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| 1 | Association of genetic variants with diabetic nephropathy显示文摘Diabetic nephropathy accounts for the most serious microvascular complication of diabetes mellitus. It is suggested that the prevalence of diabetic nephropathy will continue to increase in future posing a major challenge to the healthcare system resulting in increased morbidity and mortality. It occurs as a result of interaction between both genetic and environmental factors in individuals with both type 1 and type 2 diabetes. Genetic susceptibility has been proposed as an important factor for the development and progression of diabetic nephropathy, and various research efforts are being executed worldwide to identify the susceptibility gene for diabetic nephropathy. Numerous single nucleotide polymorphisms have been found in various genes giving rise to various gene variants which have been found to play a major role in genetic susceptibility to diabetic nephropathy. The risk of developing diabetic nephropathy is increased several times by inheriting risk alleles at susceptibility loci of various genes like ACE, IL, TNF-α, COL4A1, e NOS, SOD2, APOE, GLUT, etc. The identification of these genetic variants at a biomarker level could thus, allow the detection of those individuals at high risk for diabetic nephropathy which could thus help in the treatment, diagnosis and early prevention of the disease. The present review discusses about the various gene variants found till date to be associated with diabetic nephropathy. | Saliha Rizvi Syed Tasleem Raza Farzana Mahdi | 2014 | World Journal of Diabetes2014，5，6： | 20 |
| 2 | Nutritional support in chronic liver disease and cirrhotics显示文摘The liver is a major organ and an essential componentin maintaining an appropriate nutritional status in healthy individuals through metabolism of protein, carbohydrates, and fat. In individuals with chronic liver disease(CLD), along with a number of other essen-tial functions that the liver serves, its role in nutrition maintenance is severely impaired. Common causes of CLD include hepatitis C, alcoholic liver disease, and non-alcoholic liver disease. Amongst this population, the most common manifestation of impaired nutritional maintenance is protein-calorie malnutrition. Aside from inherent abnormalities in metabolism, such as malab-sorption and maldigestion, CLD can be associated with anorexia as well as increased metabolic requirements, all of which contribute to a state of malnutrition. Given the systemic implications and impact on prognosis of malnutrition, proper nutritional assessment is essential and can be achieved through a thorough history and physical, as well as biochemical investigations and anthropometry as needed. Following an appropriate assessment of a patient's nutritional status, an approach to management can be decided upon and is based on the extent of malnutrition which directly reflects the severity of disease. Management options can be grossly separated into enteral and parenteral nutrition. The former is usually sufficient in the form of oral supplements in less severe cases of malnutrition, but as the CLD worsens, parenteral nutrition becomes necessary. With appropriate assessment and early intervention, many of the complications of CLD can be avoided, and ultimately better outcomes can be achieved. | Ravi Shergill Wajahat Syed Syed Ali Rizvi Ikjot Singh | 2018 | World Journal of Hepatology2018，10，10： | 17 |
