of liver fibrosis,focusing on the putative role of the ACE2-Ang-(1-7)-Mas receptor axis. | Regina Maria Pereira Robson Augusto Souza dos Santos Filipi Leles da Costa Dias Mauro Martins Teixeira Ana Cristina Simoes e Silva | 2009 | World Journal of Gastroenterology2009，15，21： | 37 |
| 3 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 4 | Hypospadias: an update显示文摘Hypospadias 是阴茎的最普通的先天的异例。这个问题通常偶发地并且没有一个明显的位于下面原因发展。宫外的联盟者放了对正常地点近似的尿道的道谎言并且在阴茎的腹的方面上,并且在严重情况中通向阴囊或会阴。当那在背面的表面上是丰富的时,腹的表面上的包皮是缺乏的,给一个背面的无赖的外观。阴茎痛性勃起在严重情况中是更普通的。Cryptorchidism 和腹股沟的脱肠是最普通的联系异例。联系异例的频率与 hypospadias 的严厉增加。Forisolated 前面或中间的 hypospadias,实验室研究不通常是必要的。为尿道异例屏蔽应该与至少一个另外的机关系统的一个异例与以后的 hypospadias 并且在那些在病人被考虑。为在一个健康孩子的外科的修理的理想的年龄在年龄的 6 和 12 个月之间。大多数盒子能在单个操作并且在一个门诊病人基础上被修理。甚至有不到完美的外科的结果的病人通常能享受令人满意的性生活。 | Alexander K. C. Leung William L. M. Robson | 2007 | Asian Journal of Andrology2007，9，1： | 16 |
| 5 | Relationship between angiotensin-(1-7) and angiotensin Ⅱ correlates with hemodynamic changes in human liver cirrhosis显示文摘AIM:To measure circulating angiotensins at different stages ofhuman cirrhosis and to further evaluate a possible relationship between renin angiotensin system (RAS) components and hemodynamic changes.METHODS: Patients were allocated into 4 groups: mild-to-moderate liver disease (MLD), advanced liver disease (ALD), patients undergoing liver transplantation, and healthy controls. Blood was collected to determine plasma renin activity (PRA), angiotensin (Ang) , Ang Ⅱ, and Ang-(1-7) levels using radioimmunoassays. During liver transplantation, hemodynamic parameters were determined and blood was simultaneously obtained from the portal vein and radial artery in order to measure RAS components.RESULTS: PRA and angiotensins were elevated in ALD when compared to MLD and controls (P < 0.05). In contrast, Ang was signicantly reduced in MLD. Ang-(1-7)/Ang Ⅱ ratios were increased in MLD when compared to controls and ALD. During transplantation, Ang Ⅱ levels were lower and Ang-(1-7)/Ang Ⅱ ratios were higher in the splanchnic circulation than in the peripheral circulation (0.52 ± 0.08 vs 0.38 ± 0.04, P < 0.02), whereas the peripheral circulating Ang /Ang ratio was elevated in comparison to splanchnic lev-els (0.18 ± 0.02 vs 0.13 ± 0.02, P < 0.04). Ang-(1-7)/Ang Ⅱ ratios positively correlated with cardiac output (r= 0.66) and negatively correlated with systemic vascular resistance (r =-0.70).CONCLUSION: Our ndings suggest that the relation-ship between Ang-(1-7) and Ang Ⅱmay play a role in the hemodynamic changes ofhuman cirrhosis. | Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Regina Maria Pereira Renata da Cunha Ribeiro Jerusa Almeida Ana Paula Nadu Ana Cristina Simoes e Silva Robson Augusto Souza dos Santos | 2009 | World Journal of Gastroenterology2009，15，20： | 11 |
| 6 | Video capsule endoscopy vs double-balloon enteroscopy in the diagnosis of small bowel bleeding:A systematic review and metaanalysis显示文摘AIM To compare the diagnostic accuracy of video capsule endoscopy(VCE) and double-balloon enteroscopy(DBE) in cases of obscure gastrointestinal bleeding(OGIB) of vascular origin.METHODS MEDLINE(via PubMed), LILACS(via BVS) and Cochrane/CENTRAL virtual databases were searched for studies dated before 2017. We identified prospective and retrospective studies, including observational, cohort, single-blinded and multicenter studies, comparing VCE and DBE for the diagnosis of OGIB, and data of all the vascular sources of bleeding were collected. All patients were subjected to the same gold standard method. Relevant data were then extracted from each included study using a standardized extraction form. We calculated study variables(sensitivity, specificity, prevalence, positive and negative predictive values and accuracy) and performed a meta-analysis using Meta-Disc software.RESULTS In the per-patient analysis, 17 studies(1477 lesions) were included. We identified3150 exams(1722 VCE and 1428 DBE) in 2043 patients and identified 2248 sources of bleeding, 1467 of which were from vascular lesions. Of these lesions, 864(58.5%) were diagnosed by VCE, and 613(41.5%) were diagnosed by DBE. The pretest probability for bleeding of vascular origin was 54.34%. The sensitivity of DBE was 84%(95%CI: 0.82-0.86; heterogeneity: 78.00%), and the specificity was92%(95%CI: 0.89-0.94; heterogeneity: 92.0%). For DBE, the positive likelihood ratio was 11.29(95%CI: 4.83-26.40; heterogeneity: 91.6%), and the negative likelihood ratio was 0.20(95%CI: 0.15-0.27; heterogeneity: 67.3%). Performing DBE after CE increased the diagnostic yield of vascular lesion by 7%, from 83% to90%.CONCLUSION The diagnostic accuracy of detecting small bowel bleeding from a vascular source is increased with the use of an isolated video capsule endoscope compared with isolated DBE. However, concomitant use increases the detection rate of the bleeding source. | Hélcio Pedrosa Brito Igor Braga Ribeiro Diogo Turiani Hourneaux de Moura Wanderley Marques Bernardo Dalton Marques Chaves Rogério Kuga Ethan Dwane Maahs Robson Kiyoshi Ishida Eduardo Turiani Hourneaux de Moura Eduardo Guimaraes Hourneaux de Moura | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，12： | 10 |
