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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | S3-Leitlinie Kolorektales Karzinom Version 1.0 - Juni 2013 AWMF-Registernummer: 021/007OL显示文摘 | C. Pox S. Aretz S. Bischoff U. Graeven M. Hass P. Heu?ner W. Hohenberger A. Holstege J. Hübner F. Kolligs M. Kreis P. Lux J. Ockenga R. Porschen S. Post N. Rahner A. Reinacher-Schick J. Riemann R. Sauer A. Sieg W. Scheppach W. Schmitt H. Schmoll K. Schulm | 2013 | Z Gastroenterol2013，，08： | 2 |
| 3 | Insertion/deletion polymorphism in the promoter of NFKB1 as a potential molecular marker for the risk of recurrence in superficial bladder cancer显示文摘 | Riemann K Becker L Struwe H | 2007 | Int J Clin Pharmacol Ther2007，45，8： | 1 |
| 4 | Effects of nutrient limitation and irradiance on marine phytoplankton pigments显示文摘 | Henriksen P Riemann B Kaas H | 2002 | Journal of Plankton Research2002，24，： | 1 |
| 5 | No association of the NFKB1 insertion/deletion promoter polymorphism with survival in color- ectal and renal cell carcinoma as well as disease progression in B -cell chronic lymphocytic leukemia 显示文摘 | Riemann K Becker L Struwe H | 2006 | Pharmacogenet Ge- nomics2006，16，11： | 1 |
| 6 | A survey for Salmonella by drag swabbing manure piles in California egg ranches 显示文摘 | Riemann H Himathongkham S Willoughby D | 1998 | Avian Dis1998，42，1： | 1 |
| 7 | Modulation of cutane- ous inflammation by angiotensin-converting enzyme 显示文摘 | Scholzen TE St? nder S Riemann H | 2003 | J Immu- nol2003，170，7： | 1 |
| 8 | IL-12 suppression during experimental endotoxin tolerance:Dendritic cell loss and macrophage hyporesponsiveness显示文摘 | Wysocka M Robertson S Riemann H | 2001 | J Immunol2001，166，12： | 1 |
| 9 | Transient total sleep loss in cerebral Whipple's disease:a longitudinal study显示文摘 | Voderholzer U Riemann D Gann H | 2002 | J Sleep Res2002，11，4： | 1 |
| 10 | A survey for Salmonella by drag swabbing manure piles in California egg ranches显示文摘 | Riemann H Himathongkham S Willoughby D | 1998 | Avian Dis1998，42，1： | 1 |
| 11 | A survey for Salmonella by drag swabbing manure piles in California egg ranches显示文摘 | Riemann H Himathongkham S Willoughby D | 1998 | Avian Dis1998，42，1： | 1 |
| 12 | Neutralization of IL-12 in vivo prevents induction of contact hypersensitivity and induces hapten - specific tolerance 显示文摘 | Riemann H Schwarz A Grabbe S | 1996 | J Immunol1996，156，3： | 1 |
| 13 | In vivo effects of interleukin-10 on contact hypersensitivity and delayed-type hypersensitivity reactions显示文摘 | Grabbe S Riemann H | 1994 | J Invest Dermatol1994，103，2： | 1 |
| 14 | Detection and enrichment of disseminated renal carcinoma cells from peripheral blood by immunomagnetic cell separation显示文摘 | Bilkenroth U Taubert H Riemann D | 2001 | Int J Cancer2001，92，4： | 1 |
| 15 | Modulation of cutaneous inflammation by angiotensin- converting en- zyme显示文摘 | Scholzen TE Stander S Riemann H | 2003 | J Immunol2003，70，7： | 1 |
| 16 | ComparingSensitivity of Ecotoxicological Effect Endpoints between Laboratoryand Field 显示文摘 | SELCK H RIEMANN B CHRISTOFFERSEN K | 2002 | Ecotoxicology and Environmental Safety2002，52，： | 1 |
| 17 | Lateral photovoltage scanning(LPS) method for the visualization of the solid-liquid interface of Si1-x Gex single crystals 显示文摘 | ABROSIMOV NV LUDGE A RIEMANN H | 2002 | J of Crystal Growth2002，，： | 1 |
| 18 | Neutralization of IL-12 in vivo prevents induction of contact hypersensitivity and induces hapten - specific tolerance显示文摘 | RIEMANN H SCHWARZ A GRABBE S | 1996 | J Immunol1996，156，5： | 1 |
| 19 | DNA flow cytometric measurements in inflammatory and malignant human gastric lesions显示文摘 | Dernlein E Schmidt H Riemann JF | 1983 | Virchows Arch1983，402，2： | 1 |
| 20 | Trefoil factor 3 is induced during degenerative and inflammatory joint disease,activates matrix metalloproteinases,and enhances apoptosis of articular cartilage chondrocytes显示文摘 | R(o)sler S Haase T Claassen H Schulze U Schicht M Riemann D Brandt J Wohlrab D Müller-Hilke B Goldring MB Sel S Varoga D Garreis F Paulsen FP | | 0，，03： | 1 |
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