| 3 | Approach to pseudomyxoma peritonei显示文摘Pseudomyxoma peritonei(PMP) is a mucinous tumour of the appendix that spreads into the peritoneal cavity in the form of gelatinous deposits. The incidence of PMP is believed to be approximately 1-3 out of a million per year. Nonetheless, due to its indolent nature, it is usually discovered at an advanced stage and severely impacts quality of life. Curative treatment for PMP is complete cytoreductive surgery(CRS) with hyperthermic intraperitoneal chemotherapy(HIPEC). An extensive literature review was conducted searching EMBASE, MEDLINE, Pub Med, and Google Scholar databases for PMP in aims to delineate a clinical approach to diagnosis and treatment. Literature was limited to the years 2007-2018. We found the 5-year overall survival with CRS and HIPEC estimated to be between 23%-82% and rates of major complications as high as 24%. Therefore, it is important to appropriately stage and select patients that should undergo CRS with HIPEC. Modalities like MDCT radiological scores have been shown to have sensitivity and specificity of 94% and 81%, respectively, in being able to predict resectability and survival. Despite treatment, the disease often recurs. Tumor markers have significant potential for establishing prognosis preoperatively, and this paper will review the most recent evidence in support of them. | Syed Ali Rizvi Wajahat Syed Ravi Shergill | 2018 | World Journal of Gastrointestinal Surgery2018，10，5： | 15 |
| 4 | 套筒灌浆密实度直接冲击振动检测方法显示文摘装配式建筑结构一般由多个预制构件,通过钢筋套筒灌浆连接形成。然而,目前工程上对套筒内的灌浆密实度还没有可靠的检测和分析判断方法。本文设计一种带有全桥应变片的装置,可对套筒内钢筋产生短脉冲激振,然后对振动信号的时域和频域进行分析,从而实现对套筒灌浆密实度的定性及定量判断。结合室内原型试验,分析不同灌浆密实度的钢筋套筒受冲击后的振动信号,研究冲击信号时域曲线中的波峰幅值A_(Peak)、半峰全宽Δt_(FWHM)和峰宽比R_(Pt)以及频域信号曲线中的峰值频率Ω_(Peak)等特征参数的变化规律。研究结果表明:随着套筒灌浆密实度n增加,冲击信号的时域曲线衰减速率增大,包括波峰幅值APeak、半峰全宽Δt_(FWHM)和峰宽比R_(Pt)等特征参数也均随之增大;随着套筒灌浆密实度n增加,冲击信号的频域曲线的峰频率Ω_(Peak)趋于减小;对于未知灌浆密度的套筒,将冲击信号所得的峰宽比RPt或峰频率Ω_(Peak)代入曲线拟合的计算公式,可直接计算套筒灌浆密实度n,从而实现灌浆密实度的定量判断。 | 王奎华 郑茗旺 涂园 项驰轩 刘鑫 谭婕 RIZVI Faheem 杨学林 余亚超 | 2021 | 中南大学学报(自然科学版)2021，52，3： | 6 |
| 5 | Reflectometric and interferometric fiber optic sensor's principles and applications显示文摘Fiber optic sensors have been widely used and studied in recent times. This paper presents operating principles and applications of fiber optic sensors namely reflectometric and interferometric fiber optic sensors. Majority of optical fiber sensors fall under these two broad categories. Both interferometric and reflectometric fiber optic sensors are becoming popular for their ease of use, flexibility, long distance sensing, and potentially noise free detection. Also, these sensors can easily be used in various applications such as structural health monitoring, perimeter intrusion detection, temperature monitoring, and other numerous applications. This paper broadly classifies fiber optic sensors into two subtypes. The paper further highlights different sensors based on their sensing resolution, range, spatial advantages, and applications. | Muhammad Noaman ZAHID Jianliang JIANG Saad RIZVI | 2019 | Frontiers of Optoelectronics2019，12，2： | 6 |
| 6 | 纬度依赖背景场误差协方差及其对台风同化和预报的影响研究显示文摘合理的背景场误差协方差矩阵是做好变分同化的关键。为进一步认识背景场误差协方差矩阵在中尺度预报中的作用,对背景场误差协方差中平衡关系的纬度依赖特征及其对中尺度同化及预报效果的影响进行了研究。为使得平衡关系既包含纬度依赖特征,又降低纬度依赖带来的非平衡的噪音信息,在背景场误差协方差矩阵构造的平衡变换过程中引入了递归滤波的方法,对平衡变换中的回归系数进行了滤波平滑。同化单点观测的理想试验表明纬度依赖的背景场误差协方差具有更合理的动力关系,且滤波后的背景场误差协方差既保持了纬度依赖特征且明显平滑了噪音信息。台风'莫拉克'同化数值模拟试验表明纬度依赖的背景场误差协方差明显提高了36 h及以上的中心海平面最低气压和路径预报的预报效果。 | 陈耀登 曾腊梅 HUANG Xiang-yu WANG Hong-li 高玉芳 RIZVI S R H | 2014 | 热带气象学报2014，30，4： | 6 |