| 7 | Lipoprotein metabolism in nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease (NAFLD),an escalating health problem worldwide,covers a spectrum of pathologies characterized by fatty accumulation in hepatocytes in early stages,with potential progression to liver inflammation,fibrosis,and failure.A close,yet poorly understood link exists between NAFLD and dyslipidemia,a constellation of abnormalities in plasma lipoproteins including triglyceride-rich very low density lipoproteins.Apolipoproteins are a group of primarily liver-derived proteins found in serum lipoproteins;they not only play an extracellular role in lipid transport between vital organs through circulation,but also play an important intracellular role in hepatic lipoprotein assembly and secretion.The liver functions as the central hub for lipoprotein metabolism,as it dictates lipoprotein production and to a significant extent modulates lipoprotein clearance.Lipoprotein metabolism is an integral component of hepatocellular lipid homeostasis and is implicated in the pathogenesis,potential diagnosis,and treatment of NAFLD. | Zhenghui Gordon Jiang Simon C. Robson Zemin Yao | 2013 | The Journal of Biomedical Research2013，27，1： | 8 |
| 8 | Occlusion of the anterior cerebral artery after head trauma显示文摘Intracranial arterial occlusion is rarely encountered in association with head injury.Only six cases of traumatic occlusion of the anterior cerebral artery(ACA) have previously been reported.In this paper,the authors describe a case of a posttraumatic occlusion of ACA.A 35-year-old male presented to the emergency room with severe head injury.Computed tomography(CT) scan displayed diffuse brain swelling with multiple skull fractures.Follow up CT scan showed extensive cerebral infarction in the territory of ACA.The patient underwent CT angiography that demonstrated occlusion of the ACA by a fracture of the anterior fossa.He died after 3 d.ACA traumatic occlusion is a rare condition,with poor prognosis.In this case,fracture was responsible for dissection and direct obstruction of the artery. | Wellingson Silva Paiva Almir Ferreira de Andrade Matheus Schmidt Soares Robson Luis Amorim Eberval Gadelha Figueiredo Manoel Jacobsen Teixeira | 2013 | World Journal of Radiology2013，5，5： | 7 |
| 9 | The role and clinical implications of microRNAs in hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is common and one of the most aggressive of all human cancers. Recent studies have indicated that miRNAs, a class of small noncoding RNAs that regulate gene expression post-transcriptionally, directly contribute to HCC by targeting many critical regulatory genes. Several miRNAs are involved in hepatitis B or hepatitis C virus replication and virus-induced changes, whereas others participate in multiple intracellular signaling pathways that modulate apoptosis, cell cycle checkpoints, and growth-factor-stimulated responses. When disturbed, these pathways appear to result in malignant transformation and ultimately HCC development. Recently, miRNAs circulating in the blood have acted as possible early diagnostic markers for HCC. These miRNA also could serve as indicators with respect to drug efficacy and be prognostic in HCC patients. Such biomarkers would assist stratification of HCC patients and help direct personalized therapy. Here, we summarize recent advances regarding the role of miRNAs in HCC development and progression. Our expectation is that these and ongoing studies will contribute to the understanding of the multiple roles of these small noncoding RNAs in liver tumorigenesis. | ZHAO Xue YANG Zhen LI GuangBing LI DongKai ZHAO Yi WU Yan ROBSON Simon C. HE Lian XU YiYao MIAO R-uoYu ZHAO HaiTao | 2012 | Science China(Life Sciences)2012，55，10： | 6 |
