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246篇 您的检索式：作者名="REIMANN M"

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	题名	作者	年代	出处	被引量
1	Increased liver stiffness in alcoholic liver disease:Differentiating fibrosis from steatohepatitis显示文摘AIM:To test if inflammation also interferes with liver stiffness (LS) assessment in alcoholic liver disease (ALD) and to provide a clinical algorithm for reliable fibrosis assessment in ALD by FibroScan (FS).METHODS:We first performed sequential LS analysis before and after normalization of serum transaminases in a learning cohort of 50 patients with ALD admitted for alcohol detoxification. LS decreased in almost all patients within a mean observation interval of 5.3 d. Six patients (12%) would have been misdiagnosed with F3and F4 fibrosis but LS decreased below critical cut-off values of 8 and 12.5 kPa after normalization of trans-aminases. RESULTS:Of the serum transaminases,the decrease in LS correlated best with the decrease in glutamic oxaloacetic transaminase (GOT). No significant chang-es in LS were observed below GOT levels of 100 U/L. After establishing the association between LS and GOT levels,we applied the rule of GOT < 100 U/L for reliable LS assessment in a second validation cohort of 101 patients with histologically confi rmed ALD. By ex-cluding those patients with GOT > 100 U/L at the time of LS assessment from this cohort,the area under the receiver operating characteristic (AUROC) for cirrhosis detection by FS improved from 0.921 to 0.945 while specificity increased from 80% to 90% at a sensitivity of 96%. A similar AUROC could be obtained for lower F3 fibrosis stage if LS measurements were restricted to patients with GOT < 50 U/L. Histological grading of inflammation did not further improve the diagnostic accuracy of LS.CONCLUSION:Coexisting steatohepatitis markedly increases LS in patients with ALD independent of fibrosis stage. Postponing cirrhosis assessment by FS during alcohol withdrawal until GOT decreases to < 100 U/mL signif icantly improves the diagnostic accuracy.	Sebastian Mueller Gunda Millonig Lucie Sarovska Stefanie Friedrich Frank M Reimann Maria Pritsch Silke Eisele Felix Stickel Thomas Longerich Peter Schirmacher Helmut Karl Seitz	2010	World Journal of Gastroenterology2010，16，8：	10
2	Hypertension in the transgenic rat TGR (mRen-2)27 may be due to enhanced kinetics of the reaction between mouse renin and rat angiotensinogen 显示文摘	Tokita Y Franco-Saenz R Reimann E M etal	1994	Hypertension1994，23，4：	1
3	Guiding ACO by problem relaxtion: a case study on the symmetric TSP 显示文摘	REIMANN M	2007	Lecture Notes in Computer Science2007，4771，：	1
4	Carcinomashowing thymus-like differentiation of the thyroid(CASTLE):a comparative study:evidence of thymicdifferentiation and solid cell nest origin显示文摘	Reimann J D Dorfman D M Nos V	2006	Am J SurgPathol2006，30，8：	1
5	TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for neurokinin B in the central control of reproduc- tion显示文摘	Topaloglu A K Reimann F Guclu M	2009	Nat Genet2009，，41：	1
6	Olfactory training is helpful in postinfectious olfactory loss: A randomized, controlled, multicenter study显示文摘	Damm M Pikart L K Reimann H	2014	LARYNGOSCOPE2014，124，4：	1
7	The influence of growth rate on the formation and avoidance of C and N related precipitates during directional solidification of multi crystalline silicon显示文摘	M. Trempa C. Reimann J. Friedrich G. Müller	2010	Journal of Crystal Growth2010，，：	1
8	Quality information systems in advanced environments显示文摘	Srakis J Reimann M	1996	Quality Engineering1996，8，：	1
9	Electronic structure ofquantum dots 显示文摘	Reimann S M Manninen M	2002	Rev Mod Phys2002，74，：	1
10	Electronic structure of quantum dots显示文摘	Stephanie M Reimann Matti Manninen	2002	Review of Modern Physics2002，74，：	1
11	Analysis of the differential modulation of sulphonylurea block of β-cell and cardiac KATP channels by Mg-nucleotides 显示文摘	Reimann F Dabrowski M Jones P	2003	J Physiol2003，547，：	1
12	Competition-motivated Corporate Social Responsibility显示文摘	Kemper J Schilke O Reimann M Wang X Brettel M	2013	Journal of Business Research2013，66，10：	1
13	Theoretical analysis of dynamic force spectroscopy experiments on ligand-receptor complexes显示文摘	Raible M Evstigneev M Reimann P	2004	J Biotechnnl2004，112，12：	1
14	Comparing backhauling strategies in vehicle routing using ant colony optimization显示文摘	REIMANN M ULRICH U		0，，02：	1
15	Indications for the applicability of element signature analysis for the determination of the geographic origin of dried beef and poultry meat显示文摘	FRANKE B M HALDIMANN M REIMANN J		0，，3：	1
16	H-type Groups and Clifford Modules显示文摘	Reimann H M	2001	Advances in Applied Clifford Algebras2001，11，2：	1
17	Characterization of coronary atherosclerosis by dual-source computed tomography and HU-based color mapping: a pilot study显示文摘	Brodoefel H Reimann A Heuschmid M	2008	Eur Radiol2008，18，11：	1
18	Upregulation of gap junction protein connexin43 in alveolar epithelial cells of rats with radiation-induced pulmonary fibrosis显示文摘	Michael Kasper Otto Traub Thomas Reimann Leif Bjermer Heinz Gro?mann Martin Müller Klaus-Wolfgang Wenzel	1996	Histochemistry and Cell Biology1996，，4：	1
19	Usefulness of noninvasive cardiac imaging using dual-source computed tomography in an unselected population with high prevalence of coronary artery disease 显示文摘	Heuschmid M Burgstahler C Reimann A	2007	Am J Cardiol2007，100，4：	1
20	Vehicle routing with multiple deliverymen: Modeling and heuristic approaches for the VRPTW显示文摘	Pureza V Morabito R Reimann M	2012	European Journal of Operational Research2012，218，3：	1

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