| 7 | Optimal trajectory and heat load analysis of different shape lifting reentry vehicles for medium range application显示文摘The objective of the paper is to compute the optimal burn-out conditions and control requirements that would result in maximum down-range/cross-range performance of a waverider type hypersonic boost-glide(HBG) vehicle within the medium and intermediate ranges,and compare its performance with the performances of wing-body and lifting-body vehicles vis-a-vis the g-load and the integrated heat load experienced by vehicles for the medium-sized launch vehicle under study.Trajectory optimization studies were carried out by considering the heat rate and dynamic pressure constraints.The trajectory optimization problem is modeled as a nonlinear,multiphase,constraint optimal control problem and is solved using a hp-adaptive pseudospectral method.Detail modeling aspects of mass,aerodynamics and aerothermodynamics for the launch and glide vehicles have been discussed.It was found that the optimal burn-out angles for waverider and wing-body configurations are approximately 5° and 14.8°,respectively,for maximum down-range performance under the constraint heat rate environment.The down-range and cross-range performance of HBG waverider configuration is nearly 1.3 and 2 times that of wing-body configuration respectively.The integrated heat load experienced by the HBG waverider was found to be approximately an order of magnitude higher than that of a lifting-body configuration and 5 times that of a wing-body configuration.The footprints and corresponding heat loads and control requirements for the three types of glide vehicles are discussed for the medium range launch vehicle under consideration. | S.Tauqeer ul Islam RIZVI Lin-shu HE Da-jun XU | 2015 | Defence Technology(防务技术)2015，11，4： | 5 |
| 8 | Association of gene variants with susceptibility to type 2 diabetes among Omanis显示文摘AIM:To investigate the association of 10 known common gene variants with susceptibility to type 2diabetes mellitus(T2D)among Omanis.METHODS:Using case-control design,a total of992 diabetic patients and 294 normoglycemic Omani Arabs were genotyped,by an allelic discrimination assay-by-design TaqMan method on fast real time polymerase chain reaction system,for the following gene variants:KCNJ11(rs5219),TCF7L2(rs7903146),CDKAL1(rs10946398),CDKN2A/B(rs10811661),FTO(rs9939609 and rs8050136),IGF2BP2(rs4402960),SLC30A8(rs13266634)CAPN10(rs3792267)and HHEX(rs1111875).T2D patients were recruited from the Diabetes Clinic(n=243)and inpatients(n=749)at Sultan Qaboos Univesity Hospital(SQUH),Muscat,Oman.Adult control participants(n=294)were volunteers from the community and from those visiting Family Medicine Clinic at SQU,for regular medical checkup.The difficulty in recruiting Omani participants with no family history of diabetes was the main reason behind the small number of control participants in this study.Almost all volunteers questioned had a relativewith diabetes mellitus.Inspite of the small number of normoglycemic controls in this study,this sample was sufficient for detection of genes and loci for common alleles influencing T2D with an odds ratio of≥1.3reaching at least 80%power.Data was collected from June 2010 to February 2012.RESULTS:Using binary logistic regression analysis,four gene variants showed significant association with T2D risk:KCNJ11(rs5219,P=5.8×10^(-6),OR=1.74),TCF7L2(rs7903146,P=0.001,OR=1.46),CDKAL1(rs10946398,P=0.002,OR=1.44)and