| 10 | Using induced pluripotent stem cells as a tool for modelling carcinogenesis显示文摘Cancer is a highly heterogeneous group of diseases that despite improved treatments remain prevalent accounting for over 14 million new cases and 8.2 million deaths per year. Studies into the process of carcinogenesis are limited by lack of appropriate models for the development and pathogenesis of the disease based on human tissues. Primary culture of patient samples can help but is difficult to grow for a number of tissues. A potential opportunity to overcome these barriers is based on the landmark study by Yamanaka which demonstrated the ability of four factors;Oct4, Sox2, Klf4, and c-Myc to reprogram human somatic cells in to pluripotency. These cells were termed induced pluripotent stem cells(i PSCs) and display characteristic properties of embryonic stem cells. This technique has a wide range of potential uses including disease modelling, drug testing and transplantation studies. Interestingly i PSCs also share a number of characteristics with cancer cells including self-renewal and proliferation, expression of stem cell markers and altered metabolism. Recently, i PSCs have been generated from a number of human cancer cell lines and primary tumour samples from a range of cancers in an attempt to recapitulate the development of cancer and interrogate the underlying mechanisms involved. This review will outline the similarities between the reprogramming process and carcinogenesis, and how these similarities have been exploited to generate i PSC models for a number of cancers. | Emma L Curry Mohammad Moad Craig N Robson Rakesh Heer | 2015 | World Journal of Stem Cells2015，7，2： | 5 |
| 11 | Molecular Discrimination of Wild Philippine Paddy Straw Mushroom ( Volvariella volvacea)显示文摘 | Evaristo A. Abella Geoff D. Robson Richard F. Preziosi | 2014 | Journal of Life Sciences2014，8，1： | 3 |
| 12 | Calcitonin gene-related peptide and traumatic brain injury显示文摘Dear editor,It is with great interest that we read the article“Relationship of calcitonin gene-related peptide with disease progression and prognosis of patients with severe traumatic brain injury”(Chen et al.,2018).In this study,the authors evaluated 121 patients who were divided into mild/moderate traumatic brain injury(TBI)(n=61),severe TBI(n=35)and control(n=25)groups,and measured serum levels of calcitonin gene-related peptide(CGRP)and serum endothelin-1(ET-1).They found that low levels of CGRP and high levels of ET-1 were associated with high mortality at 6 months.Identification of morphological abnormalities on CT scans is very important for evaluating patients with TBI because different diagnoses are made based on different imaging findings(Maas et al.,2005). | Saul Almeida da Silva Almir F.de Andrade Robson Luis Oliveira de Amorim Wellingson S.Paiva | 2019 | Neural Regeneration Research2019，14，4： | 3 |
| 13 | Immunological homologies between wheat gluten and starch granule proteins显示文摘 | Skerritt J H Frend A J Robson L G | 1990 | J Cereal Sci1990，，12： | 2 |
| 14 | 3D assessment of intervertebral disc degeneration in zebrafish identifies changes in bone density that prime disc disease显示文摘Back pain is a common condition with a high social impact and represents a global health burden.Intervertebral disc disease(IVDD)is one of the major causes of back pain;no therapeutics are currently available to reverse this disease.The impact of bone mineral density(BMD)on IVDD has been controversial,with some studies suggesting osteoporosis as causative for IVDD and others suggesting it as protective for IVDD.Functional studies to evaluate the influence of genetic components of BMD in IVDD could highlight opportunities for drug development and repurposing.By taking a holistic 3D approach,we established an aging zebrafish model for spontaneous IVDD.Increased BMD in aging,detected by automated computational analysis,is caused by bone deformities at the endplates.However,aged zebrafish spines showed changes in bone morphology,microstructure,mineral heterogeneity,and increased fragility that resembled osteoporosis.Elements of the discs recapitulated IVDD symptoms found in humans:the intervertebral ligament(equivalent to the annulus fibrosus)showed disorganized collagen fibers and herniation,while the disc center(nucleus pulposus equivalent)showed dehydration and cellular abnormalities.We manipulated BMD in young zebrafish by mutating sp7 and cathepsin K,leading to low and high BMD,respectively.Remarkably,we detected IVDD in both groups,demonstrating that low BMD does not protect against IVDD,and we found a strong correlation between high BMD and IVDD.Deep learning was applied to high-resolution synchrotron\iCJ image data to analyze osteocyte 3D lacunar distribution and morphology,revealing a role of sp7 in controlling the osteocyte lacunar 3D profile.Our findings suggest potential avenues through which bone quality can be targeted to identify beneficial therapeutics for IVDD. | Erika Kague Francesco Turci Elis Newman Yushi Yang Kate Robson Brown Mona S.Aglan Ghada A.Otaify Sarnia A.Temtamy Victor L.Ruiz-Perez Stephen Cross C.Patrick Royall P.Eckhard Witten Chrissy L.Hammond | 2021 | Bone Research2021，9，4： | 2 |