CDKN2A/B(rs10811661,P=0.020,OR=1.40).The fixation index analysis of these four gene variants indicated significant genetic differentiation between diabetics and controls{[KCNJ11(rs5219),P<0.001],[TCF7L2(rs7903146),P<0.001],[CDKAL1(rs10946398),P<0.05],[CDKN2A/B(rs10811661),P<0.05]}.The highest genotype variation%between diabetics and controls was found at KCNJ11(2.07%)and TCF7L2(1.62%).This study was not able to detect an association of T2D risk with gene variants of IGF2BP2(rs4402960),SLC30A8(rs13266634),CAPN10(rs3792267)and HHEX(rs1111875).Moreover,no association was found between FTO gene variants(rs9939609 and rs8050136)and T2D risk.However,T2D risk was found to be significantly associated with obesity(P=0.002,OR=2.22);and with the Waist-to-Hip ratio(n=532,P=1.9×10^(-7),OR=2.4),[among males(n=234,P=1.2×10^(-4),OR=2.0)and females(n=298,P=0.001,OR=6.3)].CONCLUSION:Results confirmed the association of KCNJ11(rs5219),TCF7L2(rs7903146),CDKAL1(rs10946398)and CDKN2A/B(rs10811661)gene variants with susceptibility to T2D among Omani Arabs. | Sawsan Al-Sinani Nicolas Woodhouse Ali Al-Mamari Omaima Al-Shafie Mohammed Al-Shafaee Said Al-Yahyaee Mohammed Hassan Deepali Jaju Khamis Al-Hashmi Mohammed Al-Abri Khalid Al-Rassadi Syed Rizvi Yengo Loic Philippe Froguel Riad Bayoumi | 2015 | World Journal of Diabetes2015，6，2： | 3 |
| 9 | Effects of Ferulago angulata Extract on Serum Lipids and Lipid Peroxidation显示文摘 | Mahmoud Rafieian-kopaei Najmeh Shahinfard Hojjat Rouhi-Boroujeni Mojgan Gharipour Pariya Darvishzadeh-Boroujeni Syed Ibrahim Rizvi | 2014 | Evidence-Based Complementary and Alternative Medicine2014，，： | 2 |
| 10 | Local Therapy with Continued EGFR Tyrosine Kinase Inhibitor Therapy as a Treatment Strategy in EGFR-Mutant Advanced Lung Cancers That Have Developed Acquired Resistance to EGFR Tyrosine Kinase Inhibitors显示文摘 | Helena A. Yu Camelia S. Sima James Huang Stephen B. Solomon Andreas Rimner Paul Paik M. Catherine Pietanza Christopher G. Azzoli Naiyer A. Rizvi Lee M. Krug Vincent A. Miller Mark G. Kris Gregory J. Riely | 2013 | Journal of Thoracic Oncology2013，，3： | 2 |
| 11 | A rabbit model of non- cirrhotic portal hypertension by repeated injections of E. coli through indwelling cannulation of the gastrosplenic vein显示文摘BACKGROUND: Non-cirrhotic portal hypertension is acommon cause of portal hypertension in developing coun-tries. To understand its etiopathogenesis we developed ananimal model by repeated portal endotoxemia inducedthrough the gastrosplenic vein.METHODS: Twenty-nine rabbits (1.5-2.0 kg) were divid-ed into control (group n = 13) and experimental ( groupn = 16) groups. Heat killed E. coli were injected throughan indwelling cannula into the gastrosplenic vein in pre-sensitized animals. The animals were sacriflced at 1, 3 and6 months.RESULTS: The mean portal pressure in group animalswas significantly (P < 0. 05) higher than in group at 1(17.5 ±3.4 vs 10.4±2.2 mmHg), 3 (17.8±1.3 vs7.2 +3.6mmHg), and 6 (19.8±3.1 vs 10.3±4.8 mmHg) months.Similarly, the mean splenic weight in group was signifi-cantly greater than in group (P <0.05). Histopathologi-cally, the spleen showed medullary congestion, hemosid-rin-laden macrophages and mild fibrosis. Histologically,the liver had normal parenchyma with mild portal lympho-cytic infiltrates and kupffer cell hyperplasia. No significantanomalies were detected by liver function tests.CONCLUSIONS: The rabbit model showed significantsplenomegaly with a persistent increase in portal pressureand mild fibrosis without hepatic parenchymal injury, quiteakin to non-cirrhotic portal fibrosis as seen in humans. Re-current intra-abdominal infection may play an importantrole in the pathogenesis of non-cirrhotic portal fibrosis. | Swati Omanwar Moattar R. Rizvi Rachna Kathayat Brij K. Sharma Giryesh K. Pandey Mohammad A. Alam Veena Malhotra Shiv K. Sarin | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，3： | 2 |