| 15 | Emerging artificial intelligence applications in liver magnetic resonance imaging显示文摘Chronic liver diseases(CLDs)are becoming increasingly more prevalent in modern society.The use of imaging techniques for early detection,such as magnetic resonance imaging(MRI),is crucial in reducing the impact of these diseases on healthcare systems.Artificial intelligence(AI)algorithms have been shown over the past decade to excel at image-based analysis tasks such as detection and segmentation.When applied to liver MRI,they have the potential to improve clinical decision making,and increase throughput by automating analyses.With Liver diseases becoming more prevalent in society,the need to implement these techniques to utilize liver MRI to its full potential,is paramount.In this review,we report on the current methods and applications of AI methods in liver MRI,with a focus on machine learning and deep learning methods.We assess four main themes of segmentation,classification,image synthesis and artefact detection,and their respective potential in liver MRI and the wider clinic.We provide a brief explanation of some of the algorithms used and explore the current challenges affecting the field.Though there are many hurdles to overcome in implementing AI methods in the clinic,we conclude that AI methods have the potential to positively aid healthcare professionals for years to come. | Charles E Hill Luca Biasiolli Matthew D Robson Vicente Grau Michael Pavlides | 2021 | World Journal of Gastroenterology2021，27，40： | 2 |
| 16 | A highly conserved aminoacid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite 显示文摘 | Robson KJ Hall JR Jennings MW | 1988 | Nature1988，335，： | 2 |
| 17 | Making sense of regulatory T cell suppressive function显示文摘 | Itay Shalev Moritz Schmelzle Simon C. Robson Gary Levy | 2011 | Seminars in Immunology2011，，4： | 2 |
| 18 | Ultrastructural Aspects of Cooled Thermal Injury显示文摘 | DONNA L. de CAMARA TALMAGE RAINE MARTIN C. ROBSON | 1981 | The Journal of Trauma: Injury Infection and Critical Care1981，，11： | 2 |
| 19 | Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients显示文摘AIM:To evaluate the effect of β-blockade on angiotensins in the splanchnic and peripheral circulation of cirrhotic patients and also to compare hemodynamic parameters during liver transplantation according to propranolol pre-treatment or not. METHODS:Patients were allocated into two groups:outpatients with advanced liver disease(LD) and during liver transplantation(LT). Both groups were subdivided according to treatment with propranolol or not. Plasma was collected through peripheral venipuncture to determine plasma renin activity(PRA),Angiotensin(Ang) Ⅰ,Ang Ⅱ,and Ang-(1-7) levels by radioimmunoassay in LD group. During liver transplantation,hemodynamic parameters were determined and blood samples were obtained from the portal vein to measure renin angiotensin system(RAS) components.RESULTS:PRA,Ang Ⅰ,Ang Ⅱ and Ang-(1-7) were signifi cantly lower in the portal vein and periphery in all subgroups treated with propranolol as compared to non-treated. The relationships between Ang-(1-7) and Ang Ⅰ levels and between Ang Ⅱ and Ang Ⅰ were significantly increased in LD group receiving propranolol. The ratio between Ang-(1-7) and Ang Ⅱ remained unchanged in splanchnic and peripheral circulation in patients under β-blockade,whereas the relationship between Ang Ⅱ and Ang Ⅰ was significantly increased in splanchnic circulation of LT patients treated with propranolol. During liver transplantation,cardiac output and index as well systemic vascular resistance and index were reduced in propranolol-treated subgroup. CONCLUSION:In LD group,propranolol treatment reduced RAS mediators,but did not change the ratio between Ang-(1-7) and Ang Ⅱ in splanchnic and peripheral circulation. Furthermore,the modification of hemodynamic parameters in propranolol treated patients was not associated with changes in the angiotensin ratio. | Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Renata da Cunha Ribeiro Renata Lúcia Pereira Vieira Jerusa Almeida Ana Paula Nadu Ana Cristina Sim■es e Silva Robson Augusto Souza Santos | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 20 | The CONSTANS gene of arabidopsis promotes flowering and encodes a protein showing similarities to zinc finger transcription factors显示文摘 | Joanna Putterill Frances Robson Karen Lee Rüdiger Simon George Coupland | 1995 | Cell1995，，6： | 2 |
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