| 12 | A modular clutter rejection technique for FLIR imagery using region-based principal component analysis显示文摘 | Syed A Rizvi Nasser M Nasrabadi | 2002 | Pattern Recognition2002，35，： | 2 |
| 13 | Foaming of PS/wood-fiber composites using moisture as a blowing agent显示文摘 | Rizvi G Matuana L M Park C B | 2000 | Polymer Engineering and Science2000，40，10： | 2 |
| 14 | A novel system design for continuous processing of plastic/wood-fiber composite foams with improved cell morphology显示文摘 | Rizvi G M Pop-Iliev R Park C B | 2002 | Journal of Cellular Plastics2002，38，5： | 2 |
| 15 | Serum levels of TNF-α in peripheral neuropathy patients and its correlation with nerve conduction velocity in type 2 diabetes mellitus显示文摘 | Gauhar Hussain S. Aijaz Abbas Rizvi Sangeeta Singhal Jamal Ahmad | 2013 | Diabetes & Metabolic Syndrome: Clinical Research & Reviews2013，，： | 2 |
| 16 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 17 | Altered Redox Status in Erythrocytes From Hypertensive Subjects: Effect of(-)Epicatechin显示文摘Hypertension is a major problem worldwide. There is much evidence to suggest that reactive oxygen species (ROS) radical may play a role in the development of organ damage associated with cardiovascular disease and hypertension. (-)Epicatechin, a member of tea catechins belonging to flavonoid group, is known to be a potent anti-oxidant. The study has been undertaken to evaluate the effect of (-)epicatechin on markers of oxidative stress: reduced glutathione (GSH) and membrane sulfhydryl (-SH) groups in erythrocytes from hypertensive patients. The effect of (-)epicatechin was also compared with a known anti-oxidant L-ascorbic acid. The erythrocyte intracellular GSH content and membrane -SH group content were significantly (P<0.01) decreased in hypertensive subjects. In vitro incubation with (-)epicatechin caused an increase in GSH and -SH content, the effect was more pronounced in hypertensive erythrocytes. Similar results were obtained with L-ascorbic acid. The observed decrease in the level of GSH and -SH groups in hypertension is an indicator of oxidative stress condition. Observation of an increase in red cell GSH content and the protection of membrane -SH group oxidation by (-)epicatechin in hypertensive subjects is a convincing reason to suggest that high dietary intake of foods rich in catechins may help to reduce oxidative stress and concomitant free radical damage in hypertensive patients. | SYED IBRAHIM RIZVI NAVNEET KUMAR | 2005 | 生物化学与生物物理进展2005，32，3： | 2 |
| 18 | The FERET evaluation methodology for face-recognition algorithms显示文摘 | PHILLIPS P J MOON H RIZVI S A | 2000 | IEEE Transactions on PAM12000，22，10： | 1 |
| 19 | Carbon tetrachloride-induced nephrotoxicity in rats: Protective role of Digera muricata显示文摘 | Muhammad R. Khan Wajiha Rizvi Gul N. Khan Rahmat A. Khan Saima Shaheen | 2008 | Journal of Ethnopharmacology2008，，1： | 1 |
| 20 | EMT in cervical cancer: its role in tumour progression and response to therapy 显示文摘 | Qureshi R Arora H Rizvi MA | 2015 | Cancer Lett2015，356，2： | 1 |
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